| AUTHORS |
TITLE |
JOURNAL |
MILLAR EQPT. |
SUBJECT |
application |
---------------------------------------------Published in 2008--------------------------------------------- |
| Jin J-K, Whittaker R, Glassy MS, Barlow SB, Gottlieb RA, Glembotski CC |
Localization of phosphorylated αB-crystallin to heart mitochondria during ischemia-reperfusion |
Am J Physiol Heart Circ Physiol, Jan 2008; 294: H337 - H344 |
Millar pressure transducer |
mouse |
mitochondrial permeability transition; cardioprotection |
| Lorenz JN, Arend LJ, Robitz R, Paul RJ, MacLennan AJ |
Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice |
Am J Physiol Regulatory Integrative Comp Physiol, Jan 2007; 292: R440 - R446 |
SPR-671 |
mouse |
lysosphingolipids; endothelium; vascular smooth muscle; blood flow; myocardial contractility |
| Kiriazis H, Wang K, Xu Q, Gao X-M, Ming Z, Su Y, Moore X-L, Lambert G, Gibbs ME, Dart AM, Du X-J |
Knockout of [beta]1- and [beta]2-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis |
British Journal of Pharmacology 153, 684 - 692 (14 Jan 2008) |
1.4-Fr Millar catheter |
mouse |
adrenoceptors |
| Xiao HD, Fuchs S, Bernstein EA, Li P, Campbell DJ, Bernstein KE |
Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H659 - H667 |
SPR-671 |
mouse |
connexin; gene targeting; blood pressure; genetically modified mice |
| Esaki M, Takemura G, Kosai K, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H |
Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H1048 - H1057 |
SPR-671 |
mouse |
heart failure |
| Zhu M, Gach AA, Liu GX, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U |
Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active Gαo* protein |
Am J Physiol Heart Circ Physiol, Mar 2008; 294: H1335 - H1347 |
1.4-Fr high-fidelity micromanometer catheter |
mouse |
G proteins; signal transduction; calcium; contraction; transgenic mice |
| Kontaridis MI, WYang W, Bence KK, Cullen D, Wang B, NBodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG |
Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways |
Circulation, Mar 2008; 117: 1423 - 1435 |
SPR-671 |
mouse |
cardiomyocyte signaling pathways, protein tyrosine kinases |
| Yang Y, Ma Y, Han W, Li J, Xiang Y, Liu F, Ma X,Zhang J, Fu Z, Su Y-D, Du X-J, Gao X-M |
Age-related differences in postinfarct left ventricular rupture and remodeling |
Am J Physiol Heart Circ Physiol, Apr 2008; 294: H1815 - H1822. |
1.4 F Millar catheter |
mouse |
infarct expansion; collagen; matrix metalloproteinase; inflammatory cytokines |
| Mito S, Ozono R, Oshima T, Y, Watari Y, Yamamoto Y, Brydun A, Igarashi K, Yoshizumi M |
Myocardial Protection Against Pressure Overload in Mice Lacking Bach1, a Transcriptional Repressor of Heme Oxygenase-1 |
Hypertension, Apr 2008; doi:10.1161/HYPERTENSIONAHA.107.102566 |
1.4F Millar pressure catheter |
mouse |
hypertrophy • HO-1 • mice • oxidative stress • Bach1 • remodeling |
| Drouin A, Gendron M-È, Thorin E, Gillis M-A,Mahlberg-Gaudin , Tardif J-C |
Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice |
British Journal of Pharmacology (14 Apr 2008), doi: 10.1038/bjp.2008.116, Research Paper |
Millar catheter |
mouse |
hypercholesterolaemia, vasodilatation and acetylcholine, cardiac dysfunction, metoprolol, telemetry |
| Parrish DC, Gritman K, Van Winkle DM, Woodward WR, Bader M, Habecker BA |
Postinfarct sympathetic hyperactivity differentially stimulates expression of tyrosine hydroxylase and norepinephrine transporter |
Am J Physiol Heart Circ Physiol, Jan 2008; 294: H99 - H106 |
microtipped pressure transducer (2.0 French; Millar) |
rat |
ischemia-reperfusion; sympathetic hyperactivity; autonomic |
| Chen L,Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM |
Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia |
J Appl Physiol, Jan 2008; 104: 218 - 223 |
micromanometer-tipped catheters, 2.5 F |
rat |
obstructive sleep apnea; cardiac hypertrophy; apoptosis |
| El-Helou V, Proulx C, Gosselin H, Clement R, Mimee A, Villeneuve L, Calderone A |
Dexamethasone treatment of post-MI rats attenuates sympathetic innervation of the infarct region |
J Appl Physiol, Jan 2008; 104: 150 - 156 |
SPR-407 |
rat |
dexamethasone; neural remodeling; myocardial infarction; myofibroblasts; nerve growth factor |
| Yeih D-F, Lin L-Y, Yeh H-I, Lai Y-J, Chiang F-T, Tseng C-D, Chu S-H, Tseng Y-Z |
Temporal changes in cardiac force- and flow-generation capacity, loading conditions, and mechanical efficiency in streptozotocin-induced diabetic rats |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H867 - H874 |
2-Fr Millar catheter |
rat |
diabetes; contractile function; hemodynamics; mechanical efficiency; ventriculoarterial coupling |
| Varagic J, Frohlich ED, Susic D, Ahn J, López B, Díez J |
AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H853 - H858 |
Micro-Tip 3F |
rat |
left ventricular function; fibrosis; coronary circulation; angiotensi II type 1 receptor blocker |
| Fregosi RF |
Influence of tongue muscle contraction and dynamic airway pressure on velopharyngeal volume in the rat |
J Appl Physiol, Mar 2008; 104: 682 - 693 |
nonmagnetic pressure transducer |
rat |
apnea; functional electrical stimulation; hypoglossal nerve; magnetic resonance imaging; pharynx; upper airway |
| Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, Meloni M, Escher F, Filenberg E, Demir O, Li J, Shakibaei M, Schimke I, Staudt A, Felix SB, Schultheiss H-P, De Geest B, Tschöpe C |
Human Apolipoprotein A-I Gene Transfer Reduces the Development of Experimental Diabetic Cardiomyopathy |
Circulation, Mar 2008; 117: 1563 - 1573 |
2F-tip catheter |
rat |
cardiac oxidative stress, intramyocardial inflammation, cardiac fibrosis, and cardiac apoptosis. |
| Wu M-S, Liang J-T , Lin Y-D, Wu E-T, Tseng Y-Z, Chang K-C |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes |
British Journal of Pharmacology (31 Mar 2008), doi: 10.1038/bjp.2008.119, Research Paper |
SPC-320 |
rat |
advanced glycation end products, aminoguanidine, maximal systolic elastance, theoretical maximum flow, streptozotocin–nicotinamide diabetic rats |
| Lee T-M, Chen C-C, Lin M-S, Chang N-C |
Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats |
Am J Physiol Heart Circ Physiol, Apr 2008; 294: H1871 - H1879 |
SPR-407 |
rat |
myocardial infarction; nerve growth factor; rats; sympathetic reinnervation |
| Mito S, Ozono R, Oshima T, Yano Y, Watari Y, Yamamoto Y, Brydun A, Igarashi K, Yoshizumi M |
Myocardial Protection Against Pressure Overload in Mice Lacking Bach1, a Transcriptional Repressor of Heme Oxygenase-1 |
Hypertension, Jun 2008; 51: 1570 - 1577 |
1.4F Millar pressure catheter |
mouse |
hypertrophy • HO-1 • mice • oxidative stress • Bach1 • remodeling |
| Matsuhisa S, Otani H, Okazaki T, Yamashita K, Akita Y, Sato D, Moriguchi A, Imamura H, Iwasaka T |
Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart |
Am J Physiol Heart Circ Physiol, Jun 2008; 294: H2473 - H2479 |
2 F |
rat |
antioxidant; nitric oxide synthase |
| DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Heller RL, Bosanquet JP, Hayden MR, Delcour K, Cooper SA, Andresen BT, Sowers JR, Dellsperger KC |
Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat |
Am J Physiol Heart Circ Physiol, Jun 2008; 294: H2659 - H2668. |
Mikro-tip catheter |
rat |
renin; angiotensin II; NADPH oxidase |
| Yu Q, Nguyen T, Ogbi M, Caldwell RW, Johnson JA |
Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-ε inhibition |
Am J Physiol Heart Circ Physiol, Jun 2008; 294: H2637 - H2645 |
water-filled balloon-tipped Millar catheter |
rat |
preconditioning; protein kinase C; cytochrome oxidase subunit; coronary ligation; mitochondria |
| Kleiber AC, Zheng H, Schultz HD, Peuler JD, Patel KP |
Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure |
Am J Physiol Regulatory Integrative Comp Physiol, Jun 2008; 294: R1863 - R1872 |
Mikro-Tip catheter |
rat |
paraventricular nucleus; N-methyl-D-aspartic acid receptors; sympathetic nerve activity |
| Mczewski M, Mczewska J, Duda M |
Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptors |
British Journal of Pharmacology (09 Jun 2008), doi: 10.1038/bjp.2008.218 |
SPC-320 |
rat |
myocardial infarction, hypercholesterolaemia, statin, sartan, heart failure, remodelling, rat |
| Aubin M-C, Lajoie C, Clément R, Gosselin H, Calderone A, Perrault LP |
Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol |
J. Pharmacol. Exp. Ther. 2008 325: 961-968 |
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|
|
| Whiteaker P, Marks MJ, Christensen S, Dowell C, Collins AC, McIntosh MJ |
Synthesis and Characterization of 125 I-α-Conotoxin ArIB[V11L;V16A], a Selective α7 Nicotinic Acetylcholine Receptor Antagonist |
J. Pharmacol. Exp. Ther. 2008 325: 910-919 |
|
mouse |
|
| Oudit G Y,Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM |
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress |
Cardiovasc Res, 1 June 2008; 78: 505 - 514 |
1.4 French Millar catheter |
mouse |
Heart failure; Hypertrophy; Angiogenesis; Angiotensin II; Signalling |
---------------------------------------------Published in 2007--------------------------------------------- |
| Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L |
Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide-Gated Pacemaker Channels by Clonidine |
Circulation, Jan 2007; doi:10.1161/CIRCULATIONAHA.106.667675 |
1.4F Millar microtip device |
mouse |
receptors, adrenergic, alpha • heart rate • ion channels • pharmacology |
| Li Y, Takemura G, Okada H, Miyata S, Kanamori H, Maruyama R, Esaki M, Li L, Ogino A, Ohno T, Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H |
ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart |
Am J Physiol Heart Circ Physiol, Feb 2007; 292: H946 - H953 |
SPR-671 |
mouse |
angiotensin II; apoptosis; granulation tissue; heart failure; myocardial infarction; myofibroblast; scar |
| Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M,Lutz Hein L |
Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide–Gated Pacemaker Channels by Clonidine |
Circulation, Feb 2007; 115: 872 - 880 |
1.4F Millar microtip device |
mouse |
HCN channel inhibitors |
| Sekiguchi K, Tian Q, Ishiyama M, Burchfield J, Gao F, Mann DL, Barger PM |
Inhibition of PPAR-α activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-β/Smad3 |
Am J Physiol Heart Circ Physiol, Mar 2007; 292: H1443 - H1451 |
1.4-Fr microtipped Millar catheter |
mouse |
metabolism; inflammation; genes; signal transduction |
| Zhao X, Chen Y-R, He G, Zhang A, Druhan LJ, Strauch AR, Zweier JL |
Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart |
Am J Physiol Heart Circ Physiol, Mar 2007; 292: H1541 - H1550 |
SPR-261, 1.4 Fr |
mouse |
oxygen; superoxide; peroxynitrite; mitochondria; electron paramagnetic resonance; ischemia-reperfusion |
| Hanada K, Vermeij M, Garinis GA, de Waard MC, Kunen MGS, Myers L, Maas A, Duncker DJ, Meijers C, Dietz HC, Kanaar R, Essers J |
Perturbations of Vascular Homeostasis and Aortic Valve Abnormalities in Fibulin-4 Deficient Mice |
Circ. Res., Mar 2007; 100: 738 - 746 |
SPR-671 |
mouse |
aneurysm • aortic valve • mouse |
| Hansmann G, Wagner RA, Schellong S, Perez VAdJ, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M |
Pulmonary Arterial Hypertension Is Linked to Insulin Resistance and Reversed by Peroxisome Proliferator–Activated Receptor-γ Activation |
Circulation, Mar 2007; 115: 1275 - 1284 |
1.4F |
mouse |
insulin resistance, low plasma adiponectin levels, and deficiency of apoE |
| Said SI, Hamidi SA, Dickman KG, Szema AM, Lyubsky S, Lin RZ, Jiang Y-P, Chen JJ, Waschek JA, Kort S |
Moderate Pulmonary Arterial Hypertension in Male Mice Lacking the Vasoactive Intestinal Peptide Gene |
Circulation, Mar 2007; 115: 1260 - 1268 |
1.4F 3-cm Mikro-Tip catheter |
mouse |
VIP knockout (VIP–/–) |
| Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ |
Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease With Rescue by Resynchronization |
Hypertension, Mar 2007; doi:10.1161/HYPERTENSIONAHA.106.083568 |
1.4 French catheter |
mouse |
cardiac hypertrophy • renin-angiotensin-aldosterone system pathway • remodeling • gene expression microarrays •circadian |
| Belke DD, Swanson E, Suarez J, Scott BT, Stenbit AE, Dillmann WH |
Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1755 - H1763 |
2-Fr miniature pressure transducer |
mouse |
mitochondrial calcium; pyruvate dehydrogenase; cardiac energetics; sarco(endo)plasmic reticulum calcium-adenosine 5'-triphosphatase |
| Kanamori H, Takemura H, Li Y, Okada H, Maruyama R, Aoyama T, Miyata S, Esaki M, Ogino A, Nakagawa M, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara H |
Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2184 - H2194. |
SPR-671 |
mouse |
angiotensin; apoptosis; heart failure; myocardial infarction |
| Bendall JK, Rinze R, Adlam D, Tatham AL, de Bono J, Channon KM |
Endothelial Nox2 Overexpression Potentiates Vascular Oxidative Stress and Hemodynamic Response to Angiotensin II: Studies in Endothelial-Targeted Nox2 Transgenic Mice |
Circ. Res., Apr 2007; 100: 1016 - 1025 |
Millar catheter system |
mouse |
NADPH oxidase • oxidative stress • endothelium • hemodynamics |
| Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM |
A1 Adenosine Receptor Upregulation Accompanies Decreasing Myocardial Adenosine Levels in Mice With Left Ventricular Dysfunction |
Circulation, May 2007; 115: 2307 - 2315 |
1.4F micromanometer catheter |
mouse |
myocardial adenosine system |
| Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ |
Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease With Rescue by Resynchronization |
Hypertension, May 2007; 49: 1104 - 1113 |
1.4 French catheter |
mouse |
cardiac hypertrophy • renin–angiotensin–aldosterone system pathway • remodeling • gene expression microarrays • circadian |
| Monden Y, Kubota T, Inoue T, Tsutsumi T, Kawano S, Ide T, Tsutsui T, Sunagawa K |
Tumor necrosis factor-α is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H743 - H753 |
1.4-Fr micromanometer-tipped catheter |
mouse |
cytokines; heart failure; remodeling; interstitial fibrosis |
| Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M |
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H620 - H627 |
SPR-671 |
mouse |
echocardiography; heart failure; hypertrophy; mice |
| Wagenseil JE, Knutsen RH, Li DY, Mecham RP |
Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H574 - H582 |
catheter |
mouse |
arterial mechanics; extracellular matrix; high blood pressure; cardiac hypertrophy; two-kidney, one-clip hypertension |
| Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh GY, Kodama T, Hirota H, Otsu K, Hirano T, Mochizuki N |
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling |
J. Clin. Invest., Jul 2007; 117: 1771 - 1781 |
1.4 French high-fidelity pressure transducer catheter |
mouse |
scaffolding adaptor proteins |
| Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM |
Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload |
Circ. Res., Aug 2007; 101: e32 - e42 |
1.4 French Millar catheter, TCP-500 |
mouse |
aging • angiotensin • cardiac failure • cardiac function • pressure overload |
| Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S |
Soluble Guanylate Cyclase-α1 Deficiency Selectively Inhibits the Pulmonary Vasodilator Response to Nitric Oxide and Increases the Pulmonary Vascular Remodeling Response to Chronic Hypoxia |
Circulation, Aug 2007; 116: 936 - 943 |
1.4F Millar catheter |
mouse |
guanylate cyclase • nitric oxide • hypoxia • hypertension, pulmonary • remodeling |
| Huggins GS, Lepore JJ, Greytak S, Patten R, McNamee R, Aronovitz M, Wang PJ, Reed GL |
The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1877 - H1882 |
1.4-Fr Millar pressure catheter |
mouse |
adenosine 3',5'-cyclic monophosphate responsive element binding protein |
| Palmer LA, Doctor A, Chhabra P, Sheram M:,Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B |
S-Nitrosothiols signal hypoxia-mimetic vascular pathology |
J. Clin. Invest., Sep 2007; 117: 2592 - 2601 |
Millar 1.4 F catheter/transducer |
mouse |
chronic NAC administration, pulmonary arterial hypertension |
| Khan M, Kutala VK, Vikram DS, Wisel S, Chacko SM, Kuppusamy ML, Mohan IK, Zweier JL, Kwiatkowski P, Kuppusamy P |
Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2129 - H2139 |
SPR-1000 |
mouse |
ischemic heart; myocardial infarction; electron paramagnetic resonance oximetry; OxySpin |
| Ogino A, Takemura G, Kanamori H, Okada H, Maruyama R, Miyata S, Esaki M, Nakagawa M, Aoyama T, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara T, Fujiwara H |
Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2271 - H2280 |
SPR 671 |
mouse |
Ca2+ channels; heart failure |
| Gendron M-E, Thorin E |
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2508 - H2515 |
Millar catheter |
mouse |
nitric oxide; cyclooxygenase; reactive oxygen species |
| Bostick B, Yue Y, Long C, Duan D |
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression |
Circ. Res., Oct 2007; doi:10.1161/CIRCRESAHA.107.162982 |
closed-chest Millar catheter |
mouse |
cardiomyopathy • gene therapy • myocardium • genetics • heart disease |
| Desjardins J-F, Teichert-Kuliszewska K, Quan A, Verma S, Stewart DJ, Parker TG |
Abstract 444: Absence of S100A1 in Mice is Associated With a Hypertensive Phenotype Dependent on Both Gender and Endothelial Function |
Circulation, Oct 2007; 116: II_74 |
Millar catheter |
mouse |
cardiac muscle Ca2+ homeostasis |
| Partovian C, Zhuang ZW, Martin KA, Simons M |
Abstract 326: Syndecan-4 Knockout Mice Exhibit Decreased eNOS Activity And Increased Blood Pressure Via Disruption Of mTOR Complex Assembly In Raft Domains |
Circulation, Oct 2007; 116: II_47 |
Millar transducer |
mouse |
eNOS activity and angiogenesis |
| Horstkotte J, Lange P, Schroeder M, Schneider M, Perisic T, Hinkel R, Kiermayer C, Brielmeier M, Boekstegers P, Markus C, Kupatt C |
Abstract 1010: Endogenous Mitochondrial, But Not Cytosolic Thioredoxin Reductase Protects Against Myocardial Ischemia-reperfusion Injury |
Circulation, Oct 2007; 116: II_201 |
Millar tip catheter |
mouse |
protective ROS-scavenging, knock-out mouse |
| Iwasaki M, Koyanagi M, Rapp S, Schuetz C, Bushoven P, Schranz D, Galvez BG, Cossu G, Zeiher AM, Urbich C, Dimmeler S |
Abstract 855: Circulating Mesoangioblasts Differentiate Into Cardiac Myocytes And Improve Function After Acute Myocardial Infarction |
Circulation, Oct 2007; 116: II_166 |
Millar catheter |
mouse |
Cardiac Regeneration/Cellular Therapy-Experimental: Stem Cell Origin and Myocardial Homing, nude mouse |
| Tang YL, Shen L, Qian K, Phillips MI |
Abstract 859: Hypoxia-activated CXCR4 Expression In Cardiac Progenitor Cells For Replenishing Stem Cell Pool In Acute Ischemic Myocardium |
Circulation, Oct 2007; 116: II_167 |
Millar catheter |
mouse |
Cardiac Regeneration/Cellular Therapy-Experimental: Stem Cell Origin and Myocardial Homing |
| Urashima T, Zhao M, Wagner R, Fajardo G, Farahani S, Quertermous T, Bernstein D |
Abstract 3129: Molecular and Physiologic Characterization of RV Remodeling and Failure in a Murine Model of Mild, Moderate and Severe Pulmonary Stenosis |
Circulation, Oct 2007; 116: II_702 |
Millar catheter |
mouse |
Mechanical Regulation of the Right Side of the Heart in Congenital Heart Disease: Influence of Age and Hemodynamic Load |
| Diwan A, Krenz M, Syed FM, Wansapura J, Ren X, Koesters AG, Li H, Kirshenbaum LA, Hahn HS, Robbins J, Jones WK, Dorn II GW |
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice |
J. Clin. Invest., Oct 2007; 117: 2825 - 2833 |
1.4 French Millar solid-state catheters |
mouse |
proapoptotic gene |
| Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, Molkentin JD |
Inducible and myocyte-specific inhibition of PKC enhances cardiac contractility and protects against infarction-induced heart failure |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3768 - H3771 |
1.4 F Millar catheter |
mouse |
protein kinase C; signaling; myocardial infarction |
| El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M |
Smooth Muscle Protein 22–Mediated Patchy Deletion of Bmpr1a Impairs Cardiac Contractility but Protects Against Pulmonary Vascular Remodeling |
Circ. Res., Dec 2007; doi:10.1161/CIRCRESAHA.107.161059 |
1.4F Millar catheter |
mouse |
Bmpr1a (Alk3) • pulmonary hypertension • hypoxia • vascular remodeling • smooth muscle cell • pericytes • proliferation • apoptosis • transgenic mice |
| Rose RA,Kabir MG, Backx PH |
Altered Heart Rate and Sinoatrial Node Function in Mice Lacking the cAMP Regulator Phosphoinositide 3-Kinase-g |
Circ. Res., Dec 2007; 101: 1274 - 1282. |
pressure catheter |
mouse |
ion channels • electrophysiology • action potentials • arrhythmia |
| Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Ogino A, Maruyama R, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H, Takemura G |
Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy |
Laboratory Investigation 87, 440 - 455 (05 Mar 2007) |
SPR 671 |
mouse |
cardiomyopathy, cytokines, doxorubicin, ERK, G-CSF, heart failure |
| Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, Koike K, Tsujimoto G, Tanoue A |
α1-Adrenoceptors are required for normal male sexual function |
British Journal of Pharmacology 152, 332 - 340 (01 Oct 2007) |
SPR-671 |
mouse |
α1-Adrenoceptor, ejaculation, vas deferens |
| Johns, DG Behm DJ, Walker DJ, Ao Z, Shapland EM, Daniels DA, Riddick M, Dowell S, Staton PC, Green P, Shabon U, Bao W, Aiyar N, Yue T-L, Brown AJ, Morrison AD, Douglas SA |
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects |
British Journal of Pharmacology 152, 825 - 831 (20 Aug 2007) |
SPR-671 |
mouse |
GPR55, cannabinoid receptors, abnormal cannabidiol, CBx receptor |
| Reddy MK, Schultz HD, Zheng H, Patel KP |
Altered nitric oxide mechanism within the paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failure |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H149 - H157 |
2-Fr micromanometer-tipped catheter |
rat |
renal sympathetic nerve activity; phrenic nerve activity; hypothalamus |
| Susic D, Varagic J, Ahn J, Matavelli L, Frohlich ED |
Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H175 - H179 |
catheter-tip transducer |
rat |
aldosterone; myocardial fibrosis; left ventricular diastolic function; minimal vascular resistance; antihypertensive/diuretics |
| Pan Y-X, Gao L, Wang W-Z, Zheng H, Liu D, Patel KP, Zucker IH, Wang W |
Exercise Training Prevents Arterial Baroreflex Dysfunction in Rats Treated With Central Angiotensin II |
Hypertension, Jan 2007; doi:10.1161/01.HYP.0000256955.74461.93 |
SPR-524 |
rat |
exercise • baroreflex • sympathetic nerve activity • reactive oxygen species • AT1 receptor |
| Li J, Gao Z, Kehoe V, Sinoway LI |
Interstitial K+ concentration in active muscle after myocardial infarction |
Am J Physiol Heart Circ Physiol, Feb 2007; 292: H808 - H813 |
2-Fr microMillar pressure transducer catheter |
rat |
sympathetic nervous system; exercise; blood flow |
| Gao Z, Xing J, Sinoway L, Li J |
P2X receptor-mediated muscle pressor reflex in myocardial infarction |
Am J Physiol Heart Circ Physiol, Feb 2007; 292: H939 - H945 |
Millar catheter |
rat |
exercise; blood pressure; sympathetic nervous system; dorsal root ganglion; heart failure |
| Rennison JH, McElfresh TA, Okere IC, Vazquez EJ, Patel HV, Foster AB, Patel KK, Chen Q, Hoit BD, Tserng K-Y, Hassan MO, Hoppel CL, Chandler MP |
High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction |
Am J Physiol Heart Circ Physiol, Mar 2007; 292: H1498 - H1506 |
3.5 Fr |
rat |
oxidative phosphorylation; electron transport chain; ceramide; lipotoxicity |
| Helwig BG, Musch TI, Craig RA, Kenney MJ |
Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure |
Am J Physiol Regulatory Integrative Comp Physiol, Mar 2007; 292: R1165 - R1173. |
2-Fr catheter-tip pressure manometer |
rat |
signal transduction; gp130; hypothalamic-pituitary axis |
| Sethi R, Saini HK, Wang X, Elimban V, Dhalla NS |
Dependence of changes in β-adrenoceptor signal transduction on type and stage of cardiac hypertrophy |
J Appl Physiol, Mar 2007; 102: 978 - 984 |
SPR-249 |
rat |
pressure overload; volume overload; cardiac function; β-adrenoceptors; adenylyl cyclase; intracellular calcium concentr |
| Pan Y-X, Gao L, Wang W-Z, Zheng H, Liu D, Patel KP, Zucker IH, Wang W |
Exercise Training Prevents Arterial Baroreflex Dysfunction in Rats Treated With Central Angiotensin I |
Hypertension, Mar 2007; 49: 519 - 527 |
SPR-524 |
rat |
exercise • baroreflex • sympathetic nerve activity • reactive oxygen species • AT1 receptor |
| Milano G, Morel S, Bonny C, Samaja M, von Segesser LK, Nicod P, Vassalli G |
A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1828 - H1835 |
MPC-500 |
rat |
myocardium; mitogen-activated protein kinases; apoptosis; isolated |
| Simpson JA, Iscoe S |
Cardiorespiratory failure in rat induced by severe inspiratory resistive loading |
J Appl Physiol, Apr 2007; 102: 1556 - 1564 |
SPR 524 |
rat |
diaphragm; fatigue; heart; injury; troponin |
| Cosson E, Herisse M, Laude E, Thomas F, Valensi P, Attali J-R, Safar ME, Dabire H |
Aortic stiffness and pulse pressure amplification in Wistar-Kyoto and spontaneously hypertensive rats |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2506 - H2512 |
SPR-330 |
rat |
pulse wave velocity; body weight; conscious rat; autonomic nervous system |
| Garg P, Martin CF, Elms SC, Gordon FJ, Wall SM, Garland CJ, Sutliff RL, O'Neill WC |
Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2100 - H2105 |
SPR-671 |
rat |
resistance arteries; hypertension; bumetanide |
| Chicco AJ, Johnson MS, Armstrong CJ, Lynch JM, Gardner RT, Fasen GS, Gillenwater CP, Moore RL |
Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2432 - H2437 |
3-Fr pressure-transducing catheter |
rat |
ischemia; infarction; sex differences; gender |
| Gao E, Boucher M, Chuprun JK, Zhou R-H, Eckhart AD, Koch WJ |
Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H60 - H68 |
2-Fr micromanometer |
rat |
myocardial ischemia; ischemia-reperfusion injury; apoptosis |
| van Hees HWH, van der Heijden HFM, Ottenheijm CAC, Heunks LMA, Pigmans CJC, Verheugt FWA, Brouwer RMHJ, Dekhuijzen PNR |
Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H819 - H828 |
SPC-330 |
rat |
skinned muscle single fibers; cross-bridge cycling kinetics; Ca2+ sensitivity; proteasome; caspase-3 |
| Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K |
Adenoassociated Virus-Mediated Prostacyclin Synthase Expression Prevents Pulmonary Arterial Hypertension in Rats |
Hypertension, Jul 2007; doi:10.1161/HYPERTENSIONAHA.107.091348 |
SPC-320 |
rat |
hypertension • pulmonary • gene therapy • remodeling • prostacyclin synthase |
| Henkens IR, Mouchaers KTB, Vliegen HW, van der Laarse WJ, Swenne CA, Maan AC, Draisma HHM, Schalij I, van der Wall EE, Schalij MJ, Vonk-Noordegraaf A |
Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1300 - H1307 |
Millar pressure catheter |
rat |
right ventricular hypertrophy; monocrotaline; electrocardiogram |
| Lee T-M, Lin M-S, Chang N-C |
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H968 - H977 |
SPR-407 |
rat |
hypertrophy; infarction |
| Xing J, Koba S, Kehoe V, Gao Z, Rice K, King N, Sinoway L, Li J |
Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1190 - H1195 |
2-Fr micro-Millar pressure transducer catheter |
rat |
nervous system; sympathetic; exercise; blood flow |
| Yamamoto T, Shirayama T, Sakatani T, Takahashi T, Tanaka H, Takamatsu T, Spitzer KW, Matsubara H |
Enhanced activity of ventricular Na+-HCO3– cotransport in pressure overload hypertrophy |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1254 - H1264 |
Microtip catheter |
rat |
cardiac myocytes; intracellular pH regulation; messenger ribonucleic acid; polymerase chain reaction |
| Schultz RL, Swallow JG, Waters RP, Kuzman JA, Redetzke RA, Said S, de Escobar GM, Gerdes AM |
Effects of Excessive Long-Term Exercise on Cardiac Function and Myocyte Remodeling in Hypertensive Heart Failure Rats |
Hypertension, Jun 2007; doi:10.1161/HYPERTENSIONAHA.106.086371 |
Millar Mikro-tip catheter |
rat |
hypertension • heart failure • exercise • hypertrophy • myocytes • voluntary wheel running • SHHF |
| Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K |
Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats |
Circ. Res., Aug 2007; doi:10.1161/CIRCRESAHA.107.153023 |
SPC-320 |
rat |
pulmonary hypertension • interleukins • gene therapy • inflammation • vascular smooth muscle cell proliferation |
| Chandler MP, Morgan EE, McElfresh TA, Kung TA, Rennison JH, Hoit BD, Young ME |
Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1609 - H1616 |
3.5-Fr pressure transducer |
rat |
contractile function; left ventricular remodeling; gene expression |
| Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K |
Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats |
Circ. Res., Sep 2007; 101: 734 - 741 |
SPC-320 |
rat |
pulmonary hypertension • interleukins • gene therapy • inflammation • vascular smooth muscle cell proliferation |
| Yildirim Y, Naito H, Didié M, Karikkineth BC, Biermann D, Eschenhagen T, Zimmermann W-H |
Development of a Biological Ventricular Assist Device: Preliminary Data From a Small Animal Model |
Circulation, Sep 2007; 116: I-16 - I-23 |
Millar-tip catheter |
rat |
tissue engineering • myocardium • cardiomyocyte • regeneration • transplantation |
| Sartório CL, Fraccarollo D, Galuppo P, Leutke M, Ertl G, Stefanon I, Bauersachs J |
Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction |
Hypertension, Sep 2007; doi:10.1161/HYPERTENSIONAHA.107.093450 |
micromanometer |
rat |
aldosterone • acute myocardial infarction • endothelial dysfunction • oxidative stress |
| Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K |
Adenoassociated Virus–Mediated Prostacyclin Synthase Expression Prevents Pulmonary Arterial Hypertension in Rats |
Hypertension, Sep 2007; 50: 531 - 536 |
SPC-320 |
rat |
hypertension • pulmonary • gene therapy • remodeling • prostacyclin synthase |
| Farahmand P, Weisel RD, Menasche P, Li R-K |
Abstract 2673: Myoblast Transplantation Improves Cardiac Function Whether the Cells are Implanted Early or Late After Coronary Ligation |
Circulation, Oct 2007; 116: II_592 |
Millar catheter |
rat |
myocardial infarction |
| Behnke BJ, Delp MD, Poole DC, Musch TI |
Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenation |
J Appl Physiol, Nov 2007; 103: 1757 - 1763 |
2-Fr catheter-tip pressure manometer |
rat |
heart failure; skeletal muscle; oxygen exchange |
| Sartório CL, Fraccarollo D, Galuppo P, Leutke M, Ertl G, Stefanon I, Bauersachs J |
Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction |
Hypertension, Nov 2007; 50: 919 - 925 |
micromanometer |
rat |
aldosterone • acute myocardial infarction • endothelial dysfunction • oxidative stress |
| Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, zu LT, Balke CW |
Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3301 - H3310 |
SPR-249A, SPR-671 |
rat |
heart failure; action potential; L-type Ca2+ channel; ryanodine receptor |
| Lee T-M, Lin M-S, Chang N-C |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3617 - H3626 |
SPR-407 |
rat |
immunohistochemistry; ion channels; myocardial infarction; norepinephrine; polymerase chain reaction |
| Hydock DS, Lien C-Y, Schneider CM, Hayward R |
Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3254 - H3264 |
SPR-671 |
rat |
echocardiography; myosin heavy chain; orchiectomy; ovariectomy; sex hormones |
| Chang K-C, Liang J-T, Tseng C-D, Wu E-T, Hsu K-L, Wu M-S, Lin Y-T, Tseng Y-Z |
Aminoguanidine prevents fructose-induced deterioration in left ventricular?arterial coupling in Wistar rats |
British Journal of Pharmacology 151, 341 - 346 (02 Apr 2007) |
SPC-320 |
rat |
aminoguanidine, effective arterial volume elastance, fructose loading, end-systolic elastance, ventricular–arterial coupling |
| |
---------------------------------------------Published in 2006--------------------------------------------- |
| Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R |
Apoptosis Repressor With Caspase Recruitment Domain Is Required for Cardioprotection in Response to Biomechanical and Ischemic Stress |
Circulation, Mar 2006; 113: 1203 - 1212 |
high-fidelity catheter tip transducer, 1.4F |
mouse |
apoptosis, heart failure, hypertophy, ischemia, myocardial infarction |
| Peng X, Kraus MS, Wei H, Shen T-L, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan J-L |
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice |
J Clin Invest. 2006 January 4; 116(1): 217–227 |
1.4-F Millar catheter–tip micromanometer catheter |
mouse |
cytoplasmic tyrosine kinase, CFKO |
| Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA |
Soy diet worsens heart disease in mice |
J. Clin. Invest. 116:209-216 (2006). |
1.4-fr Millar Mikro-tip pressure transducer |
mouse |
glycogen synthase kinase 3ß, caspase-3 activation, fibrosis, ß-myosin heavy chain, hypertrophic cardiomyopathy |
| Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, McClister Jr DM, Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG |
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction |
Am J Physiol Heart Circ Physiol, Jan 2006; 290: H232 - H239 |
SPR-671 |
mouse |
leukocytes; remodeling; imaging |
| Li Y, Takemura G, Okada H, Miyata S, Esaki M, Maruyama R, Kanamori H, Li L, Ogino A, Misao Y, Khai NC, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H |
Treatment with granulocyte colony-stimulating factor ameliorates chronic heart failure |
Laboratory Investigation 86, 32-44 (01 Jan 2006) |
SPR-407 |
mouse |
chronic heart failure; cytokines; G-CSF; remodeling; signal transduction |
| Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD |
GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation |
Circ. Res., Feb 2006; 98: 342 - 350 |
1.4F Millar catheter |
mouse |
cardiac • signaling • hypertrophy • growth factors • mouse genetics |
| Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, . Wollert KC |
The Transforming Growth Factor-ß Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury |
Circ. Res., Feb 2006; 98: 351 - 360 |
1.4 F Millar catheter |
mouse |
growth-differentiation factor-15 • ischemia/reperfusion • apoptosis • PI3K • Akt |
| Fitch RM, Rutledge JC, Wang Y-X, Powers AF, Tseng J-L, Clary T, Rubanyi GM |
Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice |
Am J Physiol Heart Circ Physiol, Mar 2006; 290: H1190 - H1198 |
1.4-Fr Millar Mikrotip pressure transducer |
mouse |
blood pressure; vascular smooth muscle; collagen; elastin; Nω-nitro-L-arginine methyl ester |
| Kakkar R, Ye B, Stoller DA, Smelley M, Shi N-Q, Galles K, Hadhazy M, Makielski JC, McNally EM |
Spontaneous Coronary Vasospasm in KATP Mutant Mice Arises From a Smooth Muscle–Extrinsic Process |
Circ. Res., Mar 2006; 98: 682 - 689 |
pressure-sensing catheter |
mouse |
KATP channel • sulfonylurea receptor • vasospasm • smooth muscle |
| Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R |
Apoptosis Repressor With Caspase Recruitment Domain Is Required for Cardioprotection in Response to Biomechanical and Ischemic Stress |
Circulation, Mar 2006; 113: 1203 - 1212 |
1.4F |
mouse |
ARC, tissue-specific antiapoptotic factor |
| Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim I-H, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld A-J, Collen D, Busse R, Janssens S |
Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling |
Hypertension, Apr 2006; 47: 762 - 770 |
1.4F Millar catheter |
mouse |
endothelium-derived factors • arachidonic acids • endothelium-derived factors • lung • remodeling |
| Matsushima S, Ide T, Yamato M, Matsusaka H, Hattori F, Ikeuchi M, Kubota T, Sunagawa K, Hasegawa Y, Kurihara T, Oikawa S, Kinugawa S, Tsutsui H |
Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice |
Circulation, Apr 2006; 113: 1779 - 1786 |
Millar catheter (1.4 F) |
mouse |
myocyte hypertrophy, interstitial fibrosis, apoptosis |
| Yamamoto K, Ohishi M, Katsuya T, Ito N, Ikushima M, Kaibe M, Tatara Y, Shiota A, Sugano S, Takeda S, Rakugi H, Ogihara T |
Deletion of Angiotensin-Converting Enzyme 2 Accelerates Pressure Overload-Induced Cardiac Dysfunction by Increasing Local Angiotensin II |
Hypertension, Apr 2006; 47: 718 - 726 |
micro-tip catheter |
mouse |
hypertrophy • remodeling • angiotensin antagonist • receptors, angiotensin |
| Matsusaka H, Ide T, Matsushima S, Ikeuchi M, Kubota T, Sunagawa K, Kinugawa S, Tsutsui H |
Targeted Deletion of Matrix Metalloproteinase 2 Ameliorates Myocardial Remodeling in Mice With Chronic Pressure Overload |
Hypertension, Apr 2006; 47: 711 - 717 |
1.4-Fr micromanometer-tipped catheter |
mouse |
hypertrophy • heart failure • fibrosis • extracellular matrix • hypertension, experimental • myocardium |
| Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS |
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin |
J. Clin. Invest., May 2006; 116: 1337 - 1345 |
Millar 1.4 French blood pressure probe and transducer |
mouse |
FSGS, end-stage renal disease |
| MacGowan GA, Kirk JA, Evans C, Shroff SG |
Pressure-calcium relationships in perfused mouse hearts |
Am J Physiol Heart Circ Physiol, Jun 2006; 290: H2614 - H2624 |
MPC-500 |
mouse |
murine heart; length-dependent activation; load-dependent relaxation; excitation-contraction coupling; model-based analysis |
| Okere IC, MChandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, Tserng K-Y, Hoit BD, Ernsberger P, Young ME, Stanley WC |
Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H38 - H44 |
3.5-Fr pressure transducer |
mouse |
myocardial infarction; cardiac injury; murine model |
| Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M |
Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H379 - H384 |
SPR-671 |
mouse |
myocardial infarction; cardiac injury; murine model |
| Rodriguez WE,Joshua IG, Falcone JC, Tyagi SC |
Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H81 - H87 |
pressure-tipped Millar catheter |
mouse |
endothelial myocyte coupling; nitric oxide; matrix metalloproteinase; homocysteine; heart failure; acetylcholine; nitroprusside; cardiac rings; peroxisome proliferator |
| Kuhlencordt PJ, Hötten S, Schödel J, Rützel S, Hu K, Widder J, Marx A, Huang PL, Ertl G |
Atheroprotective Effects of Neuronal Nitric Oxide Synthase in Apolipoprotein E Knockout Mice |
Arterioscler. Thromb. Vasc. Biol., Jul 2006; 26: 1539 - 1544 |
1.4 F |
mouse |
nitric oxide • nitric oxide synthase • arteriosclerosis • blood pressure • gene expression |
| Larsen K-O, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G |
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H507 - H516 |
SPR-671 |
mouse |
diastole; calcium; echocardiography |
| Neilan TG, Doherty GA, Chen G, Deflandre C, McAllister H, Butler RK, McClelland SE, Kay E, Ballou LR, Fitzgerald DJ |
Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H532 - H536 |
SPR-671, ARIA pressure conductance system |
mouse |
apoptosis; cyclooxygenase |
| Zhou H_Z, Swanson RA, Simonis U, Ma X, Cecchini G, Gray MO |
Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse hearts |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H714 - H723 |
micromanometer catheter |
mouse |
oxidative stress; energetics; metabolism; glycolysis |
| Tong XY, Porter LM, Liu GX, Dhar-Chowdhury P, Srivastava S, Pountney DJ, Yoshida H, Artman M, Fishman GI, Yu C, Iyer R, Morley GE, Gutstein DE, Coetzee WA |
Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H543 - H551 |
1.4F Mikro-Tip catheter pressure transducer |
mouse |
potassium channels; ATP-sensitive K+ channel; heart; ventricle; stress responses |
| Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, Kimball TF, Hewett TE, Dorn II GW, Koch WJ, Molkentin JD |
Pharmacological- and Gene Therapy-Based Inhibition of Protein Kinase Cα/ß Enhances Cardiac Contractility and Attenuates Heart Failure |
Circulation, Aug 2006; 114: 574 - 582 |
1.4F Millar catheter |
mouse |
Ro-32-0432, Ro-31-8220 |
| Kawano S, Kubota T, Monden Y, Tsutsumi T,Inoue T, Kawamura N, Tsutsui T, Sunagawa K |
Blockade of NF-κB improves cardiac function and survival after myocardial infarction |
Am J Physiol Heart Circ Physiol, Sep 2006; 291: H1337 - H1344 |
1.4-F micromanometer-tipped catheter |
mouse |
cardiac remodeling; inflammation; mitogen-activated protein kinases |
| Sheikh F, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard J-C, Chen J |
α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture |
Circulation, Sep 2006; 114: 1046 - 1055 |
1.4F Millar catheter-tip micromanometer catheter |
mouse |
cardiomyocyte |
| Matsushima S, Kinugawa S, Ide T, Matsusaka H, Inoue N, Ohta Y, Yokota T, Sunagawa L, Tsutsui H |
Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart |
Am J Physiol Heart Circ Physiol, Nov 2006; 291: H2237 - H2245 |
1.4-Fr micromanometer-tipped catheter |
mouse |
oxidative stress; diabetes mellitus; heart failure; antioxidant; hypertrophy; glutathione peroxidase |
| Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD |
Calcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice |
Circulation, Nov 2006; 114: 2065 - 2069 |
1.4F microtransducer-tipped catheter |
mouse |
calcification and oxidative stress in the aortic valve |
| Belke DD, Gloss B, Hollander JM, Swanson EA, Duplain H, Dillmann WH |
n vivo gene delivery of HSP70i by adenovirus and adeno-associated virus preserves contractile function in mouse heart following ischemia-reperfusion |
Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2905 - H2910 |
2-Fr Millar pressure transducer |
mouse |
inducible heat shock protein 70; left ventricle |
| Bloch O, Auguste KI, Manley GT, Verkman AS |
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice |
Journal of Cerebral Blood Flow & Metabolism 26, 1527 - 1537 |
SPR-320, TC-510 |
mouse |
AQP4, blood–brain barrier, hydrocephalus, interstitial edema, water channel |
| Sakamoto M, Minamino M, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I |
Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy |
Circ. Res., Dec 2006; 99: 1411 - 1418 |
polyethylene catheter |
mouse |
pressure overload • exercise • heart failure |
| Vercauteren M, Remy E, Devaux C, Dautreaux B, Henry J-P, Bauer F, Mulder P, van Huijsduijnen RH, Bombrun A, Thuillez C, Richard V |
Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure |
Circulation, Dec 2006; 114: 2498 - 2507 |
1.2F micromanometer |
mouse |
Chronic heart failure |
| Krummen S, Drouin A, Gendron M-E, Falck JR, Thorin E |
ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice |
British Journal of Pharmacology 147, 897 - 904 (01 Apr 2006) |
Millar catheter |
mouse |
Endothelium, gracilis artery, EDHF, hypercholesterolaemia, triglycerides, ageing, reactive oxygen species, mouse |
| Zhou H, Liu H, Porvasnik SL, Terada N, Agarwal A, Cheng Y, Visner GA |
Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension |
Laboratory Investigation (2006) 86, 62-71 |
Millar catheter |
rat |
animal model; aorta; heme oxygenase; monocrotaline; pulmonary hypertension; rapamycin |
| Hacker TA, McKiernan SH, Douglas PS, Wanagat J, Aiken JM |
Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats |
Am J Physiol Heart Circ Physiol, Jan 2006; 290: H304 - H311 |
2-French micromanometer-tipped catheter |
rat |
hybrid rat; echocardiography |
| Souzeau E, Llamas B, Bélanger S, Picard S, Deschepper CF |
A Genetic Locus Accentuates the Effect of Volume Overload on Adverse Left Ventricular Remodeling in Male and Female Rats |
Hypertension, Jan 2006; 47: 128 - 133 |
2-F single sensor pressure catheter |
rat |
hypertrophy • myocardium • myocytes • heart failure • genetics • gender • natriuretic peptides |
| Chicco AJ, Hydock DS, Schneider CM, Hayward R |
Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity |
J Appl Physiol, Feb 2006; 100: 519 - 527 |
microtip catheter pressure transducer |
rat |
adriamycin; apoptosis; physical activity; cardioprotection; myosin heavy chain |
| Burgoyne JR, Brennan JP, Eaton P |
BSCR AUTUMN MEETING 2005, 001 STUDIES ASSESSING PROTEIN S-NITROSYLATION IN THE RAT HEART |
Heart, Feb 2006; 92: e1 |
1.4 F Millar catheter |
rat |
S-nitrosylated proteins |
| Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C |
Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo |
Am J Physiol Heart Circ Physiol, Mar 2006; 290: H985 - H994 |
microconductance pressure catheter |
rat |
dominant negative myeloid differentiation factor-88; nuclear factor-κB; signal transduction |
| Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, Lakatta EG, Fedorova OV, Bagrov AY, Shapiro JI |
Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy |
Hypertension, Mar 2006; 47: 488 - 495 |
2F Millar Microtip Catheter |
rat |
cardiomyopathy • sarcoplasmic reticulum • cardiotonic agents • fibrosis • renal failure • reactive oxygen species |
| Schellings MWM, Baumann M, van Leeuwen REW, Duisters RFJJ, Janssen SHP, Schroen B, Peutz-Kootstra CJ, Heymans S, Pinto YM |
Imatinib Attenuates End-Organ Damage in Hypertensive Homozygous TGR(mRen2)27 Rats |
Hypertension, Mar 2006; 47: 467 - 474 |
2F Millar microtip catheter |
rat |
platelet-derived growth factor • angiotensin II • hypertrophy • fibrosis |
| Varagic J, Frohlich ED, Díez J, Susic D, Ahn J, González A, López B |
Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1503 - H1509 |
Micro-Tip 3F |
rat |
sodium excess; left and right ventricular function; spontaneously hypertensive rats; Wistar-Kyoto rats |
| Frank Langer , Filiberto Rodriguez, Allen Cheng, Saskia Ortiz, Tom C. Nguyen, Mary K. Zasio, David Liang, George T. Daughters, Neil B. Ingels, and D. Craig Miller |
Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarction |
J. Thorac. Cardiovasc. Surg., Apr 2006; 131: 889 - 897 |
Millar catheter |
rat |
Ventricular function, regional blood flow, and arteriole density |
| Morgan EE, Rennison JH, Young ME, McElfresh TA, Kung TA, Tserng K-Y, Hoit BD, Stanley WC, Chandler MP |
Effects of chronic activation of peroxisome proliferator-activated receptor- or high-fat feeding in a rat infarct model of heart failure |
Am J Physiol Heart Circ Physiol, May 2006; 290: H1899 - H1904 |
3,5 Fr |
rat |
cardiac; left ventricular dysfunction; ceramide; triglycerides; fatty acids |
| Carroll JF, Zenebe WJ, Strange TB |
Cardiovascular Function in a Rat Model of Diet-Induced Obesity |
Hypertension, May 2006; doi:10.1161/01.HYP.0000224147.01024.77 |
SPR-249 |
rat |
hypertrophy • echocardiography • blood pressure • cardiac output • rats • diurnal rhythm |
| Lunde PK, Sejersted OM, Thorud H-MS, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J |
Effects of Congestive Heart Failure on Ca2+ Handling in Skeletal Muscle During Fatigue |
Circ. Res., May 2006; doi:10.1161/01.RES.0000226529.66545.e5 |
SPR-407 |
rat |
skeletal muscle • congestive heart failure • muscle fatigue • Ca2+ |
| Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL |
An Abnormal Mitochondrial–Hypoxia Inducible Factor-1–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension |
Circulation, Jun 2006; 113: 2630 - 2641 |
1.4F Millar catheters |
rat |
Serial Doppler echocardiograms |
| Lunde PK, Sejersted OM, Thorud H-MS, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J |
Effects of Congestive Heart Failure on Ca2+ Handling in Skeletal Muscle During Fatigue |
Circ. Res., Jun 2006; 98: 1514 - 1519 |
SPR-407 |
rat |
skeletal muscle • congestive heart failure • muscle fatigue • Ca2+ |
| Sekine H, Shimizu T, Yang J, Kobayashi E, Okano T |
Pulsatile myocardial tubes fabricated with cell sheet engineering |
Circulation 2006;114;87-93 |
SPR-320 |
rat |
cardiac tube cell sheet transplantation |
| Okere IC, Chandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, Tserng K-Y, Hoit BD,Ernsberger P, Young ME, Stanley WC |
Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H38 - H44 |
3.5-Fr pressure transducer |
rat |
ceramide; fatty acids; heart; lipotoxicity; mitochondria; obesity |
| Dean SA, Tan J, White R, O’Brien ER, Leenen FHH |
Regulation of components of the brain and cardiac renin-angiotensin systems by 17β-estradiol after myocardial infarction in female rats |
Am J Physiol Regulatory Integrative Comp Physiol, Jul 2006; 291: R155 - R162 |
SPR-407 |
rat |
ovariectomy; heart failure; estrogens |
| Sekine H, Shimizu T, Yang J, Kobayashi E, Okano T |
Pulsatile Myocardial Tubes Fabricated With Cell Sheet Engineering |
Circulation, Jul 2006; 114: I-87 - I-93 |
SPR-320 |
rat |
cardiac tube • cell sheet • transplantation |
| Carroll JF, Zenebe WJ, Strange TB |
Cardiovascular Function in a Rat Model of Diet-Induced Obesity |
Hypertension, Jul 2006; 48: 65 - 72 |
SPR-249 |
rat |
hypertrophy • echocardiography • blood pressure • cardiac output • rats • diurnal rhythm |
| Jasmin J-F, Mercier I, Dupuis J, Tanowitz HB, Lisanti MP |
Short-Term Administration of a Cell-Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy |
Circulation, Aug 2006; 114: 912 - 920 |
SPR-249 |
rat |
pulmonary artery medial hypertrophy |
| Jazbutyte V, Hu K, Kruchten P, Bey E, Maier SKG, Fritzemeier K-H, Prelle K, Hegele-Hartung C, Hartmann RW, Neyses L, Ertl G, Pelzer T |
Aging Reduces the Efficacy of Estrogen Substitution to Attenuate Cardiac Hypertrophy in Female Spontaneously Hypertensive Rats |
Hypertension, Aug 2006; doi:10.1161/01.HYP.0000240053.48517.c7 |
microtip manometer |
rat |
estrogen receptors • cardiac hypertrophy • aging • hypertension |
| Masuyama H, Tsuruda T, Kato J, Imamura T, Asada Y, Stasch J-P, Kitamura K, Eto T |
Soluble Guanylate Cyclase Stimulation on Cardiovascular Remodeling in Angiotensin II-Induced Hypertensive Rats |
Hypertension, Sep 2006; doi:10.1161/01.HYP.0000241087.12492.47 |
SPC-721, TCB-500 |
rat |
hypertension • fibrosis • soluble guanylate cyclase • cGMP • extracellular matrix |
| Kang Y-M, Zhang Z-H, Johnson RF, Yu Y, Beltz T, Johnson AK, Weiss RM, Felder RB |
Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Proinflammatory Cytokines and Hypothalamic Activation in Rats With Ischemia-Induced Heart Failure |
Circ. Res., Sep 2006; 99: 758 - 766 |
SPR-671 |
rat |
congestive heart failure • aldosterone • cytokines • cyclooxygenase-2 • nervous system |
| Lourenço AP, Roncon-Albuquerque Jr R, Brás-Silva C, Faria B, Wieland J, Henriques-Coelho T, Correia-Pinto J, Leite-Moreira AF |
Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1587 - H1594 |
SPR-407 |
rat |
gene expression; myocardial contractility; neuroendocrine stimulation; endothelin |
| Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH |
Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1927 - H1934 |
transmyocardial Millar 1.5-F pressure transducer |
rat |
adenosine monophosphate-activated protein kinase; ischemia; subunits; isoforms |
| Thai H, Castellano L, Juneman E, Phan H, Do R, Gaballa MA, Goldman S |
Pretreatment With Angiotensin Receptor Blockade Prevents Left Ventricular Dysfunction and Blunts Left Ventricular Remodeling Associated With Acute Myocardial Infarction |
Circulation, Oct 2006; 114: 1933 - 1939 |
1-mm micromanometer-tipped catheter |
rat |
candesartan |
| Jazbutyte V, Hu K, Kruchten P, Bey E, Maier SKG, Fritzemeier K-H, Prelle K, Hegele-Hartung C, Hartmann RW, Neyses L, Ertl G, Pelzer T |
Aging Reduces the Efficacy of Estrogen Substitution to Attenuate Cardiac Hypertrophy in Female Spontaneously Hypertensive Rats |
Hypertension, Oct 2006; 48: 579 - 586 |
microtip manometer |
rat |
estrogen receptors • cardiac hypertrophy • aging • hyperten |
| Wakeno M, Minamino T, Seguchi O, Okazaki H, Tsukamoto O, Okada K, Hirata A, Fujita M, Asanuma H, Kim J, Komamura K, Takashima S, Mochizuki N, Kitakaze M |
Long-Term Stimulation of Adenosine A2b Receptors Begun After Myocardial Infarction Prevents Cardiac Remodeling in Rats |
Circulation, Oct 2006; 114: 1923 - 1932 |
3.5F Millar pressure catheter |
rat |
hypertrophy of cardiomyocytes, heart failure |
| Masuyama H, Tsuruda T, Kato J, Imamura T, Asada Y, Stasch J-P, Kitamura K, Eto T |
Soluble Guanylate Cyclase Stimulation on Cardiovascular Remodeling in Angiotensin II–Induced Hypertensive Rats |
Hypertension, Nov 2006; 48: 972 - 978 |
SPC-721, TCB-500 |
rat |
hypertension • fibrosis • soluble guanylate cyclase • cGMP • extracellular matrix |
| Chang K-C, Hsu K-L, Tseng C-D, Lin Y-D, Cho Y-L, Tseng Y-Z |
Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats |
British Journal of Pharmacology 147, 944 - 950 (01 Apr 2006) |
SPC-320 |
rat |
Advanced glycation endproducts, aminoguanidine, aortic input impedance, streptozotocin-diabetic rats, pulse wave reflection |
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| Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG |
S100B Expression Modulates Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2005;111:598-606 |
Millar microtip catheter transducer |
mouse |
hypertrophy • proteins • myocardial infarction • apoptosis • remodeling |
| Chiu H-C, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE |
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy |
Circulation Research. 2005;96:225 |
1.4 Fr micromanometer catheter |
mouse |
lipids • metabolism • cardiomyopathy |
| Finsen AV, Christensen G, Sjaastad I |
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse |
J Appl Physiol 98: 680-689, 2005 |
SPR-671 |
mouse |
hemodynamic measurements; left ventricular function; heart failure |
| Ozerdem U, Hargens AR |
A simple method for measuring intersitial fluid pressure in cancer tissues |
Microvascular Research 70 (2005) 116 – 120 |
SPC-320, TC-510 |
mouse |
| cancer, pericyte, NG2, interstitial, fluid, pressure, targeting, wick-in-needle |
|
| Jones SP, Greer JJM, Ware PD, Yang Y, Walsh K, Lefer DJ |
Deficiency of iNOS does not attenuate severe congestive heart failure in mice |
Am J Physiol Heart Circ Physiol 288: H365-H370, 2005 |
SPR-671 |
mouse |
myocardial infarction; nitric oxide; physiology; inducible nitric oxide synthase |
| Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG |
S100B Expression Modulates Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2005;111:598-606 |
Millar microtip catheter transducer |
mouse |
hypertrophy • proteins • myocardial infarction • apoptosis • remodeling |
| Chiu H-C, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE |
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy |
Circulation Research. 2005;96:225 |
1.4 Fr micromanometer catheter |
mouse |
lipids • metabolism • cardiomyopathy |
| Finsen AV, Christensen G, Sjaastad I |
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse |
J Appl Physiol 98: 680-689, 2005 |
SPR-671 |
mouse |
hemodynamic measurements; left ventricular function; heart failure |
| Segers P, Georgakopoulos D, Afanasyeva M, Champion HC, Judge DP, Millar HD, Verdonck P, Kass DA, Stergiopulos N, Westerhof N |
Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice |
Am J Physiol Heart Circ Physiol, Mar 2005; 288: H1157 - H1164 |
catheter with a dual-pressure sensor |
mouse |
hemodynamics; augmentation index; windkessel; arterial stiffness; compliance; ventriculovascular coupling |
| Nassar R, Malouf NN, Mao L, Rockman HA, Oakeley AE, Frye JR, Herlong JR, Sanders SP, Anderson PAW |
cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform |
Am J Physiol Heart Circ Physiol, Mar 2005; 288: H1147 - H1156 |
1.4-Fr micromanometer catheter |
mouse |
thin filaments; transgenic mice; ventricular function; myocardium |
| Xiao C-Y, Chen M, Zsengellér Z, Li H, Kiss L, Kollai M, Szabó C |
Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure |
JPET 312:891-898, 2005 |
1.4F |
mouse |
hypertrophy, mouse |
| Kuzume K, Kuzume K, Cao Z, Liu L, Van Winkle DM |
Long-term infusion of Met5-enkephalin fails to protect murine hearts against ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1717 - H1723 |
SPR-671 |
mouse |
infarction; ischemic preconditioning; myocardial; peptides; opioid |
| Royer A, van Veen TAB, Le Bouter S, Marionneau C, Griol-Charhbili V, Léoni A-L, Steenman M, van Rijen HVM, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JMT, Grace AA, Escande D, Charpentier F |
Mouse Model of SCN5A-Linked Hereditary Lenègre’s Disease: Age-Related Conduction Slowing and Myocardial Fibrosis |
Circulation, Apr 2005; 111: 1738 - 1746 |
Mikrotip 1.4F |
mouse |
conduction • ion channels • remodeling |
| Hayashida K, Fujita J, Miyake Y, Kawada H, Ando K, Ogawa S, Fukuda K |
Bone Marrow-Derived Cells Contribute to Pulmonary Vascular Remodeling in Hypoxia-Induced Pulmonary Hypertension |
Chest, May 2005; 127: 1793 - 1798 |
SPR-671 |
mouse |
bone marrow transplantation • hypoxia • myofibroblast • progenitor cell • pulmonary hypertension • vascular remodeling |
| Sebag IA, Handschumacher MD, Ichinose F, Morgan JG, Hataishi R, Rodrigues ACT, Guerrero JL, Steudel W, Raher MJ, Halpern EF, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M |
Quantitative Assessment of Regional Myocardial Function in Mice by Tissue Doppler Imaging: Comparison With Hemodynamics and Sonomicrometry |
Circulation, May 2005; 111: 2611 - 2616 |
1.4F high-fidelity micromanometer catheter |
mouse |
echocardiography • systole • inotropic agents |
| Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H |
Postinfarction Gene Therapy Against Transforming Growth Factor-ß Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure |
Circulation, May 2005; 111: 2430 - 2437 |
SPR-407 |
mouse |
heart failure • gene therapy • myocardial infarction • transforming growth factors |
| Katada J, Meguro T, Saito H, Ohashi A, Anzai T, Ogawa S, Yoshikawa T |
Persistent Cardiac Aldosterone Synthesis in Angiotensin II Type 1A Receptor–Knockout Mice After Myocardial Infarction |
Circulation, May 2005; 111: 2157 - 2164 |
1.4F high-fidelity catheter |
mouse |
myocardial infarction • remodeling • angiotensin |
| Gao X-M, Kiriazis H, Moore X-L, Feng X-H, Sheppard K, Dart A, Du X-J |
Regression of pressure overload-induced left ventricular hypertrophy in mice |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2702 - H2707 |
1.4-Fr Millar catheter |
mouse |
aortic banding; cardiac function/remodeling; model |
| Moshal KS, Tyagi N, Henderson B, Ovechkin AV, Tyagi SC |
Protease-activated receptor and endothelial-myocyte uncoupling in chronic heart failure |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2770 - H2777 |
pressure-tipped Millar catheter |
mouse |
proteomics; shedding; nitric oxide; NADPH oxidase; cardiac ring; contraction; relaxation; dilatation; matrix metalloproteinase; nitrotyrosine; tissue inhibitors of metalloproteinase; coupling |
| Barandon L, Dufourcq P, Costet P, Moreau C, Allières C, Daret D, Dos Santos P, Lamazière J-M, Couffinhal T, Duplàa C |
Involvement of FrzA/sFRP-1 and the Wnt/Frizzled Pathway in Ischemic Preconditioning |
Circ. Res., Jun 2005; 96: 1299 - 1306 |
1.4 Fr microtipped transducer |
mouse |
animal models of human disease • cell signaling/signal transduction • genetically-altered mice • ischemia • heart |
| Zhao X, He G, Chen Y-R, Pandian RP, Kuppusamy P, Zweier JL |
Endothelium-Derived Nitric Oxide Regulates Postischemic Myocardial Oxygenation and Oxygen Consumption by Modulation of Mitochondrial Electron Transport |
Circulation, Jun 2005; 111: 2966 - 2972 |
SPR-261 |
mouse |
nitric oxide • enzymes • free radicals • reperfusion • ischemia |
| Song Y, Jones JE, Beppu H, Keaney Jr JF, Loscalzo J, Zhang Y-Y |
Increased Susceptibility to Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice |
Circulation, Jul 2005; 112: 553 - 562 |
1.4F Millar Mikro-Tip pressure catheter |
mouse |
inflammation • hypertension, pulmonary • vasoconstriction • bone morphogenetic proteins • thromboxane |
| Qianli Yu, Ronald R. Watson, John J. Marchalonis, and Douglas F. Larson |
A role for T lymphocytes in mediating cardiac diastolic function |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H643 - H651 |
1.4-Fr |
mouse |
LP-BM5 retrovirus; T-helper cell; cardiac fibroblast; extracellular matrix; collagen types I and III; T helper 1; T helper 2; cross-linking; T-cell receptor peptide |
| Woldbæk PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T |
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H708 - H714 |
SPR-671 |
mouse |
cytokines; heart failure; contractile function; calcium |
| Gaussin V, Morley GE, Cox L, Zwijsen A, Vance KM, Emile L, Tian Y, Liu J, Hong C, Myers D, Conway SJ, Depre C, Mishina Y, Behringer RR, Hanks MC, Schneider MD, Huylebroeck D, Fishman GI, Burch JBE, Vatner SF |
Alk3/Bmpr1a Receptor Is Required for Development of the Atrioventricular Canal Into Valves and Annulus Fibrosus |
Circ. Res., Aug 2005; 97: 219 - 226 |
1.4F micromanometer catheter |
mouse |
bone morphogenetic protein signaling • heart development • atrioventricular canal • Cre-lox system |
| Ikeuchi M, Matsusaka H, Kang D, Matsushima S, Ide T, Kubota T, Fujiwara T, Hamasaki N, Takeshita A, Sunagawa K, Tsutsui H |
Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction |
Circulation, Aug 2005; 112: 683 - 690 |
1.4F micromanometer-tipped catheter |
mouse |
free radicals • genes • heart failure • myocardial infarction • remodeling |
| Patel JB, Valencik ML, Pritchett AM,Burnett Jr JC, McDonald JA, Redfield MM |
Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H777 - H784 |
1.4-Fr manometer-tipped catheter |
mouse |
natriuretic peptides; diastole; hypertrophy; fibrosis |
| Bridgman P, Aronovitz MA, Kakkar R, Oliverio MI, Coffman TM, Rand WM, Konstam MA, Mendelsohn ME, Patten RD |
Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor |
Am J Physiol Heart Circ Physiol 289: H586-H592, 2005 |
1.4-Fr micro-tip pressure transducer |
mouse |
angiotensin II receptors; ventricular remodeling; myocyte; hypertrophy |
| van den Bos EJ, Mees BME, de Waard MC, de Crom R, Duncker DJ |
A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1291 - H1300 |
1.4-Fr Millar catheter |
mouse |
heart function; cardiac remodeling; echocardiography |
| Gutstein DE, Danik SB, Lewitton S, France D, Liu F, Chen FL, Zhang J, Ghodsi N, Morley GE, Fishman GI |
Focal gap junction uncoupling and spontaneous ventricular ectopy |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1091 - H1098 |
1.4-Fr Mikro-Tip catheter pressure transducer |
mouse |
connexin43; ventricular dysfunction; chimera |
| Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP |
Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1209 - H1217 |
catheter |
mouse |
catheter |
| Kiriazis HK, Du X-J, Feng X, Hotchkin E, Marshall T, Finch S, Gao X-M, Lambert G, Choate JK, Kaye DM |
Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation |
Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1359 - H1365 |
1.4-Fr Millar Mikro-Tip catheter |
mouse |
echocardiography; myocardial contraction; catecholamine; transgenic; nerve growth factor |
| Boudina S, Sena S, O’Neill BT, Tathireddy P, Young ME, Abel ED |
Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity |
Circulation, Oct 2005; 112: 2686 - 2695 |
Millar transducer |
mouse |
myocardial oxygen consumption, reduced cardiac efficiency |
| Limana F, Germani A, Zacheo A, Kajstura J, Di Carlo A, Borsellino G, Leoni O, Palumbo R, Battistin L, Rastaldo R, Müller S, Pompilio G, Anversa P, Bianchi ME, Capogrossi MC |
Exogenous High-Mobility Group Box 1 Protein Induces Myocardial Regeneration After Infarction via Enhanced Cardiac C-Kit+ Cell Proliferation and Differentiation |
Circ. Res., Oct 2005; 97: e73 - e83 |
Millar 1.4F |
mouse |
myocardial infarction • regeneration • stem cells • cytokines |
| Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA |
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt |
J. Clin. Invest., Oct 2005; 115: 2716 - 2730 |
Millar transducer |
mouse |
cardioprotective stimuli |
| Arteaga GM, Warren CM, Milutinovic S, Martin AF, Solaro RJ |
Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H2183 - H2192 |
SPR-671, TCB-500 |
mouse |
troponin I; calcium sensitizers; phosphorylation; stunning; cross bridge-dependent activation |
| Matsusaka H, Ikeuchi M, Matsushima S, Ide T, Kubota T, Feldman AM, Takeshita A, Sunagawa K, Tsutsui H |
Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H1858 - H1864 |
1.4-Fr micromanometer-tipped catheter |
mouse |
metalloproteinases; heart failure; tumor necrosis factor |
| Zhai P, Yamamoto M, Galeotti J, Liu J, Masurekar M, Thaisz J, Irie K, Holle E, Yu X, Kupershmidt S, Roden DM, Wagner T, Yatani A, Vatner DE, Vatner SF, Sadoshima J |
Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice |
J. Clin. Invest., Nov 2005; 115: 3045 - 3056 |
1.4-French (Millar Instruments Inc.) catheter-tip micromanometer catheter, EPR-800 |
mouse |
heterotrimeric G protein–dependent |
| Liu Y-H, Carretero OA, Cingolani OH, Liao T-D, Sun Y, Xu J, Li LY, Pagano PJ, Yang JJ, Yang X-P |
Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction |
Am J Physiol Heart Circ Physiol, Dec 2005; 289: H2616 - H2623 |
4-Fr. micromanometer pressure catheter |
mouse |
oxidative stress; reactive oxygen species; ejection time |
| Ovechkin AV, Tyagi N, Rodriguez WE, Hayden MR, Moshal KS, Tyagi SC |
Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice |
J Appl Physiol, Dec 2005; 99: 2398 - 2405 |
pressure-tipped Millar catheter |
mouse |
arteriovenous fistula; endocardial dysfunction; extracellular matrix remodeling; terminal deoxynucleotidyl nick-end labeling; connexin-43; protease-activated receptors-1; a disintegrin and metalloproteinase-12; congestive heart failure |
| Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV |
Phospholipase C Modulates ß-Adrenergic Receptor– Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy |
Circ. Res., Dec 2005; 97: 1305 - 1313 |
Millar pressure transducer |
mouse |
phospholipase C • ß-adrenergic receptor • heart failure • contractility |
| Ditting T, Hilgers KF, Scrogin KE, Stetter A, Linz P, Veelken R |
Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats |
Am J Physiol Heart Circ Physiol 288: H541-H552, 2005 |
SPC-320 |
rat |
cardiac afferent C fiber; renal sympathetic nerve activity; cardiorenal reflexes |
| Wang Y, Liu X-F, Cornish KG, Zucker IH, Patel KP |
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure |
Am J Physiol Heart Circ Physiol 288: H205-H213, 2005 |
3.5-F catheter transducer |
rat |
oligonucleotides; gene expression; sympathetic nerve activity |
| Ditting T, Hilgers KF, Scrogin KE, Stetter A, Linz P, Veelken R |
Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats |
Am J Physiol Heart Circ Physiol 288: H541-H552, 2005 |
SPC-320 |
rat |
cardiac afferent C fiber; renal sympathetic nerve activity; cardiorenal reflexes |
| Izumiyama H, Tanaka H, Egi K, Sunamori M, Hirata Y, Shichiri M |
Synthetic Salusins as Cardiac Depressors in Rat |
Hypertension, Mar 2005; 45: 419 - 425 |
Millar Microtip catheter pressure transducer system |
rat |
cardiac output • heart rate • blood pressure • vascular resistance |
| Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, Stewart DJ |
Rescue of Monocrotaline-Induced Pulmonary Arterial Hypertension Using Bone Marrow–Derived Endothelial-Like Progenitor Cells: Efficacy of Combined Cell and eNOS Gene Therapy in Established Disease |
Circ. Res., Mar 2005; 96: 442 - 450 |
3F Millar microtip catheter |
rat |
progenitor cells • pulmonary hypertension • endothelium • endothelial nitric oxide synthase |
| Lou H, Danelisen I, Singal PK |
Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1925 - H1930 |
SPR-249 |
rat |
dilated cardiomyopathy; oxidative stress and apoptosis |
| Shao Q, Ren B, Saini HK, Netticadan T, Takeda N, Dhalla NS |
Sarcoplasmic reticulum Ca2+ transport and gene expression in congestive heart failure are modified by imidapril treatment |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1674 - H1682 |
SPR-249 |
rat |
myocardial infarction; cardiac gene expression; renin-angiotensin system |
| Pourdjabbar A, Parker TG, Nguyen QT, Desjardins J-F, Lapointe N, Tsoporis JN, Rouleau J-L |
Effects of pre-, peri-, and postmyocardial infarction treatment with losartan in rats: effect of dose on survival, ventricular arrhythmias, function, and remodeling |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1997 - H2005 |
microtip catheter transducer |
rat |
angiotensin II receptor blockers; heart failure; infarction; remodeling; hypotension |
| Thomas TA, Kuzman JA, Anderson BE, Andersen SMK, Schlenker EH, Holder MS, Gerdes AM |
Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure |
Am J Physiol Heart Circ Physiol, May 2005; 288: H2118 - H2122 |
Millar Mikro-tip catheter |
rat |
shape; ventricular remodeling; wall stress; myosin ratio |
| Huang BS, Leenen FHH |
Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI |
Am J Physiol Heart Circ Physiol, May 2005; 288: H2491 - H2497 |
SPC-350 |
rat |
myocardial infarction; cardiac dysfunction; aldosterone |
| Huang BS, Leenen FHH |
Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI |
Am J Physiol Heart Circ Physiol 288: H2491-H2497, 2005 |
SPR-407 |
rat |
myocardial infarction; cardiac dysfunction; aldosterone |
| Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE |
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2 |
Circulation, May 2005; 111: 2605 - 2610 |
SPR-671 |
rat |
angiotensin • receptors • inhibitors • genetics • myocardium |
| Sakaguchi G, Tambara K, Sakakibara Y, Ozeki M, Yamamoto M, Premaratne G, Lin X, Hasegawa K, Tabata Y, Nishimura K, Komeda M |
Control-Released Hepatocyte Growth Factor Prevents the Progression of Heart Failure in Stroke-Prone Spontaneously Hypertensive Rats |
Ann. Thorac. Surg., May 2005; 79: 1627 - 1634 |
2F micromanometer-tipped catheter |
rat |
hydrogel sheet |
| Shao Q, Ren B, Elimban V, Tappia PS, Takeda N, Dhalla NS |
Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2637 - H2646 |
SPR-249 |
rat |
cardiac sarcolemma; Na+-K+-ATPase isoforms; cardiac gene expression; congestive heart failure; angiotensin-converting enzyme inhibitors |
| Thukkani AK, Martinson BD, Albert CJ, Vogler GA, Ford DA |
Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2955 - H2964 |
6-F pressure-transducer catheter |
rat |
2-chlorohexadecanal; myeloperoxidase; ischemia; fatty aldehyde |
| Waller C, Engelhorn T, Hiller K-H, Heusch G, Ertl G, Bauer WR, Schulz R |
Impaired resting perfusion in viable myocardium distal to chronic coronary stenosis in rats |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2588 - H2593 |
micromanometer |
rat |
ischemic cardiomyopathy; necrosis |
| Gao L, Schultz HD, Patel KP, Zucker IH, Wang W |
Augmented Input From Cardiac Sympathetic Afferents Inhibits Baroreflex in Rats With Heart Failure |
Hypertension, Jun 2005; 45: 1173 - 1181 |
SPR-524 |
rat |
baroreflex • cardiac function • heart failure • reflex • renal nerves • sympathetic nervous system |
| McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S, Puttagunta L, Michelakis ED |
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension |
J. Clin. Invest., Jun 2005; 115: 1479 - 1491 |
high-fidelity Millar catheters |
human, rat |
bone morphogenetic protein axis, vascular mitochondria-dependent apoptosis |
| Wang X, Sentex E, Saini HK, Chapman D, Dhalla NS |
Upregulation of β-adrenergic receptors in heart failure due to volume overload |
Am J Physiol Heart Circ Physiol, Jul 2005; 289: H151 - H159 |
SPR-249 |
rat |
β-adrenoceptors; congestive heart failure; G protein-coupled receptor kinase; renin-angiotensin system blockade |
| Campbell KB, Wu Y, Simpson AM, Kirkpatrick RD, Shroff SG, Granzier HL, Slinker BK |
Dynamic myocardial contractile parameters from left ventricular pressure-volume measurements |
Am J Physiol Heart Circ Physiol, Jul 2005; 289: H114 - H130 |
3-Fr catheter-tip Millar pressure transducer |
rat |
heart function; muscle; mathematical model; cardiac fiber; force |
| Chicco AJ, Schneider CM, Hayward R |
Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart |
Am J Physiol Regulatory Integrative Comp Physiol, Aug 2005; 289: R424 - R431 |
microtip catheter pressure transducer |
rat |
adriamycin; cardioprotection; heart; physical activity; cardiac function |
| Eklund KE, K. Hageman KS, Poole DC, Musch TI |
Impact of aging on muscle blood flow in chronic heart failure |
J Appl Physiol, Aug 2005; 99: 505 - 514 |
TC-510 |
rat |
myocardial infarction; exercise; fiber type; left ventricular dysfunction; exercise hyperemia |
| Tambara K, Premaratne GU, Sakaguchi G, Kanemitsu N, Lin X, Nakajima H, Sakakibara Y, Kimura Y, Yamamoto M, Tabata Y, Ikeda T, Komeda M |
Administration of Control-Released Hepatocyte Growth Factor Enhances the Efficacy of Skeletal Myoblast Transplantation in Rat Infarcted Hearts by Greatly Increasing Both Quantity and Quality of the Graft |
Circulation, Aug 2005; 112: I-129 - I-134 |
2 F micromanometer-tipped catheter |
rat |
apoptosis • cells • muscles • myocardial infarction • transplantation |
| Nagaya N, Kangawa K, Itoh T, Iwase T, SMurakami S, Miyahara Y, Fujii T, Uematsu M, Ohgushi H, Yamagishi M, Tokudome T, Mori H, Miyatake K, Kitamura S |
Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy |
Circulation, Aug 2005; 112: 1128 - 1135 |
1.5F micromanometer-tipped catheter |
rat |
myocardial fibrosis |
| Lekgabe ED, Kiriazis H, Zhao C, Xu Q, Moore XL, Su Y, Bathgate RAD, Du X-J, Samuel CS |
Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats |
Hypertension, Aug 2005; 46: 412 - 418 |
2Fr Millar catheter |
rat |
rats • extracellular matrix • remodeling • fibrosis |
| Souzeau E, Bélanger S, Picard S, Deschepper CF |
Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H715 - H721 |
Fr-2 single sensor pressure catheter (2F) |
rat |
phytoestrogen; dilated ventricular hypertrophy; neonatal exposure; congestive heart failure; isolated adult rat cardiomyocytes |
| Phillipson A, Peterman EE, Taormina Jr P, Harvey M, Brue RJ, Atkinson N, Omiyi D, Chukwu U, Young LH |
Protein kinase C- inhibition exerts cardioprotective effects in ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H898 - H907 |
SPR-524 |
rat |
neutrophils; superoxide radicals; left ventricular developed pressure; endothelial dysfunction |
| Omiyi D, Brue RJ, Taormina II P, Harvey M, Atkinson N, Young LH |
Protein Kinase Cβ II Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury |
JPET 314:542-551, 2005 |
SPR-524 |
rat |
polymorphonuclear leukocytes |
| Slama M, Ahn J, Peltier M, Maizel J, Chemla D, Varagic J, Susic D, Tribouilloy C, Frohlich ED |
Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1131 - H1136 |
catheter-tipped transducer |
rat |
spontaneously hypertensive rats; diastolic function; left ventricle; echocardiography |
| Supinski GS, Callahan LA |
Diaphragmatic free radical generation increases in an animal model of heart failure |
J Appl Physiol, Sep 2005; 99: 1078 - 1084 |
microtip catheter |
rat |
oxidative stress |
| Partovian C, Zhuang Z, Moodie K, Lin M, Ouchi N, Sessa WC, Walsh K, Simons M |
PKα Activates eNOS and Increases Arterial Blood Flow In Vivo |
Circ. Res., Sep 2005; 97: 482 - 487 |
Millar transducer |
rat |
protein kinase C • blood flow • nitric oxide synthase • endothelial cells |
| Malhotra A, Begley R, Kang BPS, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG |
PKC-ε-dependent survival signals in diabetic hearts |
Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1343 - H1350 |
SPR-671 |
|
hyperglycemia; diabetes mellitus; protein kinase C; isozymes; translocation activator; cardioprotection |
| Thorud H-MS, Verburg E, Lunde PK, Strømme TA, Sjaastad I, Sejersted OM |
Temperature-dependent skeletal muscle dysfunction in rats with congestive heart failure |
J Appl Physiol, Oct 2005; 99: 1500 - 1507 |
SPR-407 |
rat |
soleus muscle |
| Xu J, Nagata K, Obata K, Ichihara S, Izawa H, Noda A, Nagasaka T, Iwase M, Naoe T, Murohara T, Yokota M |
Nicorandil Promotes Myocardial Capillary and Arteriolar Growth in the Failing Heart of Dahl Salt-Sensitive Hypertensive Rats |
Hypertension, Oct 2005; 46: 719 - 724 |
SPR-407 |
rat |
endothelial growth factors • fibroblast growth factor • potassium channels • heart failure |
| Zakrzeska A, Schlicker E, Kwolek G, Kozowska H, Malinowska B |
Positive inotropic and lusitropic effects mediated via the low-affinity state of β1-adrenoceptors in pithed rats |
British Journal of Pharmacology 146, 760 - 768 (01 Nov 2005) |
SPR-407 |
rat |
Pithed rat, positive chronotropic effect, positive inotropic effect, positive lusitropic effect, low-affinity state of b1-adrenoceptor, mesenteric blood flow, CGP 12177, cyanopindolol, CGP 20712A, bupranolol |
| Saini HK, Shao Q, Musat S, Takeda N, Tappia PS, Dhalla NS |
Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction |
British Journal of Pharmacology 144, 202 - 211 (01 Jan 2005) |
SPR-249 |
rat |
ATP-mediated responses, congestive heart failure, isolated cardiomyocytes, intracellular calcium, angiotensin blockade |
| Ke Q, Yang Y, Rana JS, Chen Y, Morgan JP, Xiao Y-F |
Embryonic stem cells cultured in biodegradable scaffold repair infarcted myocardium in mice |
Acta Physiologica Sinica, December 25, 2005, 57 (6): 673-681 |
pressure transducer |
mouse |
myocardial infarction; embryonic stem cell; scaffold; patch; cardiac repair |
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| Diwan A, Dibbs Z, Nemoto S, DeFreitas G, Carabello BA, Sivasubramanian N, Wilson EM, Spinale FG, Mann DL |
Targeted Overexpression of Noncleavable and Secreted Forms of Tumor Necrosis Factor Provokes Disparate Cardiac Phenotypes |
Circulation. 2004;109:262-268 |
1.4F Mikro-Tip catheter |
mouse |
hypertrophy • remodeling • metalloproteinases |
| Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M |
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency |
Am J Physiol Heart Circ Physiol 286:H1070-H1075, 2004 |
1.4F Mikro-Tip catheter |
mouse |
hert failure; remodeling |
| Shiomi T, Tsutsui H, Matsusaka H, Murakami K, Hayashidani S, Ikeuchi M, Wen J, Kubota T, Utsumi H, Takeshita A |
Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice |
Circulation. 2004;109:544-549 |
1.4F Mikro-Tip catheter |
mouse |
myocardial infarction • heart failure • remodeling • antioxidants • free radicals |
| van Rooij E, Doevendans PA, Crijns HJGM, Heeneman S, Lips DJ, van Bilsen M, Williams RS, Olson EN, Bassel-Duby R, Rothermel BA, De Windt LJ |
MCIP1 Overexpression Suppresses Left Ventricular Remodeling and Sustains Cardiac Function After Myocardial Infarction |
Circulation Research. 2004;94:e18 |
1.4F Mikro-Tip catheter |
mouse |
myocardial infarction • heart failure • calcineurin • signaling • hypertrophy |
| Wang Q, Brunner HR, Burnier M |
Determination of cardiac contractility in awake unsedated mice with a fluid-filled catheter |
Am J Physiol Heart Circ Physiol 286: H806-H814, 2004 |
1.4F Mikro-Tip catheter |
mouse |
anesthesia; Millar; Pebax catheter; frequency; deoxycorticosterone acetate-salt |
| Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, Takeshita A |
Long-Term Inhibition of Rho-Kinase Suppresses Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2004;109:2234-2239 |
1.4F Mikro-Tip Catheter |
|
myocardial infarction • heart failure • myocardium • remodeling • signal transduction |
| Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard MH, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch KD |
Cardiomyocyte-Specific Overexpression of Nitric Oxide Synthase 3 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy After Myocardial Infarction |
Circulation Research. 2004;94:1256 |
1.4F Mikro-Tip Catheter |
mouse |
nitric oxide synthase • myocardial infarction • left ventricular remodeling • myocyte hypertrophy |
| Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH |
Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function in an Iron-Overload Murine Model |
Circulation. 2004;109:1877-1885 |
1.4F Mikro-Tip Catheter |
mouse |
hemochromatosis • cardiomyopathy • taurine • stress, oxidative • glutathione |
| Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM |
Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo |
Am J Physiol Heart Circ Physiol 286: H2089-H2095, 2004 |
1.4F Mikro-Tip Catheter |
mouse |
troponin; protein kinase C; contractility; mouse |
| Yang LL, Gros R, Kabir MG, Sadi A, Gotlieb AI, Husain M, Stewart DJ |
Conditional Cardiac Overexpression of Endothelin-1 Induces Inflammation and Dilated Cardiomyopathy in Mice |
Circulation. 2004;109:255-261 |
1.4F sensor, 2F catheter |
mouse |
endothelin • myocarditis • hypertrophy • heart failure |
| Suarez J, Belke DD, Gloss B, Dieterle T, McDonough PM, Kim Y-K, Brunton LL, Dillmann WH |
In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy |
Am J Physiol Heart Circ Physiol 286: H68-H75, 2004 |
2F Mikro-Tip catheter |
mouse |
calcium handling; gene therapy |
| Schultz JEJ, Glascock BJ, Witt SA, Nieman ML, Nattamai KJ, Liu LH, Lorenz JN, Shull GE, Kimball TR, Periasamy M |
Accelerated onset of heart failure in mice during pressure overload with chronically deceased SERCA2 calcium pump activity |
|
Mikro-Tip catheter |
mouse |
sarco(endo)plasmic reticulum calcium-adenosine 5'-triphosphatase pump; knockout mice; echocardiography; cardiac dysfunction |
| Abella BS, Zhao D, Alvarado J, Hamann K, Vanden Hoek TL, Becker LB |
Intra-Arrest Cooling Improves Outcomes in a Murine Cardiac Arrest Model |
Circulation. 2004;109:2786-2791 |
SPR-671 |
mouse |
cardiopulmonary resuscitation • heart arrest • death, sudden • circulation |
| Ishizaka S, Sievers RE, Zhu B-Q, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W |
New technique for measurement of left ventricular pressure in conscious mice |
Am J Physiol Heart Circ Physiol 286: H1146-h1153, 2004 |
SPR-671 |
mouse |
left ventricular hemodynamics; first derivative of left ventricular pressure; anesthesia; mouse physiology |
| Jones SP, Greer JJM, Kakkar AK, Ware D, Turnage RH, Hicks M, van Haperen R, de Crom R, Kawashima S, Yokoyama M, Lefer DJ |
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury |
Am J Physiol Heart Circ Physiol 286: H276-H282, 2004 |
SPR-671 |
mouse |
myocardial infarction; cardiac dysfunction; murine model |
| Chen H, Liu LL, Ye LL, McGuckin C, Tamowski S, Scowen P, Tian H, Murray K, Hatton WJ, Duan D |
Targeted Inactivation of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Gene Prevents Ischemic Preconditioning in Isolated Mouse Heart |
Circulation. 2004;110:700-704 |
1.4/0.8F pressure transducer |
mouse |
ischemia • myocardial infarction • hemodynamics • ion channels • genes |
| Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang Y-Y |
Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats |
Am J Physiol Heart Circ Physiol 286: H1775-H1784, 2004 |
1.4-Fr Millar Mikro-Tip pressure catheter |
rat |
inflammation; monocrotaline |
| Bos R, Mougenot N, Médiani O, Vanhoutte PM, Lechat P |
Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat |
JPET 309:1160-1166, 2004 |
2F Mikro-Tip Catheter |
rat |
norepinephrine |
| Kuwahara F; Kai H; Tokuda T; Takeya M; Takeshita A; Egashira K; Imaizumi T |
Hypertensive Myocardial Fibrosis and Diastolic Dysfunction: Another Model of Inflammation? |
Hypertension. 2004;43:73 |
2F Mikro-Tip Catheter |
rat |
macrophages • fibrosis • hypertension • diastole |
| Wang H, Huang BS, Ganten D, Leenen FHH |
Prevention of Sympathetic and Cardiac Dysfunction After Myocardial Infarction in Transgenic Rats Deficient in Brain Angiotensinogen |
Circulation Research. 2004;94:843 |
2F Mikro-Tip Catheter |
rat |
angiotensin • brain • cardiac remodeling • left ventricular dysfunction • arterial baroreflex |
| Hu K, Naumann A, Fraccarollo D, Gaudron P, Kaden JJ, Neubauer S, Ertl G |
Heart rate reduction by zatebradine reduces infarct size and mortality but promotes remodeling in rats with experimental myocardial infarction |
Am J Physiol Heart Circ Physiol 286: H1281-H1288, 2004 |
Mikro-Tip Catheter |
rat |
neurohumoral systems; heart failure; bradycardia |
| Mulder P, Barbier S, Chagraoui A, Richard V, Henry JP; Lallemand F; Renet S; Lerebours G, Mahlberg-Gaudin F, Thuillez C |
Long-Term Heart Rate Reduction Induced by the Selective If Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure |
Circulation. 2004;109:1674-1679 |
Mikro-Tip Catheter |
rat |
heart failure • heart rate • drugs • pathology |
| Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K |
Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats |
Circulation. 2004;109:120-124.) |
SPC-320 |
rat |
electrical stimulation • heart failure • myocardial infarction • remodeling • vagus nerve |
| Chen L, Chen CX, Gan XT, Beier N, Scholz, W, Karmazyn M |
Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition |
Am J Physiol Heart Circ Physiol 286: H381-H387, 2004 |
SPR 249 |
rat |
coronary artery ligation; EMD-87580; atrial natriuretic peptide; Na-H exchange |
| Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, Simonsen S, Frøland S, Gullestad L, Christensen G, Damås JK, Aukrust P |
Elevated Levels of Activin A in Heart Failure |
Circulation. 2004; 109: 1379-1385 |
SPR-407 |
rat |
heart failure • inflammation • leukocytes • myocardium |
| Gao L, Zhu Z, Zucker IH, Wang W |
Cardiac sympathetic afferent stimulation impairs baroreflex control of renal sympathetic nerve activity in rats |
Am J Physiol Heart Circ Physiol 286: H1706-H1711, 2004 |
SPR-524 |
rat |
angiotensin type 1 receptor |
Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A. Wagner, George
Kunos |
Cannabinoid antagonist SR141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors |
Am J Physiol Heart Circ Physiol (April 1, 2004). 10.1152/ajpheart.00184.2004 |
SPR-524 |
rat |
trangenics, toxemia, pharmaceuticals, endotoxin; cannabinoids; hypotension; negative inotropy |
| Jin H, Fedorowicz G, Yang R, Ogasawara A, Peale F, Pham T, Paoni NF |
Thyrotropin-Releasing Hormone Is Induced in the Left Ventricle of Rats With Heart Failure and Can Provide Inotropic Support to the Failing Heart |
Circulation. 2004;109:2240-2245 |
SPR-629 |
rat |
hormones • heart failure • myocardial infarction • inotropic agents |
| Pearson JT, PhD; Mikiyasu Shirai M, Ito H, Tokunaga N, Tsuchimochi H, Nishiura N; Schwenke DO, Ishibashi-Ueda H, Akiyama R, Mori H, Kangawa K, Suga H, Yagi N |
In Situ Measurements of Crossbridge Dynamics and Lattice Spacing in Rat Hearts by X-Ray Diffraction |
Circulation. 2004;109:2976-2979 |
SPR-671 |
rat |
ischemia • myocardial contraction • myosin • radiography |
| Dent MR, Dhalla NS, Tappia PS |
Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload |
Am J Physiol Heart Circ Physiol 287: H719-H727, 2004. |
SPR-249 |
rat |
cardiac sarcolemma; signal transduction |
| Xiao C-Y, Chen M, Zsengellér Z, Szabó C |
Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor |
JPET 310:498-504, 2004 |
SPR-524 |
rat |
myocardial infarction, diabetes, streptozotocin |
| Zhu G-Q, Gao L, Li Y, Patel KP, Zucker IH, Wang W |
AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure |
Am J Physiol Heart Circ Physiol 287: H1828-H1835, 2004 |
pressure transducer |
rat |
angiotensin II; renal sympathetic nerve activity; paraventricular nucleus |
| McMurtry MS, Bonnet S, Wu X, Dyck JRB, Haromy A, Hashimoto L, \Michelakis ED |
Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis |
Circulation Research. 2004;95:830 |
1.4-French Millar catheters |
rat |
apoptosis • proliferation • smooth muscle • vascular remodeling |
| Holmes JW |
Candidate mechanical stimuli for hypertrophy during volume overload |
J Appl Physiol 97: 1453-1460, 2004 |
SPR-671 |
rat |
arteriovenous fistula; sonomicrometry; rat; growth; mechanics; stress |
| Corno AF, Milano G, Morel S, Tozzi P, Genton CY, Samaja M, von Segesser LK |
Hypoxia: Unique myocardial morphology? |
J. Thorac. Cardiovasc. Surg., May 2004; 127: 1301 - 1308 |
MPC-500 |
rat |
polycythemia, cardiopulmonary support and physiology |
| |
|
|
|
|
|
---------------------------------------------Published in 2003---------------------------------------------
|
Farjah M; Roxas BP; Geenen DL; Danziger RS
|
Dietary Salt Regulates Renal SGK1 Abundance
|
Hypertension. 2003;41:874
|
|
|
hypertension, aldosterone, rat, Dahl , glucocorticoids, kinase, hypertension, renal, sodium, dietary, blood pressure |
Woldbaek PR, Strømme TA, ,Sande JB,
Christensen G, Tønnessen T, Ilebekk A
|
"Evaluation of a new fiber-optic pressure recording system for cardiovascular
measurements in mice"
|
Am J Physiol Heart Circ Physiol 285: H2233-H2239, 2003
|
SPR-671 |
|
catheter size, fiberoptic, aortic pressure
|
| Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, Izumo S |
Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice |
Circulation 2003 107:1664-1670 |
1.4F high-fidelity pressure catheter |
mouse |
hypertrophy, heart failure, signal transduction
|
Hu P, Zhang D, Swenson L, Chakrabarti G,
Abel ED, Litwin SE
|
"Minimally invasive aortic banding in mice: effects of altered cardiomyocyte
insulin signaling during pressure overload"
|
Am J Physiol Heart Circ Physiol 285: H1261-H1269, 2003
|
1.4-F micromanometer-tipped catheter
|
mouse |
hypertrophy, contractility; fibrosis
|
| Hayashidani S, Tsutsui H, Ikeuchi M, Shiomi T, Matsusaka H, Kubota T, Imanaka-Yoshida K, Itoh T, Takeshita A |
"Targeted deletion of MMP-2 attenuates early LV rupture and late remodeling
after experimental myocardial infarction" |
Am J Physiol Heart Circ Physiol 285: H1229-H1235, 2003
|
1.4-F micromanometer-tipped catheter
|
mouse |
Transgenics, myocardial infarction, matrix metalloproteinase; cardiac rupture; heart failure; myocyte; extracellular matrix |
Brede M; Roell W; Ritter O; Wiesmann F; Jahns R; Haase A; Fleischmann BK; Hein L
|
Cardiac Hypertrophy Is Associated With Decreased eNOS Expression in Angiotensin AT2 Receptor–Deficient Mice
|
Hypertension. 2003;42:1177
|
1.4F Mikro-Tip catheter
|
mouse |
myocardial infarction • cryoinjury • animals, transgenic • mice • nitric oxide synthase
|
| Hayashidani S, Tsutsui H, Shiomi T, Ikeuchi M, Matsusaka H, Suematsu N, Wen J, Egashira K, Takeshita A |
Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction |
Circulation. 2003;108:2134 |
1.4F Mikro-Tip catheter |
mouse |
heart failure • remodeling • inflammation |
Flesch M, Höper A, Dell’Italia L, Evans K, Bond R, Peshock R, Diwan A, Brinsa TA, Wei C-C, Sivasubramanian N, Spinale FG, Mann DL
|
Activation and Functional Significance of the Renin-Angiotensin System in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor
|
Circulation. 2003;108:598
|
1.4F Mikro-Tip catheter |
mouse |
hypertrophy • genes • heart failure • remodeling • apoptosis
|
Ishibashi Y, Takahashi M, Isomatsu Y, Qiao F,
Iijima Y, Shiraishi H, Simsic JM, Baicu CF, Robbins J, Zile MR, Cooper IV G
|
"Role of microtubules versus myosin heavy chain isoforms in contractile
dysfunction of hypertrophied murine cardiocytes"
|
Am J Physiol Heart Circ Physiol 285: H1270-H1285, 2003
|
1.4-F Mikro-Tip catheter transducer
|
mouse |
Transgenics, hypertrophy, left ventricle; heart failure; cytoskeleton; contractile proteins; sarcomeres
|
Eigenthaler M, Engelhardt S, Schinke B, Kobsar A, Schmitteckert E, Gambaryan S, Engelhardt CM, Krenn V, Eliava M, Jarchau T, Lohse MJ, Walter U, Hein L
|
Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy
|
Am J Physiol Heart Circ Physiol 285: H2471-H2481, 2003
|
1.4-F Mkro-Tip catheter
|
mouse
|
transgenic mice; hypertrophy; arrhythmia
|
Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues ACT, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, Zapol WM
|
A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice
|
Am J Physiol Heart Circ Physiol 285: H2524-H2530, 2003
|
1.4-Fr high-fidelity pressure catheter
|
mouse
|
nitric oxide synthase; inflammation; inhibitors
|
Keys JR, Greene EA, Cooper CJ, Prasad SVN, Rockman HA, Koch WJ
|
"Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice
that express the amino terminus of beta-ARK1"
|
Am J Physiol Heart Circ Physiol 285: H2201-H2211, 2003
|
1.8-Fr high-fidelity micromanometer catheter
|
mouse |
Transgenics, hypertrophy, left ventricle; heart failure; cytoskeleton; contractile proteins; sarcomeres
|
Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT
|
Effect of a Cleavage-Resistant Collagen Mutation on Left Ventricular Remodeling
|
Circulation Research. 2003;93:238
|
Mikro-Tip catheter |
mouse |
matrix metalloproteinases • collagen • left ventricular remodeling • myocardial infarction
|
Flesch M, Höper A, Dell’Italia L, Evans K, Bond R, Peshock R, Diwan A, Brinsa TA, Wei C-C, Sivasubramanian N, Spinale FG, Mann DL
|
Activation and Functional Significance of the Renin-Angiotensin System in Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor
|
Circulation. 2003;108:598
|
Mikro-Tip catheter |
mouse |
hypertrophy • genes • heart failure • remodeling • apoptosis
|
Lindsey ML, Yoshioka J, MacGillivray C, Muangman S, Gannon J, Verghese A, Aikawa M, Libby P, Krane SM, Lee RT
|
Effect of a Cleavage-Resistant Collagen Mutation on Left Ventricular Remodeling
|
Circulation Research. 2003;93:238
|
SPR-671 |
mouse |
matrix metalloproteinases • collagen • left ventricular remodeling • myocardial infarction
|
| Gros R, Afroze T, You X-M, Kabir G, Van Wert R, Kalair W, Hoque AE, Mungrue IN, Husain M |
Plasma Membrane Calcium ATPase Overexpression in Arterial Smooth Muscle Increases Vasomotor Responsiveness and Blood Pressure |
Circulation Research. 2003;93:614 |
SPR-671 |
mouse |
transgenic mice • blood pressure • nitric oxide synthase • intracellular calcium • myogenic tone |
| Herrmann KL, McCulloch AD, Omens JH |
Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy |
Am J Physiol Heart Circ Physiol 284: H1277-H1284, 2003 |
1.4F |
rat |
Cardiac hypertrophy, ventricle; strain; stress; material properties |
Zlatko I, Dyck JRB, Hashimoto K, Wang S, Moudgil R, Harry G, Sultanian R, Koshal A, MD; Archer SL
|
In Vivo Gene Transfer of the O2-Sensitive Potassium Channel Kv1.5 Reduces Pulmonary Hypertension and Restores Hypoxic Pulmonary Vasoconstriction in Chronically Hypoxic Rats
|
Circulation. 2003;107:2037
|
1.4F Mikro-Tip catheter |
rat |
transgenics, pulmonary hypertension, catheterization, hypoxia, cardiac output, oxygen, gene therapy
|
| Iglarz M; Touyz RM; Viel EC; Paradis P; Amiri F; Diep QN; Schiffrin EL |
Peroxisome Proliferator-Activated Receptor- and Receptor- Activators Prevent Cardiac Fibrosis in Mineralocorticoid-Dependent Hypertension |
Hypertension. 2003;42:737 |
1.5F nylon with single 2F pressure sensor |
rat |
endothelin • remodeling • fibrosis • hypertension, mineralocorticoid • collagen • hypertrophy |
David A. Brown,1 Korinne N. Jew,1 Genevieve C. Sparagna,1 Timothy I. Musch,2 and Russell L. Moore
|
Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart
|
J Appl Physiol 95: 2510-2518, 2003
|
3F Mikro-Tip Catheter |
rat
|
cardioprotection; superoxide dismutase
|
Thai H, Wollmuth J, Goldman S, Gaballa M
|
Angiotensin Subtype 1 Receptor (AT1) Blockade Improves Vasorelaxation in Heart Failure by Up-Regulation of Endothelial Nitric-Oxide Synthase via Activation of the AT2 Receptor
|
JPET 307:1171-1178, 2003
|
A 1-mm micromanometer tipped catheter
|
rat
|
candesartan
|
Lapointe N, Nguyen QT, Desjardins J-F, 1Marcotte F, Pourdjabbar A, Moe G, Calderone A, Rouleau J-L
|
Effects of pre-, peri-, and postmyocardial infarction treatment with omapatrilat in rats: survival, arrhythmias, ventricular function, and remodeling
|
Am J Physiol Heart Circ Physiol 285: H398-H405, 2003
|
Micro-Tip catheter
|
rat |
vasopeptidase inhibitor
|
| Fechner H, Noutsias M, Tschoepe C, Hinze K, Wang X, Escher F, Pauschinger M, Dekkers D, Vetter R, Paul M, Lamers J, Schultheiss H-P, Poller W |
Induction of Coxsackievirus-Adenovirus-Receptor Expression During Myocardial Tissue Formation and Remodeling: Identification of a Cell-to-Cell Contact-Dependent Regulatory Mechanism |
Circulation 2003 107:876-882 |
Mikro-Tip catheter |
rat |
viruses • receptors • signaling • myocardial infarction • remodeling
|
| Nahrendorf M, Hu K, Fraccarollo D, Hiller K-H, Haase A, Bauer WR, Ertl G |
Time course of right ventricular remodeling in rats with experimental myocardial infarction |
Am J Physiol Heart Circ Physiol 284: H241-H248, 2003 |
Mikro-Tip manometer |
rat |
rat heart; magnetic resonance imaging
|
Wang Y, Patel KP, Cornish KG, Channon KM, Zucker IH
|
"nNOS gene transfer to RVLM improves baroreflex function in rats with chronic
heart failure"
|
Am J Physiol Heart Circ Physiol 285: H1660-H1667, 2003
|
Mikro-Tip transducer |
rat |
sympathetic nerve activity; heart rate; nitric oxide; adenovirus
|
Sato T, Kawada T, Inagaki M, Shishido T, Sugimachi M, Sunagawa K
|
Dynamics of sympathetic baroreflex control of arterial pressure in rats
|
Am J Physiol Regul Integr Comp Physiol 285: R262-R270, 2003
|
SPC-320 |
rat |
baroreflex sensitivity; dynamic system; feedback system; mechanoneural arc; neuromechanical arc
|
Koch M, ,Wendorf M, Dendorfer A, Wolfrum S, Schulze K, Spillmann F, 1Schultheiss H-P, Tschöpe C
|
Cardiac kinin level in experimental diabetes mellitus: role of kininases
|
Am J Physiol Heart Circ Physiol 285: H418-H423, 2003
|
SPR 407
|
rat |
bradykinin; kininase; myocardial ischemia
|
Wang X, Ren B, Liu S, Sentex E, Tappia PS, Dhalla NS
|
Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat
|
J Appl Physiol 94: 752-763, 2003
|
SPR-249 |
rat |
aortocaval fistula; beta-adrenergic mechanisms
|
| Deten A, Volz HC, Briest W, Zimmer H-G |
Differential Cytokine Expression in Myocytes and Non-myocytes after Myocardial Infarction in Rats |
Molecular and Cellular Biochemistry 242: 47-55, 2003 |
SPR-249
SPR-291 |
rat |
myocardial infarction, chronic heart failure, cytokine expression
|
Wei C-C, Lucchesi PA, Tallaj J, Bradley WE, Powell PC, Dell'Italia LJ
|
Cardiac interstitial bradykinin and mast cells modulate pattern of LV remodeling in volume overload in rats
|
Am J Physiol Heart Circ Physiol 285: H784-H792, 2003
|
SPR-249A |
rat |
hypertrophy; chymase; angiotensin-converting enzyme
|
Hayakawa K, Takemura G, Kanoh M, Li Y, Koda M, Kawase Y, Maruyama R, Okada H, Minatoguchi S, Fujiwara T, Fujiwara H
|
Inhibition of Granulation Tissue Cell Apoptosis During the Subacute Stage of Myocardial Infarction Improves Cardiac Remodeling and Dysfunction at the Chronic Stage
|
Circulation. 2003;108:104
|
SPR-407 |
rat |
apopstosis • heart failure • myocardial infarction • remodeling
|
Tanaka T, Kono T, Terasaki F, Kintaka T, Sohmiya K,
Mishima T, Kitaura Y
|
"Gene-environment interactions in wet beriberi: effects of thiamine depletion
in CD36-defect rats"
|
Am J Physiol Heart Circ Physiol 285: H1546-H1553, 2003
|
SPR-407 |
rat |
CD36 deficiency
|
Schlenker EH, Tamura T, Gerdes AM
|
Gender-specific effects of thyroid hormones on cardiopulmonary function in SHHF rats
|
J Appl Physiol 95: 2292-2298, 2003
|
SPR-407, curved
|
rat
|
hypertension; sick euthryoid syndrome; hyperthyroidism
|
Bagi Z, Csekö C, Tóth E, Koller A
|
Oxidative stress-induced dysregulation of arteriolar wall shear stress and blood pressure in hyperhomocysteinemia is prevented by chronic vitamin C treatment
|
Am J Physiol Heart Circ Physiol 285: H2277-H2283, 2003
|
SPR-524
|
rat
|
homocysteine; nitric oxide; thromboxane A2 power dissipation
|
Kamo I, Torimoto K, Chancellor MB, de Groat WC, Yoshimura N
|
Kamo I, Torimoto K, Chancellor MB, de Groat WC, Yoshimura N
|
Am J Physiol Regul Integr Comp Physiol 285: R356-R365, 2003
|
SPR-524 |
rat |
urethral resistance; active urethral closure; sneeze leak point pressure
|
Deten A, Millar H, Zimmer H-G
|
"Catheterization of pulmonary artery in rats with an ultraminiature catheter
pressure transducer"
|
Am J Physiol Heart Circ Physiol 285: H2212-H2217, 2003
|
SPR-671 |
rat |
cardiac output; contractility; norepinephrine; right heart
|
| Briest W, Holzl A, Raffler B, Deten A, Baba HA, Zimmer H-G |
Significance of Matrix Metalloproteinases in Norepinephrine-induced Remodelling of Rat Hearts |
Cardiovascular Research I (2003) 000-000 (in press) |
Ultra-miniature Catheter Pressure Transducer |
rat |
adrenergic (ant)agonists, extracellular matrix, fibrosis, hemodynamics, remodeling
|
| Min J-Y, Yang Y, Sullivan MF, Ke Q, Converso KL, Chen Y, Morgan JP, Xiao Y-F |
Long-term improvement of cardiac function in rats after infarction by transplantation of embryonic stem cells |
J. Thorac. Cardiovasc. Surg., Feb 2003; 125: 361 - 369 |
3F high-fidelity microtip catheter connected to a pressure transducer |
rat |
mouse embryonic stem cells |
| |
|
|
|
|
|
| ---------------------------------------------Published in 2002--------------------------------------------- |
| Lorenz, John N. |
A practical guide to evaluating cardiovascular, renal, and pulmonary function in mice |
Am J Physiol Regulatory Integrative Comp Physiol 282: R1565-R1582; 10.1152/ajpregu.00759.2001. |
1.4 F Mikro-Tip catheter |
mouse |
phenotype, methods, surgery, heart, lung, kidney
|
Huke S, Prasad V, Nieman ML, Nattamai KJ, Grupp IL, Lorenz JN, Periasamy M
|
Altered dose response to -agonists in SERCA1a-expressing hearts ex vivo and in vivo
|
Am J Physiol Heart Circ Physiol 283: H958-H965, 2002
|
1.4F Mikro-Tip catheter |
mouse |
transgenic mice; contractility; sarco(endo)plasmic reticulum calcium adenosinetriphosphatase; phospholamban
|
Liao R, Jain M, Cui L, D’Agostino J, Aiello F, Luptak I, Ngoy S; Mortensen RM, Tian R
|
Cardiac-Specific Overexpression of GLUT1 Prevents the Development of Heart Failure Attributable to Pressure Overload in Mice |
Circulation. 2002;106:2125
|
1.4F Mikro-Tip catheter
|
mouse |
glucose • heart failure • metabolism
|
Hardouin SN, Richmond KN, Zimmerman A, Hamilton SE, Feigl EO, Nathanson NM
|
Altered Cardiovascular Responses in Mice Lacking the M1 Muscarinic Acetylcholine Receptor |
JPET, Vol. 301, Issue 1, 129-137, April 2002
|
1.4F Mikro-Tip catheter |
mouse |
arrhythmia, catecholamines, Immunoprecipitation
|
Hahn HS, Yussman MG, Toyokawa T, Marreez Y, Barrett TJ, Hilty KC, Osinska H, Robbins J, Dorn II GW
|
Ischemic Protection and Myofibrillar Cardiomyopathy
|
Circulation Research. 2002;91:741
|
1.4F Mikro-Tip catheter |
mouse |
ischemia/reperfusion • protein kinase C • myofibrillar cardiomyopathy • congestive heart failure
|
Funakoshi H, Kubota T, Machida Y, Kawamura N, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A
|
Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha
|
Am J Physiol Heart Circ Physiol 282: H2159-H2166, 2002. First published February 14, 2002; 10.1152/ajpheart.00872.2001
|
1.4-F Mikro-Tip catheter
|
mouse
|
cytokine; heart failure; transgenic mice
|
Nemoto S, Vallejo JG, Knuefermann P, Misra A, Defreitas G, Carabello BA, Mann DL
|
Escherichia coli LPS-induced LV dysfunction: role of toll-like receptor-4 in the adult heart
|
Am J Physiol Heart Circ Physiol 282: H2316-H2323, 2002; 10.1152/ajpheart.00763.2001
|
1.4-F Mikro-Tip catheter
|
mouse
|
innate immunity; endotoxic shock; proinflammatory cytokine; myocardial depression
|
Jin Z-Q, Zhou H-Z, Zhu P, Honbo N, Mochly-Rosen D, Messing RO, Goetzl EJ, Karliner JS, Gray MO
|
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKCepsilon knockout mouse hearts
|
Am J Physiol Heart Circ Physiol 282: H1970-H1977, 2002. First published February 14, 2002; 10.1152/ajpheart.01029.2001
|
1.4-F Mikro-Tip catheter
|
mouse
|
ischemia-reperfusion injury; epsilon -isoform of protein kinase C
|
Shiomi T, Hiroyuki Tsutsui H, Hayashidani S, Suematsu N, Ikeuchi M, Wen J, Ishibashi M, Kubota T, Egashira K, Takeshita A
|
Pioglitazone, a Peroxisome Proliferator–Activated Receptor- Agonist, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction
|
Circulation. 2002;106:3126
|
1.4F Mikro-Tip Catheter |
mouse |
myocardial infarction • heart failure • myocardium • remodeling • receptors
|
Brum, PC, Kosek J, Patterson A, Bernstein D, Kobilka B
|
Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice
|
Am J Physiol Heart Circ Physiol 283: H1838-H1845, 2002
|
1.8-Fr high-fidelity catheter-tipped micromanometer
|
mouse |
alpha2-adrenergic receptor; knockout mice; heart failure
|
Aasum E, Belke DD, Severson DL, Riemersma RA, Cooper M, Andreassen M, Larsen TS
|
Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a novel PPAR- activator
|
Am J Physiol Heart Circ Physiol 283: H949-H957, 2002
|
2.5F Mikro-Tip |
mouse |
substrate oxidation; isolated working mouse hearts
|
Alan Y. H. Wong, Shathiyah Kulandavelu, Kathie J. Whiteley, Dawei Qu, B. Lowell Langille and S. Lee Adamson
|
Maternal cardiovascular changes during pregnancy and postpartum in mice
|
Am J Physiol Heart Circ Physiol 282: H918-H925, 2002; 10.1152/ajpheart.00641.2001
|
5F Catheter-tip PressureTransducer
|
mouse
|
cardiac output; blood pressure; angiotensin; hematocrit; heart rate; Doppler ultrasound; aortic blood velocity waveform
|
Hui-Zhong Zhou, Joel S. Karliner, and Mary O. Gray
|
Moderate alcohol consumption induces sustained cardiac protection by activating PKC- and Akt
|
Am J Physiol Heart Circ Physiol 283: H165-H174, 2002. First published February 28, 2002; 10.1152/ajpheart.00408.2001
|
Micromanometer
|
mouse
|
heart; ischemia; reperfusion; ethanol; signaling
|
Weiss RG, Chatham JC, Charron MJ, Georgakopolous D, Wallimann T, Kay L, Walzel B, Wang Y, Kass DA, Gerstenblith G, Chacko VP
|
An increase in the myocardial PCr/ATP ratio in GLUT4 null
mice
|
The FASEB Journal express article 10.1096/fj.01-0462fje
|
Mikro-Tip Catheter |
mouse |
phosphocreatine • glucose • left ventricular hypertrophy • 31P NMR spectroscopy • magnetic resonance imaging
|
Takimoto E, Yao A, Toko H, Takano H, Shimoyama M, Sonoda M, Wakimoto K, Takahashi T, Akazawa H, Mizukami M, Nagai T, Nagai Y, Komuro I
|
Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload
|
The FASEB Journal. 2002;16:373-378
|
SPR-612 |
mouse |
Na+-Ca2+ exchanger • sarcoplasmic reticulum • knockout mice • NCX
|
Iversen PO, Woldbaek PR, Tønnessen T, Christensen G
|
Decreased hematopoiesis in bone marrow of mice with congestive heart failure
|
Am J Physiol Regul Integr Comp Physiol 282: R166-R172, 2002
|
SPR-671 |
mouse |
blood cells; bone marrow cells; immunity; myocardial infarction
|
| Zaidi SHE, You X-M, Ciura S, Husain M, Rabinovitch M |
Overexpression of the Serine Elastase Inhibitor Elafin Protects Transgenic Mice From Hypoxic Pulmonary Hypertension |
Circulation. 2002;105:516 |
SPR-671 |
mouse |
hypoxia • hypertension, pulmonary • lung
|
Pieples K, Arteaga G, Solaro J, Grupp I, Lorenz JN, Boivin GP, Jagatheesan G, Labitzke E, deTombe PP, Konhilas JP, Irving TC, Wieczorek DF
|
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca2+ activation
|
Am J Physiol Heart Circ Physiol 283: H1344-H1353, 2002
|
SPR-671
|
mouse |
heart; cardiac muscle; thin filament regulation
|
| Pacher P, Liaudet L, Bai P, Virag L, Mabley JG, Hasko G, Szabo C |
Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure |
The Journal of Pharmacology and Experimental Therapeutics, Vol. 300, No. 3, 862-867, 2002 |
SPR-671 |
mouse |
hypertension, aging, atherosclerosis, vasorelaxation, acetylcholine, oxidative stress, blood pressure
|
Meyer JW, Flagella M, Sutliff RL, Lorenz JN, Nieman ML, Weber CS, Paul RJ, Shull GE
|
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na+-K+-2Cl cotransporter
|
Am J Physiol Heart Circ Physiol 283: H1846-H1855, 2002
|
SPR-612 |
mouse |
vasculature; hypotension; bumetanide
|
Jones JE, Mendes L, Rudd MA, Russo G, Loscalzo J, Zhang Y-Y
|
Serial noninvasive assessment of progressive pulmonary hypertension in a rat model
|
Am J Physiol Heart Circ Physiol 283: H364-H371, 2002; 10.1152/ajpheart.00979.2001
|
1.4-F Mikro-Tip catheter
|
rat
|
echocardiography; monocrotaline; pulmonary artery acceleration time
|
| Michelakis ED, McMurtry MS, Wu X-C, Dyck JRB, Moudgil R, Hopkins TA, Lopaschuk GD, Puttagunta L, Waite R, Archer SL |
Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats |
Circulation. 2002;105:244 |
1.4F Mikro-Tip Catheter |
rat |
hypertension, pulmonary • kinases • dichloroacetate • metabolism • ion channels
|
Musch TI, Wolfram S, Hageman KS, Pickar JG
|
Skeletal muscle ouabain binding sites are reduced in rats with chronic heart failure
|
J Appl Physiol 92: 2326-2334, 2002 |
2F Mikro-Tip catheter |
rat |
Na+-K+ pump; exercise; performance; oxygen uptake; congestive failure
|
Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T
|
Transforming Growth Factor-ß Function Blocking Prevents Myocardial Fibrosis and Diastolic Dysfunction in Pressure-Overloaded Rats
|
Circulation. 2002;106:130
|
2F Mikro-Tip catheter
|
rat
|
growth substances, fibrosis, hypertension, diastole
|
Zhang K, Li Y-F, Patel KP
|
Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure
|
Am J Physiol Regul Integr Comp Physiol 282: R1006-R1015, 2002
|
2F Mikro-Tip catheter |
rat |
paraventricular nucleus; renal sympathetic nerve activity; muscimol; bicuculline
|
Sakakibara Y, Tambara K, Lu F, Nishina T, Sakaguchi G, Nagaya N, Nishimura K, Li R-K, Weisel RD, Komeda M
|
Combined Procedure of Surgical Repair and Cell Transplantation for Left Ventricular Aneurysm: An Experimental Study
|
Circulation. 2002;106:I-193
|
2F Mikro-Tip Catheter |
rat |
aneurysm • cells • myocardial infarction • surgery • transplantation
|
Nomoto T, Nishina T, Miwa S, Tsuneyoshi H, Maruyama I, Nishimura K, Komeda M
|
Angiotensin-Converting Enzyme Inhibitor Helps Prevent Late Remodeling After Left Ventricular Aneurysm Repair in Rats
|
Circulation. 2002;106:I-115
|
3F Fogarty baloon catheter |
rat |
surgery • myocardial infarction • aneurysm • remodeling • angiotensin
|
Bates K, Ruggeroli CE, Goldman S, Gaballa MA
|
Simvastatin restores endothelial NO-mediated vasorelaxation in large arteries after myocardial infarction
|
Am J Physiol Heart Circ Physiol 283: H768-H775, 2002
|
Mikro-Tip Dual Sensor catheter
|
rat
|
congestive heart failure; arterial relaxation; endothelial nitric oxide synthase; 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors
|
| Pacher P, Mabley JG, Soriano FG, Liaudet L, Komjati K, Szabo C |
Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation |
British Journal of Pharmacology 2002 Mar;135(6):1347-50 |
Millar |
rat |
reperfusion, shock, diabetes, oxidant induced cell injury
|
Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi, M, Irukayama-Tomobe Y, Sakai S, Ohmori H, Matsuda M, Yamaguchi I
|
Aging-induced decrease in the PPAR- level in hearts is improved by exercise training
|
Am J Physiol Heart Circ Physiol 283: H1750-H1760, 2002.
|
SPC-320 |
rat |
peroxisome proliferator-activated receptor-alpha; swimming training; aged rat; fatty acid
|
Sato T, Kawada T, Sugimachi M, Sunagawa K
|
Bionic Technology Revitalizes Native Baroreflex Function in Rats With Baroreflex Failure
|
Circulation. 2002;106:730
|
SPC-320
|
rat
|
baroreceptors • blood pressure • dynamics • electrical stimulation • nervous system, sympathetic
|
Mulder P, Boujedaini H, Richard V, Henry J-P, Renet S, Münter K, Thuillez C
|
Long-Term Survival and Hemodynamics After Endothelin-A Receptor Antagonism and Angiotensin-Converting Enzyme Inhibition in Rats With Chronic Heart Failure
|
Circulation. 2002;106:1159
|
SPR-407
|
rat
|
endothelin • hemodynamics • heart failure • inhibitors, angiotensin-converting enzyme
|
Podesser BK, Schirnhofer J, Bernecker OY, Kröner A, Franz M, Semsroth S, Fellner B, Neumüller J, Hallström S, Wolner E
|
Optimizing Ischemia/Reperfusion in the Failing Rat Heart—Improved Myocardial Protection With Acute ACE Inhibition
|
Circulation. 2002;106:I-277
|
SPR-407 |
rat |
heart failure • cardiopulmonary bypass • ACE inhibitors
|
| Deschepper CF, Picard S, Thibault G, Touyz R, Rouleau J-L |
Characterization of Myocardium, Isolated Cardiomyocytes, and Blood Pressure in WKHA and WKY rats |
Am J Physiol Heart Circ Physiol 282: H149-H155, 2002. First published September 27, 2001; 10.1152/ajpheart.00672.2001 |
SPR-407 |
rat |
cell width; intracellular free calcium concentration; left ventricular hypertrophy; cardiac morphology; cardiac function
|
Sjaastad I, Bøkenes J, Swift F, Wasserstrom JA, Sejersted OM
|
Normal contractions triggered by ICa,L in ventricular myocytes from rats with postinfarction CHF
|
Am J Physiol Heart Circ Physiol 283: H1225-H1236, 2002
|
SPR-407 |
rat |
electrophysiology; myocardial infarction; sarcoplasmic reticulum Ca2+ ATPase; phospholamban; caffeine; L-type Ca2+ current; congestive heart failure
|
Prunier F, Gaertner R, Louedec L, Michel J-B, Mercadier J-J, Escoubet B
|
Doppler echocardiographic estimation of left ventricular end-diastolic pressure after MI in rats
|
Am J Physiol Heart Circ Physiol 283: H346-H352, 2002. First published March 28, 2002; 10.1152/ajpheart.01050.2001
|
SPR-524
|
rat
|
myocardial infarction; echocardiography; heart failure; tissue, Doppler imaging
|
Pal Pacher, MD, PHD, Lucas Liaudet, MD, Jon G. Mabley, PHD, Katalin Komjati, MD, PHD,
Csaba Szabo´, MD, PHD |
Pharmacologic Inhibition of Poly(Adenosine Diphosphate-Ribose) Polymerase May Represent a Novel Therapeutic Approach in Chronic Heart Failure |
JACC Vol. 40, No. 5, 2002 September 4, 2002:1006–16 |
SPR-524 |
rat |
PARP
|
| Corno AF, Milano G, Samaja M, Tozzi P, von Segesser LK |
Chronic hypoxia: A model for cyanotic congenital heart defects
|
J. Thorac. Cardiovasc. Surg., Jul 2002; 124: 105 - 112 |
MPC-500 |
rat |
reoxygenation injury, cardiopulmonary bypass. |
| Sakakibara Y, Nishimura K, Tambara T, Yamamoto M, Lu F, Tabata Y, Komeda M |
Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation |
J. Thorac. Cardiovasc. Surg., Jul 2002; 124: 50 - 56 |
2Fr micromanometer-tipped catheter |
rat |
fibroblast growth factor-incorporated microspheres |
Gao F, Yao C-L, Gao E, Mo Q-Z, Yan W-L, McLaughlin R, Lopez BL, Christopher TA, Ma XL
|
Enhancement of Glutathione Cardioprotection by Ascorbic Acid in Myocardial Reperfusion Injury
|
JPET Vol. 301, Issue 2, 543-550, May 2002
|
SPR-524 |
rat, isolated heart |
glutathione monoethyl ester (GSHme)
|
| Pacher P, Mabley JG, Soriano FG, Liaudet L, Szabo C |
Activation of poly(ADP-ribose) polymerase contributes to the endothelial dysfunction associated with hypertension and aging |
International Journal of Molecular Medicine, 9:659-664, 2002 |
SPR-524 |
rat, mouse |
hypertension, aging, atherosclerosis, vasorelaxation, acetylcholine, oxidative stress, blood pressure
|
| Pacher P, Cziraki A, Mabley JG, Liaudet L, Papp L, Szabo C |
Role of Poly(ADP-ribose) Polymerase Activation in Endotoxin-induced Cardiac Collapse in Rodents |
Biochemical Pharmacology 64 (2002) 1785-1791 |
SPR-671, SPR-524 |
mice, rats |
systolic pressure increment; dP/dt, systolic pressure decrement; PARP, poly(ADP-ribose) polymerase; STZ, streptozotocin
|
| Pacher P, Liaudet L, Soriano FG, Mabley JG, Szabo E, Szabo C |
The role of poly(ADP-ribose) polymerase activation in the development of myocardial and endothelial dysfunction in diabetes |
Diabetes 51:514-521, 2002 |
SPR-671, SPR-524 |
rat, mouse |
cardiomyopathy, streptozotocin, hypertension, retinopathy, nephropathy, neuropathy
|
| Deten A, Zimmer H-G |
Heart Function andCytokine Expression is Similar in Mice and Rats after Myocardial Infarction but Differences occur in TNFalpha Expression |
Eur J. Physiol (2002) 445:289-296 |
SPR-291, SPR-612, SPR-249, SPR-671 |
mouse, rat |
cytokines, growth factors, heart failure, hemodynamics, hypertrophy, infarction, remodeling
|
| |
|
|
|
|
|
| ---------------------------------------------Published in 2001--------------------------------------------- |
| Kohout TA, Takaoka H, McDonald PH, Perry SJ, Mao L, Lafkowitz RJ, Rockman HA |
Augmentation of cardiac contractility mediated by the human b3-adrenergic receptor overexpressed in the hearts of transgenic mice |
Circulation. 2001;104:2485 |
1.4F Mikro-Tip Pressure Transducer |
mouse |
signal transduction • pharmacology • gene therapy • inotropic agents
|
| Marielle Scherrer-Crosbie, MD*; Roman Ullrich, MD*; Kenneth D. Bloch, MD; Hiroshi Nakajima, MD; Boris Nasseri, MD; H. Thomas Aretz, MD; Merry L. Lindsey, MD; Anne-Claire Vançon, MD; Paul L. Huang, MD; Richard T. Lee, MD; Warren M. Zapol, MD; Michael H. Picard, MD |
Endothelial Nitric Oxide Synthase Limits Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2001;104:1286 |
1.4F Mikro-Tip Pressure Transducer |
mouse |
echocardiography • ventricles • hypertrophy
|
| Brian B. Roman, David L. Geenen, Michael Leitges, and Peter M. Buttrick |
PKC-beta is not necessary for cardiac hypertrophy |
AJP Heart Circ Physiol 280(5):H2264-H2270 |
1.4FMikro-Tip Pressure Transducer |
mouse |
transgenic mouse; LacZ; cell signaling
|
Engelhardt S, Boknik P, Keller U, Neumann J, Lohse MJ, Hein L
|
"Early impairment of calcium handling and altered
expression of junctin in hearts of mice overexpressing the ß1- adrenergic receptor"
|
The FASEB Journal express article 10.1096/fj.01-0107fje.
|
1.8 French Mikro-Tip Catheter
|
mouse |
transgenic mouse • heart failure • triadin • sarcoplasmic reticulum
|
| Markus Meyer, Susanne U. Trost, Wolfgang F. Bluhm, Harm J. Knot, Eric Swanson, and Wolfgang H. Dillmann |
Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy |
AJP Heart Circ Physiol 280(5):H2046-H2052 |
1.8F Mikro-Tip Pressure Transducer |
mouse |
growth; inotropic agents; myocardial contraction; Ca2+ handling; endothelial cell coupling
|
Marc Brede; Kerstin Hadamek; Lorenz Meinel; Frank Wiesmann, MD; Jörg Peters, MD; Stefan Engelhardt, MD; Andreas Simm, MD; Axel Haase, PhD; Martin J. Lohse, MD; Lutz Hein, MD
|
Vascular Hypertrophy and Increased P70S6 Kinase in Mice Lacking the Angiotensin II AT2 Receptor
|
Circulation. 2001;104:2602 |
1.8F Mikro-Tip; Pressure Transducer |
mouse |
angiotensin • receptors • hypertrophy • vasculature • magnetic resonance imaging
|
| Kalev Freeman, Cynthia Colon-Rivera, M. Charlotte Olsson, Russell L. Moore, Howard D. Weinberger, Ingrid L. Grupp, Karen L. Vikstrom, Guido Iaccarino, Walter J. Koch, and Leslie A. Leinwand |
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene
|
AJP Heart Circ Physiol., Vol. 280, Issue 1, H151-H159, January 2001
|
3F Mikro-Tip Pressure Transducer |
mouse |
myosin heavy chain; cardiac decompensation; exercise intolerance; beta-adrenergic receptor kinase 1
|
| M. Charlotte Olsson, Bradley M. Palmer, Leslie A. Leinwand, and Russell L. Moore |
Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy
|
AJP Heart Circ Physiol., Vol. 280, Issue 3, H1136-H1144, March 2001 |
3F Mikro-Tip Pressure Transducer |
mouse |
myosin; isovolumic; diastolic; systolic
|
| Shi J, Larson DF, Yang B, Hunter K, Gorman M, Montes S, Beischel J, Watson RR |
Differential effects of acute ethanol treatment on cardiac contractile function in young adult and senescent mice |
Alcohol 24(2001) 197-204 |
CCS, MCS-100, TCB-100 |
mouse |
alcohol, aging, nitric oxide, cGMP
|
Jiqiu Chen, MD; Peter J. Kuhlencordt, MD; Joshua Astern, BS; Robert Gyurko, DDS, PhD; Paul L. Huang, MD, PhD
|
Hypertension Does Not Account for the Accelerated Atherosclerosis and Development of Aneurysms in Male Apolipoprotein E/Endothelial Nitric Oxide Synthase Double Knockout Mice |
Circulation. 2001;104:2391 |
Mikro-Tip Pressure Transducer |
mouse |
arteriosclerosis • nitric oxide synthase • aneurysm • hypertension • hydralazine
|
| Bradley K. McConnell, Diane Fatkin, Christopher Semsarian, Karen A. Jones, Dimitrios Georgakopoulos, Colin T. Maguire, Michael J. Healey, James O. Mudd, Ivan P. G. Moskowitz, David A. Conner, Michael Giewat, Hiroko Wakimoto, Charles I. Berul, Frederick J. Schoen, David A. Kass, Christine E. Seidman, J. G. Seidman |
Comparison of Two Murine Models of Familial Hypertrophic Cardiomyopathy |
Circulation Research. 2001;88:383 |
Mikro-Tip Pressure Transducer |
mouse |
cardiomyopathy • hypertrophy • genetics • myosin • cardiac myosin binding protein C
|
| Xuejun Wang, Hanna Osinska, Raisa Klevitsky, A. Martin Gerdes, Michelle Nieman, John Lorenz, Timothy Hewett, Jeffrey Robbi |
Expression of R120G–B-Crystallin Causes Aberrant Desmin and B-Crystallin Aggregation and Cardiomyopathy in Mice
|
Circulation Research. 2001;89:84 |
Mikro-Tip Pressure Transducer |
mouse |
transgenic • heart disease • mouse • cardiac • genetics
|
Qingping Feng, MD, PhD; Xiangru Lu, MD; Douglas L. Jones, PhD; Ji Shen, MD; J. Malcolm O. Arnold, MD
|
Increased Inducible Nitric Oxide Synthase Expression Contributes to Myocardial Dysfunction and Higher Mortality After Myocardial Infarction in Mice
|
Circulation. 2001;104:700 |
SPR-671 |
mouse |
heart failure • nitric oxide • nitric oxide synthase • myocardial infarction
|
| Chari Y. T. Hart, John C. Burnett Jr., and Margaret M. Redfield |
Effects of avertin versus xylazine-ketamine anesthesia on cardiac function in normal mice
|
AJP Heart Circ Physiol Vol. 281, Issue 5, H1938-H1945, November 2001
|
SPR-671 |
mouse |
echocardiography; left ventricular function; murine physiology
|
| Valérie Marque; Pascal Kieffer; Barbara Gayraud; Isabelle Lartaud-Idjouadiene; Francesco Ramirez; Jeffrey Atkinson |
Aortic Wall Mechanics and Composition in a Transgenic Mouse Model of Marfan Syndrome |
Arteriosclerosis, Thrombosis, and Vascular Biology. 2001;21:1184 |
SPR-671 |
mouse |
fibrillin-1 • elastic modulus • aneurysm • desmosines • elastic fibers
|
J. Thomas Peterson, PhD; Hussein Hallak, PhD; Linda Johnson, MS; Hua Li, MD; Patrick M. O’Brien, MS; Drago R. Sliskovic, PhD; Thomas M. A. Bocan, PhD; Mytsi L. Coker, PhD; Takuma Etoh, MD; Francis G. Spinale, MD, PhD
|
Matrix Metalloproteinase Inhibition Attenuates Left Ventricular Remodeling and Dysfunction in a Rat Model of Progressive Heart Failure |
Circulation. 2001;103:2303 |
|
rat |
ventricles • remodeling • hypertrophy • hypertension • systole
|
| Federica del Monte, MD, PhD; Eric Williams, BS; Djemal Lebeche, PhD; Ulrich Schmidt, MD, PhD; Anthony Rosenzweig, MD; Judith K. Gwathmey, VMD, PhD; E. Douglas Lewandowski, PhD; Roger J. Hajjar, MD |
Improvement in Survival and Cardiac Metabolism After Gene Transfer of Sarcoplasmic Reticulum Ca2+-ATPase in a Rat Model of Heart Failure |
Circulation. 2001;104:1424 |
1.4F Mikro-Tip Pressure Transducer |
rat |
gene therapy • heart failure • calcium • excitation • contractility
|
| Takashi Matsui, MD, PhD; Jingzang Tao, MD; Federica del Monte, MD, PhD; Kyung-Han Lee, MD, PhD; Ling Li, MD; Michael Picard, MD; Thomas L. Force, MD; Thomas F. Franke, MD, PhD; Roger J. Hajjar, MD; Anthony Rosenzweig, MD |
Akt Activation Preserves Cardiac Function and Prevents Injury After Transient Cardiac Ischemia In Vivo |
Circulation. 2001;104:330 |
1.8F LV pressure transducer |
rat |
apoptosis • signal transduction • gene therapy • ischemia
|
| Teruo Noguchi, Zengyi Chen, Stephen P. Bell, Lori Nyland, and Martin M. LeWinter |
Activation of PKC decreases myocardial O2 consumption and increases contractile efficiency in rats
|
AJP Heart Circ Physiol Vol. 281, Issue 5, H2191-H2197, November 2001
|
2.5F Mikro-Tip Pressure Transducer |
rat |
mechanoenergetics; protein kinase C; excitation-contraction coupling; inotropy; phorbol ester
|
Okada M, Fujita T, Sakaguchi T, Olson KE, Collins T, Stern DM, Yan SF, Pinsky DJ
|
"Extinguishing Egr-1-dependent inflammatory and
thrombotic cascades following lung transplantation"
|
The FASEB Journal express article 10.1096/fj.01-0490fje.
|
2F |
rat |
"early growth response-1 • antisense oligodeoxyribonucleotide • transcription factor •
ischemia"
|
Sullivan DM, Watts JA, Kline JA
|
Biventricular cardiac dysfunction after acute massive pulmonary embolism in the rat
|
J Appl Physiol 90: 1648-1656, 2001
|
2F Mikro-Tip catheter |
rat |
pulmonary heart disease; tumor necrosis factor-; myocardial contraction; shock; animal model; fibrinolysis
|
| J. David Symons and Saul Schaefer |
Na+/H+ exchange subtype 1 inhibition reduces endothelial dysfunction in vessels from stunned myocardium |
AJP Heart Circ. Physiol., Vol. 281, Issue 4, H1575-H1582, October 2001 |
2F Mikro-Tip Pressure Transducer |
rat |
coronary resistance vessels; myocardial function; endothelium; vascular smooth muscle; acetylcholine; myocardial ischemia; myocardial stunning
|
| Kun Zhang, Yi-Fan Li, and Kaushik P. Patel |
Blunted nitric oxide-mediated inhibition of renal nerve discharge within PVN of rats with heart failure |
AJP Heart Circ Physiol Vol. 281, Issue 3, H995-H1004, September 2001 |
2F Mikro-Tip Pressure Transducer |
rat |
hypothalamus; sympathetic outflow; cardiovascular regulation
|
| Bruno K. Podesser, Deborah A. Siwik, Franz R. Eberli, Flora Sam, Soeun Ngoy, Julie Lambert, Khahn Ngo, Carl S. Apstein, and Wilson S. Colucci |
ETA-receptor blockade prevents matrix metalloproteinase activation late post myocardial infarction in the rat |
AJP Heart Circ Physiol 280(3):H984-H991 |
2F Mikro-Tip Pressure Transducer |
rat |
endothelin; left ventricle; remodeling
|
| Julia H. Indik, Steven Goldman, and Mohamed A. Gaballa |
Oxidative stress contributes to vascular endothelial dysfunction in heart failure |
AJP Heart Circ. Physiol., Vol. 281, Issue 4, H1767-H1770, October 2001
|
2-Fr solid-state micromanometer-tipped catheter with two pressure sensors, 3-Fr echo-Doppler catheter |
rat |
congestive heart failure; superoxide dismutase; nitric oxide; endothelial function
|
| Zhenhai Gao1 , Zhihe Li1 , Stephen P. Baker, Robert D. Lasley, Stephanie Meyer, Elfatih Elzein, Venkata Palle, Jeff A. Zablocki, Brent Blackburn and Luiz Belardinelli |
Novel Short-Acting A2A Adenosine Receptor Agonists for Coronary Vasodilation: Inverse Relationship between Affinity and Duration of Action of A2A Agonists
|
Journal of Pharmacology and Experimental Therapeutics, Vol. 298, Issue 1, 209-218, July 2001 |
5F high-fidelity pressure sensitive tip transducer |
rat, pig |
coronary vasodilators, myocardial imaging
|
Thomas A. Fischer; Stephan Ludwig; Egbert Flory; Stepan Gambaryan; Krishna Singh; Peter Finn; Marc A. Pfeffer; Ralph A. Kelly; Janice M. Pfeffer
|
Activation of Cardiac c-Jun NH2-Terminal Kinases and p38-Mitogen–Activated Protein Kinases With Abrupt Changes in Hemodynamic Load |
Hypertension. 2001;37:1222
|
5F Mikro-Tip |
rat |
hypertrophy • protein kinases • transcription, genetic • hemodynamics
|
| Mohamed A. Gaballa, Andrea Eckhart, Walter J. Koch, and Steven Goldman |
Vascular beta-adrenergic receptor system is dysfunctional after myocardial infarction |
AJP Heart Circ Physiol 280(3):H1129-H1135 |
Dual Sensor Mikro-Tip Pressure Transducer |
rat |
heart failure; G protein; hemodynamics, cAMP/cGMP; beta-adrenergic receptor-coupled kinase
|
Jew KN, Moore RL
|
Glibenclamide improves postischemic recovery of myocardial contractile function in trained and sedentary rats
|
J Appl Physiol 91: 1545-1554, 2001
|
Mikro-Tip catheter |
rat |
exercise; myocardial recovery
|
| Terrence M. Yau, MD, MSc; Karen Fung, BSc; Richard D. Weisel, MD; Takeshiro Fujii, MD; Donald A.G. Mickle, MD; Ren-Ke Li, MD, PhD |
Enhanced Myocardial Angiogenesis by Gene Transfer With Transplanted Cells |
Circulation. 2001;104:I-218 |
Mikro-Tip Pressure Transducer |
rat |
gene therapy • cells • transplantation • angiogenesis
|
| Andrew I.M. Campbell, MD; Yidan Zhao, MD, PhD; Reena Sandhu, PhD; Duncan J. Stewart, MD |
Cell-Based Gene Transfer of Vascular Endothelial Growth Factor Attenuates Monocrotaline-Induced Pulmonary Hypertension |
Circulation. 2001;104:2242 |
Mikro-Tip Pressure Transducer |
rat |
angiogenesis • gene therapy • endothelium-derived factors • hypertension, pulmonary • remodeling
|
| Zhu-Shan Zhang, Heng-Jie Cheng, Tomohiko Ukai, Hideo Tachibana and Che-Ping Cheng |
Enhanced Cardiac L-Type Calcium Current Response to 2-Adrenergic Stimulation in Heart Failure |
Journal of Pharmacology and Experimental Therapeutics,Vol. 298, Issue 1, 188-196, July 2001 |
Mikro-Tip Pressure Transducer |
rat |
zinterol, isolated left ventricular cardiomyocytes
|
| Christiane Waller, MD; Karl-Heinz Hiller, PhD; Elke Kahler, PhD; Kai Hu, MD; Matthias Nahrendorf, MD; Sabine Voll, MA; Axel Haase, PhD; Georg Ertl, MD; Wolfgang Rudolf Bauer, MD |
Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart |
Circulation. 2001;103:1564 |
Mikro-Tip Pressure Transducer |
rat |
remodeling • microcirculation • magnetic resonance imaging
|
| Takeshi Nishina, MD; Kazunobu Nishimura, MD; Sadatoshi Yuasa, MD; Senri Miwa, MD; Takuya Nomoto, MD; Yutaka Sakakibara, MD; Nobuhiro Handa, MD; Ichiro Hamanaka, MD; Yoshihiko Saito, MD; Masashi Komeda, MD |
Initial Effects of the Left Ventricular Repair by Plication May Not Last Long in a Rat Ischemic Cardiomyopathy Model |
Circulation. 2001;104:I-241 |
Mikro-Tip Pressure Transducer |
rat |
surgery • ischemia • cardiomyopathy • infarction • natriuretic peptides
|
Tian-li Yue, PhD; Jun Chen, MS; Weike Bao, MD; Padma K. Narayanan, PhD; Antoine Bril, PhD; Wen Jiang, MD; Paul G. Lysko, PhD; Juan-Li Gu, MD; Rogely Boyce, PhD; Dawn M. Zimmerman, MS; Timothy K. Hart, PhD; Robin E. Buckingham, PhD; Eliot H. Ohlstein, PhD
|
In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor- Agonist Rosiglitazone |
Circulation. 2001;104:2588 |
Mikro-Tip Pressure Transducer |
rat |
ischemia • myocardial infarction • diabetes • PPAR- • rosiglitazone
|
| Karel Rakusan, N. Cicutti, and F. Kolar |
Effect of anemia on cardiac function, microvascular structure, and capillary hematocrit in rat hearts |
AJP Heart Circ Physiol 280(3):H1407-H1414 |
Mikro-Tip Pressure Transducer |
rat |
coronary microcirculation; hemodilution; arterioles; capillaries
|
| Gary J. Grover, Albert J. D'Alonzo, Keith D. Garlid, Robert Bajgar, Nicholas J. Lodge, Paul G. Sleph, Raymond B. Darbenzio, Thomas A. Hess, Mark A. Smith, Petr Paucek and Karnail S. Atwal |
Pharmacologic Characterization of BMS-191095, a Mitochondrial KATP Opener with No Peripheral Vasodilator or Cardiac Action Potential Shortening Activity
|
Journal of Pharmacology and Experimental Therapeutics, Vol. 297, Issue 3, 1184-1192, June 2001 |
Mikro-Tip Pressure Transducer |
rat, guinea pig, dog |
glyburide-reversible cardioprotective activity, cromakalim, ischemia, reperfusion
|
Li W, Gan R, Sun G
|
Chronic treatment of enbrel in rats with isoproterenol-induced congestive heart failure limits left ventricular dysfunction and remodeling
|
Department of Cardiology, The First Clinical College, Harbin Medical University,Harbin 150001, China (Li WM, Gan RT and Sun GF)
|
SPC-320
|
rat |
TNF-a • antagonist • isoproterenol • heart failure • hemodynamics • remodeling |
| Giuseppe Rossoni , Barbara Manfredi, Vito De Gennaro Colonna, Micaela Bernareggi and Ferruccio Berti |
The Nitroderivative of Aspirin, NCX 4016, Reduces Infarct Size Caused by Myocardial Ischemia-Reperfusion in the Anesthetized Rat
|
Journal of Pharmacology and Experimental Therapeutics, Vol. 297, Issue 1, 380-387, April 2001
|
SPR-249 |
rat |
plasma creatine phosphokinase, antithrombotic
|
Aschenbach WG, Brower GL, Talmadge RJ, Dobson JL, Gladden LB
|
Effect of a myocardial volume overload on lactate transport in skeletal muscle sarcolemmal vesicles
|
Am J Physiol Regul Integr Comp Physiol 281: R176-R186, 2001
|
SPR-249A |
rat |
congestive heart failure; monocarboxylate transporter proteins; monocarboxylate; membrane diffusion
|
| Jan P. Loennechen, Asbjørn Støylen, Vidar Beisvag, Ulrik Wisløff, and Øyvind Ellingsen |
Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart |
AJP Heart Circ Physiol 280(6):H2902-H2910 |
SPR-407 |
rat |
heart failure; myocardial infarction; cardiomyocytes
|
| Lindon H. Young, Yasuhiko Ikeda, and Allan M. Lefer |
Caveolin-1 peptide exerts cardioprotective effects in myocardial ischemia-reperfusion via nitric oxide mechanism |
AJP Heart Circ Physiol., Vol. 280, Issue 6, H2489-H2495, June 2001 |
SPR-524 |
rat |
contractile dysfunction; polymorphonuclear leukocytes; polymorphonuclear neutrophil adherence
|
| John I. Nwogu, MD; David Geenen, PhD; Maurice Bean, BS; Mitchell C. Brenner, PhD; Xinfan Huang, MD; Peter M. Buttrick, MD |
Prolyl 4-Hydroxylase Inhibitor Improves Left Ventricular Function and Alters the Pattern of Left Ventricular Dilatation After Myocardial Infarction |
Circulation. 2001;104:2216 |
SPR-671 |
rat |
myocardial infarction • collagen • remodeling
|
| Karck M, Tanaka S, Berenshtein E, Sturm C, Haverich A, Chevion M |
The push-and-pull mechanism to scavenge redox-active transition metals: A novel concept in myocardial protection |
J. Thorac. Cardiovasc. Surg., Jun 2001; 121: 1169 - 1178 |
Mikro-Tip catheter |
rat heart |
desferrioxamine, zinc-histidinate, gallium-nitrate |
| Karck M, Tanaka S, Bolling SF, Simon A, Su T-P, Oeltgen PR, Haverich A |
Myocardial protection by ischemic preconditioning and -opioid receptor activation in the isolated working rat heart |
J. Thorac. Cardiovasc. Surg., Nov 2001; 122: 986 - 992 |
Mikro-Tip catheter connected to a pressure transducer |
rat heart |
D-Ala2-D-Leu5 enkephalin (DADLE) |
| |
|
|
|
|
|
---------------------------------------------Published in 2000--------------------------------------------- |
| Bing H. Wang, Xiao-Jun Du, Dominic J. Autelitano, Carmelo A. Milano, and Elizabeth A. Woodcock |
Adverse effects of constitutively active alpha1B-adrenergic receptors after pressure overload in mouse hearts |
AJP Heart Circ Physiol 279(3):H1079-H1086 |
1.4F Mikro-Tip catheter |
mouse |
|
| Brian D. Hoit, Vivek J. Kadambi, Daniel A. Tramuta, Nancy Ball, Evangelia G. Kranias, and Richard A. Walsh |
Influence of sarcoplasmic reticulum calcium loading on mechanical and relaxation restitution |
AJP Heart Circ Physiol 278(3):H958-H963 |
1.4F Mikro-Tip catheter |
mouse |
|
| Dorothy E. Vatner, Gui-Ping Yang, Yong-Jian Geng, Kuniya Asai, Jeung S. Yun, Thomas E. Wagner, Yoshihiro Ishikawa, Sanford P. Bishop, Charles J. Homcy, Stephen F. Vatner |
Determinants of the Cardiomyopathic Phenotype in Chimeric Mice Overexpressing Cardiac Gsalpha |
Circulaton Research 2000;86:802 |
1.4F Mikro-Tip catheter |
mouse |
|
| Roman Ullrich, MD; Marielle Scherrer-Crosbie, MD; Kenneth D. Bloch, MD; Fumito Ichinose, MD; Hiroshi Nakajima, MD; Michael H. Picard, MD; Warren M. Zapol, MD; Zenaide M. N. Quezado, MD |
Congenital Deficiency of Nitric Oxide Synthase 2 Protects Against Endotoxin-Induced Myocardial Dysfunction in Mice |
Circulation 2000;102:1440 |
1.4F Mikro-Tip catheter |
mouse |
|
| Giovanni Esposito, L. F. Santana, Keith Dilly, Jader Dos Santos Cruz, Lan Mao, W. J. Lederer, and Howard A. Rockman |
Cellular and functional defects in a mouse model of heart failure |
AJP Heart Circ Physiol 279(6):H3101-H3112 |
1.4F Mikro-Tip catheter |
mouse |
|
| Larissa Lipskaia, Nicole Defer, Giovanni Esposito, Iman Hajar, Marie-Claude Garel, Howard A. Rockman, Jacques Hanoune |
Enhanced Cardiac Function in Transgenic Mice Expressing a Ca2+-Stimulated Adenylyl Cyclase |
Circulation Research 2000;86:795 |
1.4F Mikro-Tip catheter |
mouse |
|
| Xiao-Jun Du, Xiao-Ming Gao, Garry L. Jennings, Anthony M. Dart, and Elizabeth A. Woodcock |
Preserved ventricular contractility in infarcted mouse heart overexpressing beta2-adrenergic receptors |
AJP Heart Circ Physiol 279(5):H2456-H2463 |
1.4F Mikro-Tip catheter |
mouse |
|
| Xiao-Jun Du, MBBS, PhD; Dominic J. Autelitano, PhD; Rodney J. Dilley, PhD; Binghui Wang, PhD; Anthony M. Dart, FRCP, PhD; Elizabeth A. Woodcock, PhD |
ß2-Adrenergic Receptor Overexpression Exacerbates Development of Heart Failure After Aortic Stenosis |
Circulation 2000;101:71 |
1.4F Mikro-Tip catheter |
mouse |
|
| Yi-Xin Wang, Meredith Halks-Miller, Ron Vergona, Mark E. Sullivan, Richard Fitch, Cornell Mallari, Baby Martin-McNulty, Valdeci da Cunha, Ana Freay, Gabor M. Rubanyi, and Katalin Kauser |
. Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice |
AJP Heart Circ Physiol 278(2):H428-H434 |
1.4F, 1.8F |
mouse |
|
| Robert Gyurko, Peter Kuhlencordt, Mark C. Fishman, and Paul L. Huang |
Modulation of mouse cardiac function in vivo by eNOS and ANP |
AJP Heart Circ Physiol 278(3):H971-H981 |
1.8F Mikro-Tip catheter |
mouse |
|
| William J. Karlon, Andrew D. McCulloch, James W. Covell, John J. Hunter, and Jeffrey H. Omens |
Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras |
AJP Heart Circ Physiol 278(3):H898-H906 |
Mikro-Tip catheter |
mouse |
|
| Antine E. Stenbit, Ellen B. Katz, John C. Chatham, David L. Geenen, Stephen M. Factor, Robert G. Weiss, Tsu-Shuen Tsao, Ashwani Malhotra, V. P. Chacko, Christopher Ocampo, Linda A. Jelicks, and Maureen J. Charron |
Preservation of glucose metabolism in hypertrophic GLUT4-null hearts |
AJP Heart Circ Physiol 279(1):H313-H318 |
SPR-407 |
mouse |
|
| Christian C. Evans, James R. Pena, Ronald M. Phillips, Mariappan Muthuchamy, David F. Wieczorek, R. John Solaro, and Beata M. Wolska |
Altered hemodynamics in transgenic mice harboring mutant tropomyosin linked to hypertrophic cardiomyopathy |
AJP Heart Circ Physiol 279(5):H2414-H2423 |
SPR-671 |
mouse |
|
| Jin H, Yang R, Li W, Lu H, Ryan AM, Ogasawara AK, Van Peborgh J, Paoni NF |
Effects of exercise training on cardiac function, gene expression, and apoptosis in rats |
AJP Heart Circ Physiol, Vol. 279, Issue 6, H2994-H3002, December 2000 |
|
rat |
|
| Ulrich Schmidt, MD, PhD; Federica del Monte, MD, PhD; Michael I. Miyamoto, MD; Takashi Matsui, MD, PhD; Judith K. Gwathmey, VMD, PhD; Anthony Rosenzweig, MD; Roger J. Hajjar, MD |
Restoration of Diastolic Function in Senescent Rat Hearts Through Adenoviral Gene Transfer of Sarcoplasmic Reticulum Ca2+-ATPase |
Circulation 2000;101:790 |
1.8F Mikro-Tip catheter |
rat |
|
| Hans-Jörg Weig, MD; Karl-Ludwig Laugwitz, MD; Alessandra Moretti, PhD; Kai Kronsbein, BS; Christian Städele, MD; Stefan Brüning, MD; Melchior Seyfarth, MD; Thomas Brill, MD; Albert Schömig, MD; Martin Ungerer, MD |
Enhanced Cardiac Contractility After Gene Transfer of V2 Vasopressin Receptors In Vivo by Ultrasound-Guided Injection or Transcoronary Delivery |
Circulation 2000;101:1578 |
2.5F Mikro-Tip catheter |
rat, rabbit |
|
Symons JD, Rendig SV, Stebbins CL, Longhurst JC
|
Microvascular and myocardial contractile responses to ischemia: influence of exercise training
|
J Appl Physiol 88: 433-442, 2000
|
2F Mikro-Tip catheter |
rat |
myocardial function; coronary vascular function; coronary resistance arteries; endothelium; vascular smooth muscle; acetylcholine; sodium nitroprusside; endothelin-1; thromboxane A2; U-46619
|
| Akihiko Igawa, Takashi Nozawa, Naohiro Yoshida, Nozomu Fujii, Minoru Inoue, Shusaku Tazawa, Hidetsugu Asanoi, and Hiroshi Inoue |
Heterogeneous cardiac sympathetic innervation in heart failure after myocardial infarction of rats |
AJP Heart Circ Physiol 278(4):H1134-H1141 |
2F Mikro-Tip Catheter |
rat |
|
Lars Rothermund, MD; Yigal M. Pinto, MD, PhD; Berthold Hocher, MD; Roland Vetter, MD; Stefan Leggewie, MS; Peter Koßmehl, MS; Hans-Dieter Orzechowski, MD; Reinhold Kreutz, MD; Martin Paul, MD
|
Cardiac Endothelin System Impairs Left Ventricular Function in Renin-Dependent Hypertension via Decreased Sarcoplasmic Reticulum Ca2+ Uptake |
Circulation. 2000;102:1582 |
3F Mikro-Tip catheter |
rat |
|
| Yigal M. Pinto; Sara-Joan Pinto-Sietsma; Tobias Philipp; Sonja Engler; Peter Koßmehl; Berthold Hocher; Heike Marquardt; Svenja Sethmann; Roland Lauster; Hans-Joachim Merker; Martin Paul |
Reduction in Left Ventricular Messenger RNA for Transforming Growth Factor ß1 Attenuates Left Ventricular Fibrosis and Improves Survival Without Lowering Blood Pressure in the Hypertensive TGR(mRen2)27 Rat |
Hypertension. 2000;36:747 |
3F Mikro-Tip catheter |
rat |
|
| Hiroshi Miyashita, Masaru Sugimachi, Takayuki Sato, Toru Kawada, Toshiaki Shishido, Tsutomu Nakahara, Ryoichi Yoshimura, Hiroshi Takaki, Hiroshi Miyano, and Kenji Sunagawa |
A novel servo-control system that imposes desired aortic input impedance on in situ rat heart |
AJP Heart Circ Physiol 278(3):H998-H1007 |
SPC-320 |
rat |
|
| G. Kissling, B. Blickle, and U. Pascht |
Modified heart-lung preparation for the evaluation of systolic and diastolic coronary flow in rats |
AJP Heart Circ Physiol 278(1):H277-284 |
SPC-320 |
rat |
|
| Jianming Hao, Baiqiu Wang, Stephen C. Jones, Davinder S. Jassal, and Ian M. C. Dixon |
Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro
|
AJP Heart Circ Physiol., Vol. 279, Issue 6, H3020-H3030, December 2000
|
SPR-249 |
rat |
|
| Hideaki Yoshida; Jenny J Zhang; Lee Chao; Julie Chao |
Kallikrein Gene Delivery Attenuates Myocardial Infarction and Apoptosis After Myocardial Ischemia and Reperfusion |
Hypertension 2000;35:25 |
SPR-320 |
rat |
|
| J. Andrew Wasserstrom, Even Holt, Ivar Sjaastad, Per Kristian Lunde, Annlaug Odegaard, and Ole M. Sejersted |
Altered E-C coupling in rat ventricular myocytes from failing hearts 6 wk after MI |
AJP Heart Circ Physiol 279(2):H798-H807 |
SPR-407 |
rat |
|
| Erik Oie, Reidar Bjornerheim, Ole Petter F. Clausen, and Havard Attramadal |
Cyclosporin A inhibits cardiac hypertrophy and enhances cardiac dysfunction during postinfarction failure in rats |
AJP Heart Circ Physiol 278(6):H2115-H2123 |
SPR-407 |
rat |
|
| Nathalie Niederhoffer; Pascal Kieffer; Dominique Desplanches; Isabelle Lartaud-Idjouadiene; Marie-Hélène Sornay; Jeffrey Atkinson |
Physical Exercise, Aortic Blood Pressure, and Aortic Wall Elasticity and Composition in Rats |
Hypertension 2000;35:919 |
SPR-407 |
rat |
|
| Erik Øie, MD; Leif Erik Vinge, MD; Arne Yndestad, MSc; Cecilie Sandberg, MSc; Haakon K. Grøgaard, MD; Håvard Attramadal, MD, PhD |
Induction of a Myocardial Adrenomedullin Signaling System During Ischemic Heart Failure in Rats |
Circulation 2000;101:415 |
SPR-407 |
rat |
|
| Rémi Varin, BS; Paul Mulder, PhD; Fabienne Tamion, MD; Vincent Richard, PhD; Jean-Paul Henry, BS; Françoise Lallemand, BS; Guy Lerebours, MD, PhD; Christian Thuillez, MD, PhD |
Improvement of Endothelial Function by Chronic Angiotensin-Converting Enzyme Inhibition in Heart Failure |
Circulation 2000;102:351 |
SPR-407 |
rat |
|
Sjaastad I, Sejersted OM, Ilebekk A, Bjørnerheim R
|
Echocardiographic criteria for detection of postinfarction congestive heart failure in rats
|
J Appl Physiol 89: 1445-1454, 2000
|
SPR-407 |
rat |
|
| Lindon H. Young2, Yasuhiko Ikeda3, Rosario Scalia and Allan M. Lefer |
Wortmannin, a Potent Antineutrophil Agent, Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion1 |
Journal of Pharmacology and Experimental Therapeutics, Vol. 295, Issue 1, 37-43, October 2000 |
SPR-524 |
rat |
|
| Lindon H. Young, Yasuhiko Ikeda, Rosario Scalia, and Allan M. Lefer |
C-peptide exerts cardioprotective effects in myocardial ischemia-reperfusion |
AJP Heart Circ Physiol 279(4):H1453-H1459 |
SPR-524 |
rat |
|
| Kai C. Wollert, MD; Jörg Heineke, BS; Jürgen Westermann, MD; Mark Lüdde, BS; Beate Fiedler, PhD; Wolfgang Zierhut, MD; Didier Laurent, PhD; Manuel K. A. Bauer, PhD; Klaus Schulze-Osthoff, PhD; Helmut Drexler, MD |
The Cardiac Fas (APO-1/CD95) Receptor/Fas Ligand System |
Circulation 2000;101:1172 |
Ultra-miniature Mikro-Tip catheter |
rat |
|
| Fogelson BG, Nawas SI, Law WR |
MECHANISMS OF MYOCARDIAL PROTECTION BY ADENOSINE-SUPPLEMENTED CARDIOPLEGIC SOLUTION: MYOFILAMENT AND METABOLIC RESPONSES |
J Thorac Cardiovasc Surg 2000;119:601-609 |
microtransducer-tipped Millar catheter with lumen |
rat |
postarrest myocardial recovery |
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