| AUTHORS |
TITLE |
JOURNAL |
MILLAR EQPT. |
SUBJECT |
application |
---------------------------------------------Published in 2008--------------------------------------------- |
| Bostick B, Yue Y, Long C, Duan D |
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression |
Circ. Res., Jan 2008; 102: 121 - 130 |
SPR-839 |
mouse |
cardiomyopathy • gene therapy • myocardium • genetics • heart disease |
| LaCroix C, Freeling J, Giles A, Wess J, Li Y-F |
Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H810 - H820 |
Millar pressure-volume (P-V) catheter |
mouse |
muscarinic; cardiac; contractility; matrix metalloproteinase; isoproterenol |
| Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia L-G, Tucker AL, Moorman JR, Marber MS, Eaton P, Dunn MJ, Shattock MJ |
Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H613 - H621 |
SPR-839 |
mouse |
FXYD1; contractile function; intracellular sodium regulation |
| Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lüllmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrman SM, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger Zacharowski K, Tschöpe C, Fischer JW |
Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction |
Circulation, Feb 2008; doi:10.1161/CIRCULATIONAHA.107.714147 |
ARIA, SPR-719 |
mouse |
collagen • myocardial infarction • extracellular matrix • fibrosis • proteoglycans |
| Karatas A, BHegner B, de Windt LJ, Luft FC, Schubert C, Gross V, Akashi YJ, Gürgen D, Kintscher U, da Costa Goncalves AC, Regitz-Zagrosek V, Dragun D |
Deoxycorticosterone Acetate-Salt Mice Exhibit Blood Pressure–Independent Sexual Dimorphism |
Hypertension, Feb 2008; doi:10.1161/HYPERTENSIONAHA.107.107938 |
1.4F catheter tip micromanometer , ARIA |
mouse |
heart • kidney • hypertrophy • inflammation • fibrosis • calcineurin • MCIP1 • NFATc2 |
| Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lüllmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrmann S-M, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger R, Zacharowski L, Tschöpe C, Fischer JW |
Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction |
Circulation, Mar 2008; 117: 1269 - 1276 |
ARIA, SPR-719 |
mouse |
collagen matrix, cardiac hemodynamic function |
| Li H-L, Liu C, de Couto G, Ouzounian M, Sun M, Wang A-B, Huang Y, He C-W, Shi Y, Chen X, Nghiem MP, Liu Y, Chen M, Dawood F, Fukuoka M, Maekawa Y, Zhang L, Leask A , Ghosh AK, Kirshenbaum LA, Liu PP |
Curcumin prevents and reverses murine cardiac hypertrophy |
J. Clin. Invest. Hong-Liang Li, et al. 118:879 doi:10.1172/JCI32865 |
SPR-839 |
mouse |
turmeric |
| Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik S-C, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li R-K, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson P-J, Rubin BB |
Microsomal Prostaglandin E2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction |
Circulation, Apr 2008; 117: 1701 - 1710 |
SPR-839, PVAN 3.3 |
mouse |
PGE2, cardiac ischemic injury |
| Karatas A, Hegner B, de Windt LJ, Luft FC, Schubert C, Gross V, Akashi YJ, Gürgen D, Kintscher U, da Costa Goncalves AC, Regitz-Zagrosek V, Dragun D |
Deoxycorticosterone Acetate-Salt Mice Exhibit Blood Pressure–Independent Sexual Dimorphism |
Hypertension, Apr 2008; 51: 1177 - 1183 |
1.4F catheter tip micromanometer, ARIA |
mouse |
heart • kidney • hypertrophy • inflammation • fibrosis • calcineurin • MCIP1 • NFATc2 |
| Bal MP, de Vries WB, van Oosterhout MFM, Baan J, van der Wall EE, van Bel F, Steendijk P |
Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats |
J Appl Physiol, Feb 2008; 104: 446 - 450 |
SPR-878 |
rat |
cardiac function; pressure-volume relations; rats; glucocorticoids |
| Fraccarollo D, Galuppo P, Schraut S, Kneitz S, van Rooijen N, Ertl G, Bauersachs J |
Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response |
Hypertension, Feb 2008; doi:10.1161/HYPERTENSIONAHA.107.100941 |
SPR-774 |
rat |
aldosterone • healing • inflammation • myocardial infarction • heart failure |
| Murray DB, Gardner JD, Brower GL, Janicki JS |
Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats |
Am J Physiol Heart Circ Physiol, Mar 2008; 294: H1251 - H1257 |
SPR-838 |
rat |
bosentan; heart; extracellular matrix; cardiac function |
| Phrommintikul A, Tran L, Kompa A, Wang B, Adrahtas A, Cantwell D, Kelly DJ, Krum H |
Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction |
Am J Physiol Heart Circ Physiol, Apr 2008; 294: H1804 - H1814 |
SPR-838 |
rat |
Rho kinase; hypertrophy; fibrosis; pressure overload; hypertension; diastolic function; myocardium |
| Fraccarollo D, Galuppo P, Schraut S, Kneitz S, van Rooijen N, Ertl G, Bauersachs J |
Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response |
Hypertension, Apr 2008; 51: 905 - 914 |
SPR-774 |
rat |
aldosterone • healing • inflammation • myocardial infarction • heart failure |
| Xu X, Wan W, Ji L, Lao S, Powers AS, Zhao W, Erikson JM, Zhang JQ |
Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats |
Cardiovasc Res, 1 June 2008; 78: 523 - 532 |
SPR-838 |
rat |
Myocardial infarction; Remodelling; Exercise; Angiotensin; Metalloproteinases |
---------------------------------------------Published in 2007--------------------------------------------- |
| Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W |
Left ventricular pressure-volume relationship in conscious mice |
J Physiol Heart Circ Physiol, Jan 2007; 292: H369 - H377 |
SPR-719, PVAN 3.2 |
mouse |
ventricular function; mouse physiology |
| Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum L, Arnold M, Khokha R, Liu PP |
Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State |
Circulation, Mar 2007; 115: 1398 - 1407 |
SPR-839, PVAN |
mouse |
cardiac inflammatory response, extracellular matrix homeostasis, and ventricular hypertrophy |
| Clark JE, Flavell RA, Faircloth ME, Davis RJ, Heads RJ, Marber MS |
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) |
Cardiovascular Research |
SPR-839 |
mouse |
Infarction; Remodeling; MKK3; p38-MAPK; Haemodynamics |
| Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu B-Q, Nguyen A, Dahi S, Karliner JS, Lovett DH |
Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1847 - H1860 |
1.4-Fr PV conductance catheter, PVAN 3.2 |
mouse |
heart failure; fibrosis; mitochondria; sarcomere |
| Brickson S, Fitzsimons DP, Pereira L, Hacker T, Valdivia H, Moss RL |
In vivo left ventricular functional capacity is compromised in cMyBP-C null mice |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1747 - H1754 |
1.4-Fr high-fidelity Mikro-Tip conductance catheter |
mouse |
aortic banding; pressure-volume relations; dobutamine |
| Takimoto E, Belardi D, Tocchetti CG, Vahebi S, Cormaci G, Ketner EA, Moens AL, Champion HC, Kass DA |
Compartmentalization of Cardiac ß-Adrenergic Inotropy Modulation by Phosphodiesterase Type 5 |
Circulation, Apr 2007; 115: 2159 - 2167 |
SPR-839 PV |
mouse |
C57/BL6 mouse hearts |
| Galvez AS, Diwan A, Odley AM, Hahn HS, Osinska H, Melendez JG, Robbins J, Lynch RA, Marreez Y, Dorn II GW |
Cardiomyocyte Degeneration With Calpain Deficiency Reveals a Critical Role in Protein Homeostasis |
Circ. Res., Apr 2007; 100: 1071 - 1078 |
1.4 French Millar solid-state catheters |
mouse |
metabolism • protease • ubiquitin, mouse hearts |
| Yue P, Arai T, Terashima M, Sheikh AY, Cao F, Charo D, Hoyt G, Robbins RC, Ashley EA, Wu J, Yang PC, Tsao PS |
Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2106 - H2118 |
catheter tip containing both pressure and conductance transducers, PVAN 3.4 software |
mouse |
diabetes mellitus; insulin resistance; heart failure; metabolism |
| Zhang H, Wang H-Y, Bassel-Duby R, Maass DL, Johnston WE, W. Horton JW, Tao W |
Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2408 - H2416 |
SPR 839, PVAN version 3.1 |
mouse |
tumor necrosis factor-α; α-myosin heavy chain; cardiac contractile function; fibrosis; apoptosis |
| Mukhopadhyay P, Ba´tkai S, Rajesh M, Czifra N, Harvey-White J, Hasko´ G, Zsengeller Z, Gerard NP, Liaudet L, MD, Kunos G, Pa´l Pacher P |
Pharmacological Inhibition of CB1 Cannabinoid Receptor
Protects Against Doxorubicin-Induced Cardiotoxicity |
Journal of the American College of Cardiology, Vol. 50, No. 6, 2007 |
PVR 1045 P-V catheter, ARIA |
mouse |
cardiodepressive effects |
| Nielsen JM, Kristiansen SB, Ringgaard S, Nielsen TT, Flyvbjerg A, Redington AN, Bøtker HE |
Left ventricular volume measurement in mice by conductance catheter: evaluation and optimization of calibration |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H534 - H540 |
SPR-839, MPCU-200 |
mouse |
contractile function; ventricular function; hemodynamics; magnetic resonance imaging |
| Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS, Furutani E, Perez-Sanz TM, Graveline A, Janssens SP, Picard MH, Scherrer-Crosbie M, Bloch KD |
Disruption of Nitric Oxide Synthase 3 Protects Against the Cardiac Injury, Dysfunction, and Mortality Induced by Doxorubicin |
Circulation, Jul 2007; 116: 506 - 514 |
SPR-837 |
mouse |
flavoprotein reductase |
| Bátkai S, Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Cravatt BF, Csiszár A, Ungvári Z, Pacher P |
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H909 - H918 |
SPR-839, PVAN 3.5, ARIA |
mouse |
cardiac function; anandamide; pressure-volume relationship; endocannabinoids |
| Moss NC, Stansfield WE, Willis MS, Tang R-H, Selzman CH |
IKKβ inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2248 - H2253 |
PVR-1045, PVAN |
mouse |
inhibitory κB kinase-β; myocardial infarction; nuclear factor-κB |
| Gao J, Chua CC, Yin D, Wang H, Hamdy RC, Chua B |
Abstract 3292: Cardiac Dysfunction Induced By Chronic Restrain Stress Is Mediated By Opioid Receptors |
Circulation, Oct 2007; 116: II_741 - II_742 |
ARIA pressure-volume conductance system |
mouse |
naltrexone |
| Chua B, Gao J, Wang H, Hamdy RC, Chua CC |
Abstract 3296: Phenolic Compounds Present In Danshen Extract Protect Against Doxorubicin-induced Cardiotoxicity |
Circulation, Oct 2007; 116: II_742 |
ARIA pressure-volume conductance system |
mouse |
Salvia miltiorrhiza |
| Buys ES, Sips PY, Raher MJ, Graveline AR, Searles RJ, Ichinose F, Brouckaert P, Bloch KD |
Abstract 1293: Gender-specific And Testosterone-dependent Hypertension In Soluble Guanylate Cyclase α1-deficient Mice |
Circulation, Oct 2007; 116: II_264 |
Millar pressure volume catheter |
mouse |
nitric oxide |
| Palpant N, Day S, Converso K, Metzger J |
Abstract 219: Histidine Substituted Cardiac Troponin I (a164h) Improves Survival And Protects Cardiac Contractility During Acute Hypoxia In The Aged Murine Heart |
Circulation, Oct 2007; 116: II_23 |
microconductance Millar catheterization |
mouse |
Contractile dysfunction |
| Willis MS, Rojas , Lockyer P, Hampton TG, Li L, Meredith D, Patterson C |
Abstract 1008: A Protective Role for Cardiac Specific Muscle Ring Finger-1 (MuRF1) in Ischemia/Reperfusion Injury In Vivo |
Circulation, Oct 2007; 116: II_200 - II_201 |
Millar pressure volume catheterization |
mouse |
Langendorff, cardiac physiology |
| Lu S, Lei M, Xiang F, Feng Q |
Abstract 162: c-fos Protects the Myocardium from Ischemic Injury and Improves Cardiac Function |
Circulation, Oct 2007; 116: II_10 |
Millar pressure conductance catheter |
mouse |
myocardial infarction |
| Shioura KM, Geenen DL, Goldspink PH |
Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice |
Am J Physiol Heart Circ Physiol, Nov 2007; 293: H2870 - H2877 |
SPR-839 |
mouse |
gene expression; contractility |
| Nagayama T, Takimoto E, Sadayappan S, Mudd JO, Seidman JG, Robbins J, Kass DA |
Control of In Vivo Contraction/Relaxation Kinetics by Myosin Binding Protein C: Protein Kinase A Phosphorylation–Dependent and –Independent Regulation |
Circulation, Nov 2007; 116: 2399 - 2408 |
SPR-839 |
mouse |
Molecular Cardiology |
| Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M |
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice |
J. Clin. Invest., Nov 2007; 117: 3188 - 3197 |
PVAN 3.2 |
mouse |
angiogenic growth factor PR39 |
| Luo J, Hill BG, Gu Y, Cai J, Srivastava S, Bhatnagar A, Prabhu SD |
Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3673 - H3684 |
SPR-839, ARIA-1 |
mouse |
oxidative stress; myocardial contraction; protein adducts; aldehydes |
| Patrizio M, Musumeci M, Stati T, Fasanaro P, Palazzesi S, Catalano L, Marano G |
Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli |
British Journal of Pharmacology 152, 216 - 222 (01 Sep 2007) |
SPR-839 |
mouse |
propranolol, phenylephrine, pressure overload, hypertrophy, heart, gene expression |
| Prunier F, Pfister O, Hadri L, Liang L, del Monte F, Liao R, Hajjar RJ |
Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H522 - H529 |
SPR-838, MPVS-400, PVAN 3.3 |
rat |
erythropoietin; cardioprotection; myocardial infarction; remodeling; cells |
| Bostick B, Yue Y, Long C, Duan D |
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression |
DOI: 10.1161/CIRCRESAHA.107.162982 |
SPR-839, PVAN |
mouse |
cardiomyopathy gene therapy myocardium genetics heart disease |
| Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B |
Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H259 - H269 |
SPR-838 |
rat |
hypertrophy; mechanosensing; cytoskeleton; nucleocytoplasmic shuttling |
| Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, Kim EGR, Smaili S, Periyasamy SM, Hariri IM, Fedorova L, Liu J, Wu L, M. Kahaleh MB, Xie Z, Malhotra D, Fedorova OV, Kashkin VA, Bagrov AY, Shapiro JI |
Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy |
Hypertension, Jan 2007; 49: 215 - 224 |
pressure/volume sensor catheter |
rat |
cardiomyopathy • renal failure • transforming growth factor (TGF) ß • cardiotonic steroids • reactive oxygen species • fibrosis |
| Walther T, Tschöpe C, Sterner-Kock A, Westermann D, Heringer-Walther S, Riad A, Nikolic A, Wang Y, Ebermann L, Siems W-E, Bader M, Shakibaei M, Schultheiss H-P, Dörner A |
Accelerated Mitochondrial Adenosine Diphosphate/Adenosine Triphosphate Transport Improves Hypertension-Induced Heart Disease |
Circulation, Jan 2007; 115: 333 - 344 |
SPR-719 |
rat |
renin-overexpressing, ANT1 |
| Jegger D, Mallik AS, Nasratullah M, Jeanrenaud X, da Silva R, Tevaearai H, von Segesser LK, Stergiopulos N |
The effect of a myocardial infarction on the normalized time-varying elastance curve |
J Appl Physiol, Mar 2007; 102: 1123 - 1129 |
SPR-838, Aria |
rat |
compliance; ischemia; contractility; ventricular function; hemodynamics; conductance volumetry |
| Woo YJ, Panlilio CM, Cheng RK, Liao GP, Suarez EE, Atluri P, Chaudhry HW |
Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2 |
J. Thorac. Cardiovasc. Surg., April 2007; 133: 927 - 933 |
2F pressure conductance microcatheter, ARIA 1 |
rat |
cardiomyocyte mitosis |
| Wang Y, Ahmad N, Wang B, Ashraf M |
Chronic preconditioning: a novel approach for cardiac protection |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2300 - H2305 |
SPR-869, PVAN 3.2 |
rat |
mitochondrial ATP-sensitive K+ channels; BMS-191095; heart function |
| Popovic ZB, Benejam C, Bian J, Mal N, Drinko J, Lee K, Forudi F, Reeg R, Greenberg NL, Thomas JD, Penn MS |
Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction |
Am J Physiol Heart Circ Physiol, Jun 2007; 292: H2809 - H2816 |
SPR-838, MPCU-200 |
rat |
infarction; collagen; contractility |
| Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR |
Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H448 - H456 |
Millar Mikro-Tip 2.0F, ARIA |
rat |
sepsis; microcirculation; inflammation; heart |
| Liu X, Simpson JA, Brunt KR, Ward CA, Hall SRR, Kinobe RT, Barrette V, Tse MY, Pang SC, Pachori AS, Dzau VJ, Ogunyankin KO, Melo LG |
Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H48 - H59 |
SPR-838, PVAN |
rat |
adeno-associated virus; echocardiography; fibrosis; heart failure; pressure-volume analysis; ventricular remodeling |
| Marsh SA, Powell PC, Agarwal A, Dell'Italia LJ, Chatham JC |
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H292 - H298 |
combined-conductance catheter-micromanometer, PVAN 3.0 |
rat |
diabetes; cardiac function; renal function |
| Deng J-Y, Huang J-P, Lu L-S, L-M |
Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H978 - H987 |
SPR-838, PVAN 3.2 |
rat |
Akt; glucose transporter; cardiac dysfunction; high cholesterol-fructose diet; insulin resistance |
| Murray DB, Gardner JD, Levick SP, Brower GL, Morgan LG, Janicki JS |
Response of cardiac mast cells to atrial natriuretic peptide |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1216 - H1222 |
high-fidelity Millar conductance catheter, Millar calibration cuvette |
rat |
atrial natriuretic factor; isolated heart; extracellular matrix; ventricular remodeling; fistula |
| Bátkai S, Mukhopadhyay P, Harvey-White J, Kechrid R, Pacher P, Kunos G |
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1689 - H1695 |
SPR-838, ARIA |
rat |
cirrhosis; cannabinoid CB1 receptors; endocannabinoids; cardiac contractility; pressure-volume loops |
| Jegger D, da Silva RF, Lartaud I, Gaillard V, Jeanrenaud X, Nasratullah M, von Segesser LK, Atkinson J, Segers P, Tevaearai H, Stergiopulos N |
Effects of an aging vascular model on healthy and diseased hearts |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1334 - H1343 |
SPR-838, ARIA |
rat |
calcium; echocardiography; hypertrophy; hypertension; infarction |
| Segers VFM, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT |
Local Delivery of Protease-Resistant Stromal Cell Derived Factor-1 for Stem Cell Recruitment After Myocardial Infarction |
Circulation, Sep 2007; doi:10.1161/CIRCULATIONAHA.107.718718 |
2F pressure-volume sensing catheters, PVAN 3.2 |
rat |
angiogenesis • chemokines • heart failure • myocardial infarction • stem cells • tissue |
| Segers VFM, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT |
Local Delivery of Protease-Resistant Stromal Cell Derived Factor-1 for Stem Cell Recruitment After Myocardial Infarction |
Circulation, Oct 2007; 116: 1683 - 1692 |
2F pressure-volume sensing catheter, PVAN 3.2 |
rat |
nanofiber-mediated delivery |
| |
---------------------------------------------Published in 2006--------------------------------------------- |
| Alwardt CM, Yu Q, Brooks HL, McReynolds MR, Vazquez R, Watson RR, Larson DF |
Comparative effects of dehydroepiandrosterone sulfate on ventricular diastolic function with young and aged female mice |
Am J Physiol Regulatory Integrative Comp Physiol, Jan 2006; 290: R251 - R256 |
1.4-Fr Millar conductance catheter |
mouse |
cardiac fibroblast; left ventricle; cross-linking; collagen |
| Wang Y, Haider HK, Ahmad N, Xu M, Ge R, Ashraf M |
Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair |
J Mol Cell Cardiol. 2006;40(5):736-745 |
SPR-839, MPCU-200 |
mouse |
angiogenesis; bone marrow stem cells; cytokines; heart infarction; myocyte regeneration |
| Tam CW, Husmann K, Clark NC, Clark JE, Lazar Z, Ittner LM, Götz J, Douglas G, Grant AD, Sugden D, Poston L, Poston R, McFadzean I, Marber MS, Fischer JA, Born W, Brain SD |
Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity–Modifying Protein |
Circ. Res., Feb 2006; 98: 262 - 270 |
SPR-839, PVAN 2.9 |
mouse |
adrenomedullin • blood pressure • CGRP • receptor-activity–modifying protein • RAMP2 • transgenic mouse |
| Claessens TE, Georgakopoulos D, Afanasyeva M, Vermeersch SJ, Millar HD, Stergiopulos N, Westerhof N, Verdonck PR, Segers P |
Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold? |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1474 - H1483 |
dual-pressure sensor |
mouse |
ventricular function; curvilinear; end-systolic pressure-volume relationship |
| Hataishi R, Zapol WM, Bloch KD, Ichinose F |
Inhaled nitric oxide does not reduce systemic vascular resistance in mice |
Am J Physiol Heart Circ Physiol, May 2006; 290: H1826 - H1829 |
SPR-839 |
mouse |
peripheral vasodilation; endothelial nitric oxide synthase; telemetry; tail cuff |
| Yu Q, Horak K, Larson DF |
Role of T Lymphocytes in Hypertension-Induced Cardiac Extracellular Matrix Remodeling |
Hypertension, May 2006; doi:10.1161/01.HYP.0000227247.27111.b2 |
1.4-fr Millar Conductance Catheter |
mouse |
lymphocytes • ventricular function • collagen |
| Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I |
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension |
Hypertension, Jun 2006; 47: 1108 - 1116 |
1.4F catheter tip micromanometer, ARIA |
mouse |
hypertension, obesity • nitric oxide synthase • sodium, dietary • L-NAME |
| Perrino C, Prasad SVN, Mao L, Noma T, Yan Z, Kim H-S, Smithies O, Rockman HA |
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction |
J. Clin. Invest., Jun 2006; 116: 1547 - 1560 |
1.4 French (0.46 mm) conductance catheter, PVAN analysis software version 3.3 |
mouse |
pathogenic signaling pathways |
| Yu Q, Horak K, Larson DF |
Role of T Lymphocytes in Hypertension-Induced Cardiac Extracellular Matrix Remodeling |
Hypertension, Jul 2006; 48: 98 - 104 |
1.4-fr Millar Conductance Catheter |
mouse |
lymphocytes • ventricular function • collagen |
| Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, Verma S, Weisel RD, Keating A, Li R-K |
Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines |
J. Clin. Invest., Jul 2006; 116: 1865 - 1877 |
SPR-839, PVAN 3.3 |
mouse |
bone marrow stem/progenitor cell therapy after myocardial infarction |
| Neilan TG, Doherty GA, Chen G, Deflandre C, McAllister H, Butler RK, McClelland SE, Kay E, Ballou LR, Fitzgerald DJ |
Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H532 - H536 |
SPR-671, ARIA pressure conductance system |
mouse |
apoptosis; cyclooxygenase |
| Reyes M, Steinhelper ME, Alvarez JA, Escobedo D, Pearce J, Valvano JW, Pollock BH, Wei C-L, Kottam A, Altman D, Bailey S, Thomsen S, Lee S, Colston JT, Oh JH, Freeman GL, Feldman MD |
Impact of physiological variables and genetic background on myocardial frequency-resistivity relations in the intact beating murine heart |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1659 - H1669 |
miniaturized conductance catheter |
mouse |
gene-altered mouse; diabetes; left ventricular volume; dual-frequency conductance method; myocardial resistivity |
| Ha T, Hua F, Grant D, Xia Y, Ma J, Gao X, Kelley J, Williams DL, Kalbfleisch J, Browder IW, Kao RL, Li C |
Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1910 - H1918 |
microconductance pressure catheter, Millar pressure-volume conductance system |
mouse |
cardiac function; phosphoinositide 3-kinase/Akt signaling; migration inhibition factor |
| Curcio A, Noma T, Prasad SVN, Wolf MJ, Lemaire A, Perrino C, Mao L, Rockman HA |
Competitive displacement of phosphoinositide 3-kinase from β-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1754 - H1760 |
MPCU-200 |
mouse |
heart failure; ventricular remodeling; transgenic models |
| Costandi PN, Frank LR, McCulloch AD, Omens JH |
Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation |
Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2971 - H2979 |
SPR-839, PVAN 3.3 |
mouse |
magnetic resonance imaging; finite element modeling |
| Wang Y, Haider HK, Ahmad N, Xu M, Ge R, Ashraf M |
Combining pharmacological mobilization
with intramyocardial delivery of bone marrow cells
over-expressing VEGF is more effective for cardiac repair |
Journal of Molecular and Cellular Cardiology 40 (2006) 736–745 |
SPR-839, MPCU-200 P-V signal conditioning hardware |
mouse |
Angiogenesis; Bone marrow stem cells; Cytokines; Heart infarction; Myocyte regeneration |
| Iwasaki H, Kawamoto A, Ishikawa M, Oyamada A, Nakamori S, Nishimura H, Sadamoto K, Horii M, Matsumoto T, Murasawa S, Shibata T, Suehiro S, Asahara T |
Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction |
Circulation, Mar 2006; 113: 1311 - 1325 |
SPR-838, PVAN |
rat |
cardiomyocytes, ischemia |
| Minhas KM, Saraiva RM, Schuleri KH, Lehrke S, Zheng M, Saliaris AP, Berry CE, Vandegaer KM, Li D, Hare JM |
Xanthine Oxidoreductase Inhibition Causes Reverse Remodeling in Rats With Dilated Cardiomyopathy |
Circ. Res., Feb 2006; 98: 271 - 279 |
SPR-838 |
rat |
xanthine oxidoreductase • remodeling • gene expression • heart failure |
| Iwasaki H, Kawamoto A, Ishikawa M, Oyamada A, Nakamori S, Nishimura H, Sadamoto K, Horii M, Matsumoto T, Murasawa S, Shibata T, Suehiro S, Asahara T |
Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction |
Circulation, Mar 2006; 113: 1311 - 1325 |
SPR-838 |
rat |
angiogenesis • cell therapy • myocardial infarction • transplantation • vasculogenesis |
| Connelly KA, Prior DL, Kelly DJ, Feneley MP, Krum H, Gilbert RE |
Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1699 - H1705 |
SPR-838 |
rat |
hypertension; conductance catheter; echocardiography; transgenic rat |
| Jegger D, Jeanrenaud X, Nasratullah M, Chassot P-G, Mallik A, Tevaearai H, von Segesser LK, Segers P, Stergiopulos N |
Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1540 - H1548 |
SPR-838, ARIA |
rat |
echocardiography; heart failure; hemodynamics; ventricular function |
| Klotz S, Hay I, Zhang G, Maurer M, Wang J, Burkhoff D |
Development of Heart Failure in Chronic Hypertensive Dahl Rats: Focus on Heart Failure With Preserved Ejection Fraction |
Hypertension, May 2006; 47: 901 - 911 |
1.4 Fr, 5-F Millar micromanometer, PVAN 3.2 |
rat |
remodeling • heart failure • diastole • hypertrophy • renal disease |
| Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL |
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance |
Am J Physiol Heart Circ Physiol, Jun 2006; 290: H2196 - H2203 |
2-Fr pressure-volume conductance catheter, ARIA 1 Pressure-Volume Analysis software |
rat |
cell transplantation; myocardial remodeling |
| Woo YJ, Panlilio CM, Cheng RK, Liao GP, Atluri P, Hsu VM, Cohen JE, Chaudhry HW |
Therapeutic Delivery of Cyclin A2 Induces Myocardial Regeneration and Enhances Cardiac Function in Ischemic Heart Failure |
Circulation, Jul 2006; 114: I-206 - I-213 |
SPR-838, ARIA 1 |
rat |
cyclin • heart failure • myocardial regeneration |
| Hsieh PCH, MacGillivray C, Gannon J;, Cruz FU, Lee RT |
Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity |
Circulation, Aug 2006; 114: 637 - 644 |
2F pressure-volume sensing catheters, PVAN 3.2 |
rat |
pulmonary toxicity |
| Jegger D, da Silva R, Jeanrenaud X, Nasratullah M, Tevaearai H, von Segesser LK, Segers P, Gaillard V, Atkinson J, Lartaud I, Stergiopulo N |
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1942 - H1951 |
SPR-838, Aria |
rat |
blood flow; calcium; hypertension; hemodynamics; ventr |
| Li Z, Ma JY,Kerr I, Chakravarty S, Dugar S, Schreiner G, Protter AA |
Selective inhibition of p38α MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1972 - H1977 |
SPR-719, PVAN 2.9 software, ARIA Pressure-Volume Conductance System |
rat |
p38 mitogen-activated protein kinase; remodeling |
| Faber MJ, Dalinghaus M, Lankhuizen IM, Steendijk P, Hop WC, Schoemaker RG, Duncker DJ, Lamers JMJ, Helbing WA |
Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1580 - H1586 |
pressure-tip catheter |
rat |
right ventricle; hypertrophy; congenital heart disease; pressure-volume |
| Hessel MHM, Steendijk P, den Adel B, Schutte CI, van der Laarse A |
Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat |
Am J Physiol Heart Circ Physiol, Nov 2006; 291: H2424 - H2430 |
SPR-878 |
rat |
right ventricular hypertrophy; right ventricular failure; pressure-volume relations |
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---------------------------------------------Published in 2005--------------------------------------------- |
Pacher, Pa´l, Sa´ndor Ba´tkai, Douglas Osei-Hyiaman, La´szlo´
Offerta´ler, Jie Liu, Judy Harvey-White, Attila Brassai, Zolta´n
Ja´rai, Benjamin F. Cravatt, and George Kunos |
Hemodynamic profile, responsiveness to anandamide, and baroreflex
sensitivity of mice lacking fatty acid amide hydrolase |
Am J Physiol Heart Circ Physiol 289: H533–H541, 2005 |
SPR-839, ARIA Pressure-Volume Conductance System |
mouse |
contractility; hypertension; cannabinoids; endocannabinoids |
| Montgomery DE, Rundell VLM, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM |
Protein kinase C induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism |
Am J Physiol Heart Circ Physiol 289: H1881-H1888, 2005 |
1.4-Fr pressure-conductance catheter, ARIA |
mouse |
pressure-volume loops; cardiac myofilaments |
| Ikonomidis JS, Hendrick JW, Parkhurst AM, Herron AR, Escobar PG, Dowdy KB, Stroud RE, Hapke E, Zile MR, Spinale FG |
Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition |
Am J Physiol Heart Circ Physiol 288: H149-H158, 2005; doi:10.1152/ajpheart.00370.2004 |
SPR-839, ARIA, MPCU-200, DAQ, PV Analysis Software, PVAN |
mouse |
transgenic model; heart failure; myocardial hypertrophy |
| Witzenbichler B, MWestermann D, Knueppel S, Schultheiss H-P, Tschope C |
Protective Role of Angiopoietin-1 in Endotoxic Shock |
Circulation. 2005;111:97-105 |
ARIA, SPR-719 |
mouse |
shock • genes • cell adhesion molecules • lung • angiogenesis |
| Montgomery DE, Rundell VLM, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM |
Protein kinase C induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism |
Am J Physiol Heart Circ Physiol 289: H1881-H1888, 2005 |
1.4-Fr pressure-conductance catheter, ARIA |
mouse |
pressure-volume loops; cardiac myofilaments |
| MacGowan GA, Rager J, Shroff SG, Mathier MA |
In vivo -adrenergic responses and troponin I phosphorylation: anesthesia interactions |
J Appl Physiol, Apr 2005; 98: 1163 - 1170 |
1.4-Fr. conductance catheter |
mouse |
protein kinase C; ventricular function |
| ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, sbrandt D, Wallis J, Neubauer S |
Reduced Inotropic Reserve and Increased Susceptibility to Cardiac Ischemia/Reperfusion Injury in Phosphocreatine-Deficient Guanidinoacetate-N-Methyltransferase–Knockout Mice |
Circulation, May 2005; 111: 2477 - 2485 |
SPR-839, PVAN software version 3.0 |
mouse |
creatine kinase • metabolism • hemodynamics • ischemia • myocardium |
| Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J, Wang Y |
p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart |
Circulation, May 2005; 111: 2494 - 2502 |
SPR-839 |
mouse |
inflammation • cardiomyopathy • signal transduction • heart failure |
| Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA |
Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load |
J. Clin. Invest., May 2005; 115: 1221 - 1231 |
SPR-839 |
mouse |
hypertrophy, chamber dilation and dysfunction |
| How O-J, Aasum E, Kunnathu S, Severson DL, Myhre ESP, Larsen TS |
Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2979 - H2985 |
1.4-F-conductance catheter |
mouse |
oxygen consumption; pressure-volume area; cardiac metabolism; compliance; steady state |
| Pacher P, Bátkai S, Osei-Hyiaman D, Offertáler L, Liu J, JHarvey-White J, Brassai A, Járai Z, Cravatt BF, Kunos G |
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H533 - H541 |
SPR-839 |
mouse |
contractility; hypertension; cannabinoids; endocannabinoids |
| Jung AS, Harrison R, Lee KH, Genut J, Nyhan D, Brooks-Asplund EM, Shoukas AA, Hare JM, Berkowitz DE |
Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H600 - H607 |
1.4-Fr micromanometer-conductance catheter |
mouse |
hindlimb unweighting; microgravity; baroreflex; orthostatic hypotension; mouse; cardiovascular deconditioning |
| Tao W, Enoh VT, Lin CY, Johnston WE, Li P, Sherwood ER |
Cardiovascular dysfunction caused by cecal ligation and puncture is attenuated in CD8 knockout mice treated with anti-asialoGM1 |
Am J Physiol Regulatory Integrative Comp Physiol, Aug 2005; 289: R478 - R485 |
SPR-839, Aria 1, wells with known diameters of 2-6 mm |
mouse |
blood pressure; vascular resistance; cardiac output; left ventricular function; perfusion |
| Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M |
Increased Fibulin-5 and Elastin in S100A4/Mts1 Mice With Pulmonary Hypertension |
Circ. Res., Sep 2005; 97: 596 - 604 |
Aria System |
mouse |
elastin • fibulin-5 • hypoxia • mouse • pulmonary hypertension • smooth muscle cells • S100 proteins • vascular smooth muscle cells • vascular disease |
| Hilfiker-Kleiner D, Hilfiker A, Kaminski K, Schaefer A, Park J-K, Michel K, Quint A, Yaniv M, Weitzman JB, Drexler H |
Lack of JunD Promotes Pressure Overload–Induced Apoptosis, Hypertrophic Growth, and Angiogenesis in the Heart |
Circulation, Sep 2005; 112: 1470 - 1477 |
SPR-719 |
mouse |
angiogenesis • apoptosis • hypertrophy |
| Wang J, Xu N, Feng X, Hou N, Zhang JS, Cheng X, Chen Y, Zhang Y, Yang X |
Targeted Disruption of Smad4 in Cardiomyocytes Results in Cardiac Hypertrophy and Heart Failure |
Circ. Res., Oct 2005; 97: 821 - 828 |
1.4-F micro-manometer conductance catheter |
mouse |
Smad4 • cardiac hypertrophy • heart failure • mitogen-activated protein kinase • Cre–LoxP system |
| Montgomery DE, Rundell VLM, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM |
Protein kinase Cε induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H1881 - H1888 |
4-Fr pressure-conductance catheter, ARIA, PVAN |
mouse |
pressure-volume loops; cardiac myofilaments |
| Saraiva RM, Minhas KM, Raju SVY, Barouch LA, Pitz E, Schuleri KH, Vandegaer K, Li D, Hare JM |
Deficiency of Neuronal Nitric Oxide Synthase Increases Mortality and Cardiac Remodeling After Myocardial Infarction: Role of Nitroso-Redox Equilibrium |
Circulation, Nov 2005; 112: 3415 - 3422 |
SPR-719 |
mouse |
myocardial infarction • nitric oxide synthase • heart failure • receptors, adrenergic, beta |
| Wallis J, Lygate CA, Fischer A, ten Hove M, Schneider JE, Sebag-Montefiore L, Dawson D, Hulbert K, Zhang W, hang MH, Watkins H, Clarke K, Neubauer S |
Supranormal Myocardial Creatine and Phosphocreatine Concentrations Lead to Cardiac Hypertrophy and Heart Failure: Insights From Creatine Transporter–Overexpressing Transgenic Mice |
Circulation, Nov 2005; 112: 3131 - 3139 |
SPR-839, PVAN software, version 3.0 |
mouse |
myocardial creatine transporter |
| Fazel S, Chen L, Weisel RD, Angoulvant D, Seneviratne C, Fazel A, Cheung P, Lam J, Fedak PWM, Yau TM, Li R-K |
Cell transplantation preserves cardiac function after infarction by infarct stabilization: Augmentation by stem cell factor |
J. Thorac. Cardiovasc. Surg., Nov 2005; 130: 1310 |
micromanometer and conductance 1.4F catheter |
mouse |
endogenous infarct repair |
| Dawson D, Lygate CA, Zhang M-H, Hulbert K, Neubauer S, Casadei B |
nNOS Gene Deletion Exacerbates Pathological Left Ventricular Remodeling and Functional Deterioration After Myocardial Infarction |
Circulation, Dec 2005; 112: 3729 - 3737 |
SPR-839 |
mouse |
contractility, preload-recruitable stroke work |
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