| AUTHORS |
TITLE |
JOURNAL |
MILLAR EQPT. |
SUBJECT |
application |
---------------------------------------------Published in 2010--------------------------------------------- |
| Wang Y, Zhang D, Ashraf M, Zhao T, Huang W, Ashraf A, Balasubramaniam A |
Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction |
Am J Physiol Heart Circ Physiol, Jan 2010; 298: H275 - H286 |
SPR-839, MPCU-200 P-V signal conditioning hardware, PVAN software (Version 3.2). |
rat |
deoxyribonucleic acid synthesis |
| Levick SP, Murray DB, Janicki JS, Brower GL |
Sympathetic Nervous System Modulation of Inflammation and Remodeling in the Hypertensive Heart |
Hypertension, Feb 2010; 55: 270 - 276 |
high fidelity Millar catheter, PVAN 3.5 |
rat |
sympathectomy • fibrosis • mast cell • cytokines • inflammation • substance P • sympathetic nervous system |
| Gilsbach R, Schneider J, Lother A, Schickinger S, Leemhuis J, Hein L |
Sympathetic α2-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload |
Cardiovasc Res cvq014published ahead of print January 18, 2010, doi:10.1093/cvr/cvq014 |
1.4 F pressure-volume catheter |
mouse |
Adrenoceptors-Norepinephrine-Transgenic mouse model-Pressure overload-Cardiac hypertrophy |
| Ha T, Lu C, Liu L, Hua F, Hu Y, Kelley J, Singh K, Kao RL, Kalbfleisch J, Williams DL, Gao X, Li C |
TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism |
Am J Physiol Heart Circ Physiol, Mar 2010; 298: H984 - H991 |
Millar conductance catheter system |
mouse |
Toll-like receptor 2; Pam3CSK4; Akt, cardiac function |
| Koyanagi M, Iwasaki M, Rupp S, Tedesco FS, Yoon C-H, Boeckel J-N, Trauth J, Schütz C, Ohtani K, Goetz R, Iekushi K, Bushoven P, Momma S, Mummery C, Passier R, Henschler R, Akintuerk H, Schranz D, Urbich C, Galvez BG, Cossu G, Zeiher AM, Dimmeler S |
Sox2 Transduction Enhances Cardiovascular Repair Capacity of Blood-Derived Mesoangioblasts |
Circ. Res., Apr 2010; 106: 1290 - 1302 |
micromanometer-tipped conductance catheter |
mouse |
|
| Loganathan S, Radovits T, Hirschberg K, Korkmaz S, Koch A, Karck M, Szabó G |
Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury |
J. Thorac. Cardiovasc. Surg., April 2010; 139: 1048 - 1056 |
Millar micromanometer, PVAN 3.6 software |
rat |
|
| Wang G, Hamid T, Keith RJ, Zhou G, Partridge CR, Xiang X, Kingery JR, Lewis RK, Li Q, Rokosh DG, Ford R, Spinale FG, Riggs DW, Srivastava S, Bhatnagar A, Bolli R, Prabhu SD |
Cardioprotective and Antiapoptotic Effects of Heme Oxygenase-1 in the Failing Heart |
Circulation, May 2010; 121: 1912 - 1925. |
Millar pressure-conductance catheter |
mouse |
|
| Ha T, Hu Y, Liu L, Lu C, McMullen JR, Kelley J, Kao RL, Williams DL, Gao X, Li C |
TLR2 ligands induce cardioprotection against ischaemia/reperfusion injury through a PI3K/Akt-dependent mechanism |
Cardiovasc Res cvq116published ahead of print April 26, 2010 doi:10.1093/cvr/cvq116 |
Millar conductance catheter system |
mouse |
Toll-like receptorsMyocardial ischaemia/reperfusionSignalling pathwaysPI3K/Akt signalling |
| Abe K, Toba M, Alzoubi A, Ito M, Fagan KA, Cool CD, Voelkel NF, McMurtry IF, Oka M |
Formation of Plexiform Lesions in Experimental Severe Pulmonary Arterial Hypertension |
Circulation, Jun 2010; 121: 2747 - 2754 |
SPR-838 |
rat |
|
| Beiser DG, Wojcik KR, Zhao D, Orbelyan GA, Hamann KJ, Vanden Hoek TL |
Akt1 genetic deficiency limits hypothermia cardioprotection following murine cardiac arrest |
Am J Physiol Heart Circ Physiol, Jun 2010; 298: H1761 - H1768 |
SPR-839 |
mouse |
sudden cardiac death; asystole; cardiopulmonary resuscitation; therapeutic hypothermia; protein kinase B |
| Riad A, Westermann D, Escher F, Becher PM, Savvatis K, Lettau O, M. Heimesaat MM, Bereswill S, Volk HD, Schultheiss HP, Tschöpe C |
Myeloid differentiation factor-88 contributes to TLR9-mediated modulation of acute coxsackievirus B3-induced myocarditis in vivo |
Am J Physiol Heart Circ Physiol, Jun 2010; 298: H2024 - H2031 |
ARIA, SPR-719 |
mouse |
heart failure; inflammation; innate immunity |
| Axelsen LN, Lademann JB, Petersen JS, Holstein-Rathlou N-H,Ploug T, Prats C, Pedersen HD, Kjølbye AL |
Cardiac and metabolic changes in long-term high fructose-fat fed rats with severe obesity and extensive intramyocardial lipid accumulation |
Am J Physiol Heart Circ Physiol, Jun 2010; 298: H2024 - H2031 |
SPR-838 |
rat |
metabolic syndrome; glucose intolerance; diabetes; animal model; myocardial contractile performance |
---------------------------------------------Published in 2009--------------------------------------------- |
| Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD |
Estrogen Attenuates Left Ventricular and Cardiomyocyte Hypertrophy by an Estrogen Receptor–Dependent Pathway That Increases Calcineurin Degradation |
Circ. Res., Jan 2009; 104: 265 - 275 |
PVR-1045 |
mouse |
estrogen • left ventricular remodeling • pressure overload • myocyte hypertrophy • calcineurin proteasome • ubiquitin |
| Pokreisz P, Vandenwijngaert S, Bito V, Van den Bergh A, Lenaerts I, Busch C, Marsboom G, Gheysens O, Vermeersch P, Biesmans L, Liu X, Gillijns H, Pellens M, Van Lommel A, Buys E, Schoonjans L, Vanhaecke J, Verbeken E, Sipido K, Herijgers P, Bloch KD, Janssens SP |
Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation, Jan 2009; 119: 408 - 416 |
SPR-839 |
mouse |
heart failure, PDE5-TG |
| Sun Y, OCarretero OA, Xu J, Rhaleb N-E, Yang JJ, Pagano PJ, Yang X-P |
Deletion of Inducible Nitric Oxide Synthase Provides Cardioprotection in Mice With 2-Kidney, 1-Clip Hypertension |
Hypertension, Jan 2009; 53: 49 - 56. |
Millar pressure system, PVAN |
mouse |
NO synthase • DOCA-salt hypertension • cardiac function • oxidative stress |
| Plante E, Lachance D, Beaudoin J, Champetier S, Roussel E, Arsenault M, Couet J |
Comparative Study of Vasodilators in an Animal Model of Chronic Volume Overload Caused by Severe Aortic Regurgitation |
Circ Heart Fail, Jan 2009; 2: 25 - 32. |
2F impedance catheter |
rat |
heart diseases • valves • renin-angiotensin system • vasodilators |
| Sun J, Li S-H, Liu S-M, Wu J, Weisel RD, Zhuo Y-F, Yau TM, Li R-K, Fazel SS |
Improvement in cardiac function after bone marrow cell thearpy is associated with an increase in myocardial inflammation |
Am J Physiol Heart Circ Physiol, Jan 2009; 296: H43 - H50 |
micromanometer and conductance 1.4-Fr catheter |
mouse |
cell transplantation; myocardial infarction; cell therapy; myofibroblasts |
| Buyse GM, Van der Mieren G, Erb M, D'hooge J, Herijgers P, Verbeken E, Jara A, Van Den Bergh A, Mertens L, Courdier-Fruh I, Barzaghi P, Meier T |
Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance |
Eur. Heart J., January 2009; 30: 116 - 124 |
SPR-839 |
mouse |
Muscular dystrophy • Therapy • Cardiomyopathy • Hemodynamics • Heart failure • Animal model |
| Marsh SA, Powell PC, Agarwal A, Dell'Italia LJ, Chatham JC |
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis |
Am J Physiol Heart Circ Physiol, Feb 2009; 296: H282 - H292 |
2F-combined conductance catheter-micromanometer, PVAN 3.0 |
rat |
diabetes; cardiac function; renal function |
| Nagayama T, Hsu S, Zhang M, Koitabashi N, Bedja D, Gabrielson KL, Takimoto E, Kass DA |
Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload |
J. Am. Coll. Cardiol., January 13, 2009; 53: 207 - 215 |
SPR-839 |
mouse |
PDE5 • pressure overload • hypertrophy • myocyte • cardiac function |
| Marsh SA, Dell'Italia LJ, Chatham JC |
Interaction of diet and diabetes on cardiovascular function in rats |
Am J Physiol Heart Circ Physiol, Feb 2009; 296: H282 - H292 |
2F-combined conductance catheter-micromanometer, PVAN 3.0 |
rat |
cardiac function; high-fat diet; Western diet |
| Hsu S, Nagayama T, Koitabashi N, Zhang M, Zhou L, Bedja D, Gabrielson KL, Molkentin JD, Kass DA, Takimoto E |
Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway |
Cardiovasc Res, 1 February 2009; 81: 301 - 309 |
SPR-839 |
mouse |
Calcineurin; Phosphodiesterase 5; Cyclic GMP; CGMP-dependent protein kinase; Sildenafil; Heart; Hypertrophy |
| Takimoto E, Koitabashi N, Hsu S, Ketner EA, Zhang M, Nagayama T, Bedja D, Gabrielson KL, Blanton R, \Siderovski DP, Mendelsohn ME, Kass DA |
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice |
J. Clin. Invest. doi:10.1172/JCI35620 |
SPR-839 |
mouse |
|
| Mukaddam-Daher S, Menaouar A, Paquette P-A, Jankowski M, Gutkowska J, Gillis M-A, Shi Y-F, Calderone A, Tardif J-C |
Hemodynamic and Cardiac Effects of Chronic Eprosartan and Moxonidine Therapy in Stroke-Prone Spontaneously Hypertensive Rats |
Hypertension, Mar 2009; doi:10.1161/HYPERTENSIONAHA.108.126524 |
conductance catheter |
rat |
hypertension • hypertrophy • hemodynamics • natriuretic peptides • moxonidine • eprosartan |
| Peng T, Zhang T, Lu X, Feng Q |
JNK1/c-fos inhibits cardiomyocyte TNF-α expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia |
Cardiovasc Res, 1 March 2009; 81: 733 - 741. |
SPR-839, PVAN |
mouse |
Sepsis; Cytokine; Signal transduction; Cardiomyocytes; Cardiac function |
| Li Z, Lee A, Huang M, Chun H, Chung J, Chu P, Hoyt G, Yang P, Rosenberg J, Robbins RC, Wu JC |
Imaging Survival and Function of Transplanted Cardiac Resident Stem Cells |
J. Am. Coll. Cardiol., April 7, 2009; 53: 1229 - 1240 |
1.4 conductance catheter, PVAN 3.4 |
mouse |
molecular imaging • cardiac stem cells • ischemic heart disease • differentiation |
| Shi Y, Chen C, Lisewski U, Wrackmeyer U, Radke M, Westermann D, Sauter M, Tschöpe C, Poller W, Klingel K, Gotthardt M |
Cardiac Deletion of the Coxsackievirus-Adenovirus Receptor Abolishes Coxsackievirus B3 Infection and Prevents Myocarditis In Vivo |
J. Am. Coll. Cardiol., April 7, 2009; 53: 1219 - 1226 |
SPR-719, ARIA |
mouse |
cell adhesion molecules • myocarditis • receptors • viruses |
| Mukhopadhyay P,Rajesh M, Bátkai S, Kashiwaya Y, Haskó G, Liaudet L, Szabó C, Pacher P |
Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1466 - H1483 |
PVR 1045, ARIA P-V conductance system |
mouse |
heart failure; apoptosis; inducible nitric oxide synthase; hemodynamics |
| Liu Y, Wang D, Redetzke RA, Sherer BA, Gerdes AM |
Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1551 - H1557 |
ultraminiature pressure transducer catheter, MPVS-400 pressure-volume unit |
rat |
hypothyroidism; myocardial arterioles; vascular disease |
| Boardman N, Hafstad AD, Larsen TS, Severson DL, Aasum E |
Increased O2 cost of basal metabolism and excitation-contraction coupling in hearts from type 2 diabetic mice |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1373 - H1379 |
1.0-Fr conductance catheter |
mouse |
cardiac efficiency; pressure-volume area; myocardial oxygen consumption; substrate oxidation |
| Palpant NJ, D'Alecy LG, Metzger JM |
Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo |
FASEB J. 2009 23: 1529-1540 |
pressure-conductance |
mouse |
myocardial function • myofilaments • pH |
| Chang SA, Kim Y-J, Lee H-W, Kim D-H, Kim H-K, Chang H-J, Sohn D-W, Oh B-H, Park Y-B |
Effect of Rosuvastatin on Cardiac Remodeling, Function, and Progression to Heart Failure in Hypertensive Heart With Established Left Ventricular Hypertrophy |
Hypertension, Jun 2009; doi:10.1161/HYPERTENSIONAHA.109.131243 |
SPR-838, PVAN 3.5 |
rat |
heart failure • ventricular hypertrophy • hypertension • statin |
| Levick SP,McLarty JL, Murray DB, Freeman RM, Carver WE, Brower GL |
Cardiac Mast Cells Mediate Left Ventricular Fibrosis in the Hypertensive Rat Heart |
Hypertension, Jun 2009; 53: 1041 - 1047 |
high fidelity Millar conductance catheter |
rat |
hypertension • collagen • cytokines • inflammation |
| Xu J, Ismat FA, Wang T, Lu MM, Antonucci N, Epstein JA |
Cardiomyocyte-Specific Loss of Neurofibromin Promotes Cardiac Hypertrophy and Dysfunction |
Circ. Res., Jul 2009; 105: 304 - 311. |
1.4 French Millar catheter-tip micromanometer catheter, SPR-839 |
mouse |
NF1 • neurofibromatosis • cardiac hypertrophy |
| Spinale FG, Escobar GP, Mukherjee R, Zavadzkas JA, Saunders SM, Jeffords LB, Leone AM,Beck C, Bouges S, Stroud RE |
Cardiac-Restricted Overexpression of Membrane Type-1 Matrix Metalloproteinase in Mice: Effects on Myocardial Remodeling With Aging |
Circ Heart Fail, Jul 2009; 2: 351 - 360 |
SPR-839, ARIA, MPCU-200, DAQ, PV Analysis Software |
mouse |
matrix • myocardial remodeling • ventricular function • aging |
| Radovits T, Korkmaz S, Loganathan S, Barnucz E, Bömicke T, Arif R, Karck M, Szabó G |
Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H125 - H133 |
SPR-838, MPVS-400, PVAN |
rat |
systolic dysfunction; diastolic dysfunction; systolic function; diastolic function |
| Murray DB, McMillan R, Brower GL, Janicki JS |
ETA selective receptor antagonism prevents ventricular remodeling in volume-overloaded rats |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H109 - H116 |
SPR-838 |
rat |
endothelin-1; mast cell; matrix metalloproteinase; TBC-3214 |
| Yu Q, Vazquez R, Khojeini EV, Patel C, Venkataramani R, Larson DF |
IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H76 - H85 |
Millar conductance catheter system |
mouse |
extracellular matrix; remodeling; T lymphocyte; interferon regulatory factor 1; toll-like receptor-9; lysyl oxidase |
| Hassink RJ, Nakajima H, Nakajima HO, Doevendans PA, Field LJ |
Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction |
Heart, Jul 2009; 95: 1159 - 1164 |
SPR-839 |
mouse |
|
| Naghshin J, McGaffin KR, Witham WG, Mathier MA, Romano LC, Smith SH, Janczewski AM, Kirk JA, Shroff SG, O'Donnell CP |
Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice |
J Appl Physiol, Jul 2009; doi:10.1152/japplphysiol.91256.2008 |
PVR-1045, MVPS-400 |
mouse |
cardiac beta-adrenergic pathways |
| Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Ulrich Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XHT |
Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice |
J. Clin. Invest. 119(7): 1940-1951 (2009). doi:10.1172/JCI37059. |
EPR-800 |
mouse |
|
| Korkmaz S, Radovits T, Barnucz E, Hirschberg K, Neugebauer P, Loganathan S, Veres G, Páli S, Seidel B, Zöllner S, Karck M, Szabó G |
Pharmacological Activation of Soluble Guanylate Cyclase Protects the Heart Against Ischemic Injury |
Circulation, Aug 2009; 120: 677 - 686 |
Millar microtip pressure-volume conductance catheter |
rat |
cinaciguat |
| Oceandy D, Pickard A, Prehar S, Zi M, Mohamed TMA, Stanley PJ, Nadif R, Tommasi S, Pfeifer GP, Armesilla AL, Cartwright EJ, Neyses LN |
Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy |
Circulation, Aug 2009; 120: 607 - 616 |
SPR-839 |
mouse |
|
| Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NMP, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M |
Truncation of Titin's Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction |
Circ. Res., Aug 2009; doi:10.1161/CIRCRESAHA.109.200964 |
SPR-719, ARIA |
mouse |
diastole • connectin • hypertrophy • compliance • FHL |
| Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD |
sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models |
Am J Physiol Heart Circ Physiol, Aug 2009; 297: H654 - H663 |
SPR-839 |
mouse |
soluble guanylate cyclase; left ventricular function; sepsis; mice; nitric oxide |
| Hafstad AD, Khalid AM, Hagve M, Lund T, Larsen TS, Severson DL, Clarke K, Berge RK, Aasum E |
Cardiac peroxisome proliferator-activated receptor- activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss |
Cardiovasc Res, 1 August 2009; 83: 519 - 526 |
1.4 F micromanometer-conductance catheter |
mouse |
Cardiac metabolism; Glucose oxidation; Fatty acid oxidation; Ischaemia-reperfusion; Cardiac function; Cardiac efficiency; PPARα target genes |
| Chang S-A, Kim Y-J, Lee H-W, Kim D-H, Kim H-K, Chang H-J, Sohn D-W, Oh B-H, Park Y-B |
Effect of Rosuvastatin on Cardiac Remodeling, Function, and Progression to Heart Failure in Hypertensive Heart With Established Left Ventricular Hypertrophy |
Hypertension, Sep 2009; 54: 591 - 597. |
SPR-838, ARIA, PVAN3 .5 |
rat |
heart failure • ventricular hypertrophy • hypertension • statin |
| Champion HC, Michelakis ED, Hassoun PM |
Comprehensive Invasive and Noninvasive Approach to the Right Ventricle–Pulmonary Circulation Unit: State of the Art and Clinical and Research Implications |
Circulation, Sep 2009; 120: 992 - 1007 |
conductance catheter |
|
|
| Granzier HL, Radke MH, Peng J, Westermann D, Nelson OL, Rost K, King NMP, Yu Q, Tschöpe C, McNabb M, Larson DF, Labeit S, Gotthardt M |
Truncation of Titin’s Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction |
Circ. Res., Sep 2009; 105: 557 - 564 |
ARIA, SPR-719 |
mouse |
diastole • connectin • hypertrophy • compliance • FHL |
| Lachance D, Plante É, Bouchard-Thomassin A-A, Champetier S, Roussel É, Drolet M-C, Arsenault M, Couet J |
Moderate Exercise Training Improves Survival and Ventricular Remodeling in an Animal Model of Left Ventricular Volume Overload |
Circ Heart Fail, Sep 2009; 2: 437 - 445 |
2F pressure volume catheter |
rat |
survival • exercise • hypertrophy • valves • collagen |
| Naghshin J, McGaffin KR, Witham WG, Mathier MA, Romano LC, Smith SH, anczewski AM, Kirk JA, Shroff SG, O'Donnell CP |
Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice |
J Appl Physiol, Sep 2009; 107: 787 - 793 |
MVPS-400, PVR-1045 |
mouse |
blood pressure; cAMP; echocardiography; ejection fraction; pressure-volume loop; propranolol; sympathetic activation |
| Burger DE, Lu X, Lei M, Xiang F-L, Hammoud L, Jiang M, Wang H, Jones DL, Sims SM, Feng Q |
Neuronal Nitric Oxide Synthase Protects Against Myocardial Infarction-Induced Ventricular Arrhythmia and Mortality in Mice |
Circulation, Oct 2009; 120: 1345 - 1354 |
Millar catheter |
mouse |
L-type Ca2+ channel activity |
| Schaeffer PJ, DeSantiago J, Yang J, Flagg TP, Kovacs A, Weinheimer CJ, Courtois M, Leone TC, Nichols CG, Bers DM, Kelly DP |
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice |
Am J Physiol Heart Circ Physiol, Oct 2009; 297: H1263 - H1273 |
1.4F Millar catheter |
mouse |
calcium signaling; restrictive cardiomyopathy; cardiac hypertrophy; excitation-contraction coupling; cardiac mitochondria |
| Vessey DA, Li L, Honbo N, Karliner JS |
Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning |
Am J Physiol Heart Circ Physiol, Oct 2009; 297: H1429 - H1435 |
Millar micromanometer-tipped catheter |
rat |
preconditioning; ischemia-reperfusion injury; cardioprotection |
| Li L, Okada H, Takemura G, Kosai K, Kanamori H, Esaki M, Takahashi T, Goto K, Tsujimoto A, Maruyama R, Kawamura I, Kawaguchi T, Takeyama T, Fujiwara T, Fujiwara H, Minatoguchi S |
Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction |
Am J Physiol Heart Circ Physiol, Oct 2009; 297: H1504 - H1513 |
SPR-671 |
mouse |
heart failure; myocardial infarction; transforming growth factor-β |
| Béguin , El-Helou V, Assimakopoulos J, Clément R, Gosselin H, Brugada R, Villeneuve L, Rohlicek CV, Del Duca D, Lapointe N, Rouleau JL, Calderone A |
The phenotype and potential origin of nestin+ cardiac myocyte-like cells following infarction |
J Appl Physiol, Oct 2009; 107: 1241 - 1248 |
Millar catheter |
rat |
neural stem cells; ischemia; scar formation; β1-adrenergic receptor; connexin-43 |
| Graham DA. Rush JWE |
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats |
J Appl Physiol, Oct 2009; 107: 1059 - 1067 |
Mikro-Tip Pressure Transducer catheter |
rat |
endothelium-derived contracting factor; prostanoid; nitric oxide; sex difference; endothelium-dependent relaxation; prostaglandin I2; thromboxane/prostaglandin receptor; SQ-29548 |
| Tao L, Wang Y, Gao E, Zhang H, Yuan Y, Lau WB, Chan L, Koch WJ, Ma XL |
Adiponectin. An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction |
Circ. Res., Nov 2009; doi:10.1161/CIRCRESAHA.109.211797 |
1.2-Fr micromanometer |
mouse |
diabetes • myocardial infarction • adipocytokine • signaling |
| Meloni M, Caporali A, Zentilin L, Madeddu P, Giacca M, Emanueli C |
Abstract 1161: AAV-2-mediated Nerve Growth Factor Gene Transfer Prevents the Development of Experimental Diabetic Cardiomyopathy in Mice |
Circulation, Nov 2009; 120: S458 |
Millar catheter |
mouse |
systolic dysfunction, heart failure |
| Meloni M, Caporali A, Lagrasta C, Graiani G, Katare R, Madeddu P, Quaini F, Emanueli C |
Abstract 3492: Nerve Growth Factor Exerts Protective and Regenerative Actions on the Post-Infarct Heart |
Circulation, Nov 2009; 120: S810 |
Millar mikrotip catheter |
mouse |
cardiac regeneration |
| Santulli G, ECipolletta E, Campanile A, Maione S, Trimarco V, Marino M, Trimarco B, Illario M, Iaccarino G |
Abstract 2271: Deletion of the CaMK4 Gene in Mice Determines a Hypertensive Phenotype |
Circulation, Nov 2009; 120: S613. |
invasive (Millar) arterial BP measurement |
mouse |
calcium-dependent signaling, blood pressure |
| Vandenwijngaert S, Pokreisz P, Pellens M, Gillijns H, Veulemans P, Liu X, Herijgers P, D’hooge J, Bloch KD, Janssens S |
Abstract 3543: Myocardial Phosphodiesterase 5 Expression Contributes to Left Ventricular Dysfunction in the Pressure-Overloaded Heart |
Circulation, Nov 2009; 120: S820 |
transaortic pressure gradient (deltaP), LV systolic and diastolic function (Millar) |
mouse |
heart failure, remodeling |
| Tveita T, Sieck GC, Solaro RJ, Arteaga GM |
Abstract 3573: Protection of Hypothermia-induced Contractile Dysfunction in Mice With Cardiac Specific Expression of Slow Skeletal Troponin I |
Circulation, Nov 2009; 120: S828 |
1.4F pressure-volume Millar catheter |
mouse |
heart failure |
| Urboniene D, Haber I, Fang Y-H, Archer SL |
Abstract 3631: Validation of Two Non-invasive Imaging Methods, High-resolution Echocardiography (ECHO) and Magnetic Resonance Imaging (MRI) for Assessment of Pulmonary Hemodynamics in Rats With Pulmonary Arterial Hypertension |
Circulation, Nov 2009; 120: S840 - S841 |
1.4F Millar micromanometer catheter |
rat |
pulmonary hypertension |
| Ohanyan V, Bratz IN, Chilian WM |
Abstract 5255: Kv1.3 Channels Play a Role in Coronary Metabolic Dilation |
Circulation, Nov 2009; 120: S1075 |
Millar transducer |
mouse |
coronary flow |
| Zheng H, Li YF, Wang W, Patel KP |
Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure |
Am J Physiol Regulatory Integrative Comp Physiol, Nov 2009; 297: R1364 - R1374 |
Mikro-Tip catheter |
rat |
angiotensin; sympathetic activity; blood pressure; AT1 receptor |
| van den Borne SWM, van de Schans VAM, Strzelecka AE, Vervoort-Peters HTM, Lijnen PM, Cleutjens JPM, Smits JFM, Daemen MJAP, Janssen BJA, Blankesteijn WB |
Mouse strain determines the outcome of wound healing after myocardial infarction |
Cardiovasc Res, 1 November 2009; 84: 273 - 282 |
SPR-671 |
mouse |
Myocardial infarction; Inflammatory cells; Infarct rupture; Heart failure; Genetic background |
| Nakayama H, Bodi I, Correll RN, Chen X, Lorenz J, Houser SR, Robbins J, Schwartz A, Molkentin JD |
α1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice |
J. Clin. Invest. 119(12): 3787-3796 (2009). doi:10.1172/JCI39724. |
1.4F Millar catheter |
mouse |
|
| Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O, Tremblay J, Kotchen TA, Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley Jr AW, Biel M, Stoll M, Martin J. Lohse MJ, Broeckel U, Hein L |
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice |
J Clin Invest. 2009;119(12):3597–3612. doi:10.1172/JCI38433 |
1.4F Millar microtip catheter |
mouse |
|
| Yoo BS, Lemaire A, Mangmool S, Wolf MJ, Curcio A, Mao L, Rockman HA |
β1-Adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction |
Am J Physiol Heart Circ Physiol, Oct 2009; 297: H1377 - H1386. |
1.4-Fr pressure-conductance catheter, PVAN data analysis software version 3.3 |
mouse |
Ca2+/calmodulin-dependent kinase II; heart failure; apoptosis; knockout mice; pressure-volume relations |
| Unsöld B, Teucher N, Didié M, Sosalla S, Jacobshagen C, Seidler T, Schöndube F, Maier LS, WSchillinger W, Hasenfuss G |
Abstract 4027: Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in Mice |
Circulation, Nov 2009; 120: S907 |
Millar Mikrotip conductance catheter |
mouse |
heart failure |
| Buys ES, Raher MJ, Rauwerdink KM, Sips PY, Brouckaert P, Bloch KD |
Abstract 5079: Hypertension in Soluble Guanylate Cyclase α1- Deficient Mice is Associated With Hyperaldosteronism |
Circulation, Nov 2009; 120: S1045 |
Millar pressure volume catheter |
mouse |
RAS |
| Gelpi RJ, Gao S, Zhai P, Yan L, Hong C, Danridge LMA, Ge H, Maejima Y, Donato M, Yokota M, Molkentin JD, Vatner DE, Vatner SF, Sadoshima J |
Genetic inhibition of calcineurin induces diastolic dysfunction in mice with chronic pressure overload |
Am J Physiol Heart Circ Physiol, Nov 2009; 297: H1814 - H1819 |
high-fidelity catheter tip transducers (1.4 Fr, Millar) |
mouse |
hypertrophy; diastole; hemodynamics |
| Charo DN, Ho M, Fajardo G, Kawana M, Kundu RK, Sheikh AY, Finsterbach TP, Leeper NJ, Ernst KV, Chen MM, Ho YD, Chun HJ, Bernstein D, Ashley EA, Quertermous T |
Endogenous regulation of cardiovascular function by apelin-APJ |
Am J Physiol Heart Circ Physiol, Nov 2009; 297: H1904 - H1913 |
specialized conductance catheter |
mouse |
pressure-volume hemodynamics; cardiomyocyte |
| Mukhopadhyay P, Rajesh M, Bátkai S, Patel V, Kashiwaya Y, Liaudet L, Evgenov OV, Mackie K, Haskó G, Pacher P |
CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes |
Cardiovasc Res, Advance Access published on December 15, 2009; doi: doi:10.1093/cvr/cvp369 |
Millar pressure-volume conductance system |
mouse |
Heart failure; CB1 receptor; Endocannabinoids; Rimonabant; SR141716; AM281 |
---------------------------------------------Published in 2008--------------------------------------------- |
| Bostick B, Yue Y, Long C, Duan D |
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression |
Circ. Res., Jan 2008; 102: 121 - 130 |
SPR-839 |
mouse |
cardiomyopathy • gene therapy • myocardium • genetics • heart disease |
| LaCroix C, Freeling J, Giles A, Wess J, Li Y-F |
Deficiency of M2 muscarinic acetylcholine receptors increases susceptibility of ventricular function to chronic adrenergic stress |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H810 - H820 |
Millar pressure-volume (P-V) catheter |
mouse |
muscarinic; cardiac; contractility; matrix metalloproteinase; isoproterenol |
| Bell JR, Kennington E, Fuller W, Dighe K, Donoghue P, Clark JE, Jia L-G, Tucker AL, Moorman JR, Marber MS, Eaton P, Dunn MJ, Shattock MJ |
Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H613 - H621 |
SPR-839 |
mouse |
FXYD1; contractile function; intracellular sodium regulation |
| Karatas A, BHegner B, de Windt LJ, Luft FC, Schubert C, Gross V, Akashi YJ, Gürgen D, Kintscher U, da Costa Goncalves AC, Regitz-Zagrosek V, Dragun D |
Deoxycorticosterone Acetate-Salt Mice Exhibit Blood Pressure–Independent Sexual Dimorphism |
Hypertension, Feb 2008; doi:10.1161/HYPERTENSIONAHA.107.107938 |
1.4F catheter tip micromanometer , ARIA |
mouse |
heart • kidney • hypertrophy • inflammation • fibrosis • calcineurin • MCIP1 • NFATc2 |
| Westermann D, Mersmann J, Melchior A, Freudenberger T, Petrik C, Schaefer L, Lüllmann-Rauch R, Lettau O, Jacoby C, Schrader J, Brand-Herrmann S-M, Young MF, Schultheiss HP, Levkau B, Baba HA, Unger R, Zacharowski L, Tschöpe C, Fischer JW |
Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction |
Circulation, Feb 2008; doi:10.1161/CIRCULATIONAHA.107.714147 |
ARIA, SPR-719 |
mouse |
collagen matrix, cardiac hemodynamic function |
| Li H-L, Liu C, de Couto G, Ouzounian M, Sun M, Wang A-B, Huang Y, He C-W, Shi Y, Chen X, Nghiem MP, Liu Y, Chen M, Dawood F, Fukuoka M, Maekawa Y, Zhang L, Leask A , Ghosh AK, Kirshenbaum LA, Liu PP |
Curcumin prevents and reverses murine cardiac hypertrophy |
J. Clin. Invest. Hong-Liang Li, et al. 118:879 doi:10.1172/JCI32865 |
SPR-839 |
mouse |
turmeric |
| Degousee N, Fazel S, Angoulvant D, Stefanski E, Pawelzik S-C, Korotkova M, Arab S, Liu P, Lindsay TF, Zhuo S, Butany J, Li R-K, Audoly L, Schmidt R, Angioni C, Geisslinger G, Jakobsson P-J, Rubin BB |
Microsomal Prostaglandin E2 Synthase-1 Deletion Leads to Adverse Left Ventricular Remodeling After Myocardial Infarction |
Circulation, Apr 2008; 117: 1701 - 1710 |
SPR-839, PVAN 3.3 |
mouse |
PGE2, cardiac ischemic injury |
| Karatas A, Hegner B, de Windt LJ, Luft FC, Schubert C, Gross V, Akashi YJ, Gürgen D, Kintscher U, da Costa Goncalves AC, Regitz-Zagrosek V, Dragun D |
Deoxycorticosterone Acetate-Salt Mice Exhibit Blood Pressure–Independent Sexual Dimorphism |
Hypertension, Apr 2008; 51: 1177 - 1183 |
1.4F catheter tip micromanometer, ARIA |
mouse |
heart • kidney • hypertrophy • inflammation • fibrosis • calcineurin • MCIP1 • NFATc2 |
| Bal MP, de Vries WB, van Oosterhout MFM, Baan J, van der Wall EE, van Bel F, Steendijk P |
Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats |
J Appl Physiol, Feb 2008; 104: 446 - 450 |
SPR-878 |
rat |
cardiac function; pressure-volume relations; rats; glucocorticoids |
| Fraccarollo D, Galuppo P, Schraut S, Kneitz S, van Rooijen N, Ertl G, Bauersachs J |
Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response |
Hypertension, Feb 2008; doi:10.1161/HYPERTENSIONAHA.107.100941 |
SPR-774 |
rat |
aldosterone • healing • inflammation • myocardial infarction • heart failure |
| Murray DB, Gardner JD, Brower GL, Janicki JS |
Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats |
Am J Physiol Heart Circ Physiol, Mar 2008; 294: H1251 - H1257 |
SPR-838 |
rat |
bosentan; heart; extracellular matrix; cardiac function |
| Phrommintikul A, Tran L, Kompa A, Wang B, Adrahtas A, Cantwell D, Kelly DJ, Krum H |
Effects of a Rho kinase inhibitor on pressure overload induced cardiac hypertrophy and associated diastolic dysfunction |
Am J Physiol Heart Circ Physiol, Apr 2008; 294: H1804 - H1814 |
SPR-838 |
rat |
Rho kinase; hypertrophy; fibrosis; pressure overload; hypertension; diastolic function; myocardium |
| Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA |
Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin: Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy |
Circulation, May 2008; 117: 2626 - 2636 |
SPR-839 |
mouse |
NOS, BH4, Tempol |
| Xu X, Wan W, Ji L, Lao S, Powers AS, Zhao W, Erikson JM, Zhang JQ |
Exercise training combined with angiotensin II receptor blockade limits post-infarct ventricular remodelling in rats |
Cardiovasc Res, 1 June 2008; 78: 523 - 532 |
SPR-838 |
rat |
Myocardial infarction; Remodelling; Exercise; Angiotensin; Metalloproteinases |
| Fraccarollo D, Widder JD, Galuppo P, Thum T, Tsikas D, Hoffmann M, Ruetten H, Ertl G, Bauersachs J |
Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction |
Circulation, Aug 2008; 118: 818 - 827 |
SPR-774, miniaturized 1.4F impedance pressure catheter |
rat |
LV remodeling and contractile dysfunction |
| Vinet L, Rouet-Benzineb P, Marniquet X, Pellegrin N, Mangin L, Louedec L, Samuel J-L, Mercadier J-J |
Chronic doxycycline exposure accelerates left ventricular hypertrophy and progression to heart failure in mice after thoracic aorta constriction |
Am J Physiol Heart Circ Physiol, Jul 2008; 295: H352 - H360 |
SPR-839 |
mouse |
pressure overload; matrix metalloproteinase; heart catheterization; echocardiography |
| Buys ES, Sips P, Vermeersch P, Raher MJ, Rogge E, Ichinose F, Dewerchin M, Bloch KD, Janssens S, Brouckaert P |
Gender-specific hypertension and responsiveness to nitric oxide in sGC α1 knockout mice |
Cardiovasc Res, 1 July 2008; 79: 179 - 186 |
SPR-839 |
mouse |
Nitric oxide; Gender; Hypertension; Blood pressure; Ventricular function |
| Fraccarollo D, Widder JD, Galuppo P, Thum T, Tsikas D, Hoffmann M, Ruetten H, Ertl G, Bauersachs J |
Improvement in Left Ventricular Remodeling by the Endothelial Nitric Oxide Synthase Enhancer AVE9488 After Experimental Myocardial Infarction |
Circulation, Aug 2008; 118: 818 - 827 |
SPR-774, miniaturized 1.4F impedance pressure catheter |
rat |
LV remodeling and contractile dysfunction |
| Höcherl K, Schmidt C, Kurt B, Bucher M |
Activation of the PGI2/IP System Contributes to the Development of Circulatory Failure in a Rat Model of Endotoxic Shock
Hypertension |
Hypertension, Aug 2008; 52: 330 - 335 |
SPR-838 |
rat |
prostacyclin • LPS • CAY-10441 • blood pressure • sepsis |
| Shioura KM, Geenen DL, Goldspink PH |
Sex-related changes in cardiac function following myocardial infarction in mice |
Am J Physiol Regulatory Integrative Comp Physiol, Aug 2008; 295: R528 - R534 |
SPR-839, Millar pressure-volume (P-V) conductance system |
mouse |
contractility; pressure-volume loops |
| El-Armouche A, Wittköpper K, Degenhardt F, Weinberger W, Didié M, Melnychenko I, Grimm M, Peeck M, Zimmermann WH, Unsöld B, Hasenfuss G, Dobrev D, Eschenhagen T |
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy |
Cardiovasc Res, Advance Access published on August 24, 2008; doi: doi:10.1093/cvr/cvn208 |
SPR-839 |
mouse |
Inhibitor-1; Catecholamines; Arrhythmias; Cardiac hypertrophy |
| McEvoy MD, Taylor A-G, Zavadzkas JA, Mains IM, Ford RL, Stroud RE, Jeffords LB, Beck CU, Reeves ST, Spinale FG |
Aprotinin Exerts Differential and Dose-Dependent Effects on Myocardial Contractility, Oxidative Stress, and Cytokine Release After Ischemia-Reperfusion |
Ann. Thorac. Surg., August 2008; 86: 568 - 575 |
1.4F, SPR-839, ARIA, MPCU-200,DAQ, PV Analysis Software |
mouse |
left ventricular contractility, cytokine release, and oxidative stress |
| Farahmand P, Lai TYY, Weisel RD, Fazel S, Yau T, Menasche P, Li R-K |
Skeletal Myoblasts Preserve Remote Matrix Architecture and Global Function When Implanted Early or Late After Coronary Ligation Into Infarcted or Remote Myocardium |
Circulation, Sep 2008; 118: S130 - S137 |
PVAN 3.3, Millar catheter |
rat |
cells • heart failure • myocardial infarction • remodeling • transplantation |
| Shenouda SK, Lord KC, McIlwain E, Lucchesi PA, Varner KJ |
Ecstasy produces left ventricular dysfunction and oxidative stress in rats |
Cardiovasc Res, 1 September 2008; 79: 662 - 670 |
SPR-838, MPVS-400 |
rat |
Pressure–volume loops; Cardiac myocytes; Proteomics; Ecstasy; Tyrosine nitration; MDMA |
| R. Bauer, G.A. MacGowan, A. Blain, K. Bushby, and V. Straub |
Steroid treatment causes deterioration of myocardial function in the δ-sarcoglycan-deficient mouse model for dilated cardiomyopathy |
Cardiovasc Res, 1 September 2008; 79: 652 - 661 |
1.4F conductance catheter, PVAN |
mouse |
Dilated cardiomyopathy; Muscular dystrophy; Corticosteroids; Delta-sarcogylcan |
| Tang X-L, Rokosh G, Sanganalmath SK, Peng Y, Yuan F, Dai S, Mu J, Bi Q, Li C, Chen N, Sato H, Dawn B, Anversa P, Bolli R |
Abstract 358: Beneficial Effects of Cardiac Progenitor Cells on LV Function 1 Year after Treatment in Rats with Myocardial Infarction |
Circulation, Oct 2008; 118: S_289 - S_290 |
conductance catheter |
rat |
Experimental Myocardial Infarction and Heart Failure |
| Landa N, Feinberg MS, Holbova R, Miller L, Tsur-Gang O, Tuvia S, Cohen S, Leor J |
Abstract 4299: Injectable Alginate Scaffold with Staged Transplantation of Fetal Cardiomyocytes Improves Infarct Healing and Cardiac Remodeling in Rat |
Circulation, Oct 2008; 118: S_862. |
pressure-volume system |
rat |
Heart Failure: Cell and Gene-Based Therapies |
| Zhu S-G, Das A, Xi L, Kukreja RC |
Abstract 4829: Dietary Supplementation of Nitrate Protects Against Doxorubicin-Induced Ventricular Dysfunction and Cardiomyocyte Cell Death in Mice |
Circulation, Oct 2008; 118: S_945 |
microtip pressure-volume Millar catheter transducer |
mouse |
Heart Failure: Pharmacologic Therapy |
| Derumeaux G, Ichinose F, Raher MJ, Morgan JG, Coman T, Lee C, Cuesta JM, Thibault H, Bloch KD, Picard MH, Scherrer-Crosbie M |
Myocardial Alterations in Senescent Mice and Effect of Exercise Training: A Strain Rate Imaging Study |
Circ Cardiovasc Imaging, Nov 2008; 1: 227 - 234 |
SPR-839 |
mouse |
aging • echocardiography • exercise |
| Moss NC, Tang R-H, Willis M, Stansfield WE, Baldwin AS, Selzman CH |
Inhibitory kappa B kinase-β is a target for specific nuclear factor kappa B-mediated delayed cardioprotection |
J. Thorac. Cardiovasc. Surg., November 2008; 136: 1274 - 1279 |
PVR-1045 |
mouse |
Cardiopulmonary Support and Physiology |
| Hendry II SL, van der Bogt KEA, Sheikh AY, Arai T, Dylla SJ, Drukker M, McConnell MV, Kutschka I, Hoyt G, Cao F, Weissman IL, Connolly AJ, Pelletier MP, Wu JC, Robbins RC, Yang PC |
Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells |
J. Thorac. Cardiovasc. Surg., October 2008; 136: 1028 - 1037 |
1.4F conductance catheter, PVAN 3.4 |
mouse |
Cardiopulmonary Support and Physiology |
| Donaldson C, Eder S, Baker C, Aronovitz MJ, Dabreo Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD |
Estrogen Attenuates Left Ventricular and Cardiomyocyte Hypertrophy by an Estrogen Receptor–Dependent Pathway That Increases Calcineurin Degradation |
Circ. Res., Dec 2008; doi:10.1161/CIRCRESAHA.108.190397 |
PVR-1045, SPR-1000 |
mouse |
estrogen • left ventricular remodeling • pressure overload • myocyte hypertrophy • calcineurin • proteasome • ubiquitin |
| Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell A-L, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD, Scherrer-Crosbie M |
A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload |
Am J Physiol Heart Circ Physiol, Dec 2008; 295: H2495 - H2502 |
SPR-839 |
mouse |
heart failure; myocardial perfusion |
| Sasse P, Malan D, Fleischmann M, Roell W, Gustafsson E, Bostani T, Fan Y, Kolbe T, Breitbach M, Addicks K, Welz A, Brem G, Hescheler J, Aszodi A, Costell M, Bloch W, Fleischmann BK |
Perlecan is critical for heart stability |
Cardiovasc Res, 1 December 2008; 80: 435 - 444 |
pressure-impedance catheter, PVAN software |
mouse |
Basement membranes; Extracellular matrix; Infarction; Hemopericard; Ventricular function |
| El-Armouche A, Wittköpper K, Degenhardt F, Weinberger F, Didié M, Melnychenko I, Grimm M, Peeck M, Zimmermann WH, Unsöld B, Hasenfuss G, Dobrev D, Eschenhagen T |
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy |
Cardiovasc Res, 1 December 2008; 80: 396 - 406 |
SPR-839 |
mouse |
Inhibitor-1; Catecholamines; Arrhythmias; Cardiac hypertrophy |
| Thomas CM, Smart EJ |
Abstract: The role of CD36 and Caveolin-1 in left ventricular heart function |
The FASEB Journal.2008.22.970.42 |
MPVS-300, SPR-839 |
mouse |
beta adrenergic signaling pathway, cardiac myocyte |
---------------------------------------------Published in 2007--------------------------------------------- |
| Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W |
Left ventricular pressure-volume relationship in conscious mice |
J Physiol Heart Circ Physiol, Jan 2007; 292: H369 - H377 |
SPR-719, PVAN 3.2 |
mouse |
ventricular function; mouse physiology |
| Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum L, Arnold M, Khokha R, Liu PP |
Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State |
Circulation, Mar 2007; 115: 1398 - 1407 |
SPR-839, PVAN |
mouse |
cardiac inflammatory response, extracellular matrix homeostasis, and ventricular hypertrophy |
| Clark JE, Flavell RA, Faircloth ME, Davis RJ, Heads RJ, Marber MS |
Post-infarction remodeling is independent of mitogen-activated protein kinase kinase 3 (MKK3) |
Cardiovascular Research |
SPR-839 |
mouse |
Infarction; Remodeling; MKK3; p38-MAPK; Haemodynamics |
| Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu B-Q, Nguyen A, Dahi S, Karliner JS, Lovett DH |
Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1847 - H1860 |
1.4-Fr PV conductance catheter, PVAN 3.2 |
mouse |
heart failure; fibrosis; mitochondria; sarcomere |
| Brickson S, Fitzsimons DP, Pereira L, Hacker T, Valdivia H, Moss RL |
In vivo left ventricular functional capacity is compromised in cMyBP-C null mice |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1747 - H1754 |
1.4-Fr high-fidelity Mikro-Tip conductance catheter |
mouse |
aortic banding; pressure-volume relations; dobutamine |
| Takimoto E, Belardi D, Tocchetti CG, Vahebi S, Cormaci G, Ketner EA, Moens AL, Champion HC, Kass DA |
Compartmentalization of Cardiac ß-Adrenergic Inotropy Modulation by Phosphodiesterase Type 5 |
Circulation, Apr 2007; 115: 2159 - 2167 |
SPR-839 PV |
mouse |
C57/BL6 mouse hearts |
| Galvez AS, Diwan A, Odley AM, Hahn HS, Osinska H, Melendez JG, Robbins J, Lynch RA, Marreez Y, Dorn II GW |
Cardiomyocyte Degeneration With Calpain Deficiency Reveals a Critical Role in Protein Homeostasis |
Circ. Res., Apr 2007; 100: 1071 - 1078 |
1.4 French Millar solid-state catheters |
mouse |
metabolism • protease • ubiquitin, mouse hearts |
| Yue P, Arai T, Terashima M, Sheikh AY, Cao F, Charo D, Hoyt G, Robbins RC, Ashley EA, Wu J, Yang PC, Tsao PS |
Magnetic resonance imaging of progressive cardiomyopathic changes in the db/db mouse |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2106 - H2118 |
catheter tip containing both pressure and conductance transducers, PVAN 3.4 software |
mouse |
diabetes mellitus; insulin resistance; heart failure; metabolism |
| Zhang H, Wang H-Y, Bassel-Duby R, Maass DL, Johnston WE, W. Horton JW, Tao W |
Role of interleukin-6 in cardiac inflammation and dysfunction after burn complicated by sepsis |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2408 - H2416 |
SPR 839, PVAN version 3.1 |
mouse |
tumor necrosis factor-α; α-myosin heavy chain; cardiac contractile function; fibrosis; apoptosis |
| Mukhopadhyay P, Ba´tkai S, Rajesh M, Czifra N, Harvey-White J, Hasko´ G, Zsengeller Z, Gerard NP, Liaudet L, MD, Kunos G, Pa´l Pacher P |
Pharmacological Inhibition of CB1 Cannabinoid Receptor
Protects Against Doxorubicin-Induced Cardiotoxicity |
Journal of the American College of Cardiology, Vol. 50, No. 6, 2007 |
PVR 1045 P-V catheter, ARIA |
mouse |
cardiodepressive effects |
| Nielsen JM, Kristiansen SB, Ringgaard S, Nielsen TT, Flyvbjerg A, Redington AN, Bøtker HE |
Left ventricular volume measurement in mice by conductance catheter: evaluation and optimization of calibration |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H534 - H540 |
SPR-839, MPCU-200 |
mouse |
contractile function; ventricular function; hemodynamics; magnetic resonance imaging |
| Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS, Furutani E, Perez-Sanz TM, Graveline A, Janssens SP, Picard MH, Scherrer-Crosbie M, Bloch KD |
Disruption of Nitric Oxide Synthase 3 Protects Against the Cardiac Injury, Dysfunction, and Mortality Induced by Doxorubicin |
Circulation, Jul 2007; 116: 506 - 514 |
SPR-837 |
mouse |
flavoprotein reductase |
| Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR |
Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H448 - H456 |
Millar Mikro-Tip 2.0F, ARIA |
rat |
sepsis; microcirculation; inflammation; heart |
| Bátkai S, Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Cravatt BF, Csiszár A, Ungvári Z, Pacher P |
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H909 - H918 |
SPR-839, PVAN 3.5, ARIA |
mouse |
cardiac function; anandamide; pressure-volume relationship; endocannabinoids |
| Moss NC, Stansfield WE, Willis MS, Tang R-H, Selzman CH |
IKKβ inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2248 - H2253 |
PVR-1045, PVAN |
mouse |
inhibitory κB kinase-β; myocardial infarction; nuclear factor-κB |
| Gao J, Chua CC, Yin D, Wang H, Hamdy RC, Chua B |
Abstract 3292: Cardiac Dysfunction Induced By Chronic Restrain Stress Is Mediated By Opioid Receptors |
Circulation, Oct 2007; 116: II_741 - II_742 |
ARIA pressure-volume conductance system |
mouse |
naltrexone |
| Chua B, Gao J, Wang H, Hamdy RC, Chua CC |
Abstract 3296: Phenolic Compounds Present In Danshen Extract Protect Against Doxorubicin-induced Cardiotoxicity |
Circulation, Oct 2007; 116: II_742 |
ARIA pressure-volume conductance system |
mouse |
Salvia miltiorrhiza |
| Buys ES, Sips PY, Raher MJ, Graveline AR, Searles RJ, Ichinose F, Brouckaert P, Bloch KD |
Abstract 1293: Gender-specific And Testosterone-dependent Hypertension In Soluble Guanylate Cyclase α1-deficient Mice |
Circulation, Oct 2007; 116: II_264 |
Millar pressure volume catheter |
mouse |
nitric oxide |
| Palpant N, Day S, Converso K, Metzger J |
Abstract 219: Histidine Substituted Cardiac Troponin I (a164h) Improves Survival And Protects Cardiac Contractility During Acute Hypoxia In The Aged Murine Heart |
Circulation, Oct 2007; 116: II_23 |
microconductance Millar catheterization |
mouse |
Contractile dysfunction |
| Willis MS, Rojas , Lockyer P, Hampton TG, Li L, Meredith D, Patterson C |
Abstract 1008: A Protective Role for Cardiac Specific Muscle Ring Finger-1 (MuRF1) in Ischemia/Reperfusion Injury In Vivo |
Circulation, Oct 2007; 116: II_200 - II_201 |
Millar pressure volume catheterization |
mouse |
Langendorff, cardiac physiology |
| Lu S, Lei M, Xiang F, Feng Q |
Abstract 162: c-fos Protects the Myocardium from Ischemic Injury and Improves Cardiac Function |
Circulation, Oct 2007; 116: II_10 |
Millar pressure conductance catheter |
mouse |
myocardial infarction |
| Shioura KM, Geenen DL, Goldspink PH |
Assessment of cardiac function with the pressure-volume conductance system following myocardial infarction in mice |
Am J Physiol Heart Circ Physiol, Nov 2007; 293: H2870 - H2877 |
SPR-839 |
mouse |
gene expression; contractility |
| Nagayama T, Takimoto E, Sadayappan S, Mudd JO, Seidman JG, Robbins J, Kass DA |
Control of In Vivo Contraction/Relaxation Kinetics by Myosin Binding Protein C: Protein Kinase A Phosphorylation–Dependent and –Independent Regulation |
Circulation, Nov 2007; 116: 2399 - 2408 |
SPR-839 |
mouse |
Molecular Cardiology |
| Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M |
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice |
J. Clin. Invest., Nov 2007; 117: 3188 - 3197 |
PVAN 3.2 |
mouse |
angiogenic growth factor PR39 |
| Luo J, Hill BG, Gu Y, Cai J, Srivastava S, Bhatnagar A, Prabhu SD |
Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3673 - H3684 |
SPR-839, ARIA-1 |
mouse |
oxidative stress; myocardial contraction; protein adducts; aldehydes |
| Patrizio M, Musumeci M, Stati T, Fasanaro P, Palazzesi S, Catalano L, Marano G |
Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli |
British Journal of Pharmacology 152, 216 - 222 (01 Sep 2007) |
SPR-839 |
mouse |
propranolol, phenylephrine, pressure overload, hypertrophy, heart, gene expression |
| Prunier F, Pfister O, Hadri L, Liang L, del Monte F, Liao R, Hajjar RJ |
Delayed erythropoietin therapy reduces post-MI cardiac remodeling only at a dose that mobilizes endothelial progenitor cells |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H522 - H529 |
SPR-838, MPVS-400, PVAN 3.3 |
rat |
erythropoietin; cardioprotection; myocardial infarction; remodeling; cells |
| Bostick B, Yue Y, Long C, Duan D |
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression |
DOI: 10.1161/CIRCRESAHA.107.162982 |
SPR-839, PVAN |
mouse |
cardiomyopathy gene therapy myocardium genetics heart disease |
| Boateng SY, Belin RJ, Geenen DL, Margulies KB, Martin JL, Hoshijima M, de Tombe PP, Russell B |
Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H259 - H269 |
SPR-838 |
rat |
hypertrophy; mechanosensing; cytoskeleton; nucleocytoplasmic shuttling |
| Elkareh J, Kennedy DJ, Yashaswi B, Vetteth S, Shidyak A, Kim EGR, Smaili S, Periyasamy SM, Hariri IM, Fedorova L, Liu J, Wu L, M. Kahaleh MB, Xie Z, Malhotra D, Fedorova OV, Kashkin VA, Bagrov AY, Shapiro JI |
Marinobufagenin Stimulates Fibroblast Collagen Production and Causes Fibrosis in Experimental Uremic Cardiomyopathy |
Hypertension, Jan 2007; 49: 215 - 224 |
pressure/volume sensor catheter |
rat |
cardiomyopathy • renal failure • transforming growth factor (TGF) ß • cardiotonic steroids • reactive oxygen species • fibrosis |
| Walther T, Tschöpe C, Sterner-Kock A, Westermann D, Heringer-Walther S, Riad A, Nikolic A, Wang Y, Ebermann L, Siems W-E, Bader M, Shakibaei M, Schultheiss H-P, Dörner A |
Accelerated Mitochondrial Adenosine Diphosphate/Adenosine Triphosphate Transport Improves Hypertension-Induced Heart Disease |
Circulation, Jan 2007; 115: 333 - 344 |
SPR-719 |
rat |
renin-overexpressing, ANT1 |
| Jegger D, Mallik AS, Nasratullah M, Jeanrenaud X, da Silva R, Tevaearai H, von Segesser LK, Stergiopulos N |
The effect of a myocardial infarction on the normalized time-varying elastance curve |
J Appl Physiol, Mar 2007; 102: 1123 - 1129 |
SPR-838, Aria |
rat |
compliance; ischemia; contractility; ventricular function; hemodynamics; conductance volumetry |
| Woo YJ, Panlilio CM, Cheng RK, Liao GP, Suarez EE, Atluri P, Chaudhry HW |
Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2 |
J. Thorac. Cardiovasc. Surg., April 2007; 133: 927 - 933 |
2F pressure conductance microcatheter, ARIA 1 |
rat |
cardiomyocyte mitosis |
| Wang Y, Ahmad N, Wang B, Ashraf M |
Chronic preconditioning: a novel approach for cardiac protection |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2300 - H2305 |
SPR-869, PVAN 3.2 |
rat |
mitochondrial ATP-sensitive K+ channels; BMS-191095; heart function |
| Popovic ZB, Benejam C, Bian J, Mal N, Drinko J, Lee K, Forudi F, Reeg R, Greenberg NL, Thomas JD, Penn MS |
Speckle-tracking echocardiography correctly identifies segmental left ventricular dysfunction induced by scarring in a rat model of myocardial infarction |
Am J Physiol Heart Circ Physiol, Jun 2007; 292: H2809 - H2816 |
SPR-838, MPCU-200 |
rat |
infarction; collagen; contractility |
| Bateman RM, Tokunaga C, Kareco T, Dorscheid DR, Walley KR |
Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H448 - H456 |
Millar Mikro-Tip 2.0F, ARIA |
rat |
sepsis; microcirculation; inflammation; heart |
| Liu X, Simpson JA, Brunt KR, Ward CA, Hall SRR, Kinobe RT, Barrette V, Tse MY, Pang SC, Pachori AS, Dzau VJ, Ogunyankin KO, Melo LG |
Preemptive heme oxygenase-1 gene delivery reveals reduced mortality and preservation of left ventricular function 1 yr after acute myocardial infarction |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H48 - H59 |
SPR-838, PVAN |
rat |
adeno-associated virus; echocardiography; fibrosis; heart failure; pressure-volume analysis; ventricular remodeling |
| Marsh SA, Powell PC, Agarwal A, Dell'Italia LJ, Chatham JC |
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H292 - H298 |
combined-conductance catheter-micromanometer, PVAN 3.0 |
rat |
diabetes; cardiac function; renal function |
| Deng J-Y, Huang J-P, Lu L-S, L-M |
Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H978 - H987 |
SPR-838, PVAN 3.2 |
rat |
Akt; glucose transporter; cardiac dysfunction; high cholesterol-fructose diet; insulin resistance |
| Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M |
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H620 - H627 |
SPR-671 |
mouse |
echocardiography; heart failure; hypertrophy; mice |
| Murray DB, Gardner JD, Levick SP, Brower GL, Morgan LG, Janicki JS |
Response of cardiac mast cells to atrial natriuretic peptide |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1216 - H1222 |
high-fidelity Millar conductance catheter, Millar calibration cuvette |
rat |
atrial natriuretic factor; isolated heart; extracellular matrix; ventricular remodeling; fistula |
| Bátkai S, Mukhopadhyay P, Harvey-White J, Kechrid R, Pacher P, Kunos G |
Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1689 - H1695 |
SPR-838, ARIA |
rat |
cirrhosis; cannabinoid CB1 receptors; endocannabinoids; cardiac contractility; pressure-volume loops |
| Jegger D, da Silva RF, Lartaud I, Gaillard V, Jeanrenaud X, Nasratullah M, von Segesser LK, Atkinson J, Segers P, Tevaearai H, Stergiopulos N |
Effects of an aging vascular model on healthy and diseased hearts |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1334 - H1343 |
SPR-838, ARIA |
rat |
calcium; echocardiography; hypertrophy; hypertension; infarction |
| Segers VFM, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT |
Local Delivery of Protease-Resistant Stromal Cell Derived Factor-1 for Stem Cell Recruitment After Myocardial Infarction |
Circulation, Sep 2007; doi:10.1161/CIRCULATIONAHA.107.718718 |
2F pressure-volume sensing catheters, PVAN 3.2 |
rat |
angiogenesis • chemokines • heart failure • myocardial infarction • stem cells • tissue |
| Segers VFM, Tokunou T, Higgins LJ, MacGillivray C, Gannon J, Lee RT |
Local Delivery of Protease-Resistant Stromal Cell Derived Factor-1 for Stem Cell Recruitment After Myocardial Infarction |
Circulation, Oct 2007; 116: 1683 - 1692 |
2F pressure-volume sensing catheter, PVAN 3.2 |
rat |
nanofiber-mediated delivery |
| Wei C-L, Valvano JW, Feldman MD, Peshock R, Pearce JA |
Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli |
British Journal of Pharmacology 152, 216 - 222 (01 Sep 2007) |
SPR-839 |
mouse |
propranolol, phenylephrine, pressure overload, hypertrophy, heart, gene expression |
| Pokreisz P, MarsboomG, Janssens S |
Pressure overload-induced right ventricular
dysfunction and remodelling in experimental
pulmonary hypertension: the right heart revisited |
European Heart Journal Supplements (2007) 9 (Supplement H), H75–H84 |
|
mouse, rat |
right ventricle, pulmonary hypertension, remodeling, oressure-overload |
| |
---------------------------------------------Published in 2006--------------------------------------------- |
| Alwardt CM, Yu Q, Brooks HL, McReynolds MR, Vazquez R, Watson RR, Larson DF |
Comparative effects of dehydroepiandrosterone sulfate on ventricular diastolic function with young and aged female mice |
Am J Physiol Regulatory Integrative Comp Physiol, Jan 2006; 290: R251 - R256 |
1.4-Fr Millar conductance catheter |
mouse |
cardiac fibroblast; left ventricle; cross-linking; collagen |
| Wang Y, Haider HK, Ahmad N, Xu M, Ge R, Ashraf M |
Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair |
J Mol Cell Cardiol. 2006;40(5):736-745 |
SPR-839, MPCU-200 |
mouse |
angiogenesis; bone marrow stem cells; cytokines; heart infarction; myocyte regeneration |
| Tam CW, Husmann K, Clark NC, Clark JE, Lazar Z, Ittner LM, Götz J, Douglas G, Grant AD, Sugden D, Poston L, Poston R, McFadzean I, Marber MS, Fischer JA, Born W, Brain SD |
Enhanced Vascular Responses to Adrenomedullin in Mice Overexpressing Receptor-Activity–Modifying Protein |
Circ. Res., Feb 2006; 98: 262 - 270 |
SPR-839, PVAN 2.9 |
mouse |
adrenomedullin • blood pressure • CGRP • receptor-activity–modifying protein • RAMP2 • transgenic mouse |
| Claessens TE, Georgakopoulos D, Afanasyeva M, Vermeersch SJ, Millar HD, Stergiopulos N, Westerhof N, Verdonck PR, Segers P |
Nonlinear isochrones in murine left ventricular pressure-volume loops: how well does the time-varying elastance concept hold? |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1474 - H1483 |
dual-pressure sensor |
mouse |
ventricular function; curvilinear; end-systolic pressure-volume relationship |
| Hataishi R, Zapol WM, Bloch KD, Ichinose F |
Inhaled nitric oxide does not reduce systemic vascular resistance in mice |
Am J Physiol Heart Circ Physiol, May 2006; 290: H1826 - H1829 |
SPR-839 |
mouse |
peripheral vasodilation; endothelial nitric oxide synthase; telemetry; tail cuff |
| Yu Q, Horak K, Larson DF |
Role of T Lymphocytes in Hypertension-Induced Cardiac Extracellular Matrix Remodeling |
Hypertension, May 2006; doi:10.1161/01.HYP.0000227247.27111.b2 |
1.4-fr Millar Conductance Catheter |
mouse |
lymphocytes • ventricular function • collagen |
| Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I |
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension |
Hypertension, Jun 2006; 47: 1108 - 1116 |
1.4F catheter tip micromanometer, ARIA |
mouse |
hypertension, obesity • nitric oxide synthase • sodium, dietary • L-NAME |
| Perrino C, Prasad SVN, Mao L, Noma T, Yan Z, Kim H-S, Smithies O, Rockman HA |
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction |
J. Clin. Invest., Jun 2006; 116: 1547 - 1560 |
1.4 French (0.46 mm) conductance catheter, PVAN analysis software version 3.3 |
mouse |
pathogenic signaling pathways |
| Yu Q, Horak K, Larson DF |
Role of T Lymphocytes in Hypertension-Induced Cardiac Extracellular Matrix Remodeling |
Hypertension, Jul 2006; 48: 98 - 104 |
1.4-fr Millar Conductance Catheter |
mouse |
lymphocytes • ventricular function • collagen |
| Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P, Verma S, Weisel RD, Keating A, Li R-K |
Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines |
J. Clin. Invest., Jul 2006; 116: 1865 - 1877 |
SPR-839, PVAN 3.3 |
mouse |
bone marrow stem/progenitor cell therapy after myocardial infarction |
| Neilan TG, Doherty GA, Chen G, Deflandre C, McAllister H, Butler RK, McClelland SE, Kay E, Ballou LR, Fitzgerald DJ |
Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H532 - H536 |
SPR-671, ARIA pressure conductance system |
mouse |
apoptosis; cyclooxygenase |
| Reyes M, Steinhelper ME, Alvarez JA, Escobedo D, Pearce J, Valvano JW, Pollock BH, Wei C-L, Kottam A, Altman D, Bailey S, Thomsen S, Lee S, Colston JT, Oh JH, Freeman GL, Feldman MD |
Impact of physiological variables and genetic background on myocardial frequency-resistivity relations in the intact beating murine heart |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1659 - H1669 |
miniaturized conductance catheter |
mouse |
gene-altered mouse; diabetes; left ventricular volume; dual-frequency conductance method; myocardial resistivity |
| Ha T, Hua F, Grant D, Xia Y, Ma J, Gao X, Kelley J, Williams DL, Kalbfleisch J, Browder IW, Kao RL, Li C |
Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1910 - H1918 |
microconductance pressure catheter, Millar pressure-volume conductance system |
mouse |
cardiac function; phosphoinositide 3-kinase/Akt signaling; migration inhibition factor |
| Curcio A, Noma T, Prasad SVN, Wolf MJ, Lemaire A, Perrino C, Mao L, Rockman HA |
Competitive displacement of phosphoinositide 3-kinase from β-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1754 - H1760 |
MPCU-200 |
mouse |
heart failure; ventricular remodeling; transgenic models |
| Costandi PN, Frank LR, McCulloch AD, Omens JH |
Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation |
Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2971 - H2979 |
SPR-839, PVAN 3.3 |
mouse |
magnetic resonance imaging; finite element modeling |
| Wang Y, Haider HK, Ahmad N, Xu M, Ge R, Ashraf M |
Combining pharmacological mobilization
with intramyocardial delivery of bone marrow cells
over-expressing VEGF is more effective for cardiac repair |
Journal of Molecular and Cellular Cardiology 40 (2006) 736–745 |
SPR-839, MPCU-200 P-V signal conditioning hardware |
mouse |
Angiogenesis; Bone marrow stem cells; Cytokines; Heart infarction; Myocyte regeneration |
| Iwasaki H, Kawamoto A, Ishikawa M, Oyamada A, Nakamori S, Nishimura H, Sadamoto K, Horii M, Matsumoto T, Murasawa S, Shibata T, Suehiro S, Asahara T |
Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction |
Circulation, Mar 2006; 113: 1311 - 1325 |
SPR-838, PVAN |
rat |
cardiomyocytes, ischemia |
| Minhas KM, Saraiva RM, Schuleri KH, Lehrke S, Zheng M, Saliaris AP, Berry CE, Vandegaer KM, Li D, Hare JM |
Xanthine Oxidoreductase Inhibition Causes Reverse Remodeling in Rats With Dilated Cardiomyopathy |
Circ. Res., Feb 2006; 98: 271 - 279 |
SPR-838 |
rat |
xanthine oxidoreductase • remodeling • gene expression • heart failure |
| Iwasaki H, Kawamoto A, Ishikawa M, Oyamada A, Nakamori S, Nishimura H, Sadamoto K, Horii M, Matsumoto T, Murasawa S, Shibata T, Suehiro S, Asahara T |
Dose-Dependent Contribution of CD34-Positive Cell Transplantation to Concurrent Vasculogenesis and Cardiomyogenesis for Functional Regenerative Recovery After Myocardial Infarction |
Circulation, Mar 2006; 113: 1311 - 1325 |
SPR-838 |
rat |
angiogenesis • cell therapy • myocardial infarction • transplantation • vasculogenesis |
| Connelly KA, Prior DL, Kelly DJ, Feneley MP, Krum H, Gilbert RE |
Load-sensitive measures may overestimate global systolic function in the presence of left ventricular hypertrophy: a comparison with load-insensitive measures |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1699 - H1705 |
SPR-838 |
rat |
hypertension; conductance catheter; echocardiography; transgenic rat |
| Jegger D, Jeanrenaud X, Nasratullah M, Chassot P-G, Mallik A, Tevaearai H, von Segesser LK, Segers P, Stergiopulos N |
Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1540 - H1548 |
SPR-838, ARIA |
rat |
echocardiography; heart failure; hemodynamics; ventricular function |
| Klotz S, Hay I, Zhang G, Maurer M, Wang J, Burkhoff D |
Development of Heart Failure in Chronic Hypertensive Dahl Rats: Focus on Heart Failure With Preserved Ejection Fraction |
Hypertension, May 2006; 47: 901 - 911 |
1.4 Fr, 5-F Millar micromanometer, PVAN 3.2 |
rat |
remodeling • heart failure • diastole • hypertrophy • renal disease |
| Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL |
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance |
Am J Physiol Heart Circ Physiol, Jun 2006; 290: H2196 - H2203 |
2-Fr pressure-volume conductance catheter, ARIA 1 Pressure-Volume Analysis software |
rat |
cell transplantation; myocardial remodeling |
| Woo YJ, Panlilio CM, Cheng RK, Liao GP, Atluri P, Hsu VM, Cohen JE, Chaudhry HW |
Therapeutic Delivery of Cyclin A2 Induces Myocardial Regeneration and Enhances Cardiac Function in Ischemic Heart Failure |
Circulation, Jul 2006; 114: I-206 - I-213 |
SPR-838, ARIA 1 |
rat |
cyclin • heart failure • myocardial regeneration |
| Hsieh PCH, MacGillivray C, Gannon J;, Cruz FU, Lee RT |
Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity |
Circulation, Aug 2006; 114: 637 - 644 |
2F pressure-volume sensing catheters, PVAN 3.2 |
rat |
pulmonary toxicity |
| Jegger D, da Silva R, Jeanrenaud X, Nasratullah M, Tevaearai H, von Segesser LK, Segers P, Gaillard V, Atkinson J, Lartaud I, Stergiopulo N |
Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1942 - H1951 |
SPR-838, Aria |
rat |
blood flow; calcium; hypertension; hemodynamics; ventr |
| Li Z, Ma JY,Kerr I, Chakravarty S, Dugar S, Schreiner G, Protter AA |
Selective inhibition of p38α MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1972 - H1977 |
SPR-719, PVAN 2.9 software, ARIA Pressure-Volume Conductance System |
rat |
p38 mitogen-activated protein kinase; remodeling |
| Faber MJ, Dalinghaus M, Lankhuizen IM, Steendijk P, Hop WC, Schoemaker RG, Duncker DJ, Lamers JMJ, Helbing WA |
Right and left ventricular function after chronic pulmonary artery banding in rats assessed with biventricular pressure-volume loops |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1580 - H1586 |
pressure-tip catheter |
rat |
right ventricle; hypertrophy; congenital heart disease; pressure-volume |
| Hessel MHM, Steendijk P, den Adel B, Schutte CI, van der Laarse A |
Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat |
Am J Physiol Heart Circ Physiol, Nov 2006; 291: H2424 - H2430 |
SPR-878 |
rat |
right ventricular hypertrophy; right ventricular failure; pressure-volume relations |
| |
|
|
|
|
|
---------------------------------------------Published in 2005--------------------------------------------- |
Pacher, Pa´l, Sa´ndor Ba´tkai, Douglas Osei-Hyiaman, La´szlo´
Offerta´ler, Jie Liu, Judy Harvey-White, Attila Brassai, Zolta´n
Ja´rai, Benjamin F. Cravatt, and George Kunos |
Hemodynamic profile, responsiveness to anandamide, and baroreflex
sensitivity of mice lacking fatty acid amide hydrolase |
Am J Physiol Heart Circ Physiol 289: H533–H541, 2005 |
SPR-839, ARIA Pressure-Volume Conductance System |
mouse |
contractility; hypertension; cannabinoids; endocannabinoids |
| Montgomery DE, Rundell VLM, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM |
Protein kinase C induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism |
Am J Physiol Heart Circ Physiol 289: H1881-H1888, 2005 |
1.4-Fr pressure-conductance catheter, ARIA |
mouse |
pressure-volume loops; cardiac myofilaments |
| Ikonomidis JS, Hendrick JW, Parkhurst AM, Herron AR, Escobar PG, Dowdy KB, Stroud RE, Hapke E, Zile MR, Spinale FG |
Accelerated LV remodeling after myocardial infarction in TIMP-1-deficient mice: effects of exogenous MMP inhibition |
Am J Physiol Heart Circ Physiol 288: H149-H158, 2005; doi:10.1152/ajpheart.00370.2004 |
SPR-839, ARIA, MPCU-200, DAQ, PV Analysis Software, PVAN |
mouse |
transgenic model; heart failure; myocardial hypertrophy |
| Witzenbichler B, MWestermann D, Knueppel S, Schultheiss H-P, Tschope C |
Protective Role of Angiopoietin-1 in Endotoxic Shock |
Circulation. 2005;111:97-105 |
ARIA, SPR-719 |
mouse |
shock • genes • cell adhesion molecules • lung • angiogenesis |
| Montgomery DE, Rundell VLM, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM |
Protein kinase C induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism |
Am J Physiol Heart Circ Physiol 289: H1881-H1888, 2005 |
1.4-Fr pressure-conductance catheter, ARIA |
mouse |
pressure-volume loops; cardiac myofilaments |
| MacGowan GA, Rager J, Shroff SG, Mathier MA |
In vivo -adrenergic responses and troponin I phosphorylation: anesthesia interactions |
J Appl Physiol, Apr 2005; 98: 1163 - 1170 |
1.4-Fr. conductance catheter |
mouse |
protein kinase C; ventricular function |
| ten Hove M, Lygate CA, Fischer A, Schneider JE, Sang AE, Hulbert K, Sebag-Montefiore L, Watkins H, Clarke K, sbrandt D, Wallis J, Neubauer S |
Reduced Inotropic Reserve and Increased Susceptibility to Cardiac Ischemia/Reperfusion Injury in Phosphocreatine-Deficient Guanidinoacetate-N-Methyltransferase–Knockout Mice |
Circulation, May 2005; 111: 2477 - 2485 |
SPR-839, PVAN software version 3.0 |
mouse |
creatine kinase • metabolism • hemodynamics • ischemia • myocardium |
| Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J, Wang Y |
p38 MAP Kinase Mediates Inflammatory Cytokine Induction in Cardiomyocytes and Extracellular Matrix Remodeling in Heart |
Circulation, May 2005; 111: 2494 - 2502 |
SPR-839 |
mouse |
inflammation • cardiomyopathy • signal transduction • heart failure |
| Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA |
Oxidant stress from nitric oxide synthase–3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load |
J. Clin. Invest., May 2005; 115: 1221 - 1231 |
SPR-839 |
mouse |
hypertrophy, chamber dilation and dysfunction |
| How O-J, Aasum E, Kunnathu S, Severson DL, Myhre ESP, Larsen TS |
Influence of substrate supply on cardiac efficiency, as measured by pressure-volume analysis in ex vivo mouse hearts |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2979 - H2985 |
1.4-F-conductance catheter |
mouse |
oxygen consumption; pressure-volume area; cardiac metabolism; compliance; steady state |
| Pacher P, Bátkai S, Osei-Hyiaman D, Offertáler L, Liu J, JHarvey-White J, Brassai A, Járai Z, Cravatt BF, Kunos G |
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H533 - H541 |
SPR-839 |
mouse |
contractility; hypertension; cannabinoids; endocannabinoids |
| Jung AS, Harrison R, Lee KH, Genut J, Nyhan D, Brooks-Asplund EM, Shoukas AA, Hare JM, Berkowitz DE |
Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H600 - H607 |
1.4-Fr micromanometer-conductance catheter |
mouse |
hindlimb unweighting; microgravity; baroreflex; orthostatic hypotension; mouse; cardiovascular deconditioning |
| Tao W, Enoh VT, Lin CY, Johnston WE, Li P, Sherwood ER |
Cardiovascular dysfunction caused by cecal ligation and puncture is attenuated in CD8 knockout mice treated with anti-asialoGM1 |
Am J Physiol Regulatory Integrative Comp Physiol, Aug 2005; 289: R478 - R485 |
SPR-839, Aria 1, wells with known diameters of 2-6 mm |
mouse |
blood pressure; vascular resistance; cardiac output; left ventricular function; perfusion |
| Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M |
Increased Fibulin-5 and Elastin in S100A4/Mts1 Mice With Pulmonary Hypertension |
Circ. Res., Sep 2005; 97: 596 - 604 |
Aria System |
mouse |
elastin • fibulin-5 • hypoxia • mouse • pulmonary hypertension • smooth muscle cells • S100 proteins • vascular smooth muscle cells • vascular disease |
| Hilfiker-Kleiner D, Hilfiker A, Kaminski K, Schaefer A, Park J-K, Michel K, Quint A, Yaniv M, Weitzman JB, Drexler H |
Lack of JunD Promotes Pressure Overload–Induced Apoptosis, Hypertrophic Growth, and Angiogenesis in the Heart |
Circulation, Sep 2005; 112: 1470 - 1477 |
SPR-719 |
mouse |
angiogenesis • apoptosis • hypertrophy |
| Wang J, Xu N, Feng X, Hou N, Zhang JS, Cheng X, Chen Y, Zhang Y, Yang X |
Targeted Disruption of Smad4 in Cardiomyocytes Results in Cardiac Hypertrophy and Heart Failure |
Circ. Res., Oct 2005; 97: 821 - 828 |
1.4-F micro-manometer conductance catheter |
mouse |
Smad4 • cardiac hypertrophy • heart failure • mitogen-activated protein kinase • Cre–LoxP system |
| Montgomery DE, Rundell VLM, Goldspink PH, Urboniene D, Geenen DL, de Tombe PP, Buttrick PM |
Protein kinase Cε induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H1881 - H1888 |
4-Fr pressure-conductance catheter, ARIA, PVAN |
mouse |
pressure-volume loops; cardiac myofilaments |
| Saraiva RM, Minhas KM, Raju SVY, Barouch LA, Pitz E, Schuleri KH, Vandegaer K, Li D, Hare JM |
Deficiency of Neuronal Nitric Oxide Synthase Increases Mortality and Cardiac Remodeling After Myocardial Infarction: Role of Nitroso-Redox Equilibrium |
Circulation, Nov 2005; 112: 3415 - 3422 |
SPR-719 |
mouse |
myocardial infarction • nitric oxide synthase • heart failure • receptors, adrenergic, beta |
| Wallis J, Lygate CA, Fischer A, ten Hove M, Schneider JE, Sebag-Montefiore L, Dawson D, Hulbert K, Zhang W, hang MH, Watkins H, Clarke K, Neubauer S |
Supranormal Myocardial Creatine and Phosphocreatine Concentrations Lead to Cardiac Hypertrophy and Heart Failure: Insights From Creatine Transporter–Overexpressing Transgenic Mice |
Circulation, Nov 2005; 112: 3131 - 3139 |
SPR-839, PVAN software, version 3.0 |
mouse |
myocardial creatine transporter |
| Fazel S, Chen L, Weisel RD, Angoulvant D, Seneviratne C, Fazel A, Cheung P, Lam J, Fedak PWM, Yau TM, Li R-K |
Cell transplantation preserves cardiac function after infarction by infarct stabilization: Augmentation by stem cell factor |
J. Thorac. Cardiovasc. Surg., Nov 2005; 130: 1310 |
micromanometer and conductance 1.4F catheter |
mouse |
endogenous infarct repair |
| Dawson D, Lygate CA, Zhang M-H, Hulbert K, Neubauer S, Casadei B |
nNOS Gene Deletion Exacerbates Pathological Left Ventricular Remodeling and Functional Deterioration After Myocardial Infarction |
Circulation, Dec 2005; 112: 3729 - 3737 |
SPR-839 |
mouse |
contractility, preload-recruitable stroke work |
| Sun Y, Carretero OA, Xu J, Rhaleb N-E, Wang F, Lin C, Yang JJ, Pagano PJ, Yang X-P |
Lack of Inducible NO Synthase Reduces Oxidative Stress and Enhances Cardiac Response to Isoproterenol in Mice With Deoxycorticosterone Acetate–Salt Hypertension |
Hypertension, Dec 2005; 46: 1355 - 1361 |
1.4-French micromanometer pressure catheter, PVAN |
mouse |
nitric oxide synthase • cardiac function • oxidative stress |
| Ruetten H, Gehring D, Hiss K, Schindler U, Gerl M, Busch AE, Schaefer S |
Effects of combined inhibition of the Na+–H+ exchanger and angiotensin-converting enzyme in rats with congestive heart failure after myocardial infarction |
British Journal of Pharmacology 146, 723 - 731 (01 Nov 2005) |
2.0 F impedance-micromanometer catheter |
rat |
Myocardial infarction, heart failure, remodeling, ACE inhibition, Na+–H+ exchanger-1, pressure–volume analysis |
| Janssen SPM, Gayan-Ramirez G, Van Den Bergh A, Herijgers P, Maes K, Verbeken E, Decramer M |
Interleukin-6 Causes Myocardial Failure and Skeletal Muscle Atrophy in Rats |
Circulation, Mar 2005; 111: 996 - 1005 |
SPR-847, ARIA-1 |
rat |
interleukins • cardiomyopathy • blood flow • contractility • muscles |
| Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixot A, Crowley S, Desir GV |
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure |
J. Clin. Invest., May 2005; 115: 1275 - 1280 |
SPR-838 |
rat |
end-stage renal disease |
| Dai W, Hale SL, Martin BJ, Kuang J-Q, Dow JS, Wold LE, Kloner RA |
Allogeneic Mesenchymal Stem Cell Transplantation in Postinfarcted Rat Myocardium: Short- and Long-Term Effects |
Circulation, Jul 2005; 112: 214 - 223 |
SPR-869 |
rat |
Mesenchymal stem cells |
| Woo YJ, Grand TJ, Berry MF, Atluri P, Moise MA, Hsu VM, Cohen J, Fisher O, Burdick J, Taylor M, Zentko S, Liao G, Smith M, Kolakowski S, Jayasankar V, Gardner TJ, Sweeney HL |
Stromal cell-derived factor and granulocyte-monocyte colony-stimulating factor form a combined neovasculogenic therapy for ischemic cardiomyopathy |
J. Thorac. Cardiovasc. Surg., Aug 2005; 130: 321 - 329 |
2F pressure-volume conductance catheter, ARIA 1 Pressure Volume Analysis software |
rat |
von Willebrand |
| |
|
|
|
|
|
---------------------------------------------Published in 2004--------------------------------------------- |
| Ahn D, Cheng L, Moon C, Spurgeon H, Lakatta EG, Talan MI |
Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice |
Am J Physiol Heart Circ Physiol 286: H1146-h1153, 2004 |
1.4F Mikro-Tip catheter, ARIA P-V System |
mouse |
heart; anatomy; method; cardiovascular physiology |
| Tao W, Sherwood ER |
Beta2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis |
Am J Physiol Regul Integr Comp Pyysiol 286: R569-R575, 2004 |
SPR 839, Aria 1, calibration wells with known diameters of 2-6 mm (calibration cuvette), PVAN |
mouse |
cecal ligation and puncture; blood pressure; vascular resistance; cardiac output; pressure-volume relationships |
| Champion HC, Georgakopoulos D, Takimoto E, Isoda T, Wang Y,Kass DA |
Modulation of In Vivo Cardiac Function by Myocyte-Specific Nitric Oxide Synthase-3 |
Circulaton Research. 2004;94:657 |
SPR-719 |
mouse |
nitric oxide synthase • myocyte • adenovirus • ß-adrenergic |
| Hilfiker-Kleiner D, Kaminski K, Kaminska A, Fuchs M, Klein G, Podewski E, Grote K, Kiian I, Wollert KC, Hilfiker A, Drexler H |
Regulation of Proangiogenic Factor CCN1 in Cardiac Muscle |
Circulation. 2004;109:2227-2233.) |
SPR-719 |
mouse |
angiogenesis • myocardial infarction • ischemia • pressure • signal transduction |
Pacher P, Batkai S, Kunos G.
|
Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice.
|
J Physiol. 2004 Apr 30 [Epub ahead of print] |
SPR-839 |
mouse |
transgenics, pharmaceuticals, hypotension, shock, liver cirrhosis, Bezold-Jarisch refle |
Tao W; Deyo, D, Traber DL, Johnston WE, Sherwood ER
|
Hemodynamic and Cardiac Contractile Function During Sepsis Caused by Cecal Ligation and Puncture in Mice
|
Shock: Volume 21(1) January 2004 pp 31-37
|
SPR-839
|
mouse |
sepsis, peritonitis, cardiac output, myocardial function, systemic vascular resistance |
| Weike Tao and Edward R. Sherwood |
ß2-Microglobulin knockout mice treated with anti-asialoGM1 exhibit improved hemodynamics and cardiac contractile function during acute intra-abdominal sepsis |
Am J Physiol Regul Integr Comp Physiol 286: R569-R575, 2004 |
SPR-839 |
mouse |
sepsis; cecal ligation and puncture; blood pressure; vascular resistance; cardiac output; pressure-volume relationships |
| Koszalka P, Özüyaman E, Huo Y, Zernecke A, Flögel U, Braun N, Buchheiser A, Decking UKM, Smith ML, Sévigny J, Gear A, Weber A-A, Molojavyi A, Ding Z, Weber C, Ley K, Zimmermann H, Gödecke A, Schrader J |
Targeted Disruption of cd73/Ecto-5'-Nucleotidase Alters Thromboregulation and Augments Vascular Inflammatory Response |
Circulation Research. 2004;95:814 |
1.4 French pressure-volume catheter |
mouse |
transgenic mice • adenosine • ecto-5'-nucleotidase • vascular inflammation • thrombosis |
| Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM |
Protein Kinase Cepsilon Overexpression Alters Myofilament Properties and Composition During the Progression of Heart Failure |
Circulation Research. 2004;95:424.) |
SPR-839, ARIA Pressure Volume Conductance System |
mouse |
contractile proteins • heart failure • protein kinase C |
| Cingolani OH; Yang X-P; Liu Y-H; Villanueva M; Rhaleb N-E; Carretero OA |
Reduction of Cardiac Fibrosis Decreases Systolic Performance Without Affecting Diastolic Function in Hypertensive Rats |
Hypertension. 2004;43:1067 |
SPR-819, MPCU-200 |
rat |
hypertension • rats, spontaneously hypertensive |
| Pacher P, Mabley JG, Liaudet L, Evgenov OV, Marton A, Hasko G, Kollai M, Szabo C |
Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure |
Am J Physiol Heart Circ Physiol. 2004 Jul 1 |
SPR-838 |
rat |
|
Pál Pacher, Anne Vaslin, Rita Benko, Jon G. Mabley, Lucas Liaudet5, George
Haskó, Anita Márton, Sándor Bátka, Márk Kollai and Csaba Szabó |
A new, potent poly(ADP-ribose) polymerase inhibitor improves cardiac and vascular dysfunction associated with advanced aging. |
JPET Fast Forward June 22, 2004 |
SPR-838 |
rat |
|
| Bátkai S, Pacher P, Osei-Hyiaman D, Radaeva S, Liu J, Harvey-White J, Offertáler L, Mackie K, Rudd MA, Bukoski RD, Kunos G |
Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension |
Circulation. 2004;110:1996-2002 |
SPR-838, ARIA, PVAN 2.9 |
rat |
hypertension • blood pressure • contractility • endocannabinoids • pharmacology |
| Pidgeon GP, Tamosiuniene R, Chen G, Leonard I, Belton O, Bradford A, Fitzgerald DJ |
Intravascular Thrombosis After Hypoxia-Induced Pulmonary Hypertension |
Circulation. 2004;110:2701-2707 |
SPR-671, ARIA |
rat |
thrombosis • hypoxia • hypertension, pulmonary • prostaglandins |
| Bendall JK, Damy T, Ratajczak P, Loyer X, Monceau V, Marty I, Milliez P, Robidel E, Marotte F, Samuel J-L, Heymes C |
Role of Myocardial Neuronal Nitric Oxide Synthase–Derived Nitric Oxide in ß-Adrenergic Hyporesponsiveness After Myocardial Infarction–Induced Heart Failure in Rat |
Circulation. 2004;110:2368-2375 |
SPR-819 |
rat |
nitric oxide synthase • contractility • receptors, adrenergic, ß • heart failure |
| Woo YJ, Taylor MD, Cohen JE, Jayasankar V, Bish LT, Burdick J, Pirolli TJ, Berry MF, Hsu V, Grand T |
Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia |
J. Thorac. Cardiovasc. Surg., May 2004; 127: 1262 - 1269 |
MIKRO-TIP catheter and ARIA Pressure Volume Conductance System, PVAN 2.9 |
rat |
left anterior descending coronary artery, cardiopulmonary support and physiology |
| Berry MF, Pirolli TJ, Jayasankar V, Morine KJ, Moise MA, Fisher O, Gardner TJ, Patterson PH, Woo YJ |
Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure |
J. Thorac. Cardiovasc. Surg., Dec 2004; 128: 866 - 875 |
2F pressure-volume conductance catheter |
rat |
Cardiopulmonary Support And Physiology, Myocardial gene transfer of leukemia inhibitory factor |
| |
|
|
|
|
|
---------------------------------------------Published in 2003--------------------------------------------- |
Creemers EEJM,Davis JN, Parkhurst AM,
Leenders P, Dowdy KB, Hapke E, Hauet AM, Escobar PG, Cleutjens JPM, Smits JFM, Daemen MJAP, Zile MR, Spinale FG |
Deficiency of TIMP-1 exacerbates LV remodeling after myocardial infarction
in mice |
Am J Physiol Heart Circ Physiol 284: H364-H371, 2003. |
1.4F, SPR-839 |
mouse |
Myocardial infarction, myocardial remodeling; pressure-volume loops
|
Nemoto S, Defreitas G, Carabello B
|
Cardiac catheterization technique in a closed-chest murine model
|
Contemporary Topics, Volume 42, NO. 3, May 2003
|
SPR-719 |
mouse |
left ventricle, hemodynamics, carotid
|
Barouch LA, Berkowitz DE, Harrison RW, O’Donnell CP, Hare JM
|
Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice
|
Circulation. 2003;108:754.)
|
SPR-719 |
mouse |
echocardiography • hypertrophy • leptin • obesity
|
Champion HC, Georgakopoulos D, Haldar S, Want L, Wang Y, Kass DA
|
Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart
|
Circulation. 2003;108:2790-2797
|
SPR-719
|
mouse |
gene therapy, viruses, aorta, cardioplegia, contractitility
|
| Pál Pacher, MD, PhD; Lucas Liaudet, MD; Péter Bai, MSc; Jon G. Mabley, PhD; Pawel M. Kaminski, MD, PhD; László Virág, MD, PhD; Amitabha Deb, PhD; Éva Szabó, MD; Zoltán Ungvári, MD, PhD; Michael S. Wolin, PhD; John T. Groves, PhD; Csaba Szabó, MD, PhD, DSc |
Potent Metalloporphyrin Peroxynitrite Decomposition Catalyst
Protects Against the Development of Doxorubicin-Induced
Cardiac Dysfunction |
Circulation 2003 107:896-904
Correspondence to Pál Pacher, MD, PhD |
SPR-839 |
mouse |
cardiac function • doxorubicin • oxidative stress • nitric oxide • heart failure
|
| Cingolani OH, Yang X-P, Cavasin MA, Carretero OA |
Increased Systolic Performance With Diastolic Dysfunction in Adult Spontaneously Hypertensive Rats |
Hypertension.2003;41:249-254 |
SPR-818, MPCU-200 Pressure-Volume Conductance System |
rat |
rats, spontaneously hypertensive • hypertrophy • systole • diastole • fibrosis
|
| |
|
|
|
|
|
---------------------------------------------Published in 2002--------------------------------------------- |
Michele DF, Gomez CA, Hong KE, Westfall MV, Metzger JM
|
Cardiac Dysfunction in Hypertrophic Cardiomyopathy Mutant Tropomyosin Mice Is Transgene-Dependent, Hypertrophy-Independent, and Improved by ß-Blockade
|
Circulation Research. 2002;91:255
|
SPR-719
|
mouse
|
tropomyosin • hypertrophic cardiomyopathy • calcium • heart • mice
|
Georgakopoulos D, Kass DA
|
Assessment of Cardiovascular Function
in the Mouse Using
Pressure–Volume Relationships
|
Acta Cardiol Sin 2002;18:101–12
|
SPR-719 |
mouse |
Cardiomyopathy • Conductance catheter • Elastance • Transgenic mice
|
Nemoto S, DeFreitas G, Mann DL et al.
|
The Effects of Changes in Left Ventricular Contractility on Indices of Contractility in Mice
|
Am J Physiol Heart Circ Physiol. 2002
|
SPR-719
|
mouse |
contractile indexes; echocardiography; catheterization; mouse heart
|
| |
|
|
|
|
|
---------------------------------------------Published in 2001--------------------------------------------- |
| Yang B, Larson DF, Beischel J, Kelley R, Shi J, Watson RR |
Validation of conductance catheter system for quantification of murine pressure-volume loops |
Journal of Investigative Surgery, 14:1-15 (2001) |
SPR-716 |
mouse |
ESPVR, hemodynamics, PRSW, ventricular function, ventricular mechanics
|
Georgakopoulos D, Kass DA
|
Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart
|
Journal of Physiology (2001), 534.2, pp. 535-545
|
SPR-719 |
mouse |
cardiac contraction and relaxation, ULFS-49, calcium cycling kinetics, calcium homeostasis, SR function
|
| Reyes M, Steinhelper ME, Escobedo D, Jaramillo LL, Firulli AB, Freeman GL, Feldman MD |
Augmented Myocardial Fibrosis Caused by Aortic Banding in Mice Genetically Deficient in the Antioxidant MnSOD |
Circulation, Supplement II Vol. 106, No. 19 |
Conductance Catheter |
mouse |
pressure overload hypertrophy, reacrive oxygen intermediates, collagen metabolism
|
| |
|
|
|
|
|
---------------------------------------------Published in 2000--------------------------------------------- |
| Yang B, Larson DF, Kelley R, Beischel J, Watson RR |
Conductivity: an issue for the application of the conductance catheter system in mice |
Cardiovascular Engineering Vol. 5, No. 1, March 2000, 57-60 |
SPR-719 |
mouse |
|
| Dimitrios Georgakopoulos and David A. Kass |
Estimation of parallel conductance by dual-frequency conductance catheter in mice |
AJP Heart Circ Physiol 279(1):H443-H450 |
SPR-719 |
mouse |
|
| Marc D. Feldman, Yi Mao, Jonathan W. Valvano, John A. Pearce, and Gregory L. Freeman |
Development of a multifrequency conductance catheter-based system to determine LV function in mice |
AJP Heart Circ Physiol 279(3):H1411-H1420 |
SPR-719, MCS-100 |
mouse |
|
| Marc D. Feldman, John M. Erikson, Yi Mao, Claudia E. Korcarz, Roberto M. Lang, and Gregory L. Freeman |
Validation of a mouse conductance system to determine LV volume: comparison to echocardiography and crystals |
AJP Heart Circ Physiol 279(4):H1698-H1707 |
SPR-719, MCS-100 |
mouse |
|
| Nazareno Paolocci, Ulf E. G. Ekelund, Takayoshi Isoda, Michitaka Ozaki, Koenraad Vandegaer, Dimitrios Georgakopoulos, Robert W. Harrison, David A. Kass, and Joshua M. Hare |
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation |
AJP Heart Circ Physiol., Vol. 279, Issue 4, H1982-H1988, October 2000
|
SPR-719 |
rat |
|
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