| AUTHORS |
TITLE |
JOURNAL |
MILLAR EQPT. |
SUBJECT |
application |
---------------------------------------------Published in 2010---------------------------------------------
|
| Vilarinho KAS, Petrucci O, Baker RS, Vassallo J, Schenka AA, Duffy JY, Oliveira PPM, Vieira RW |
Early changes in contractility indices and fibrosis in two minimally invasive congestive heart failure models |
Eur. J. Cardiothorac. Surg., February 2010; 37: 368 - 375 |
high-fidelity transducer-tipped catheter, 2F |
rabbit |
Animal model • Heart failure • Contractility • Fibrosis • Rabbit |
| Cour M, Loufouat J, Paillard M, Augeul L, Goudable J, Ovize M, Argaud L |
Inhibition of mitochondrial permeability transition to prevent the post-cardiac arrest syndrome: a pre-clinical study |
Eur Heart J ehq112published ahead of print April 28, 2010 doi:10.1093/eurheartj/ehq112 |
SPR-330 |
rabbit |
Cyclosporine A, Cardiac arrest, Cardiopulmonary resuscitation, Ischaemia, Reperfusion, Pharmacological post-conditioning |
| Kar S, Gao L, Zucker IH |
Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure |
J Appl Physiol, Apr 2010; 108: 923 - 932 |
SPR-524 |
rabbit |
sympathetic nerve activity; angiotensin II; angiotensin-(1–7); central nervous system; angiotensin-converting enzyme |
| Bouma W, Noma M, Kanemoto S, Matsubara M, Leshnower BG, Hinmon R, Gorman 3rd JH, Gorman RC |
Sex-related resistance to myocardial ischemia-reperfusion injury is associated with high constitutive ARC expression |
Am J Physiol Heart Circ Physiol, May 2010; 298: H1510 - H1517 |
SPR-524 |
rabbit |
17β-estradiol; cardiomyocyte apoptosis; apoptosis repressor with caspase recruitment domain; Bcl-2; Bax |
| Kamiya A, Kawada T, Mizuno M, Shimizu S, Sugimachi M |
Parallel resetting of arterial baroreflex control of renal and cardiac sympathetic nerve activities during upright tilt in rabbits |
Am J Physiol Heart Circ Physiol, Jun 2010; 298: H1966 - H1975 |
high-fidelity pressure transducer |
rabbit |
blood pressure; orthostasis; sympathetic nervous system |
---------------------------------------------Published in 2009---------------------------------------------
|
| McCully JD, Cowan DB, Pacak CA, Toumpoulis IK, Dayalan H, Levitsky S |
Injection of isolated mitochondria during early reperfusion for cardioprotection |
Am J Physiol Heart Circ Physiol, Jan 2009; 296: H94 - H105 |
catheter-tipped transducer |
rabbit |
ischemia; infarct; apoptosis |
| Kairaitis K, Howitt L, Wheatley JR, Amis TC |
Mass loading of the upper airway extraluminal tissue space in rabbits: effects on tissue pressure and pharyngeal airway lumen geometry |
J Appl Physiol, Mar 2009; 106: 887 - 892 |
MPC-500 |
rabbit |
upper airway mechanics; upper airway patency |
| Kawada T, Mizuno M, Shimizu S, Uemura K, Kamiya A, Sugimachi M |
Angiotensin II disproportionally attenuates dynamic vagal and sympathetic heart rate controls |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1666 - H1674 |
micromanometer catheter |
rabbit |
systems analysis; transfer function; heart rate variability; cardiac sympathetic nerve activity; rabbit |
| Yasuda S, Kobayashi H, Iwasa M, Kawamura I, Sumi S, Narentuoya B, Yamaki T, Ushikoshi H, Nishigaki K, Nagashima K, Takemura G, Fujiwara T, Fujiwara H, Minatoguchi S |
Antidiabetic drug pioglitazone protects the heart via activation of PPAR- receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1558 - H1565 |
SPR-671 |
rabbit |
peroxisome proliferator activated receptor-γ; phosphatidylinositol 3-kinase; endothelial nitric oxide synthase; infarct size; diabetes mellitus; ischemia-reperfusion |
| Kitahori K, He H, Kawata M, Cowan DB, Friehs I, del Nido PJ, McGowan Jr FX |
Development of Left Ventricular Diastolic Dysfunction With Preservation of Ejection Fraction During Progression of Infant Right Ventricular Hypertrophy |
Circ Heart Fail, Nov 2009; 2: 599 - 607. |
balloon-tipped Millar micromanometry pressure catheter |
rabbit |
right ventricular hypertrophy • heart failure with preserved ejection fraction • diastolic dysfunction • apoptosis • hypertrophy • right ventricle |
| Anstadt MP, Budharaju S, Darner RJ, Schmitt BA, Prochaska LJ, Pothoulakis AJ, Portner PM |
Ventricular Actuation Improves Systolic and Diastolic Myocardial Function in the Small Failing Heart |
Ann. Thorac. Surg., December 2009; 88: 1982 - 1988 |
Millar catheter |
rabbit |
|
---------------------------------------------Published in 2008---------------------------------------------
|
| Martino TA, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ |
Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters |
Am J Physiol Regulatory Integrative Comp Physiol, May 2008; 294: R1675 - R1683 |
1.4-Fr. microtip catheter |
hamster |
circadian; diurnal; tau hamsters; heart disease; renal disease; suprachiasmatic nucleus |
| Meyer K, Klocke RC, Schipke JD, Gams E, Korbmacher B |
Ca2+ sensitizer superior to catecholamine during myocardial stunning? |
Eur. J. Cardiothorac. Surg., August 2008; 34: 326 - 331 |
SPR-249 |
rabbit |
Myocardial stunning • Ca2+ sensitizing • Oxygen consumption • Ischemia/reperfusion • External efficiency • Catecholamine resistance |
| Liu D, Gao L, Roy SK, Cornish KG, Zucker IH |
Role of Oxidant Stress on AT1 Receptor Expression in Neurons of Rabbits With Heart Failure and in Cultured Neurons |
Circ. Res., Jul 2008; 103: 186 - 193 |
SPR-524 |
rabbit |
angiotensin ii • antioxidant enzymes • brain • c-jun • c-Jun NH2-terminal kinase |
| Yamamoto K, Kawada T, Kamiya A, Takaki H, Shishido T, Sunagawa K, Sugimachi M |
Muscle mechanoreflex augments arterial baroreflex-mediated dynamic sympathetic response to carotid sinus pressure |
Am J Physiol Heart Circ Physiol, Sep 2008; 295: H1081 - H1089 |
high-fidelity pressure transducer |
rabbit |
muscle stretch; transfer function; exercise pressor reflex; exercise; arterial pressure |
| Kobayashi H, Minatoguchi S, Yasuda S, Bao N, Kawamura I, Iwasa M, Yamaki T, Sumi S, Misao Y, Ushikoshi U, Nishigaki K, Takemura G, Fujiwara T, Tabata Y, Fujiwara H |
Post-infarct treatment with an erythropoietin–gelatin hydrogel drug delivery system for cardiac repair |
Cardiovasc Res, 1 September 2008; 79: 611 - 620 |
SPR-407 |
rabbit |
Drug delivery system; Erythropoietin; Akt; VEGF; Angiogenesis; Myocardial infarction |
| Miyamoto T, Kawada T, Yanagiya Y, Akiyama T, Kamiya A, Mizuno M, Takaki H, Sunagawa K, Sugimachi M |
Contrasting effects of presynaptic α2-adrenergic autoinhibition and pharmacologic augmentation of presynaptic inhibition on sympathetic heart rate control |
Am J Physiol Heart Circ Physiol, Nov 2008; 295: H1855 - H1866 |
micromanometer catheter |
rabbit |
systems analysis; transfer function; α-adrenergic blockade; rabbits |
| Leshnower BG, Kanemoto S, Matsubara M, Sakamoto H, Hinmon R, Gorman III JH, Gorman RC |
Cyclosporine Preserves Mitochondrial Morphology After Myocardial Ischemia/Reperfusion Independent of Calcineurin Inhibition |
Ann. Thorac. Surg., October 2008; 86: 1286 - 1292 |
SPR-524 |
rabbit |
Adult Cardiac |
| Fu L-W, Phan A, Longhurst JC |
Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? |
Am J Physiol Heart Circ Physiol, Dec 2008; 295: H2530 - H2540 |
PC-350 |
cat |
sympathetic nerves; U-46619; BM 13,177 |
---------------------------------------------Published in 2007---------------------------------------------
|
| Jiang Z, Yu P, Tao M, Fernandez C, Ifantides C, Moloye O, Schultz GS, Ozaki CK, Berceli SA |
TGF-β- and CTGF-mediated fibroblast recruitment influences early outward vein graft remodeling |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H482 - H488 |
SPR-671 |
rabbit |
connective tissue growth factor; transforming growth factor-; vascular remodeling; hemodynamics; wall stress |
| Barillas R, Friehs I, Cao-Danh H, Martinez JF, del Nido PJ |
Inhibition of Glycogen Synthase Kinase-3ß Improves Tolerance to Ischemia in Hypertrophied Hearts |
Ann. Thorac. Surg., July 2007; 84: 126 - 133 |
catheter-tipped micromanometer |
rabbit |
insulin-mediated glucose uptake |
| Booth EA, Lucchesi BR |
Medroxyprogesterone acetate prevents the cardioprotective and anti-inflammatory effects of 17β-estradiol in an in vivo model of myocardial ischemia and reperfusion |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1408 - H1415 |
micro-tip pressure transducer |
rabbit |
medroxyprogesterone acetate; membrane attack complex; C-reactive protein; complement; lipid peroxidation |
| Mizuno M, Kamiya A, Kawada T, Miyamoto T, Shimizu S, Sugimachi M |
Muscarinic potassium channels augment dynamic and static heart rate responses to vagal stimulation |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1564 - H1570 |
SPC-330A |
rabbit |
systems analysis; transfer function; muscarinic receptor; rabbit |
| Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, Inagaki M, Sunagawa K, Sugimachi M |
Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2254 - H2261 |
SPC-330A |
rabbit |
myocardial remodeling; matrix metalloproteinase; acetylcholine |
| Howitt L, Kairaitis K, Kirkness JP, Garlick SR, Wheatley JR, Byth K, Amis TC |
Oscillatory pressure wave transmission from the upper airway to the carotid artery |
J Appl Physiol, Nov 2007; 103: 1622 - 1627 |
SPR-524 |
rabbit |
vibration; peripharyngeal tissue pressure; snoring |
| |
---------------------------------------------Published in 2006---------------------------------------------
|
| Kairaitis K, Stavrinou R, Parikh R, Wheatley JR, Amis TC |
Mandibular advancement decreases pressures in the tissues surrounding the upper airway in rabbits |
J Appl Physiol, Jan 2006; 100: 349 - 356 |
MPC-500 |
rabbit |
upper airway extraluminal tissue pressure; upper airway patency |
| Liang C-S, Mao W, Iwai C, Fukuoka S, Stevens SY |
Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Mar 2006; 290: H995 - H1003 |
SPR-249 |
rabbit |
oxidative stress; microdialysis; tyrosine hydroxylase; norepinephrine; ceramide |
| Amatoury J, Howitt L,Wheatley JR, Avolio AP, Amis TC |
Snoring-related energy transmission to the carotid artery in rabbits |
J Appl Physiol, May 2006; 100: 1547 - 1553 |
SPR-524 |
rabbit |
stroke; atherosclerosis |
| Leshnower BG, Sakamoto H,Zeeshan A, Parish LM, Hinmon R, Plappert T, Jackson BM, Gorman III JH, Gorman RC |
Role of acetaminophen in acute myocardial infarction |
Am J Physiol Heart Circ Physiol, Jun 2006; 290: H2424 - H2431 |
SPC-350S, SPR-524 |
sheep, rabbit |
reperfusion therapy; nonsteroidal anti-inflammatory drugs; sonomicrometry array localization |
| Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M |
Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H318 - H326 |
SPC-330A |
rabbit |
arterial pressure; equilibrium diagram |
| Logeart D, Vinet L, Ragot T, Heimburger M, Louedec L, Michel J-B, Escoubet B, Mercadier J-J |
Percutaneous intracoronary delivery of SERCA gene increases myocardial function: a tissue Doppler imaging echocardiographic study |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1773 - H1779 |
2-Fr micromanometer-tipped catheter |
rabbit |
gene therapy; ventricular function; sarco(endo)plasmic reticulum Ca2+-ATPase; echocardiogr |
| Liu D, Gao L, Roy SK, Cornish KG, Zucker IH |
Neuronal Angiotensin II Type 1 Receptor Upregulation in Heart Failure: Activation of Activator Protein 1 and Jun N-Terminal Kinase |
Circ. Res., Oct 2006; 99: 1004 - 1011 |
SPR-524 |
rabbit |
angiotensin II • sympathetic nerve activity • chronic tach |
| Leite-Moreira AF, Castro-Chaves P, Pimentel-Nunes P, Lima-Carneiro A, Guerra MS, Soares JB, Ferreira-Martins J |
Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect |
British Journal of Pharmacology 147, 690 - 697 (01 Mar 2006) |
SPR-524 |
rabbit |
Angiotensin II, diastolic function, distensibility, myocardial stiffness, AT1 receptor |
| |
|
|
|
|
|
---------------------------------------------Published in 2005---------------------------------------------
|
| Lauver DA, Booth EA, White AJ, Poradosu E, Lucchesi BR |
Sulodexide Attenuates Myocardial Ischemia/Reperfusion Injury and the Deposition of C-Reactive Protein in Areas of Infarction without Affecting Hemostasis |
JPET 312:794-800, 2005 |
Millar catheter microtip pressure transducer |
rabbit |
MAC, membrane attack complex; GAG, glycosaminoglycan; KRX-101, sulodexide; TTC, 2,3,5-triphenyltetrazolium chloride; aPTT, activated partial thromboplastin time; PRP, platelet-rich plasma; cTnI, cardiac-specific troponin I; BSA, bovine serum albumin. |
| Lauver DA, Booth EA, White AJ, Poradosu E, Lucchesi BR |
Sulodexide Attenuates Myocardial Ischemia/Reperfusion Injury and the Deposition of C-Reactive Protein in Areas of Infarction without Affecting Hemostasis |
JPET 312:794-800, 2005 |
Millar catheter microtip pressure transducer |
rabbit |
MAC, membrane attack complex; GAG, glycosaminoglycan; KRX-101, sulodexide; TTC, 2,3,5-triphenyltetrazolium chloride; aPTT, activated partial thromboplastin time; PRP, platelet-rich plasma; cTnI, cardiac-specific troponin I; BSA, bovine serum albumin. |
| James J, Martin L, Krenz M, Quatman C, Jones F, Klevitsky R, Gulick J, Robbins J |
Forced Expression of -Myosin Heavy Chain in the Rabbit Ventricle Results in Cardioprotection Under Cardiomyopathic Conditions |
Circulation, May 2005; 111: 2339 - 2346 |
4F Millar MIKRO-TIP pressure catheter |
rabbit |
cardiomyopathy • heart failure • molecular biology • myocardial contraction |
| Khan TA, Bianchi C, Voisine P, Sandmeyer J, Feng J, Sellke FW |
Aprotinin Inhibits Protease-Dependent Platelet Aggregation and Thrombosis |
Ann. Thorac. Surg., May 2005; 79: 1545 - 1550 |
catheter-tipped manometer |
rabbit |
carotid |
| Nathan M,Friehs I, Choi Y-H, Cowan DB, Cao-Danh H, McGowan FX, del Nido PJ |
Cyclosporin A But Not FK-506 Protects Against Dopamine-Induced Apoptosis in the Stunned Heart |
Ann. Thorac. Surg., May 2005; 79: 1620 - 1626 |
fluid filled balloon, connected to a micromanometry catheter |
rabbit |
cyclophilin D binding |
| Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Miyamoto T, Uemura K, Sugimachi M, Sunagawa K |
Muscle Sympathetic Nerve Activity Averaged Over 1 Minute Parallels Renal and Cardiac Sympathetic Nerve Activity in Response to a Forced Baroreceptor Pressure Change |
Circulation, Jul 2005; 112: 384 - 386 |
high-fidelity pressure transducer |
rabbit |
catecholamines • muscles • nervous system, autonomic • nervous system, sympathetic |
| Lauver DA, Lockwood SF, Lucchesi BR |
Disodium Disuccinate Astaxanthin (Cardax) Attenuates Complement Activation and Reduces Myocardial Injury following Ischemia/Reperfusion |
JPET 314:686-692, 2005 |
catheter microtip pressure transducer |
rabbit |
carotenoids |
| Gao L, Wang W, Li Y-L, Schultz HD, Liu D, Cornish KG, Zucker IH |
Simvastatin Therapy Normalizes Sympathetic Neural Control in Experimental Heart Failure: Roles of Angiotensin II Type 1 Receptors and NAD(P)H Oxidase |
Circulation, Sep 2005; 112: 1763 - 1770 |
SPR-524 |
rabbit |
angiotensin • free radicals • statins • nervous system, sympathetic • heart failure |
| Yamamoto K, Kawada T, Kamiya A, Takaki H, Sugimachi M, Sunagawa K |
Static interaction between muscle mechanoreflex and arterial baroreflex in determining efferent sympathetic nerve activity |
Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1604 - H1609 |
high-fidelity pressure transducer |
rabbit |
muscle stretch; exercise pressor reflex; exercise; subliminal fringe |
| Booth EA, Obeid NR, Lucchesi BR |
Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H2039 - H2047 |
Millar catheter microtip pressure transducer |
rabbit |
infarct size; membrane attack complex; C-reactive protein; estrogen; 4,4&",4&"-[4-propyl-(1H)-pyrazole-1,3,5-triyl]tris-phenol |
| Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Miyamoto T, Shimizu S, Uemura K, Aiba T, Sunagawa K, Sugimachi M |
Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure |
Am J Physiol Heart Circ Physiol, Dec 2005; 289: H2641 - H2648 |
high-fidelity pressure transducer |
rabbit |
carotid sinus pressure |
| |
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---------------------------------------------Published in 2004---------------------------------------------
|
| Wehrens XHT, Lehnart SE, Reiken SR, Marks AR |
Ca2+/Calmodulin-Dependent Protein Kinase II Phosphorylation Regulates the Cardiac Ryanodine Receptor |
Circulation Research. 2004;94:e61 |
3F Mikro-Tip Catheter |
rabbit |
ryanodine receptor • calcium • Ca2+/calmodulin-dependent kinase II • protein kinase A • heart failure |
| McCully JD, Wakiyama H, Hsieh Y-J, Jones M, Levitsky S |
Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol 286: H1923-H1935, 2004 |
latex balloon containing a catheter-tipped transducer |
rabbit |
caspase; myocardium |
| Kawada T, Miyamoto T, Uemura K, Kashihara K, Kamiya A, Sugimachi M, Sunagawa K |
Effects of neuronal norepinephrine uptake blockade on baroreflex neural and peripheral arc transfer characteristics |
Am J Physiol Regul Integr Comp Physiol 286: R1110-R1120, 2004 |
Mikro-Tip Catheter |
rabbit |
systems analysis; transfer function; desipramine; sympathetic nerve activity; heart rate |
| Kawada T, Uemura K, Kashihara K, Kamiya A, Sugimachi M, Sunagawa K |
A derivative-sigmoidal model reproduces operating point-dependent baroreflex neural arc transfer characteristics |
Am J Physiol Heart Circ Physiol 286: H2272-H2279, 2004 |
Mikro-Tip Catheter |
rabbit |
systems analysis; transfer function; simulation; carotid sinus baroreflex; nonlinearity |
| Jiang Z, Wu L, Miller BL, Goldman DR, Fernandez CM, Abouhamze ZS, Ozaki CK, Berceli SA |
A novel vein graft model: adaptation to differential flow environments |
Am J Physiol Heart Circ Physiol 286: H240-H245, 2004. |
SPR-671 |
rabbit |
anastomosis; shear stress; intimal hyperplasia; rabbit model |
| Yamamoto K, Kawada T, Kamiya A, Takaki H, Miyamoto T, Sugimachi M, Sunagawa K |
Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc |
Am J Physiol Heart Circ Physiol 286: H1382-H1388, 2004 |
Mikro-Tip Catheter |
rabbit |
sympathetic nerve activity; arterial pressure; baroreflex equilibrium diagram; exercise pressor reflex; exercise |
| Miyamoto T, Kawada T, Yanagiya Y, Inagaki M, Takaki H, Sugimachi M, Sunagawa K |
Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via alpha-adrenergic mechanism |
Am J Physiol Heart Circ Physiol 287: H860-H865, 2004 |
micromanometer catheter |
rabbit |
systems analysis; transfer function; beta-adrenergic blockade; rabbits; sympathovagal interaction |
| Rungwerth K, Schindler U, Gerl M, Schäfer S, Licher T, Busch AE, Ruetten H |
Inhibition of Na+–H+ exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction |
British Journal of Pharmacology 142, 1147 - 1154 (00 Aug 2004) |
3F micromanometer-tipped catheter |
rabbit |
Myocardial infarction, rabbit, heart failure, remodeling, Na+–H+ exchanger, C-reactive protein, inflammation, PV loops |
| Emani SM, Shah AS, Bowman MK, White DC, Emani S, Glower DD, Koch WJ |
Right ventricular targeted gene transfer of a ß-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding |
J. Thorac. Cardiovasc. Surg., Mar 2004; 127: 787 - 793 |
2.5F micromanometer |
rabbit |
ß-galactosidase transgene, right ventricular afterload |
| Kirn B, Starc V |
Contraction wave in axial direction in free wall of guinea pig left ventricle |
Am J Physiol Heart Circ Physiol 287: H755-H759, 2004 |
2-Fr |
guinea pigs |
latitude; triangular area; epicardial marker; apex; base |
| Murata M, Cingolani E, McDonald AD, Donahue JK, Marbán E |
Creation of a Genetic Calcium Channel Blocker by Targeted Gem Gene Transfer in the Heart |
Circulation Research. 2004;95:398 |
micromanometer catheter |
guinea pig |
calcium channel blocker • gene therapy |
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---------------------------------------------Published in 2003---------------------------------------------
|
Nusz DJ, White DC, Dai Q, Pippen AM, Thompson MA, Walton GB, Parsa CJ, Koch WJ, Annex BH
|
"Vascular rarefaction in peripheral skeletal muscle after experimental heart
failure"
|
Am J Physiol Heart Circ Physiol 285: H1554-H1562, 2003
|
2.5-F micromanometer
|
rabbit |
Congestive heart failure, angiogenesis; endothelial cells; growth factors; apoptosis; oxidative metabolism; congestive heart failure
|
Qin F, Shite J, Liang C-S
|
Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAPK pathways
|
Am J Physiol Heart Circ Physiol 285: H822-H832, 2003
|
2F Mikro-Tip catheter |
rabbit |
congestive heart failure; signal transduction; norepinephrine; oxidative stress; mitogen-activated protein kinase
|
| Varma N, Morgan JP, Apstein CS |
Mechanisms underlying ischemic diastolic dysfunction: relation between rigor, calcium homeostasis, and relaxation rate |
Am J Physiol Heart Circ Physiol 284: H758-H771, 2003 |
High-fidelity micromanometer Millar catheter placed within the balloon in
the LV cavity |
rabbit |
stiffness; left ventricular end-diastolic pressure; quick length change; heterogeneity
|
| Kawada T, Yanagiya Y, Uemura K, Miyamoto T, Zheng C, Li M, Sugimachi M, Sunagawa K |
Input-size dependence of the baroreflex neural arc transfer characteristics |
Am J Physiol Heart Circ Physiol 284: H404-H415, 2003 |
High-fidelity pressure transducer |
rabbit |
systems analysis; transfer function; simulation; carotid sinus baroreflex; nonlinearity
|
Kawada T, Uemura K, Kashihara K, Jin Y, Li M, Zheng C, Sugimachi M, Sunagawa K
|
Uniformity in dynamic baroreflex regulation of left and right cardiac sympathetic nerve activities
|
Am J Physiol Regul Integr Comp Physiol 284: R1506-R1512, 2003
|
Mikro-Tip catheter |
rabbit |
systems analysis; transfer function; white noise; carotid sinus baroreflex; rabbits
|
| Kashihara K, Kawada T, Yanagiya Y, Uemura K, Inagaki M, Takaki H, Sugimachi M, Sunagawa K Bezold-Jarisch |
reflex attenuates dynamic gain of baroreflex neural arc |
Am J Physiol Heart Circ Physiol 285: H833-H840, 2003
|
Mikro-Tip catheter |
rabbit |
renal sympathetic nerve activity; transfer function; systems analysis; rabbits; carotid sinus baroreflex |
| Booth EA, Marchesi M, Kilbourne EJ, Lucchesi BR |
17beta-Estradiol as a Receptor-Mediated Cardioprotective Agent |
JPET 307:395-401, 2003 |
Mikro-Tip Catheter |
rabbit |
estrogen, fulvestrant |
| Kairaitis K, Parikh R, Stavrinou R, Garlick S, Kirkness JP, Wheatley JR, Amis TC |
Upper airway extraluminal tissue pressure fluctuations during breathing in rabbit |
J Appl Physiol 95: 1560-1566, 2003 |
MPC-500 |
rabbit |
hyperpnea; resistive breathing; head and neck flexion |
| Friehs I, Cao-Danh H, Stamm C, Cowan DB, McGowan FX, del Nido PJ |
Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function |
J. Thorac. Cardiovasc. Surg., Jul 2003; 126: 263 - 271 |
catheter tip pressure transducer |
rabbit |
GLUT-4 |
| Catelli M, Feldman J, Bousquet P, Tibiriçá E |
Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits |
Braz J Med Biol Res, January 2003, Volume 36(1) 85-95 |
SPR-249 |
rabbit |
Autonomic nervous system, Antihypertensive agents, Antiarrhythmic agents, Ischemia, Sudden death |
Schenkman KA, Beard DA, Ciesielski WA,
Feigl EO
|
"Comparison of buffer and red blood cell perfusion of guinea pig heart
oxygenation"
|
Am J Physiol Heart Circ Physiol 285: H1819-H1825, 2003
|
SPR-783 |
guinnea pig |
myocardial oxygen consumption; myoglobin oxygen saturation; optical spectroscopy; Langendorff-perfused heart
|
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---------------------------------------------Published in 2002---------------------------------------------
|
Hendrik T. Tevaearai, MD; Andrea D. Eckhart, PhD; G. Brant Walton, BS; Janelle R. Keys, PhD; Katrina Wilson, BS; Walter J. Koch
|
Myocardial Gene Transfer and Overexpression of ß2-Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts
|
Circulation. 2002;106:124
|
High-fidelity pressure transducer
|
rabbit
|
heart failur receptors, beta adrenergic, remodeling, heart-assist device, gene therapy
|
Kawada T, Zheng C, Yanagiya Y, Uemura K, Miyamoto T, Inagaki M, Shishido T, Sugimachi M, Sunagawa K
|
High-cut characteristics of the baroreflex neural arc preserve baroreflex gain against pulsatile pressure
|
Am J Physiol Heart Circ Physiol 282: H1149-H1156, 2002
|
High-Fidelity Pressure Transducer
|
rabbit
|
systems analysis; transfer function; simulation; carotid sinus baroreflex; frequency-dependent depression
|
| Saltman AE, Aksehirli TO, Valiunas V, Gaudette GR, Matsuyama N, Brink P, Krukenkamp IB |
Gap junction uncoupling protects the heart against ischemia |
J. Thorac. Cardiovasc. Surg., Aug 2002; 124: 371 - 376 |
Balloon pressure |
rabbit |
adenosine triphosphate-dependent potassium channel |
| Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ |
Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts |
J. Thorac. Cardiovasc. Surg., Dec 2002; 124: 1149 - 1156 |
high-fidelity pressure transducer |
rabbit |
reverse remodeling and myocardial recovery |
| Tevaearai HT, Walton GB, Eckhart AD, Keys JR, Koch WJ |
Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts |
J. Thorac. Cardiovasc. Surg., Dec 2002; 124: 1149 - 1156 |
high-fidelity pressure transducer |
rabbit |
reverse remodeling and myocardial recovery |
| Burattini R, Campbell KB |
Comparative Analysis of Aortic Impedance and Wave Reflection In Ferrets and Dogs |
Am J Physiol Heart Circ Physiol 282: H244-H255, 2002;
|
Catheter-tipped Pressure Transducers |
ferret, dog |
arterial pulse wave propagation; arterial effective reflection sites; arterial compliance; T-tube arterial model
|
| Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross Jr J |
Restoration of Deficient Membrane Proteins in the Cardiomyopathic Hamster by In Vivo Cardiac Gene Transfer |
Circulation. 2002;105:502 |
Hi-Fidelity Pressure Manometer |
hamster |
gene therapy • cardiomyopathy • adenovirus
|
Ikeda Y, Gu Y, Iwanaga Y, Hoshijima M, Oh SS, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien KR, Ross Jr J
|
Restoration of Deficient Membrane Proteins in the Cardiomyopathic Hamster by In Vivo Cardiac Gene Transfer
|
Circulation. 2002;105:502
|
Mikro-Tip catheter |
hamster |
gene therapy • cardiomyopathy • adenovirus
|
Micheletti R, Mattera GG, Rocchetti M, Schiavone A, Loi MF, Zaza A, Gagnol RJP, De Munari S, Melloni P, Carminati P, Bianchi G, Ferrari P
|
Pharmacological Profile of the Novel Inotropic Agent (E,Z)-3-((2-Aminoethoxy)imino)androstane-6,17-dione Hydrochloride (PST2744)
|
JPET, Vol. 303, Issue 2, 592-600, November 2002
|
SPR-407 |
dog, guinea pig |
isolated guinea pig myocytes, arrhythmia, digoxin
|
Tobita K, Schroder EA, Tinney JP, Garrison JB, Keller BB
|
Regional passive ventricular stress-strain relations during development of altered loads in chick embryo
|
Am J Physiol Heart Circ Physiol 282: H2386-H2396, 2002. First published February 21, 2002; 10.1152/ajpheart.00879.2001
|
SPR-631
|
chick
|
ventricle; cardiac morphogenesis; mechanical load
|
| |
|
|
|
|
|
---------------------------------------------Published in 2001---------------------------------------------
|
Ashish S. Shah, MD; David C. White, MD; Sitaram Emani, MD; Alan P. Kypson, MD; R. Eric Lilly, MD; Katrina Wilson, BS; Donald D. Glower, MD; Robert J. Lefkowitz, MD; Walter J. Koch, PhD
|
In Vivo Ventricular Gene Delivery of a ß-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction |
Circulation. 2001;103:1311 |
2.5F Mikro-Tip Pressure Transducer |
rabbit |
gene therapy • receptors • heart failure • signal transduction
|
| Hendrik T. Tevaearai, MD; Andrea D. Eckhart, PhD; Kyle F. Shotwell, BS; Katrina Wilson, BS; Walter J. Koch, PhD |
Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a ß-Adrenergic Receptor Kinase Inhibitor |
Circulation. 2001;104:2069 |
LV latex balloon was positioned and connected to a pressure transducer |
rabbit |
ischemia • reperfusion • cardiopulmonary bypass • gene therapy • signal transduction
|
| Toru Kawada, Toshiaki Shishido, Masashi Inagaki, Teiji Tatewaki, Can Zheng, Yusuke Yanagiya, Masaru Sugimachi, and Kenji Sunagawa |
Differential dynamic baroreflex regulation of cardiac and renal sympathetic nerve activities
|
AJP Heart Circ Physiol., Vol. 280, Issue 4, H1581-H1590, April 2001
|
Mikro-Tip Pressure Transducer |
rabbit |
systems analysis; transfer function; white noise; carotid sinus baroreflex; rabbits
|
| Gary J. Grover, Albert J. D'Alonzo, Keith D. Garlid, Robert Bajgar, Nicholas J. Lodge, Paul G. Sleph, Raymond B. Darbenzio, Thomas A. Hess, Mark A. Smith, Petr Paucek and Karnail S. Atwal |
Pharmacologic Characterization of BMS-191095, a Mitochondrial KATP Opener with No Peripheral Vasodilator or Cardiac Action Potential Shortening Activity
|
Journal of Pharmacology and Experimental Therapeutics, Vol. 297, Issue 3, 1184-1192, June 2001 |
Mikro-Tip Pressure Transducer |
rat, guinea pig, dog |
glyburide-reversible cardioprotective activity, cromakalim, ischemia, reperfusion
|
| |
|
|
|
|
|
---------------------------------------------Published in 2000---------------------------------------------
|
| Ashish S. Shah, MD; R. Eric Lilly, MD; Alan P. Kypson, MD; Oliver Tai, BS; Jonathan A. Hata, BA; Anne Pippen, BS; Scott C. Silvestry, MD; Robert J. Lefkowitz, MD; Donald D. Glower, MD; Walter J. Koch, PhD |
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the ß2-Adrenergic Receptor in the Heart |
Circulation 2000;101:408 |
2.5F Mikro-Tip catheter |
rabbit |
|
| Hans-Jörg Weig, MD; Karl-Ludwig Laugwitz, MD; Alessandra Moretti, PhD; Kai Kronsbein, BS; Christian Städele, MD; Stefan Brüning, MD; Melchior Seyfarth, MD; Thomas Brill, MD; Albert Schömig, MD; Martin Ungerer, MD |
Enhanced Cardiac Contractility After Gene Transfer of V2 Vasopressin Receptors In Vivo by Ultrasound-Guided Injection or Transcoronary Delivery |
Circulation 2000;101:1578 |
2.5F Mikro-Tip catheter |
rat, rabbit |
|
| Hiroya Kawai, Suzanne Y. Stevens, and Chang-Seng Liang |
Renin-angiotensin system inhibition on noradrenergic nerve terminal function in pacing-induced heart failure |
AJP Heart Circ Physiol 279(6):H3012-H3019 |
2F Mikro-Tip catheter |
rabbit |
|
| Junya Shite, Erdon Dong, Hiroya Kawai, Suzanne Y. Stevens, and Chang-Seng Liang |
Selegiline improves cardiac sympathetic terminal function and beta-adrenergic responsiveness in heart failure |
AJP Heart Circ Physiol 279(3):H1283-H1290 |
2F Mikro-Tip catheter |
rabbit |
|
| Hiroya Kawai, Amy Mohan, Jason Hagen, Erdan Dong, Jacqueline Armstrong, Suzanne Y. Stevens, and Chang-Seng Liang |
Alterations in cardiac adrenergic terminal function and beta-adrenoceptor density in pacing-induced heart failure |
AJP Heart Circ Physiol 278(5):H1708-H1716 |
2F Mikro-Tip Catheter |
rabbit |
|
| Nanritsu Matsuyama, MD; John E. Leavens, BS; David McKinnon, PhD; Glenn R. Gaudette, MSc; Tunc O. Aksehirli, BS; Irvin B. Krukenkamp, MD |
. Ischemic but Not Pharmacological Preconditioning Requires Protein Synthesis |
Circulation 2000;102:III-312 |
indwelling catheter probe |
rabbit |
|
| Yoshiya Toyoda, Ingeborg Friehs, Robert A. Parker, Sidney Levitsky, and James D. McCully |
Differential role of sarcolemmal and mitochondrial KATP channels in adenosine-enhanced ischemic preconditioning |
AJP Heart Circ Physiol., Vol. 279, Issue 6, H2694-H2703, December 2000
|
Latex balloon containing a catheter-tip transducer |
rabbit |
|
| Uwe Schwanke, Andreas Deussen, Gerd Heusch, and Jochen D. Schipke |
Heterogeneity of local myocardial flow and oxidative metabolism |
AJP Heart Circ Physiol 279(3):H1029-H1035 |
Mikro-Tip catheter |
rabbit |
|
Thakral A, Stein LH, Shenai M, Gramatikov BI, Thakor NV
|
Effects of anodal vs. cathodal pacing on the mechanical performance of the isolated rabbit heart
|
J Appl Physiol 89: 1159-1164, 2000
|
SPC-470 |
rabbit |
|
| Chang-seng Liang, MD, PhD; Naomi Kenmotsu Rounds, MD; Erdan Dong, MD, PhD; Suzanne Y. Stevens, PhD; Junya Shite, MD; Fuzhong Qin, MD |
Alterations by Norepinephrine of Cardiac Sympathetic Nerve Terminal Function and Myocardial ß-Adrenergic Receptor Sensitivity in the Ferret |
Circulation 2000;102:96 |
SPR-407 |
ferret |
|
| Pascal Trouve, François Carre, Ioulia Belikova, Christophe Leclercq, Thierry Dakhli, Lilia Soufir, Isabelle Coquard, Juan Ramirez-Gil, and Danièle Charlemagne |
Na+-K+-ATPase alpha2-isoform expression in guinea pig hearts during transition from compensation to decompensation |
AJP Heart Circ Physiol 279(4):H1972-H1981 |
Mikro-Tip catheter |
guinnea pig |
|
| Philip A. MacCarthy, BSc, MBChB, MRCP; Ajay M. Shah, MD, FRCP, FESC |
Impaired Endothelium-Dependent Regulation of Ventricular Relaxation in Pressure-Overload Cardiac Hypertrophy |
Circulation 2000;101:1854 |
2F Mikro-Tip Catheter |
guinnea pig |
|
| Simons RS, Bennett WO, Brainerd EL |
Mechanics of Lung Ventilation in a Post-Metamorphic Salamander, Ambystoma Tigrinum |
The Journal of Experimental Biology 203, 1081-1092 (2000) |
SPR-407 |
salamander |
|
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