| AUTHORS |
TITLE |
JOURNAL |
MILLAR EQPT. |
SUBJECT |
application |
---------------------------------------------Published in 2010--------------------------------------------- |
| Zaidi SHE, Huang Q, Momen A, Riazi A, Husain M |
Growth Differentiation Factor 5 Regulates Cardiac Repair After Myocardial Infarction |
J. Am. Coll. Cardiol., January 12, 2010; 55: 135 - 143 |
micromanometer catheter |
mouse |
collagen gene expression • growth differentiation factor 5 • mitogen-activated protein kinase • myocardial infarction |
| Zuckerbraun BS, Shiva S, Ifedigbo E, Mathier MA, Mollen KP, Rao J, Bauer PM, Justin J.W. Choi JJW, Curtis E, Choi AMK, Gladwin MT |
Nitrite Potently Inhibits Hypoxic and Inflammatory Pulmonary Arterial Hypertension and Smooth Muscle Proliferation via Xanthine Oxidoreductase–Dependent Nitric Oxide Generation |
Circulation, January 5/12, 2010; 121: 98 - 109 |
Millar catheter |
mouse, rat |
|
| Burchfield JS, Dong J-W, Sakata Y, Gao F, Tzeng H-P, Topkara VK, Entman ML, Sivasubramanian N, Mann DL |
The Cytoprotective Effects of Tumor Necrosis Factor Are Conveyed Through Tumor Necrosis Factor Receptor–Associated Factor 2 in the Heart |
Circ Heart Fail, Jan 2010; 3: 157 - 164 |
Millar catheters |
mouse |
ischemia-reperfusion injury • tumor necrosis factor • tumor necrosis factor receptor-associated factor 2 |
| Li P, Shibata R, Unno K, Shimano M, Furukawa M, Ohashi T, Cheng X, Nagata K, Ouchi N, Murohara T |
Evidence for the Importance of Adiponectin in the Cardioprotective Effects of Pioglitazone |
Hypertension, Jan 2010; 55: 69 - 75 |
Millar catheter |
mouse |
pioglitazone • adiponectin • cardiac hypertrophy • fibrosis • angiotensin II |
| Fomovsky GM, Holmes JW |
Evolution of scar structure, mechanics, and ventricular function after myocardial infarction in the rat |
Am J Physiol Heart Circ Physiol, Jan 2010; 298: H221 - H228 |
SP-671 (SPR-671) |
rat |
collagen; heart; pressure-volume relationship; biaxial mechanics; anisotropy |
| Chen Y-F, Redetzke RA, Said S, Beyer AJ, Gerdes AM |
Changes in left ventricular function and remodeling after myocardial infarction in hypothyroid rats |
Am J Physiol Heart Circ Physiol, Jan 2010; 298: H259 - H262 |
Millar Micro-tip catheter |
rat |
low thyroid function; cardiac ischemia; heart failure |
| Bopassa JC, Eghbali M, Toro L, Stefani E |
A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Jan 2010; 298: H16 - H23 |
SPR-671 |
mouse |
G protein-coupled receptor 30; mitochondrial permeability transition pore; cardioprotection; infarct size; heart function |
| Doenst T, Pytel G, Schrepper A, Amorim P, Färber G, Shingu Y, Mohr FW, Schwarzer M |
Decreased rates of substrate oxidation ex vivo predict the onset of heart failure and contractile dysfunction in rats with pressure overload |
Cardiovasc Res, Advance Access published on January 24, 2010; doi: doi:10.1093/cvr/cvp414 |
1.4F Millar catheter |
rat |
Echocardiography; Heart failure; Substrate oxidation predictive for diagnosis of heart failure; Pressure overload |
| Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Ooboshi H, Opthof T, Kadomatsu K, Kodama I |
Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction |
Cardiovasc Res, Advance Access published on January 19, 2010; doi: doi:10.1093/cvr/cvp386 |
1.4 F micro-tipped catheter |
rat |
Gene transfer; Coronary disease; Infarction; Haemodynamics; Remodelling |
| Lee T-M, Lai P-Y, Chang N-C |
Effect of N-acetylcysteine on sympathetic hyperinnervation in post-infarcted rat hearts |
Cardiovasc Res, 1 January 2010; 85: 137 - 146. |
SPR-407 |
rat |
Glutathione; Myocardial infarction; N-acetylcysteine; Norepinephrine; Sympathetic innervation |
| Koyanagi M, Iwasaki M, Rupp S, Tedesco FS, Yoon C-H,Boeckel J-N, Trauth J, Schütz C, Ohtani K, Goetz R, Iekushi K, Bushoven P, Momma S, Mummery C, Passier R, Henschler R, Akintuerk H, Schranz D, Urbich C, Galvez BG, Cossu G, Zeiher AM, Dimmeler S |
Sox2 Transduction Enhances Cardiovascular Repair Capacity of Blood-Derived Mesoangioblasts |
Circ. Res., Feb 2010; doi:10.1161/CIRCRESAHA.109.206045 |
micromanometer-tipped conductance catheter |
mouse |
circulating progenitors • reprogramming • differentiation • Sox2 |
| Tao L, Wang Y, Gao E, Zhang H, Yuan Y, Lau WB, Chan L, Koch WJ, Ma XL |
Adiponectin: An Indispensable Molecule in Rosiglitazone Cardioprotection Following Myocardial Infarction |
Circ. Res., Feb 2010; 106: 409 - 417 |
1.2-Fr micromanometer |
mouse |
diabetes • myocardial infarction • adipocytokine • signaling |
| Chandar S, Yeo LS, Leimena C, Tan J-C, Xiao X-H, Nikolova-Krstevski V, Yasuoka Y, Gardiner-Garden M, Wu J, Kesteven S, Karlsdotter, Natarajan S, Carlton A, Rainer S, Feneley MP, Fatkin D |
Effects of Mechanical Stress and Carvedilol in Lamin A/C–Deficient Dilated Cardiomyopathy |
Circ. Res., Feb 2010; 106: 573 - 582 |
1.4F and 1.0F microtip catheter pressure transducers |
mouse |
|
| van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG,De Windt LJ, Wehrens XHT |
Accelerated Development of Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model |
doi:10.1161/HYPERTENSIONAHA.109.146449 |
1.4F catheter |
mouse |
calcium • heart failure • hypertrophy • ryanodine receptor calcium release channel • sarcoplasmic reticulum |
| Bian Z-Y, Huang H, Jiang H, Shen D-F, Yan L, Zhu L-H, Wang L, Cao F, Liu C, Tang Q-Z, Li H |
LIM and Cysteine-Rich Domains 1 Regulates Cardiac Hypertrophy by Targeting Calcineurin/Nuclear Factor of Activated T Cells Signaling |
Hypertension, Feb 2010; 55: 257 - 263 |
1.4-F Millar catheter-tip micromanometer catheter |
mouse |
cardiac hypertrophy • fibrosis • Lmcd1 • calcineurin • NFAT |
| Yoshikawa E, Marui A, Tsukashita M, Nishina T, Wang J, Muranaka H, Ikeda T, Komeda M |
Carvedilol may alleviate late cardiac remodelling following surgical ventricular restoration |
Eur. J. Cardiothorac. Surg., February 2010; 37: 362 - 367. |
micromanometer-tipped catheter |
rat |
Heart failure • Ischaemic heart disease • Surgical ventricular restoration |
Kanazawa H, Ieda M, Kimura K, Arai T, Kawaguchi-Manabe H, Matsuhashi T, Endo J, Sano M,
Kawakami T, Kimura T, Monkawa T, Hayashi M, Iwanami A, Okano H, Okada Y, Ishibashi-Ueda H,
Ogawa S, Fukuda K |
Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents |
J. Clin. Invest. 120:2 doi:10.1172/JCI39778 |
SPR-1000 |
rat |
|
| Katare RG, Caporali A, Oikawa A, Meloni M, Emanueli C, Madeddu P |
Vitamin B1 Analog Benfotiamine Prevents Diabetes-Induced Diastolic Dysfunction and Heart Failure Through Akt/Pim-1–Mediated Survival Pathway |
Circ Heart Fail, Mar 2010; 3: 294 - 305 |
Millar transducer |
mouse |
diabetes mellitus • cardiomyopathy • diastolic dysfunction • benfotiamine • apoptosis |
| Xu Q, Chakravorty A, Bathgate RAD, Dart AM, Du X-J |
Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats |
Hypertension, Mar 2010; doi:10.1161/HYPERTENSIONAHA.109.149369 |
2-F Millar transducer catheter |
rat |
relaxin • hypertension • SHR • artery compliance • vascular remodeling • aging |
| Toporsian M, Jerkic M, Zhou Y-Q, Kabir MG, Yu LX, McIntyre BAS, Davis A, Wang YJ, Stewart DJ, Belik J, Husain M, Henkelman M, Letarte M |
Spontaneous Adult-Onset Pulmonary Arterial Hypertension Attributable to Increased Endothelial Oxidative Stress in a Murine Model of Hereditary Hemorrhagic Telangiectasia |
Arterioscler Thromb Vasc Biol, Mar 2010; 30: 509 - 517 |
Millar Mikro-tip pressure transducer |
mouse |
Alk-1 • endoglin • free radicals • nitric oxide • pulmonary arterial hypertension • transforming growth factor |
| Wang Y, Qian C, Roks AJM, Westermann D, Schumacher S-M, Escher F, Schoemaker RG, Reudelhuber TL, van Gilst WH, Schultheiss H-P, Tschöpe C, Walther T |
Circulating Rather Than Cardiac Angiotensin-(1-7) Stimulates Cardioprotection After Myocardial Infarction |
Circ Heart Fail, Mar 2010; 3: 286 - 293. |
microtip pressure transducer |
rat, mouse |
angiotensin • blood cells • myocardial infarction • revascularization |
| Gao L, Li Y, Schultz HD, Wang W-Z, Wang W, Finch M, Smith LM, Zucker IH |
Downregulated Kv4.3 expression in the RVLM as a potential mechanism for sympathoexcitation in rats with chronic heart failure |
Am J Physiol Heart Circ Physiol, Mar 2010; 298: H945 - H955. |
SPR-524 |
rat |
angiotensin II; K+ channel; reactive oxygen species; p38 mitogen-activated protein kinase |
| Wang J, Gao E, Song J, Zhang X-Q, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY |
Phospholemman and β-adrenergic stimulation in the heart |
Am J Physiol Heart Circ Physiol, Mar 2010; 298: H807 - H815. |
SPR-671 |
mouse |
FXYD1; excitation-contraction coupling; contractile function; intracellular Na+ and Ca2+ regulation; fura-2; sodium-binding benzofuran isophthalate |
| Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu Q-C, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M, Simon MC |
The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice |
J Clin Invest. 2010;120(3):827–839. doi:10.1172/JCI36362. |
SPR-1000 |
mouse |
|
| Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu Q-C, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M, Simon MC |
The von Hippel–Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice |
J Clin Invest. 2010;120(3):827–839. doi:10.1172/JCI36362. |
SPR-1000 |
mouse |
|
| Meloni M, Caporali A, Graiani G, Lagrasta C, Katare R, Van Linthout S, Spillmann F, Campesi I, Madeddu P, Quaini F, Emanueli C |
Nerve Growth Factor Promotes Cardiac Repair following Myocardial Infarction |
Circ. Res., Apr 2010; 106: 1275 - 1284 |
1.4F transducer |
mouse |
|
| Infanger DW, Cao X, Butler SD, Burmeister MA, Zhou Y, Stupinski JA, . Sharma RV, Davisson RL |
Silencing Nox4 in the Paraventricular Nucleus Improves Myocardial Infarction–Induced Cardiac Dysfunction by Attenuating Sympathoexcitation and Periinfarct Apoptosis |
Circ. Res., Apr 2010; doi:10.1161/CIRCRESAHA.109.213025 |
1.4F Millar catheter |
mouse |
heart • reactive oxygen species • NADPH oxidase • brain • sympathetic nerves |
| Lin RCY, Weeks KL, Gao X-M, Williams RBH, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du X-J, McMullen JR |
PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure: Identification of PI3K-Regulated miRNA and mRNA |
Arterioscler Thromb Vasc Biol, Apr 2010; 30: 724 - 732 |
1.4-Fr Millar MIKRO-TIP |
mouse |
|
| van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XHT |
Accelerated Development of Pressure Overload–Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model |
Hypertension, Apr 2010; 55: 932 - 938 |
1.4F catheter |
mouse |
calcium • heart failure • hypertrophy • ryanodine receptor calcium release channel • sarcoplasmic reticulum |
| Susic D, Varagic J, Frohlich ED |
Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess |
Am J Physiol Heart Circ Physiol, Apr 2010; 298: H1177 - H1181 |
Micro-Tip 3F |
rat |
ventricular function; angiotensin-converting enzyme inhibitor; angiotensin receptor blockade; mineralocorticoid receptor blocker |
| Aubin M-C, Cardin S, Comtois P, Clément R, Gosselin H, Gillis M-A , Quang KL, Nattel S, Perrault LP, Calderone A |
A high-fat diet increases risk of ventricular arrhythmia in female rats: enhanced arrhythmic risk in the absence of obesity or hyperlipidemia |
J Appl Physiol, Apr 2010; 108: 933 - 940 |
SPR-407 |
rat |
high fat; sympathetic system; ischemia |
| Reil J-C, Hohl M, Oberhofer M, Kazakov A, Kaestner L, Mueller P, Adam O, Maack C, Lipp P, Mewis C, Allessie M, Laufs U, Böhm M, Neuberger H-R |
Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling |
Cardiovasc Res cvq079published ahead of print March 7, 2010 doi:10.1093/cvr/cvq079 |
SPR-835 |
mouse |
Atrial arrythmias, Structural remodelling, Atrial conduction disturbance, RacET |
| Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Ooboshi H, Opthof T, Kadomatsu K, Kodama I |
Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction |
Cardiovasc Res (2010) 86(1): 113-121published ahead of print December 7, 2009 doi:10.1093/cvr/cvp386 |
1.4 F micro-tipped catheter |
rat |
Gene transfer, Coronary disease, Infarction, Haemodynamics, Remodelling |
| Xu Q, Chakravorty A, Bathgate RAD, Dart AM, Du X-J |
Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats |
Hypertension, May 2010; 55: 1260 - 1266 |
2-F Millar transducer catheter |
rat |
relaxin • hypertension • SHR • artery compliance • vascular remodeling • aging |
| Denniss SG, Jeffery AJ, Rush JWE |
RhoA-Rho kinase signaling mediates endothelium- and endoperoxide-dependent contractile activities characteristic of hypertensive vascular dysfunction |
Am J Physiol Heart Circ Physiol, May 2010; 298: H1391 - H1405 |
catheter-tip pressure transducer |
rat |
endothelium-dependent contraction; RhoA activation; Rho kinase; thromboxane-prostanoid receptor; carotid artery |
| Kleiber AC, Zheng H, Sharma NM, Patel KP |
Chronic AT1 receptor blockade normalizes NMDA-mediated changes in renal sympathetic nerve activity and NR1 expression within the PVN in rats with heart failure |
Am J Physiol Heart Circ Physiol, May 2010; 298: H1546 - H1555 |
Mikro-Tip catheter |
rat |
paraventricular nucleus; N-methyl-D-aspartate receptor; angiotensin type 1 receptor; sympathetic nerve activity |
| Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, . Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP |
Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure |
Am J Physiol Heart Circ Physiol, May 2010; 298: H1472 - H1483 |
1.4-Fr Mikro-tip pressure catheter |
mouse |
mesenteric arteries; myogenic tone; patch clamp; calcium sparklets; Bay K 8644 |
| Wang H-J, Pan Y-X, Wang W-Z, Gao L, Zimmerman MC,Zucker IH, Wang W |
Exercise training prevents the exaggerated exercise pressor reflex in rats with chronic heart failure |
J Appl Physiol, May 2010; 108: 1365 - 1375 |
SPR-524 |
rat |
muscle; sympathetic nerve activity; blood pressure; decerebration |
| Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T |
GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice |
J Clin Invest. doi:10.1172/JCI41407 |
SPR-671 |
mouse |
|
| Zaidi SHE, Huang Q, Momen A, Riazi A, Husain M |
Growth Differentiation Factor 5 Regulates Cardiac Repair After Myocardial Infarction |
J. Am. Coll. Cardiol. 2010;55;135-143 |
micromanometer catheter |
mouse |
collagen gene expression, growth differentiation factor, mitogen-activated protein kinase, myocardial infarction |
| Yamazaki KG, Taub PR, Barraza-Hidalgo M, Rivas MM, Zambon AC, Ceballos G, Villarreal FJ |
Effects of (–)-Epicatechin on Myocardial Infarct Size and Left Ventricular Remodeling After Permanent Coronary Occlusion |
J. Am. Coll. Cardiol., June 22, 2010; 55: 2869 - 2876 |
micromanometer, 2F, 140 cm |
rat |
cardioprotection • catechins • flavanols • infarction • ischemia |
| Hilfiker-Kleiner D, Shukla P, Klein G, Schaefer A, Stapel B, Hoch M, Müller W, Scherr M, Theilmeier G, Ernst M, Hilfiker A, Drexler H |
Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction |
Circulation, Jun 2010; doi:10.1161/CIRCULATIONAHA.109.933127 |
Millar catheter. |
mouse |
inflammation • interleukins • molecular biology • myocardial infarction • signal transduction |
| Infanger DW, Cao X, Butler SD, Burmeister MA, Zhou Y, Stupinski JA, Sharma RV, Davisson RL |
Silencing Nox4 in the Paraventricular Nucleus Improves Myocardial Infarction–Induced Cardiac Dysfunction by Attenuating Sympathoexcitation and Periinfarct Apoptosis |
Circ. Res., Jun 2010; 106: 1763 - 1774 |
1.4F Millar catheter |
mouse |
|
| Lorentz CU, Alston EN, Belcik T, Lindner JR, Giraud GD, Habecker BA |
Heterogeneous ventricular sympathetic innervation, altered β-adrenergic receptor expression, and rhythm instability in mice lacking the p75 neurotrophin receptor |
Am J Physiol Heart Circ Physiol, Jun 2010; 298: H1652 - H1660 |
SPR-1000 |
mouse |
sympathetic innervation; nerve growth factor; semaphorin 3a; ventricular arrhythmias |
| Dietrich HH, Abendschein DR, Moon SH, Nayeb-Hashemi N, Mancuso DJ, Jenkins CM, Kaltenbronn KM,Blumer KJ,Turk J, Gross RW |
Genetic ablation of calcium-independent phospholipase A2β causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine |
Am J Physiol Heart Circ Physiol, Jun 2010; 298: H2208 - H2220 |
1.4-F catheter pressure probe |
mouse |
vascular smooth muscle; vascular endothelium; calcium signaling; 12- hydroxyeicosatetraenoic acid; lysophosphatidylcholine |
Published in 2009 |
| Maizel J, Six I, Slama M, Tribouilloy C, Sevestre H, Poirot S, Giummelly P, Atkinson J, Choukroun G, Andrejak M, Kamel S, Mazière JC, Massy ZA |
Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification |
Circulation, Jan 2009; 119: 306 - 313 |
1.4F pressure transducer |
mouse |
Chronic renal failure (CRF) |
| Austinat M, Braeuninger S, Pesquero JB, Brede M, Bader M, Stoll G, Renné T, Kleinschnitz C |
Blockade of Bradykinin Receptor B1 but Not Bradykinin Receptor B2 Provides Protection From Cerebral Infarction and Brain Edema • Expanded Materials and Methods |
Stroke, Jan 2009; 40: 285 - 293 |
high-fidelity 1.4-F Millar micro-tip catheter |
mouse |
brain infarction, edema formation |
| Lindley TE, Infanger DW, Rishniw M, Zhou Y, Doobay MF, Sharma RV, Davisson RL |
Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction |
Am J Physiol Regulatory Integrative Comp Physiol, Jan 2009; 296: R1 - R8 |
1.4F Millar catheter |
mouse |
antioxidant gene therapy; survival; sympathetic nervous system |
| Sun J, Li S-H, Liu S-M, Wu J, Weisel RD, Zhuo Y-F, Yau TM, Li R-K, Fazel SS |
Improvement in cardiac function after bone marrow cell thearpy is associated with an increase in myocardial inflammation |
Am J Physiol Heart Circ Physiol, Jan 2009; 296: H43 - H50 |
micromanometer and conductance 1.4-Fr catheter |
mouse |
cell transplantation; myocardial infarction; cell therapy; myofibroblasts |
| Houng Ak, McNamee RA, Kerner A, Sharma P, Mohamad A, Tronolone J, Reed GL |
Atrial natriuretic peptide increases inflammation, infarct size and mortality after experimental coronary occlusion |
Am J Physiol Heart Circ Physiol, Jan 2009; doi:10.1152/ajpheart.00684.2008 |
SPR-671 |
mouse |
P-selectin, neutrophil infiltration, infarct size |
| Shao C-H, Wehrens XHT, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR |
Exercise Training During Disabetes Attenuates Cardiac Ryanodine Receptor Dysregulation |
J Appl Physiol, Jan 2009; doi:10.1152/japplphysiol.91280.2008 |
2F micro manometer-tipped catheter |
rat |
RyR2 function, Ca2+ release |
| Liu Y-H, D'Ambrosio M, Liao T-D, Peng H, Rhaleb N-E, Sharma U, André S, Gabius H-J, Carretero OA |
N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin |
Am J Physiol Heart Circ Physiol, Feb 2009; 296: H404 - H412 |
2-French (2F) Mikro-Tip catheter |
rat |
N-acetyl-seryl-aspartyl-lysyl-proline; cardiac dysfunction; fibrosis; inflammation |
| Salo LM, Nalivaiko E, Anderson CR, McAllen RM |
Control of cardiac rate, contractility, and atrioventricular conduction by medullary raphé neurons in anesthetized rats |
Am J Physiol Heart Circ Physiol, Feb 2009; 296: H318 - H324 |
SPR-249 |
rat |
brain stem; sympathetic; inotropic; dromotropic; lusitropic |
| Huang BS, White Ra, Ahmad M, Tan J, Jeng AY, Leenen FHH |
Central infusion of aldosterone synthase inhibitor attenuates left ventricular dysfunction and remodelling in rats after myocardial infarction |
Cardiovasc Res, 15 February 2009; 81: 574 - 581 |
Millar catheter |
rat |
Brain; Aldosterone synthase inhibitor; Central infusion; Myocardial infarction; LV dysfunction; LV remodelling; Millar catheter; Echocardiography |
| Ainscough JFX, Drinkhill MJ, Sedo A, Turner NA, Brooke DA, Balmforth AJ, Ball SG |
Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction |
Cardiovasc Res, 15 February 2009; 81: 592 - 600 |
Millar catheter |
mouse |
Angiotensin II type-1 receptor; Blood pressure; Cardiomyocyte; Remodelling; Transgenic mouse |
| Mackiewicz U, Maczewski M, Konior A, Tellez JO, Nowis D, Dobrzynski H, Boyett MR, Lewartowski B |
Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat |
Cardiovasc Res, 15 February 2009; 81: 546 - 554 |
micromanometer-tipped catheter |
rat |
Sarcolemmal Ca2+-ATPase; Calcium handling; Myocardial infarction; Heart remodelling |
| Kohno T, Anzai T, Naito K, Miyasho T, Okamoto M, Yokota H, Yamada S, Maekawa Y, Takahashi T, Yoshikawa T, Ishizaka A, Ogawa S |
Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling |
Cardiovasc Res, 15 February 2009; 81: 565 - 573 |
SPC-320 |
rat |
Heart failure; Infarction; Cytokines; Remodelling; Infection/inflammation |
| Schäfer S, Ellinghaus P, Janssen W, Kramer F, Lustig K, Milting H, Kast R , Klein M |
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling |
Cardiovasc Res, Advance Access published on February 2, 2009; doi: doi:10.1093/cvr/cvp002 |
SPR-671 |
rat |
Pulmonary hypertension; Remodelling; Sildenafil |
| Suckau L:, Fechner H, Chemaly E, Krohn S, Hadri L, Kockskämper J, Westermann D, Bisping E, Ly H, Wang X, Kawase Y, Chen J, Liang L, Sipo I, Vetter R, Weger S, Kurreck J, Erdmann V, Tschope C, Pieske B, Lebeche D, Schultheiss H-P, Hajjar RJ, Poller WC |
Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy |
Circulation, Mar 2009; 119: 1241 - 1252 |
2.0F high-fidelity pressure transducer |
rat |
rAAV9-shPLB |
| Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, R. White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC |
G-Protein–Coupled Receptor Kinase Interacting Protein-1 Is Required for Pulmonary Vascular Development |
Circulation, Mar 2009; doi:10.1161/CIRCULATIONAHA.108.823997 |
1.0F measuring catheter |
mouse |
angiogenesis • endothelial cell • G protein-coupled receptor kinase-interactor 1, mouse • PLC-gamma |
| Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan Y-T, Prabhu SD |
Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure. Role of Nuclear Factor κ-B and Inflammatory Activation |
Circulation, Mar 2009; doi:10.1161/CIRCULATIONAHA.108.802918 |
SPR-835 |
mouse |
heart failure • inflammation • remodeling • tumor necrosis factor |
| Houng AK, McNamee RA, Kerner A, Sharma P, Mohamad A, Tronolone J, Reed GL |
Atrial natriuretic peptide increases inflammation, infarct size, and mortality after experimental coronary occlusion |
Am J Physiol Heart Circ Physiol, Mar 2009; 296: H655 - H661 |
SPR-671 |
mouse |
myocardial infarction; neutrophil; P-selectin |
| Hiraumi Y, Iwai-Kanai E, Baba S, Yui Y, Kamitsuji Y, Mizushima Y, Matsubara H, Watanabe M, Watanabe K, Toyokuni S, Matsubara H, Nakahata T, Adachi S |
Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury |
Am J Physiol Heart Circ Physiol, Mar 2009; 296: H823 - H832 |
1.4-Fr micromanometer-tipped catheter, TCB-500 |
mouse |
doxorubicin; mitochondria; cardiac diastolic function; oxygen consumption |
| Okada H, Takemura G, Kosai K, Tsujimoto A, Esaki M, Takahashi T, Nagano S, Kanamori H, Miyata S, Li Y, Ohno T, Maruyama R, Ogino A, Li L, Nakagawa M, Nagashima K, Fujiwara T, Fujiwara H, Minatoguchi S |
Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure |
Am J Physiol Heart Circ Physiol, Mar 2009; 296: H616 - H626 |
SPR-671 |
mouse |
apoptosis; cytokines; gene therapy; heart failure; ischemic heart disease |
| Rueda-Clausen CF, Morton JS, Davidge ST |
Effects of hypoxia-induced intrauterine growth restriction on cardiopulmonary structure and function during adulthood |
Cardiovasc Res, 1 March 2009; 81: 713 - 722 |
1.4 Fr micromanometer |
rat |
Fetal programming; Hypoxia; Cardiac function; Ageing; Sex; Echocardiography; Pulmonary hypertension; Diastolic dysfunction |
| Shao C-H, Wehrens XHT, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR |
Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation |
J Appl Physiol, Apr 2009; 106: 1280 - 1292 |
2F micromanometer-tipped catheter |
rat |
type 1 diabetes; calcium sparks; calcium transients; phosphorylation; hemodynamics |
| Schäfer S, Ellinghaus P, Janssen W, Kramer F, Lustig K, Milting H, Kast R, Klein M |
Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling |
Cardiovasc Res, 1 April 2009; 82: 30 - 39 |
SPR-671 |
rat |
Pulmonary hypertension; Remodelling; Sildenafil |
| Nagayama T, Hsu S, Zhang M, Koitabashi N, DBedja D, Gabrielson KL, Takimoto E, Kass DA |
Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition |
Journal of Molecular and Cellular Cardiology Volume 46, Issue 4, April 2009, Pages 560-567 |
|
mouse |
Hypertrophy; Phosphodiesterase; Cyclic nucleotides; Sildenafil; Mouse models; Galphaq; PDE5A; Remodeling; Heart failure; Stress response kinase; Hemodynamics |
| Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Cordone S, Taurino M, Serino M, Marano G, Federici M, Pricci F, Pugliese G |
Accelerated Lipid-Induced Atherogenesis in Galectin-3–Deficient Mice. Role of Lipoxidation via Receptor-Mediated Mechanisms |
Arterioscler. Thromb. Vasc. Biol., Apr 2009; doi:10.1161/ATVBAHA.109.186791 |
1.4F high-fidelity trans-ducer tipped catheter |
mouse |
atherosclerosis • inflammation • advanced lipoxidation end products • galectin-3 • RAGE |
| Berni R, Savi M, Bocchi L, Delucchi F, Musso E, Chaponnier C, Gabbiani G, Clement S, Stilli D |
Modulation of actin isoform expression before the transition from experimental compensated pressure-overload cardiac hypertrophy to decompensation |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1625 - H1632 |
SPC-320 |
rat |
aortic ligature; hypertension |
| Desjardins J-F, Pourdjabbar A, Quan A, Leong-Poi H, Teichert-Kuliszewska K, Verma S, Parker TG |
Lack of S100A1 in mice confers a gender-dependent hypertensive phenotype and increased mortality after myocardial infarction |
Am J Physiol Heart Circ Physiol, May 2009; 296: H1457 - H1465. |
SPR-671 |
mouse |
Ca2+-binding protein; vascular tone; heart failure; hypertrophy; knockout |
| Palpant NJ, D'Alecy LG, Metzger JM |
Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo |
FASEB J. 2009 23: 1529-1540 |
pressure-conductance |
mouse |
myocardial function • myofilaments • pH |
| Iacobini C, Menini S, Ricci C, Scipioni A, Sansoni V, Cordone S, Taurino M, Serino M, Marano G, Federici M, Pricci F, Pugliese G |
Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice: Role of Lipoxidation via Receptor-Mediated Mechanisms |
Arterioscler. Thromb. Vasc. Biol., Jun 2009; 29: 831 - 836 |
1.4F, Millar |
mouse |
atherosclerosis • inflammation • advanced lipoxidation end products • galectin-3 • RAGE |
| Pu M, Gao Z, Zhang X, Liao D, Pu DK, Brennan T, Davidson Jr WR |
Impact of mitral regurgitation on left ventricular anatomic and molecular remodeling and systolic function: implication for outcome |
Am J Physiol Heart Circ Physiol, Jun 2009; 296: H1727 - H1732 |
Millar catheter |
rat |
molecular biology; animal model |
| Yasuno S, Usami S, Kuwahara K, Nakanishi M, Arai Y, Kinoshita H, Nakagawa Y, Fujiwara M, Murakami M, Ueshima K, Harada M, Nakao K |
Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death |
Am J Physiol Heart Circ Physiol, Jun 2009; 296: H1804 - H1810. |
2-French Millar Micro-Tip catheter |
mouse |
neuron-restrictive silencer factor; guanylyl cyclase-A; cardiomyopathy; sudden death |
| Wansapura AN, Lasko V, Xie Z, Fedorova OV, Bagrov AY, Lingrel JB, Lorenz JN |
Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive α1 Na+-K+-ATPase |
Am J Physiol Heart Circ Physiol, Jun 2009; 296: H1833 - H1839 |
SPR-671 |
mouse |
cardiotonic steroids; sodium-potassium-adenosinetriphosphatase isoforms |
| Falcão-Pires I, Gonçalves N, Henriques-Coelho T, Moreira-Gonçalves D, Roncon-Albuquerque Jr R, Leite-Moreira AF |
Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension |
Am J Physiol Heart Circ Physiol, Jun 2009; 296: H2007 - H2014 |
SPR-324 |
rat |
heart failure; angiotensin receptor like-1; right ventricle hypertrophy |
| Kang C-S, Chen C-C, Lin C-C, Chang N-C, Lee T-M |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts |
Am J Physiol Heart Circ Physiol, Jun 2009; 296: H1949 - H1959 |
SPR-407 |
rat |
adenosine 5'-triphosphate-sensitive potassium channel; myocardial infarction; norpinephrine; sympathetic innervation |
| Liu Q, Chen X, MacDonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD |
Protein Kinase C, but Not PKCβ or PKCγ, Regulates Contractility and Heart Failure Susceptibility: Implications for Ruboxistaurin as a Novel Therapeutic Approach |
Circ. Res., Jul 2009; 105: 194 - 200 |
Millar pressure transducing catheter |
mouse |
heart failure • contractility • PKC • signaling • cardiomyopathy |
| Wilson RM, De Silva DS, Sato K, Izumiya Y, Sam F |
Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure |
Hypertension, Jul 2009; doi:10.1161/HYPERTENSIONAHA.109.134932 |
Millar catheterization |
mouse |
diastolic heart failure • hydralazine • nitrates • hypertension • exercise capacity |
| Uryash A, Wu H, Bassuk J, Kurlansky P, Sackner MA, Adams JA |
Low-amplitude pulses to the circulation through periodic acceleration induces endothelial-dependent vasodilatation |
J Appl Physiol, Jun 2009; 106: 1840 - 1847. |
2F Millar Mikro-Tip pressure catheter |
rat |
vascular resistance; NG-nitro-L-arginine methyl ester, wortmannin; nitric oxide |
| Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de Cabo R, Mathew R, Wolin MS, Ungvari Z |
Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats |
Hypertension, Jul 2009; doi:10.1161/HYPERTENSIONAHA.109.133397 |
microtip Millar pressure catheter |
rat |
pulmonary hypertension • resveratrol • oxidative stress • endothelial dysfunction • inflammation |
| Handoko ML, de Man FS, Happé CM, Schalij I, Musters RJP, Westerhof N, Postmus PE, Paulus WJ, van der Laarse WJ, Vonk-Noordegraaf A |
Opposite Effects of Training in Rats With Stable and Progressive Pulmonary Hypertension |
Circulation, Jul 2009; 120: 42 - 49. |
SPR-671 |
rat |
|
| Mouchaers KTB, Schalij I, Versteilen AMG, Hadi AM, van Nieuw Amerongen GP, van Hinsbergh VWM, Postmus PE, van der Laarse WJ, Vonk-Noordegraaf A |
Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H200 - H207 |
Millar pressure catheter |
rat |
Bosentan; Sildenafil; mitochondria; oxidative capacity; chronic heart failure |
| Hu Q, Suzuki G, Young RF, Page BJ, Fallavollita JA, Canty Jr JM |
Reductions in mitochondrial O2 consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H223 - H232 |
5F end-hole micromanometer |
|
energy metabolism; mitochondrial respiration; stunned myocardium |
| Wüst RCI, Jaspers RT, an Heijst AF, Hopman MTE, Hoofd LJC, van der Laarse WJ, Degens H |
Region-specific adaptations in determinants of rat skeletal muscle oxygenation to chronic hypoxia |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H364 - H374 |
SPR-320 |
rat |
tissue oxygenation; capillarization; oxidative capacity |
| Matsushima S, Kinugawa S, Yokota T, Inoue N, Ohta Y, Hamaguchi S, Tsutsui H |
Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H409 - H416 |
1.4-Fr micromanometer-tipped catheter |
mouse |
diabetes; heart failure; remodeling; antioxidants; free radicals |
| Barrick CJ, Roberts RB, Rojas M, Rajamannan NM, Suitt CB, O'Brien KD, Smyth SS, Threadgill DW |
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice |
Am J Physiol Heart Circ Physiol, Jul 2009; 297: H65 - H75 |
1.4-Fr catheter |
mouse |
epidermal growth factor receptor aortic sclerosis; hypertrophy; aortic stenosis; valvulogenesis |
| Rehn TA, Borge BA, Lunde PK, Munkvik M, Sneve ML, Grøndahl F, Aronsen JM, Sjaastad I, Prydz K, Kolset SO, Wiig H, Sejersted OM, Iversen PO |
Temporary fatigue and altered extracellular matrix in skeletal muscle during progression of heart failure in rats |
Am J Physiol Regulatory Integrative Comp Physiol, Jul 2009; 297: R26 - R33 |
SPR-407 |
rat |
fatigue; extracellular matrix; interstitial fluid; ischemic heart failure |
| de Waard MC, Duncker DJ |
Prior Exercise Improves Survival, Infarct Healing and Left Ventricular Function after Myocardial Infarction |
J Appl Physiol, Jul 2009; doi:10.1152/japplphysiol.91281.2008 |
SPR-671 |
mouse |
|
| Simpson JA, Brunt KR, Collier CP, Iscoe S |
Hyperinflation-induced cardiorespiratory failure in rats |
J Appl Physiol, Jul 2009; 107: 275 - 282 |
SPR-524 |
rat |
diaphragm; fatigue; lung volume; right ventricle; cardiac troponin |
| van den Borne SWM, van de Schans VAM, Strzelecka AE, Vervoort-Peters HTM, Lijnen PM, Cleutjens JPM, Smits JFM, Daemen MJAP, Janssen BJA, Blankesteijn WM |
Mouse strain determines the outcome of wound healing after myocardial infarction |
Cardiovasc Res, Advance Access published on July 7, 2009; doi: doi:10.1093/cvr/cvp207 |
SPR-671 |
mouse |
Myocardial infarction; Inflammatory cells; Infarct rupture; Heart failure; Genetic background |
| Wang J, Chan TO, Zhang X-Q,Gao R, Song J, Koch WJ, Feldman AM, Cheung JY |
Induced overexpression of Na+/Ca2+ exchanger transgene: altered myocyte contractility, [Ca2+]i transients, SR Ca2+ contents, and action potential duration |
Am J Physiol Heart Circ Physiol, Aug 2009; 297: H590 - H601 |
SPR-671 |
mouse |
tet-off; excitation-contraction; fura-2; isolated mouse myocytes; electrophysiology; sarcoplasmic reticulum; intracellular Ca2+ concentration |
| Lee T-M, Chen C-C, Chang N-C |
Granulocyte colony-stimulating factor increases sympathetic reinnervation and the arrhythmogenic response to programmed electrical stimulation after myocardial infarction in rats |
Am J Physiol Heart Circ Physiol, Aug 2009; 297: H512 - H522 |
SPR-407 |
rat |
|
| Zhou W, Mahajan A, Longhurst JC |
Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats |
Am J Physiol Heart Circ Physiol, Aug 2009; 297: H859 - H865 |
SPR-524 |
rat |
nociceptin/orphanin FQ peptide receptors; pressor response; dorsal horn; intermediolateral column; acupuncture |
| Beguin PC, El-Helou V, Assimakopoulos J, Clement R, Gosselin H, Brugada R, Villeneuve L, Rohlicek CV, Del Duca D, Lapointe N, Rouleau J-L, Calderone A |
The phenotype and potential origin of nestin(+) cardiac myocyte-like cells following infarction |
J Appl Physiol, Aug 2009; doi:10.1152/japplphysiol.00564.2009 |
Millar catheter |
rat |
|
| Graham DA, Rush JWE |
Cyclooxygenase and thromboxane/prostaglandin receptor contribute to aortic endothelium-dependent dysfunction in aging female spontaneously hypertensive rats |
J Appl Physiol, Aug 2009; doi:10.1152/japplphysiol.90785.2008 |
Mikro-TipTM Pressure Transducer catheter |
rat |
|
| Beetz N, Hein L, Meszaros J, Gilsbach R, Barreto F, Meissner M, Hoppe UC, Schwartz A, Herzig S, Matthes J |
Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice |
Cardiovasc Res, Advance Access published on August 27, 2009; doi: doi:10.1093/cvr/cvp251 |
Millar microtip catheterization |
mouse |
Arrhythmia; L-type calcium channel; Cardiac fibrosis; Hypertrophy; Heart failure; Transgenic mice |
| Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F |
Hydrogen Sulfide Improves Survival After Cardiac Arrest and Cardiopulmonary Resuscitation via a Nitric Oxide Synthase 3–Dependent Mechanism in Mice |
Circulation, Sep 2009; 120: 888 - 896. |
SPR-671 |
mouse |
|
| Wilson RM, De Silva DS, Sato K, Izumiya Y, Sam F |
Effects of Fixed-Dose Isosorbide Dinitrate/Hydralazine on Diastolic Function and Exercise Capacity in Hypertension-Induced Diastolic Heart Failure |
Hypertension, Sep 2009; 54: 583 - 590 |
Millar catheter |
mouse |
diastolic heart failure • hydralazine • nitrates • hypertension • exercise capacity |
| Csiszar A, Labinskyy N, Olson S, Pinto JT, Gupte S, Wu JM, Hu F, Ballabh P, Podlutsky A, Losonczy G, de Cabo R, Mathew R, Wolin MS, Ungvari Z |
Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats |
Hypertension, Sep 2009; 54: 668 - 675 |
microtip Millar pressure catheter |
rat |
pulmonary hypertension • resveratrol • oxidative stress • endothelial dysfunction • inflammation |
| Huang BS, Ahmad M, Tan J, Leenen FHH |
Chronic central versus systemic blockade of AT1 receptors and cardiac dysfunction in rats post-myocardial infarction |
Am J Physiol Heart Circ Physiol, Sep 2009; 297: H968 - H975 |
SPR-407 |
rat |
losartan; cardiac remodeling; echocardiography; Millar catheter; brain; ANG II type 1 |
| Zibadi S, Vazquez R, Moore D, Larson DF, Watson RR |
Myocardial lysyl oxidase regulation of cardiac remodeling in a murine model of diet-induced metabolic syndrome |
Am J Physiol Heart Circ Physiol, Sep 2009; 297: H976 - H982 |
high-fidelity 1.4-Fr transducer catheter |
mouse |
heart; cross-linked collagen |
| DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Sowers JR, Andresen BT, Gutweiler AA, Ma L, Johnson MS, Ferrario CM, Dellsperger KC |
Rosuvastatin ameliorates the development of pulmonary arterial hypertension in the transgenic (mRen2)27 rat |
Am J Physiol Heart Circ Physiol, Sep 2009; 297: H1128 - H1139. |
Millar Mikro-tip catheter |
rat |
oxidative stress; NADPH oxidase |
| Parrish DC, Alston EN, Rohrer H, Hermes SM, Aicher SA, Nkadi P, Woodward WR, Stubbusch J, Gardner RT, Habecker BA |
Absence of gp130 in dopamine β-hydroxylase-expressing neurons leads to autonomic imbalance and increased reperfusion arrhythmias |
Am J Physiol Heart Circ Physiol, Sep 2009; 297: H960 - H967. |
1.0F microtipped pressure transducer |
mouse |
cardiac; sympathetic; parasympathetic; ischemia-reperfusion |
| Munkvik M, Lunde PK, Sejersted OM |
Causes of fatigue in slow-twitch rat skeletal muscle during dynamic activity |
Am J Physiol Regulatory Integrative Comp Physiol, Sep 2009; 297: R900 - R910 |
SPR-407 |
rat |
MLC phosphorylation; oxidative metabolism; isotonic contractions; work; aerobic exercise; cross-bridge |
| de Waard MC, Duncker DJ |
Prior exercise improves survival, infarct healing, and left ventricular function after myocardial infarction |
J Appl Physiol, Sep 2009; 107: 928 - 936 |
SPR-671 |
mouse |
cardiac function; infarct healing; remodeling |
| Toporsian M, Jerkic M, Zhou Y-Q, Kabir MG, Yu LX, McIntyre BAS, Davis A, Wang YJ, Stewart DJ, Belik J, Husain M, Henkelman M, Letarte M |
Spontaneous Adult-Onset Pulmonary Arterial Hypertension Attributable to Increased Endothelial Oxidative Stress in a Murine Model of Hereditary Hemorrhagic Telangiectasia |
Arterioscler Thromb Vasc Biol, Dec 2009; doi:10.1161/ATVBAHA.109.200121 |
Mikro-tip pressure transducer |
mouse |
Alk-1 • endoglin • free radicals • nitric oxide • pulmonary arterial hypertension • transforming growth factor |
| Chandar S, Yeo LS, Leimena C, Tan J-C, Xiao X-H, Nikolova-Krstevski VN, Yasuoka Y, Gardiner-Garden M, Wu J, Kesteven S, Karlsdotter L, Natarajan S, Carlton A, Rainer S, Feneley MP, Fatkin D |
Effects of Mechanical Stress and Carvedilol in Lamin A/C–Deficient Dilated Cardiomyopathy |
Circ. Res., Dec 2009; doi:10.1161/CIRCRESAHA.109.204388 |
1.4F and 1.0F microtip catheter pressure transducers |
mouse |
familial dilated cardiomyopathy • lamin A/C • mechanical stress • exercise • carvedilol |
| Carta L, Wagenseil JE, Knutsen RH, Mariko B, Faury G, Davis EC, Starcher B, Mecham RP, Ramirez F |
Discrete Contributions of Elastic Fiber Components to Arterial Development and Mechanical Compliance |
Arterioscler Thromb Vasc Biol, Dec 2009; 29: 2083 - 2089 |
catheter |
mouse |
elastin • fibrillin-1 • hypertension • Marfan syndrome • supravalvular • aortic • stenosis |
| Tian J, Shidyak A, Periyasamy SM, Haller S, Taleb M, El-Okdi N, Elkareh J, Gupta S, Gohara S, Fedorova OV, Cooper CJ, Xie Z, Malhotra D, Bagrov AY, Shapiro JI |
Spironolactone Attenuates Experimental Uremic Cardiomyopathy by Antagonizing Marinobufagenin |
Hypertension, Dec 2009; 54: 1313 - 1320 |
2.0F catheter |
rat |
cardiomyopathy • renal failure • cardiotonic steroids • collagen • fibrosis |
| Bian Y, Sun M, Silver , Ho KKL, Marchionni MA, Caggiano AO, Stone JR, Amende I, Hampton TG, Morgan JP, Yan X |
Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins |
Am J Physiol Heart Circ Physiol, Dec 2009; 297: H1974 - H1983 |
Mikro-Tip catheter transducer |
mouse |
ErbB2; troponin proteins; signaling |
| Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z |
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function |
Am J Physiol Heart Circ Physiol, Dec 2009; 297: H2096 - H2108 |
1.4 French Millar catheter |
mouse |
insulin; fibrosis; hypertrophy; sarco(endo)plasmic reticulum calcium-ATPase 2a |
| Beetz N, Hein L, Meszaros J, Gilsbach R, Barreto F, Meissner M, Hoppe UC, Schwartz A, Herzig S, Matthes J |
Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice |
Cardiovasc Res, 1 December 2009; 84: 396 - 406. |
Millar microtip catheterization |
mouse |
Arrhythmia; L-type calcium channel; Cardiac fibrosis; Hypertrophy; Heart failure; Transgenic mice |
| Beetz N, Harrison MD, Brede M, Zong X, Urbanski MJ, Sietmann A, Kaufling J, Barrot M, Seeliger MW, Vieira-Coelho MA, Hamet P, Gaudet D, Seda O,Tremblay J, Kotchen TA, Kaldunski M, Nüsing R, Szabo B, Jacob HJ, Cowley Jr AW, Biel M, Stoll M,Lohse MJ, Broeckel U, Hein L |
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice |
J Clin Invest. 2009;119(12):3597–3612. doi:10.1172/JCI38433 |
1.4F Millar microtip catheter |
human, mouse |
|
| Nakayama H, Bodi I, Correll RN, Chen X, Lorenz J, Houser SR, Robbins J, Schwartz A Molkentin JD |
α1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice |
J Clin Invest. 2009;119(12):3787–3796. doi:10.1172/JCI39724. |
1.4F Millar catheter |
mouse |
|
---------------------------------------------Published in 2008--------------------------------------------- |
| Ott HC, Matthiesen TS, Goh S-K, Black LD, Kren SM, Netoff TI, Taylor DA |
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart |
Nature 13 January 2008; dol:10.1038/nm1684 |
Mikro-tip pressure catheter, PowerLab |
rat |
|
| Jin J-K, Whittaker R, Glassy MS, Barlow SB, Gottlieb RA, Glembotski CC |
Localization of phosphorylated αB-crystallin to heart mitochondria during ischemia-reperfusion |
Am J Physiol Heart Circ Physiol, Jan 2008; 294: H337 - H344 |
Millar pressure transducer |
mouse |
mitochondrial permeability transition; cardioprotection |
| Lorenz JN, Arend LJ, Robitz R, Paul RJ, MacLennan AJ |
Vascular dysfunction in S1P2 sphingosine 1-phosphate receptor knockout mice |
Am J Physiol Regulatory Integrative Comp Physiol, Jan 2007; 292: R440 - R446 |
SPR-671 |
mouse |
lysosphingolipids; endothelium; vascular smooth muscle; blood flow; myocardial contractility |
| Kiriazis H, Wang K, Xu Q, Gao X-M, Ming Z, Su Y, Moore X-L, Lambert G, Gibbs ME, Dart AM, Du X-J |
Knockout of [beta]1- and [beta]2-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis |
British Journal of Pharmacology 153, 684 - 692 (14 Jan 2008) |
1.4-Fr Millar catheter |
mouse |
adrenoceptors |
| Xiao HD, Fuchs S, Bernstein EA, Li P, Campbell DJ, Bernstein KE |
Mice expressing ACE only in the heart show that increased cardiac angiotensin II is not associated with cardiac hypertrophy |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H659 - H667 |
SPR-671 |
mouse |
connexin; gene targeting; blood pressure; genetically modified mice |
| Esaki M, Takemura G, Kosai K, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H |
Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H1048 - H1057 |
SPR-671 |
mouse |
heart failure |
| Zhu M, Gach AA, Liu GX, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U |
Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active Gαo* protein |
Am J Physiol Heart Circ Physiol, Mar 2008; 294: H1335 - H1347 |
1.4-Fr high-fidelity micromanometer catheter |
mouse |
G proteins; signal transduction; calcium; contraction; transgenic mice |
| Kontaridis MI, WYang W, Bence KK, Cullen D, Wang B, NBodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG |
Deletion of Ptpn11 (Shp2) in Cardiomyocytes Causes Dilated Cardiomyopathy via Effects on the Extracellular Signal–Regulated Kinase/Mitogen-Activated Protein Kinase and RhoA Signaling Pathways |
Circulation, Mar 2008; 117: 1423 - 1435 |
SPR-671 |
mouse |
cardiomyocyte signaling pathways, protein tyrosine kinases |
| Yang Y, Ma Y, Han W, Li J, Xiang Y, Liu F, Ma X,Zhang J, Fu Z, Su Y-D, Du X-J, Gao X-M |
Age-related differences in postinfarct left ventricular rupture and remodeling |
Am J Physiol Heart Circ Physiol, Apr 2008; 294: H1815 - H1822. |
1.4 F Millar catheter |
mouse |
infarct expansion; collagen; matrix metalloproteinase; inflammatory cytokines |
| Mito S, Ozono R, Oshima T, Y, Watari Y, Yamamoto Y, Brydun A, Igarashi K, Yoshizumi M |
Myocardial Protection Against Pressure Overload in Mice Lacking Bach1, a Transcriptional Repressor of Heme Oxygenase-1 |
Hypertension, Apr 2008; doi:10.1161/HYPERTENSIONAHA.107.102566 |
1.4F Millar pressure catheter |
mouse |
hypertrophy • HO-1 • mice • oxidative stress • Bach1 • remodeling |
| Drouin A, Gendron M-È, Thorin E, Gillis M-A,Mahlberg-Gaudin , Tardif J-C |
Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice |
British Journal of Pharmacology (14 Apr 2008), doi: 10.1038/bjp.2008.116, Research Paper |
Millar catheter |
mouse |
hypercholesterolaemia, vasodilatation and acetylcholine, cardiac dysfunction, metoprolol, telemetry |
| Parrish DC, Gritman K, Van Winkle DM, Woodward WR, Bader M, Habecker BA |
Postinfarct sympathetic hyperactivity differentially stimulates expression of tyrosine hydroxylase and norepinephrine transporter |
Am J Physiol Heart Circ Physiol, Jan 2008; 294: H99 - H106 |
microtipped pressure transducer (2.0 French; Millar) |
rat |
ischemia-reperfusion; sympathetic hyperactivity; autonomic |
| Chen L,Zhang J, Gan TX, Chen-Izu Y, Hasday JD, Karmazyn M, Balke CW, Scharf SM |
Left ventricular dysfunction and associated cellular injury in rats exposed to chronic intermittent hypoxia |
J Appl Physiol, Jan 2008; 104: 218 - 223 |
micromanometer-tipped catheters, 2.5 F |
rat |
obstructive sleep apnea; cardiac hypertrophy; apoptosis |
| El-Helou V, Proulx C, Gosselin H, Clement R, Mimee A, Villeneuve L, Calderone A |
Dexamethasone treatment of post-MI rats attenuates sympathetic innervation of the infarct region |
J Appl Physiol, Jan 2008; 104: 150 - 156 |
SPR-407 |
rat |
dexamethasone; neural remodeling; myocardial infarction; myofibroblasts; nerve growth factor |
| Yeih D-F, Lin L-Y, Yeh H-I, Lai Y-J, Chiang F-T, Tseng C-D, Chu S-H, Tseng Y-Z |
Temporal changes in cardiac force- and flow-generation capacity, loading conditions, and mechanical efficiency in streptozotocin-induced diabetic rats |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H867 - H874 |
2-Fr Millar catheter |
rat |
diabetes; contractile function; hemodynamics; mechanical efficiency; ventriculoarterial coupling |
| Varagic J, Frohlich ED, Susic D, Ahn J, López B, Díez J |
AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure |
Am J Physiol Heart Circ Physiol, Feb 2008; 294: H853 - H858 |
Micro-Tip 3F |
rat |
left ventricular function; fibrosis; coronary circulation; angiotensi II type 1 receptor blocker |
| El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M |
Smooth Muscle Protein 22–Mediated Patchy Deletion of Bmpr1a Impairs Cardiac Contractility but Protects Against Pulmonary Vascular Remodeling |
Circulation Research. 2008;102:380. |
1.4F Millar catheter |
mouse |
Bmpr1a (Alk3) • pulmonary hypertension • hypoxia • smooth muscle cell • pericyte • transgenic mice |
| Fraccarollo D, Galuppo P, Schraut S, Kneitz S, van Rooijen N, Ertl G, Bauersachs J |
Immediate Mineralocorticoid Receptor Blockade Improves Myocardial Infarct Healing by Modulation of the Inflammatory Response |
Hypertension, Feb 2008; doi:10.1161/HYPERTENSIONAHA.107.100941 |
SPR-774 |
rat |
aldosterone • healing • inflammation • myocardial infarction • heart failure |
| Fregosi RF |
Influence of tongue muscle contraction and dynamic airway pressure on velopharyngeal volume in the rat |
J Appl Physiol, Mar 2008; 104: 682 - 693 |
nonmagnetic pressure transducer |
rat |
apnea; functional electrical stimulation; hypoglossal nerve; magnetic resonance imaging; pharynx; upper airway |
| Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, Meloni M, Escher F, Filenberg E, Demir O, Li J, Shakibaei M, Schimke I, Staudt A, Felix SB, Schultheiss H-P, De Geest B, Tschöpe C |
Human Apolipoprotein A-I Gene Transfer Reduces the Development of Experimental Diabetic Cardiomyopathy |
Circulation, Mar 2008; 117: 1563 - 1573 |
2F-tip catheter |
rat |
cardiac oxidative stress, intramyocardial inflammation, cardiac fibrosis, and cardiac apoptosis. |
| Wu M-S, Liang J-T , Lin Y-D, Wu E-T, Tseng Y-Z, Chang K-C |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes |
British Journal of Pharmacology (31 Mar 2008), doi: 10.1038/bjp.2008.119, Research Paper |
SPC-320 |
rat |
advanced glycation end products, aminoguanidine, maximal systolic elastance, theoretical maximum flow, streptozotocin–nicotinamide diabetic rats |
| Lee T-M, Chen C-C, Lin M-S, Chang N-C |
Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats |
Am J Physiol Heart Circ Physiol, Apr 2008; 294: H1871 - H1879 |
SPR-407 |
rat |
myocardial infarction; nerve growth factor; rats; sympathetic reinnervation |
| Hayashi T, Yamashita C, Matsumoto C, Kwak C-J, Fujii K, Hirata T, Miyamura M, Mori T, Ukimura A, Okada Y, Matsumura Y, Kitaura Y |
Role of gp91phox-containing NADPH oxidase in left ventricular remodeling induced by intermittent hypoxic stress |
Am J Physiol Heart Circ Physiol, May 2008; 294: H2197 - H2203 |
SPR-671 |
mouse |
oxidative stress; superoxide; cardiac hypertrophy; sleep apnea |
| Liu Y, Redetzke RA, Said S, Pottala JV, Morreale de Escobar G, Gerdes AM |
Serum thyroid hormone levels may not accurately reflect thyroid tissue levels and cardiac function in mild hypothyroidism |
Am J Physiol Heart Circ Physiol, May 2008; 294: H2137 - H2143 |
ultraminature pressure transducer catheter |
rat |
thyroidectomy; thyroxine; myocardial arterioles |
| Mito S, Ozono R, Oshima T, Yano Y, Watari Y, Yamamoto Y, Brydun A, Igarashi K, Yoshizumi M |
Myocardial Protection Against Pressure Overload in Mice Lacking Bach1, a Transcriptional Repressor of Heme Oxygenase-1 |
Hypertension, Jun 2008; 51: 1570 - 1577 |
1.4F Millar pressure catheter |
mouse |
hypertrophy • HO-1 • mice • oxidative stress • Bach1 • remodeling |
| Matsuhisa S, Otani H, Okazaki T, Yamashita K, Akita Y, Sato D, Moriguchi A, Imamura H, Iwasaka T |
Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart |
Am J Physiol Heart Circ Physiol, Jun 2008; 294: H2473 - H2479 |
2 F |
rat |
antioxidant; nitric oxide synthase |
| DeMarco VG, Habibi J, Whaley-Connell AT, Schneider RI, Heller RL, Bosanquet JP, Hayden MR, Delcour K, Cooper SA, Andresen BT, Sowers JR, Dellsperger KC |
Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat |
Am J Physiol Heart Circ Physiol, Jun 2008; 294: H2659 - H2668. |
Mikro-tip catheter |
rat |
renin; angiotensin II; NADPH oxidase |
| Yu Q, Nguyen T, Ogbi M, Caldwell RW, Johnson JA |
Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-ε inhibition |
Am J Physiol Heart Circ Physiol, Jun 2008; 294: H2637 - H2645 |
water-filled balloon-tipped Millar catheter |
rat |
preconditioning; protein kinase C; cytochrome oxidase subunit; coronary ligation; mitochondria |
| Kleiber AC, Zheng H, Schultz HD, Peuler JD, Patel KP |
Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure |
Am J Physiol Regulatory Integrative Comp Physiol, Jun 2008; 294: R1863 - R1872 |
Mikro-Tip catheter |
rat |
paraventricular nucleus; N-methyl-D-aspartic acid receptors; sympathetic nerve activity |
| Mczewski M, Mczewska J, Duda M |
Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptors |
British Journal of Pharmacology (09 Jun 2008), doi: 10.1038/bjp.2008.218 |
SPC-320 |
rat |
myocardial infarction, hypercholesterolaemia, statin, sartan, heart failure, remodelling, rat |
| Aubin M-C, Lajoie C, Clément R, Gosselin H, Calderone A, Perrault LP |
Female Rats Fed a High-Fat Diet Were Associated with Vascular Dysfunction and Cardiac Fibrosis in the Absence of Overt Obesity and Hyperlipidemia: Therapeutic Potential of Resveratrol |
J. Pharmacol. Exp. Ther. 2008 325: 961-968 |
|
|
|
| Whiteaker P, Marks MJ, Christensen S, Dowell C, Collins AC, McIntosh MJ |
Synthesis and Characterization of 125 I-α-Conotoxin ArIB[V11L;V16A], a Selective α7 Nicotinic Acetylcholine Receptor Antagonist |
J. Pharmacol. Exp. Ther. 2008 325: 910-919 |
|
mouse |
|
| Oudit G Y,Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM |
Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress |
Cardiovasc Res, 1 June 2008; 78: 505 - 514 |
1.4 French Millar catheter |
mouse |
Heart failure; Hypertrophy; Angiogenesis; Angiotensin II; Signalling |
| Cifelli C, Rose RA, Zhang H, Voigtlaender-Bolz J, Bolz S-S, Backx PH, Heximer SP |
RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node |
Circ. Res., Jul 2008; doi:10.1161/CIRCRESAHA.108.180984 |
Millar 1.4 F blood pressure catheter |
mouse |
RGS proteins • sinoatrial node • parasympathetic • GIRK channels |
| Hung T-C, oriyasu Suzuki Y, Urashima T, Caffarelli A, Hoyt G, Sheikh AY, Yeung AC, Weissman I, Robbins RC, Bulte JM, Yang PC |
Multimodality Evaluation of the Viability of Stem Cells Delivered Into Different Zones of Myocardial Infarction |
Circ Cardiovasc Imaging, Jul 2008; 1: 6 - 13 |
1.4F (0.46-mm) high-fidelity micromanometer catheter |
mouse |
heart failure • myocardial infarction • magnetic resonance imaging • stem cells, embryonic |
| Purdham DM, Rajapurohitam V, Zeidan A, Huang C, Gross GJ, Karmazyn M |
A neutralizing leptin receptor antibody mitigates hypertrophy and hemodynamic dysfunction in the postinfarcted rat heart |
Am J Physiol Heart Circ Physiol, Jul 2008; 295: H441 - H446 |
SPR-249 |
rat |
myocardial infarction; leptin receptor blockade |
| Henze M, Hart D, Samarel A, Barakat J, Eckert L, Scrogin K |
Persistent alterations in heart rate variability, baroreflex sensitivity, and anxiety-like behaviors during development of heart failure in the rat |
Am J Physiol Heart Circ Physiol, Jul 2008; 295: H29 - H38 |
SPC-320 |
rat |
telemetry; blood pressure; elevated plus maze; myocardial infarction; congestive heart failure |
| Lorenz JN, Loreaux EL, Dostanic-Larson I, Lasko V, Schnetzer JR, Paul RJ, Lingrel JB |
ACTH-induced hypertension is dependent on the ouabain-binding site of the α2-Na+-K+-ATPase subunit |
Am J Physiol Heart Circ Physiol, Jul 2008; 295: H273 - H280 |
SPR-671 |
mouse |
cardiac glycosides; telemetry; blood flow; vascular resistance; hemodynamics |
| Kang Y-M, Zhang Z-H, Xue B, Weiss RM, Felder RB |
Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure |
Am J Physiol Heart Circ Physiol, Jul 2008; 295: H227 - H236 |
1-mm micromanometer tipped catheter |
rat |
paraventricular nucleus of hypothalamus; inflammation; sympathetic nervous system; brain renin-angiotensin system; hypothalamic-pituitary-adrenal axis |
| Iemitsu M, Shimojo N, Maeda S, Irukayama-Tomobe Y, Sakai S, Ohkubo T, Tanaka Y, Miyauchi T |
The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations |
Am J Physiol Heart Circ Physiol, Jul 2008; 295: H136 - H144 |
SPC-320 |
rat |
peroxisome proliferator-activated receptor-α; CD36; c-Jun NH2-terminal kinase; myosin heavy chain; spontaneously hypertensive rats |
| Mbaki Y, Ramage AG |
Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat |
British Journal of Pharmacology (07 Jul 2008), doi: 10.1038/bjp.2008.273 |
SPR-671 |
rat |
external urethral sphincter, bladder, micturition, blood pressure, MAP, mean arterial pressure, 5-HT2A receptors, 5-HT2B receptors, 5-HT2C receptors, Ro 60-0175, mCPP, DOI |
| Maczewski M, Mackiewicz U |
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart |
Cardiovasc Res, 1 July 2008; 79: 42 - 51 |
micromanometer-tipped catheter |
rat |
Myocardial infarction; Remodelling; Calcium handling; Haemodynamics; Heart failure; Heart rate |
| Burchfield JS, Iwasaki M, Koyanagi M, Urbich C, Rosenthal N, Zeiher AM, Dimmeler S |
Interleukin-10 From Transplanted Bone Marrow Mononuclear Cells Contributes to Cardiac Protection After Myocardial Infarction |
Circ. Res., Jul 2008; 103: 203 - 211 |
micromanometer-tipped Millar catheter |
mouse |
acute myocardial infarction • remodeling • growth factors/cytokines • cell therapy |
| Tsukashita M, Marui A, Nishina T, Yoshikawa E, Kanemitsu H, Wang J, Ikeda T, Komeda M |
Spironolactone alleviates late cardiac remodeling after left ventricular restoration surgery |
J. Thorac. Cardiovasc. Surg., July 2008; 136: 58 - 64 |
micromanometer-tipped catheter |
rat |
renin-angiotensin-aldosterone system |
| Cifelli C, Rose RA, Zhang H, Voigtlaender-Bolz J, Bolz S-S, Backx PH, and Heximer SP |
RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node |
Circ. Res., Aug 2008; 103: 527 - 535 |
Millar 1.4 F blood pressure catheter |
mouse |
RGS proteins • sinoatrial node • parasympathetic • GIRK channels |
| Rensen SS, Niessen PM, van Deursen JM, Janssen BJ, Heijman E, Evelien Hermeling E, Meens M, Lie N, Gijbels MJ, Strijkers GJ, Doevendans PA, Hofker MH, De Mey JGR, van Eys GJ |
Smoothelin-B Deficiency Results in Reduced Arterial Contractility, Hypertension, and Cardiac Hypertrophy in Mice |
Circulation, Aug 2008; 118: 828 - 836 |
SPR-671 |
mouse |
actin-binding proteins |
| Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS |
Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure |
Circ. Res., Aug 2008; doi:10.1161/CIRCRESAHA.108.180778 |
1.4 Fr Millar catheter |
mouse |
arterial injury • lipids • lysophosphatidic acid • vascular remodeling • vascular smooth muscle cells |
| Hong K-H, Lee YJ, Lee E, Park SO, Han C, Beppu H, Li E, Raizada MK, Bloch KD, Oh SP |
Genetic Ablation of the Bmpr2 Gene in Pulmonary Endothelium Is Sufficient to Predispose to Pulmonary Arterial Hypertension |
Circulation, Aug 2008; 118: 722 - 730 |
SPR-835 |
mouse |
PAH |
| Song Y, Coleman L, Shi J, Beppu H, Sato K, Walsh K, Loscalzo J, Zhang Y-Y |
Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice |
Am J Physiol Heart Circ Physiol, Aug 2008; 295: H677 - H690 |
1.4-Fr Millar Mikro-Tip pressure catheter |
mouse |
heterozygous bone morphogenetic protein receptor-2 knockout mice |
| Lieber SC, Qiu H, Chen L, Shen Y-T, Hong C, Hunter WC, Aubry N, Vatner SF, Vatner DE |
Cardiac dysfunction in aging conscious rats: altered cardiac cytoskeletal proteins as a potential mechanism |
Am J Physiol Heart Circ Physiol, Aug 2008; 295: H860 - H866 |
1.4-F micromanometer |
rat |
aging cardiomyopathy; left ventricular systolic function; left ventricular diastolic function; tubulin |
| Yamazaki KG, Romero-Perez D, Barraza-Hidalgo M, Cruz M, Rivas M, Cortez-Gomez B, Ceballos G, Villarreal F |
Short- and long-term effects of (–)-epicatechin on myocardial ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Aug 2008; 295: H761 - H767 |
micromanometer, 2 French, 140 cm |
rat |
myocardial infarction; catechin; epigallocatechin; cocoa; chocolate |
| Derval N, Barandon L, Dufourcq P, Leroux L, Lamazière J-MD, Daret D, Couffinhal T, Duplàa C |
Epicardial deposition of endothelial progenitor and mesenchymal stem cells in a coated muscle patch after myocardial infarction in a murine model |
Eur. J. Cardiothorac. Surg., August 2008; 34: 248 - 254 |
1.4F Millar transducer |
mouse |
Mesenchymal stem cell • Bone marrow cells • Progenitor cells • Tissue regeneration • Engraftment • Angiogenesis |
| Willette RN, Bao W, Nerurkar S, Yue T-L, Doe CP, Stankus G, Turner GH, Ju H, Heath Thomas H, Fishman CE, Sulpizio A, Behm DJ, Hoffman S, Lin Z, Lozinskaya I, Casillas LN, Lin M, Trout REL, Votta BJ, Thorneloe K, Lashinger ESR, Figueroa DJ, Marquis R, Xu X |
Systemic Activation of the Transient Receptor Potential Vanilloid Subtype 4 Channel Causes Endothelial Failure and Circulatory Collapse: Part 2 |
J. Pharmacol. Exp. Ther. 326: 443-452 |
|
mouse, rat, dog |
circulatory collapse, microvascular congestion |
| Nagayama T , Zhang M, Hsu S, Takimoto E, Kass DA |
Sustained Soluble Guanylate Cyclase Stimulation Offsets Nitric-Oxide Synthase Inhibition to Restore Acute Cardiac Modulation by Sildenafil |
J. Pharmacol. Exp. Ther. 2008 326: 380-387 |
|
mouse |
PDE5 inhibitor |
| Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM |
Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction |
Cardiovasc Res, Advance Access published on August 27, 2008; doi: doi:10.1093/cvr/cvn198 |
Millar catheter |
mouse |
Troponin I; Ageing; Cardiac function; Hypoxia |
| Cheng Z, Ou L, Liu Y, Liu X, Li F, Sun B, Che Y, Kong D, Yu Y, Steinhoff G |
Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion |
Cardiovasc Res, Advance Access published on August 18, 2008; doi: doi:10.1093/cvr/cvn202 |
SPR-320 |
rat |
G-CSF; Myocardial infarction; Fibrosis; Infarct expansion; Remodelling |
| Copland IB, Jolicoeur EM, Gillis M-A, Cuerquis J, Eliopoulos N, Annabi B, Calderone A, Tanguay J-F, Ducharme A, Galipeau J |
Coupling erythropoietin secretion to mesenchymal stromal cells enhances their regenerative properties |
Cardiovasc Res, 1 August 2008; 79: 405 - 415 |
SPR-671 |
mouse |
Mesenchymal stromal cells; Erythropoietin; Angiogenesis; Cell therapy; Cardiovascular regeneration |
| Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS |
Lysophosphatidic Acid Receptors 1 and 2 Play Roles in Regulation of Vascular Injury Responses but Not Blood Pressure |
Circ. Res., Sep 2008; 103: 662 - 670 |
1.4 Fr Millar catheter |
mouse |
arterial injury • lipids • lysophosphatidic acid • vascular remodeling • vascular smooth muscle cells |
| Feng Y, Zhao H, Xu X, Buys ES, Raher MJ, Bopassa JC, Thibault H, Scherrer-Crosbie M, Schmidt U, Chao W |
Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice |
Am J Physiol Heart Circ Physiol, Sep 2008; 295: H1311 - H1318 |
SPR-671 |
mouse |
myocardial infarction; inflammation; echocardiography; innate immune system |
| Wang W-Z, Gao L, Wang H-J,Zucker IH, Wang W |
Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure |
Am J Physiol Heart Circ Physiol, Sep 2008; 295: H1216 - H1226 |
SPR-524 |
rat |
sympathoexcitatory reflexes; sympathetic activity; angiotensin II type 1 receptor; microinjection; extracellular recording; nucleus of tractus solitarius |
| Susic D, Zhou X, Frohlich ED, Lippton H, Knight M |
Cardiovascular effects of prorenin blockade in genetically spontaneously hypertensive rats on normal and high-salt diet |
Am J Physiol Heart Circ Physiol, Sep 2008; 295: H1117 - H1121 |
Micro-Tip 3F |
rat |
renin; prorenin inhibitor; proteinuria; left ventricular function; myocardial fibrosis |
| Urashima T, Zhao M, Wagner R, Fajardo G, Farahani S, Quertermous T, Bernstein D |
Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis |
Am J Physiol Heart Circ Physiol, Sep 2008; 295: H1351 - H1368 |
1.4 F transducer-tipped micromanometer catheter |
mouse |
gene expression; right ventricle; tetralogy of Fallot |
| J Zeller , K T Poulsen, J E Sutton, Y N Abdiche, S Collier, R Chopra, C A Garcia, J Pons, A Rosenthal, D L Shelton |
CGRP function-blocking antibodies inhibit neurogenic vasodilatation without affecting heart rate or arterial blood pressure in the rat |
British Journal of Pharmacology (08 Sep 2008), doi: 10.1038/bjp.2008.334 |
Mikro-Tip catheter |
rat |
antibody, CGRP, headache, migraine, neuropeptide, vasodilatation |
| Bidasee KR, Zheng H, Shao C-H, Parbhu SK, Rozanski GJ, Patel KP |
Exercise training initiated after the onset of diabetes preserves myocardial function: effects on expression of β-adrenoceptors |
J Appl Physiol, Sep 2008; 105: 907 - 914 |
Millar catheter |
rat |
rats; heart; streptozotocin; contractility; isoproterenol |
| Gao L, Yin H, Smith RS, Chao L,Chao J |
Role of kallistatin in prevention of cardiac remodeling after chronic myocardial infarction |
Laboratory Investigation 88, 1157 - 1166 (01 Sep 2008), doi: 10.1038/labinvest.2008.85 |
2.5 F catheter |
rat |
kallistatin, cardiac remodeling, hypertrophy, fibrosis, oxidative stress, nitric oxide, TGF-β1 |
| Moens AL, Champion HC, Claeys MJ, Tavazzi B, Kaminski PM, Wolin MS, Borgonjon DJ, Van Nassauw L, Haile A, Zviman M, Bedja D, Wuyts FL, Elsaesser RS, Cos P, Gabrielson KL, Lazzarino G, Paolocci N, Timmermans J-P, Vrints CJ, Kass DA |
High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury |
Circulation 2008;117;1810-1819 |
|
rat |
contractility folic acid ischemia infarction nitric oxide synthase reperfusion superoxide |
| Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM |
Cardiac-Specific Overexpression of Caveolin-3 Induces Endogenous Cardiac Protection by Mimicking Ischemic Preconditioning |
Circulation, Nov 2008; 118: 1979 - 1988 |
SPR-671 |
mouse |
Molecular Cardiology |
| Mueller E, Momen A, Massé S, Zhou Y-Q, Henkelman RM, Nanthakumar K, Stewart D, Husain M |
Abstract 5342: Electrical Remodeling Precedes LV Dysfunction in Endothelin-1-Induced Cardiomyopathy |
Circulation, Oct 2008; 118: S_531 |
Millar |
mouse |
Cellular/Molecular Substrates of Ventricular Arrhythmias |
| Krum H, Zhang M, Connelly K, Gilbert RE, Kelly DJ |
Abstract 315: Directly Targeting Myocardial Fibrosis with FT-011 Improves Cardiac Remodeling in Experimental Diabetic Cardiomyopathy |
Circulation, Oct 2008; 118: S_283 |
Millar cardiac catheterization |
rat |
Ventricular Remodeling |
| Brunner S, Theiss HD, Leiss M, Fischer R, Vallaster M, Huber BC, Keithahn A, Sauter M, Klingel K, Franz W-M |
Abstract 4374: G-CSF Treatment Improves Cardiac Function In postmyocarditic Cardiomyopathy By Enhanced Circulation And Homing Of CD34+ Progenitor Cell Populations |
Circulation, Oct 2008; 118: S_876. |
Millar-tip-catheter |
mouse |
Heart Failure: Pharmacologic Therapy |
| Theiss HD, Vallaster M, Brunner S, Hirsch E, David R, Zaruba M-M, Franz WM |
Abstract 1843: Combined Application Of G-csf And A Cd26-inhibitor Improves Stem Cell Homing, Cardiac Function And Survival After Myocardial Infarction In A Mouse Model |
Circulation, Oct 2008; 118: S_396 |
Millar-Tip catheter system |
mouse |
Multipotency of Progenitor Cells |
| Klein M, Schermuly RT, Ellinghaus P, Milting H, Riedl B, Nikolova S, Pullamsetti SS, Weissmann N, Dony E, Savai R, Ghofrani HA, Grimminger F, Busch AE, Schäfer S |
Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling |
Circulation, Nov 2008; 118: 2081 - 2090 |
SPR-320 |
rat |
Vascular Medicine |
| Austinat M, Braeuninger S, Pesquero JB, Brede M, Bader M, Stoll G, Renné T, Kleinschnitz C |
Blockade of Bradykinin Receptor B1 but Not Bradykinin Receptor B2 Provides Protection From Cerebral Infarction and Brain Edema |
Stroke, Nov 2008; doi:10.1161/STROKEAHA.108.526673 |
1.4-F Millar micro-tip catheter |
mouse |
bradykinin • edema • endothelin-1 • inflammation • stroke |
| Suarez J, Scott B, Dillmann, WH |
Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy |
Am J Physiol Regulatory Integrative Comp Physiol, Nov 2008; 295: R1439 - R1445 |
Millar catheter |
mouse |
transgenic mice; doxycycline; cardiac myocytes |
| Randsøe T, Kvist TM, Hyldegaard O |
Effect of oxygen and heliox breathing on air bubbles in adipose tissue during 25-kPa altitude exposures |
J Appl Physiol, Nov 2008; 105: 1492 - 1497 |
SPR-671 |
rat |
decompression sickness; preoxygenation |
| Palpant NJ, Day SM, Herron TJ, Converso KL, Metzger JM |
Single histidine-substituted cardiac troponin I confers protection from age-related systolic and diastolic dysfunction |
Cardiovasc Res, 1 November 2008; 80: 209 - 218 |
Millar catheter |
mouse |
Troponin I; Ageing; Cardiac function; Hypoxia |
| Mackiewicz U, Maczewski M, Konior A, Tellez JO, Nowis D, Dobrzynski H, Boyett MR, Lewartowski B |
Sarcolemmal Ca2+-ATPase ability to transport Ca2+ gradually diminishes after myocardial infarction in the rat |
Cardiovasc Res, Advance Access published on November 14, 2008; doi: doi:10.1093/cvr/cvn285 |
micromanometer-tipped catheter |
rat |
Sarcolemmal Ca2+-ATPase; Calcium handling; Myocardial infarction; Heart remodelling |
| Tamamori-Adachi M, Takagi H, Hashimoto K, Goto K, Hidaka T, Koshimizu U, Yamada K, Goto I, Maejima Y, Isobe M, Nakayama KI, Inomata N, Kitajima S |
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase |
Cardiovasc Res, 1 November 2008; 80: 181 - 190 |
SPC-320 |
rat |
Cardiac regeneration; Cell cycle; Mitotic proliferation; Cyclin D1; Skp2 |
| Ugurlucan M, Furlani D, Klopsch C, Steinhoff G |
eComment: Left ventricular catheterization for pressure-volume loop measurements in small laboratory animals |
Interactive CardioVascular and Thoracic Surgery, Oct 2008; 7: 927. |
0.8 or 1.1F catheters |
rat |
cannulation of both carotid arteries |
| Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, Rompe F, Sommerfeld M, Kemnitz UR, Curato C, Namsolleck P, Tschöpe C, Hallberg A, Alterman M, Hucko T, Paetsch I, Dietrich T, Schnackenburg B, Graf K, Dahlöf B, Kintscher U, Unger T, Steckelings UM |
Angiotensin II Type 2 Receptor Stimulation: A Novel Option of Therapeutic Interference With the Renin-Angiotensin System in Myocardial Infarction?
|
Circulation, Dec 2008; 118: 2523 - 2532 |
Millar catheter |
rat |
post-MI systolic and diastolic function by antiapoptotic and antiinflammatory mechanisms |
| Maizel J, Six I, Slama M, Tribouilloy C, Sevestre H, Poirot S, Giummelly P, Atkinson J, Choukroun G, Andrejak M, Kamel S, Mazière JC, Massy ZA |
Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification |
Circulation, Dec 2008; doi:10.1161/CIRCULATIONAHA.108.797407 |
Mikro-tip 1.4F pressure transducer |
mouse |
kidney failure, chronic • echocardiography • uremia |
| Kumarapeli ARK, Su H, Huang W, Tang M, Zheng H, Horak KM, Li M, Wang X |
αB-Crystallin Suppresses Pressure Overload Cardiac Hypertrophy |
Circ. Res., Dec 2008; 103: 1473 - 1482 |
SPR-835 |
mouse |
heat shock proteins • hypertrophy • nuclear factors of activated T cells (NFAT) • myocyte-enriched calcineurin interacting protein-1 (MCIP1) • fetal genes |
| Yao Y-Y, Yin H, Shen B, Smith Jr RS, Liu Y, Gao L, Chao L, Chao J |
Tissue kallikrein promotes neovascularization and improves cardiac function by the Akt-glycogen synthase kinase-3β pathway |
Cardiovasc Res, 1 December 2008; 80: 354 - 364 |
2.5 French micro-manometer |
rat |
Tissue kallikrein; Angiogenesis; Myocardial infarction; GSK-3β; VEGF |
| Cheng Z, Ou L, Liu Y, Liu X, Li F, Sun B, Che Y, Kong D, Yu Y, Steinhoff G |
Granulocyte colony-stimulating factor exacerbates cardiac fibrosis after myocardial infarction in a rat model of permanent occlusion |
Cardiovasc Res, 1 December 2008; 80: 425 - 434 |
SPR-320 |
rat |
G-CSF; Myocardial infarction; Fibrosis; Infarct expansion; Remodelling |
---------------------------------------------Published in 2007--------------------------------------------- |
| Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M, Hein L |
Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide-Gated Pacemaker Channels by Clonidine |
Circulation, Jan 2007; doi:10.1161/CIRCULATIONAHA.106.667675 |
1.4F Millar microtip device |
mouse |
receptors, adrenergic, alpha • heart rate • ion channels • pharmacology |
| Li Y, Takemura G, Okada H, Miyata S, Kanamori H, Maruyama R, Esaki M, Li L, Ogino A, Ohno T, Kondo T, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H |
ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart |
Am J Physiol Heart Circ Physiol, Feb 2007; 292: H946 - H953 |
SPR-671 |
mouse |
angiotensin II; apoptosis; granulation tissue; heart failure; myocardial infarction; myofibroblast; scar |
| Knaus A, Zong X, Beetz N, Jahns R, Lohse MJ, Biel M,Lutz Hein L |
Direct Inhibition of Cardiac Hyperpolarization-Activated Cyclic Nucleotide–Gated Pacemaker Channels by Clonidine |
Circulation, Feb 2007; 115: 872 - 880 |
1.4F Millar microtip device |
mouse |
HCN channel inhibitors |
| Sekiguchi K, Tian Q, Ishiyama M, Burchfield J, Gao F, Mann DL, Barger PM |
Inhibition of PPAR-α activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-β/Smad3 |
Am J Physiol Heart Circ Physiol, Mar 2007; 292: H1443 - H1451 |
1.4-Fr microtipped Millar catheter |
mouse |
metabolism; inflammation; genes; signal transduction |
| Zhao X, Chen Y-R, He G, Zhang A, Druhan LJ, Strauch AR, Zweier JL |
Endothelial nitric oxide synthase (NOS3) knockout decreases NOS2 induction, limiting hyperoxygenation and conferring protection in the postischemic heart |
Am J Physiol Heart Circ Physiol, Mar 2007; 292: H1541 - H1550 |
SPR-261, 1.4 Fr |
mouse |
oxygen; superoxide; peroxynitrite; mitochondria; electron paramagnetic resonance; ischemia-reperfusion |
| Hanada K, Vermeij M, Garinis GA, de Waard MC, Kunen MGS, Myers L, Maas A, Duncker DJ, Meijers C, Dietz HC, Kanaar R, Essers J |
Perturbations of Vascular Homeostasis and Aortic Valve Abnormalities in Fibulin-4 Deficient Mice |
Circ. Res., Mar 2007; 100: 738 - 746 |
SPR-671 |
mouse |
aneurysm • aortic valve • mouse |
| Hansmann G, Wagner RA, Schellong S, Perez VAdJ, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M |
Pulmonary Arterial Hypertension Is Linked to Insulin Resistance and Reversed by Peroxisome Proliferator–Activated Receptor-γ Activation |
Circulation, Mar 2007; 115: 1275 - 1284 |
1.4F |
mouse |
insulin resistance, low plasma adiponectin levels, and deficiency of apoE |
| Said SI, Hamidi SA, Dickman KG, Szema AM, Lyubsky S, Lin RZ, Jiang Y-P, Chen JJ, Waschek JA, Kort S |
Moderate Pulmonary Arterial Hypertension in Male Mice Lacking the Vasoactive Intestinal Peptide Gene |
Circulation, Mar 2007; 115: 1260 - 1268 |
1.4F 3-cm Mikro-Tip catheter |
mouse |
VIP knockout (VIP–/–) |
| Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ |
Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease With Rescue by Resynchronization |
Hypertension, Mar 2007; doi:10.1161/HYPERTENSIONAHA.106.083568 |
1.4 French catheter |
mouse |
cardiac hypertrophy • renin-angiotensin-aldosterone system pathway • remodeling • gene expression microarrays •circadian |
| Belke DD, Swanson E, Suarez J, Scott BT, Stenbit AE, Dillmann WH |
Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1755 - H1763 |
2-Fr miniature pressure transducer |
mouse |
mitochondrial calcium; pyruvate dehydrogenase; cardiac energetics; sarco(endo)plasmic reticulum calcium-adenosine 5'-triphosphatase |
| Kanamori H, Takemura H, Li Y, Okada H, Maruyama R, Aoyama T, Miyata S, Esaki M, Ogino A, Nakagawa M, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara H |
Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2184 - H2194. |
SPR-671 |
mouse |
angiotensin; apoptosis; heart failure; myocardial infarction |
| Bendall JK, Rinze R, Adlam D, Tatham AL, de Bono J, Channon KM |
Endothelial Nox2 Overexpression Potentiates Vascular Oxidative Stress and Hemodynamic Response to Angiotensin II: Studies in Endothelial-Targeted Nox2 Transgenic Mice |
Circ. Res., Apr 2007; 100: 1016 - 1025 |
Millar catheter system |
mouse |
NADPH oxidase • oxidative stress • endothelium • hemodynamics |
| Funakoshi H, Zacharia LC, Tang Z, Zhang J, Lee LL, Good JC, Herrmann DE, Higuchi Y, Koch WJ, Jackson EK, Chan TO, Feldman AM |
A1 Adenosine Receptor Upregulation Accompanies Decreasing Myocardial Adenosine Levels in Mice With Left Ventricular Dysfunction |
Circulation, May 2007; 115: 2307 - 2315 |
1.4F micromanometer catheter |
mouse |
myocardial adenosine system |
| Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ |
Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease With Rescue by Resynchronization |
Hypertension, May 2007; 49: 1104 - 1113 |
1.4 French catheter |
mouse |
cardiac hypertrophy • renin–angiotensin–aldosterone system pathway • remodeling • gene expression microarrays • circadian |
| Monden Y, Kubota T, Inoue T, Tsutsumi T, Kawano S, Ide T, Tsutsui T, Sunagawa K |
Tumor necrosis factor-α is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H743 - H753 |
1.4-Fr micromanometer-tipped catheter |
mouse |
cytokines; heart failure; remodeling; interstitial fibrosis |
| Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M |
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H620 - H627 |
SPR-671 |
mouse |
echocardiography; heart failure; hypertrophy; mice |
| Wagenseil JE, Knutsen RH, Li DY, Mecham RP |
Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H574 - H582 |
catheter |
mouse |
arterial mechanics; extracellular matrix; high blood pressure; cardiac hypertrophy; two-kidney, one-clip hypertension |
| Nakaoka Y, Nishida K, Narimatsu M, Kamiya A, Minami T, Sawa H, Okawa K, Fujio Y, Koyama T, Maeda M, Sone M, Yamasaki S, Arai Y, Koh GY, Kodama T, Hirota H, Otsu K, Hirano T, Mochizuki N |
Gab family proteins are essential for postnatal maintenance of cardiac function via neuregulin-1/ErbB signaling |
J. Clin. Invest., Jul 2007; 117: 1771 - 1781 |
1.4 French high-fidelity pressure transducer catheter |
mouse |
scaffolding adaptor proteins |
| Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, Kolm U, Metzler B, Ricci R, Hara H, Meixner A, Nghiem M, Chen X, Dawood F, Wong KM, Sarao R, Cukerman E, Kimura A, Hein L, Thalhammer J, Liu PP, Penninger JM |
Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload |
Circ. Res., Aug 2007; 101: e32 - e42 |
1.4 French Millar catheter, TCP-500 |
mouse |
aging • angiotensin • cardiac failure • cardiac function • pressure overload |
| Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S |
Soluble Guanylate Cyclase-α1 Deficiency Selectively Inhibits the Pulmonary Vasodilator Response to Nitric Oxide and Increases the Pulmonary Vascular Remodeling Response to Chronic Hypoxia |
Circulation, Aug 2007; 116: 936 - 943 |
1.4F Millar catheter |
mouse |
guanylate cyclase • nitric oxide • hypoxia • hypertension, pulmonary • remodeling |
| Huggins GS, Lepore JJ, Greytak S, Patten R, McNamee R, Aronovitz M, Wang PJ, Reed GL |
The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1877 - H1882 |
1.4-Fr Millar pressure catheter |
mouse |
adenosine 3',5'-cyclic monophosphate responsive element binding protein |
| Palmer LA, Doctor A, Chhabra P, Sheram M:,Laubach VE, Karlinsey MZ, Forbes MS, Macdonald T, Gaston B |
S-Nitrosothiols signal hypoxia-mimetic vascular pathology |
J. Clin. Invest., Sep 2007; 117: 2592 - 2601 |
Millar 1.4 F catheter/transducer |
mouse |
chronic NAC administration, pulmonary arterial hypertension |
| Khan M, Kutala VK, Vikram DS, Wisel S, Chacko SM, Kuppusamy ML, Mohan IK, Zweier JL, Kwiatkowski P, Kuppusamy P |
Skeletal myoblasts transplanted in the ischemic myocardium enhance in situ oxygenation and recovery of contractile function |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2129 - H2139 |
SPR-1000 |
mouse |
ischemic heart; myocardial infarction; electron paramagnetic resonance oximetry; OxySpin |
| Ogino A, Takemura G, Kanamori H, Okada H, Maruyama R, Miyata S, Esaki M, Nakagawa M, Aoyama T, Ushikoshi H, Kawasaki M, Minatoguchi S, Fujiwara T, Fujiwara H |
Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2271 - H2280 |
SPR 671 |
mouse |
Ca2+ channels; heart failure |
| Gendron M-E, Thorin E |
A change in the redox environment and thromboxane A2 production precede endothelial dysfunction in mice |
Am J Physiol Heart Circ Physiol, Oct 2007; 293: H2508 - H2515 |
Millar catheter |
mouse |
nitric oxide; cyclooxygenase; reactive oxygen species |
| Bostick B, Yue Y, Long C, Duan D |
Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression |
Circ. Res., Oct 2007; doi:10.1161/CIRCRESAHA.107.162982 |
closed-chest Millar catheter |
mouse |
cardiomyopathy • gene therapy • myocardium • genetics • heart disease |
| Desjardins J-F, Teichert-Kuliszewska K, Quan A, Verma S, Stewart DJ, Parker TG |
Abstract 444: Absence of S100A1 in Mice is Associated With a Hypertensive Phenotype Dependent on Both Gender and Endothelial Function |
Circulation, Oct 2007; 116: II_74 |
Millar catheter |
mouse |
cardiac muscle Ca2+ homeostasis |
| Partovian C, Zhuang ZW, Martin KA, Simons M |
Abstract 326: Syndecan-4 Knockout Mice Exhibit Decreased eNOS Activity And Increased Blood Pressure Via Disruption Of mTOR Complex Assembly In Raft Domains |
Circulation, Oct 2007; 116: II_47 |
Millar transducer |
mouse |
eNOS activity and angiogenesis |
| Horstkotte J, Lange P, Schroeder M, Schneider M, Perisic T, Hinkel R, Kiermayer C, Brielmeier M, Boekstegers P, Markus C, Kupatt C |
Abstract 1010: Endogenous Mitochondrial, But Not Cytosolic Thioredoxin Reductase Protects Against Myocardial Ischemia-reperfusion Injury |
Circulation, Oct 2007; 116: II_201 |
Millar tip catheter |
mouse |
protective ROS-scavenging, knock-out mouse |
| Farahmand P, Weisel RD, Menasche P, Li R-K |
Abstract 2673: Myoblast Transplantation Improves Cardiac Function Whether the Cells are Implanted Early or Late After Coronary Ligation |
Circulation, Oct 2007; 116: II_592 |
Millar catheter |
rat |
myocardial infarction |
| Iwasaki M, Koyanagi M, Rapp S, Schuetz C, Bushoven P, Schranz D, Galvez BG, Cossu G, Zeiher AM, Urbich C, Dimmeler S |
Abstract 855: Circulating Mesoangioblasts Differentiate Into Cardiac Myocytes And Improve Function After Acute Myocardial Infarction |
Circulation, Oct 2007; 116: II_166 |
Millar catheter |
mouse |
Cardiac Regeneration/Cellular Therapy-Experimental: Stem Cell Origin and Myocardial Homing, nude mouse |
| Tang YL, Shen L, Qian K, Phillips MI |
Abstract 859: Hypoxia-activated CXCR4 Expression In Cardiac Progenitor Cells For Replenishing Stem Cell Pool In Acute Ischemic Myocardium |
Circulation, Oct 2007; 116: II_167 |
Millar catheter |
mouse |
Cardiac Regeneration/Cellular Therapy-Experimental: Stem Cell Origin and Myocardial Homing |
| Urashima T, Zhao M, Wagner R, Fajardo G, Farahani S, Quertermous T, Bernstein D |
Abstract 3129: Molecular and Physiologic Characterization of RV Remodeling and Failure in a Murine Model of Mild, Moderate and Severe Pulmonary Stenosis |
Circulation, Oct 2007; 116: II_702 |
Millar catheter |
mouse |
Mechanical Regulation of the Right Side of the Heart in Congenital Heart Disease: Influence of Age and Hemodynamic Load |
| Rozenman Y, Brandt MC, Vanderheyden M, Wijns W, Sievert H, Tobar R, Hoppe UC |
Abstract 3278: Noninvasive Home Monitoring of Pulmonary Artery Pressure by the RemonCHF Device: First Multicenter Experience |
Circulation, Oct 2007; 116: II_738 |
Millar catheter |
human |
CHF, heart failure |
| Diwan A, Krenz M, Syed FM, Wansapura J, Ren X, Koesters AG, Li H, Kirshenbaum LA, Hahn HS, Robbins J, Jones WK, Dorn II GW |
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice |
J. Clin. Invest., Oct 2007; 117: 2825 - 2833 |
1.4 French Millar solid-state catheters |
mouse |
proapoptotic gene |
| Sartório CL, Fraccarollo D, Galuppo P, Leutke M, Ertl G, Stefanon I, Bauersachs J |
Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction |
Hypertension, Nov 2007; 50: 919 - 925 |
micromanometer |
rat |
aldosterone • acute myocardial infarction • endothelial dysfunction • oxidative stress |
| Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, Molkentin JD |
Inducible and myocyte-specific inhibition of PKC enhances cardiac contractility and protects against infarction-induced heart failure |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3768 - H3771 |
1.4 F Millar catheter |
mouse |
protein kinase C; signaling; myocardial infarction |
| El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M |
Smooth Muscle Protein 22–Mediated Patchy Deletion of Bmpr1a Impairs Cardiac Contractility but Protects Against Pulmonary Vascular Remodeling |
Circ. Res., Dec 2007; doi:10.1161/CIRCRESAHA.107.161059 |
1.4F Millar catheter |
mouse |
Bmpr1a (Alk3) • pulmonary hypertension • hypoxia • vascular remodeling • smooth muscle cell • pericytes • proliferation • apoptosis • transgenic mice |
| Rose RA,Kabir MG, Backx PH |
Altered Heart Rate and Sinoatrial Node Function in Mice Lacking the cAMP Regulator Phosphoinositide 3-Kinase-g |
Circ. Res., Dec 2007; 101: 1274 - 1282. |
pressure catheter |
mouse |
ion channels • electrophysiology • action potentials • arrhythmia |
| Li L, Takemura G, Li Y, Miyata S, Esaki M, Okada H, Kanamori H, Ogino A, Maruyama R, Nakagawa M, Minatoguchi S, Fujiwara T, Fujiwara H, Takemura G |
Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy |
Laboratory Investigation 87, 440 - 455 (05 Mar 2007) |
SPR 671 |
mouse |
cardiomyopathy, cytokines, doxorubicin, ERK, G-CSF, heart failure |
| Sanbe A, Tanaka Y, Fujiwara Y, Tsumura H, Yamauchi J, Cotecchia S, Koike K, Tsujimoto G, Tanoue A |
α1-Adrenoceptors are required for normal male sexual function |
British Journal of Pharmacology 152, 332 - 340 (01 Oct 2007) |
SPR-671 |
mouse |
α1-Adrenoceptor, ejaculation, vas deferens |
| Johns, DG Behm DJ, Walker DJ, Ao Z, Shapland EM, Daniels DA, Riddick M, Dowell S, Staton PC, Green P, Shabon U, Bao W, Aiyar N, Yue T-L, Brown AJ, Morrison AD, Douglas SA |
The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects |
British Journal of Pharmacology 152, 825 - 831 (20 Aug 2007) |
SPR-671 |
mouse |
GPR55, cannabinoid receptors, abnormal cannabidiol, CBx receptor |
| Reddy MK, Schultz HD, Zheng H, Patel KP |
Altered nitric oxide mechanism within the paraventricular nucleus contributes to the augmented carotid body chemoreflex in heart failure |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H149 - H157 |
2-Fr micromanometer-tipped catheter |
rat |
renal sympathetic nerve activity; phrenic nerve activity; hypothalamus |
| Susic D, Varagic J, Ahn J, Matavelli L, Frohlich ED |
Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR |
Am J Physiol Heart Circ Physiol, Jan 2007; 292: H175 - H179 |
catheter-tip transducer |
rat |
aldosterone; myocardial fibrosis; left ventricular diastolic function; minimal vascular resistance; antihypertensive/diuretics |
| Pan Y-X, Gao L, Wang W-Z, Zheng H, Liu D, Patel KP, Zucker IH, Wang W |
Exercise Training Prevents Arterial Baroreflex Dysfunction in Rats Treated With Central Angiotensin II |
Hypertension, Jan 2007; doi:10.1161/01.HYP.0000256955.74461.93 |
SPR-524 |
rat |
exercise • baroreflex • sympathetic nerve activity • reactive oxygen species • AT1 receptor |
| Li J, Gao Z, Kehoe V, Sinoway LI |
Interstitial K+ concentration in active muscle after myocardial infarction |
Am J Physiol Heart Circ Physiol, Feb 2007; 292: H808 - H813 |
2-Fr microMillar pressure transducer catheter |
rat |
sympathetic nervous system; exercise; blood flow |
| Gao Z, Xing J, Sinoway L, Li J |
P2X receptor-mediated muscle pressor reflex in myocardial infarction |
Am J Physiol Heart Circ Physiol, Feb 2007; 292: H939 - H945 |
Millar catheter |
rat |
exercise; blood pressure; sympathetic nervous system; dorsal root ganglion; heart failure |
| Rennison JH, McElfresh TA, Okere IC, Vazquez EJ, Patel HV, Foster AB, Patel KK, Chen Q, Hoit BD, Tserng K-Y, Hassan MO, Hoppel CL, Chandler MP |
High-fat diet postinfarction enhances mitochondrial function and does not exacerbate left ventricular dysfunction |
Am J Physiol Heart Circ Physiol, Mar 2007; 292: H1498 - H1506 |
3.5 Fr |
rat |
oxidative phosphorylation; electron transport chain; ceramide; lipotoxicity |
| Helwig BG, Musch TI, Craig RA, Kenney MJ |
Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure |
Am J Physiol Regulatory Integrative Comp Physiol, Mar 2007; 292: R1165 - R1173. |
2-Fr catheter-tip pressure manometer |
rat |
signal transduction; gp130; hypothalamic-pituitary axis |
| Sethi R, Saini HK, Wang X, Elimban V, Dhalla NS |
Dependence of changes in β-adrenoceptor signal transduction on type and stage of cardiac hypertrophy |
J Appl Physiol, Mar 2007; 102: 978 - 984 |
SPR-249 |
rat |
pressure overload; volume overload; cardiac function; β-adrenoceptors; adenylyl cyclase; intracellular calcium concentr |
| Pan Y-X, Gao L, Wang W-Z, Zheng H, Liu D, Patel KP, Zucker IH, Wang W |
Exercise Training Prevents Arterial Baroreflex Dysfunction in Rats Treated With Central Angiotensin I |
Hypertension, Mar 2007; 49: 519 - 527 |
SPR-524 |
rat |
exercise • baroreflex • sympathetic nerve activity • reactive oxygen species • AT1 receptor |
| Milano G, Morel S, Bonny C, Samaja M, von Segesser LK, Nicod P, Vassalli G |
A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo |
Am J Physiol Heart Circ Physiol, Apr 2007; 292: H1828 - H1835 |
MPC-500 |
rat |
myocardium; mitogen-activated protein kinases; apoptosis; isolated |
| Simpson JA, Iscoe S |
Cardiorespiratory failure in rat induced by severe inspiratory resistive loading |
J Appl Physiol, Apr 2007; 102: 1556 - 1564 |
SPR 524 |
rat |
diaphragm; fatigue; heart; injury; troponin |
| Cosson E, Herisse M, Laude E, Thomas F, Valensi P, Attali J-R, Safar ME, Dabire H |
Aortic stiffness and pulse pressure amplification in Wistar-Kyoto and spontaneously hypertensive rats |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2506 - H2512 |
SPR-330 |
rat |
pulse wave velocity; body weight; conscious rat; autonomic nervous system |
| Garg P, Martin CF, Elms SC, Gordon FJ, Wall SM, Garland CJ, Sutliff RL, O'Neill WC |
Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2100 - H2105 |
SPR-671 |
rat |
resistance arteries; hypertension; bumetanide |
| Chicco AJ, Johnson MS, Armstrong CJ, Lynch JM, Gardner RT, Fasen GS, Gillenwater CP, Moore RL |
Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart |
Am J Physiol Heart Circ Physiol, May 2007; 292: H2432 - H2437 |
3-Fr pressure-transducing catheter |
rat |
ischemia; infarction; sex differences; gender |
| Gao E, Boucher M, Chuprun JK, Zhou R-H, Eckhart AD, Koch WJ |
Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H60 - H68 |
2-Fr micromanometer |
rat |
myocardial ischemia; ischemia-reperfusion injury; apoptosis |
| van Hees HWH, van der Heijden HFM, Ottenheijm CAC, Heunks LMA, Pigmans CJC, Verheugt FWA, Brouwer RMHJ, Dekhuijzen PNR |
Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats |
Am J Physiol Heart Circ Physiol, Jul 2007; 293: H819 - H828 |
SPC-330 |
rat |
skinned muscle single fibers; cross-bridge cycling kinetics; Ca2+ sensitivity; proteasome; caspase-3 |
| Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K |
Adenoassociated Virus-Mediated Prostacyclin Synthase Expression Prevents Pulmonary Arterial Hypertension in Rats |
Hypertension, Jul 2007; doi:10.1161/HYPERTENSIONAHA.107.091348 |
SPC-320 |
rat |
hypertension • pulmonary • gene therapy • remodeling • prostacyclin synthase |
| Henkens IR, Mouchaers KTB, Vliegen HW, van der Laarse WJ, Swenne CA, Maan AC, Draisma HHM, Schalij I, van der Wall EE, Schalij MJ, Vonk-Noordegraaf A |
Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional electrocardiography |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1300 - H1307 |
Millar pressure catheter |
rat |
right ventricular hypertrophy; monocrotaline; electrocardiogram |
| Lee T-M, Lin M-S, Chang N-C |
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H968 - H977 |
SPR-407 |
rat |
hypertrophy; infarction |
| Xing J, Koba S, Kehoe V, Gao Z, Rice K, King N, Sinoway L, Li J |
Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1190 - H1195 |
2-Fr micro-Millar pressure transducer catheter |
rat |
nervous system; sympathetic; exercise; blood flow |
| Yamamoto T, Shirayama T, Sakatani T, Takahashi T, Tanaka H, Takamatsu T, Spitzer KW, Matsubara H |
Enhanced activity of ventricular Na+-HCO3– cotransport in pressure overload hypertrophy |
Am J Physiol Heart Circ Physiol, Aug 2007; 293: H1254 - H1264 |
Microtip catheter |
rat |
cardiac myocytes; intracellular pH regulation; messenger ribonucleic acid; polymerase chain reaction |
| Schultz RL, Swallow JG, Waters RP, Kuzman JA, Redetzke RA, Said S, de Escobar GM, Gerdes AM |
Effects of Excessive Long-Term Exercise on Cardiac Function and Myocyte Remodeling in Hypertensive Heart Failure Rats |
Hypertension, Jun 2007; doi:10.1161/HYPERTENSIONAHA.106.086371 |
Millar Mikro-tip catheter |
rat |
hypertension • heart failure • exercise • hypertrophy • myocytes • voluntary wheel running • SHHF |
| Ito T, Okada T, Miyashita H, Nomoto T, Nonaka-Sarukawa M, Uchibori R, Maeda Y, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Shimada K, Ozawa K |
Interleukin-10 Expression Mediated by an Adeno-Associated Virus Vector Prevents Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats |
Circ. Res., Aug 2007; doi:10.1161/CIRCRESAHA.107.153023 |
SPC-320 |
rat |
pulmonary hypertension • interleukins • gene therapy • inflammation • vascular smooth muscle cell proliferation |
| Chandler MP, Morgan EE, McElfresh TA, Kung TA, Rennison JH, Hoit BD, Young ME |
Heart failure progression is accelerated following myocardial infarction in type 2 diabetic rats |
Am J Physiol Heart Circ Physiol, Sep 2007; 293: H1609 - H1616 |
3.5-Fr pressure transducer |
rat |
contractile function; left ventricular remodeling; gene expression |
| Yildirim Y, Naito H, Didié M, Karikkineth BC, Biermann D, Eschenhagen T, Zimmermann W-H |
Development of a Biological Ventricular Assist Device: Preliminary Data From a Small Animal Model |
Circulation, Sep 2007; 116: I-16 - I-23 |
Millar-tip catheter |
rat |
tissue engineering • myocardium • cardiomyocyte • regeneration • transplantation |
| Sartório CL, Fraccarollo D, Galuppo P, Leutke M, Ertl G, Stefanon I, Bauersachs J |
Mineralocorticoid Receptor Blockade Improves Vasomotor Dysfunction and Vascular Oxidative Stress Early After Myocardial Infarction |
Hypertension, Sep 2007; doi:10.1161/HYPERTENSIONAHA.107.093450 |
micromanometer |
rat |
aldosterone • acute myocardial infarction • endothelial dysfunction • oxidative stress |
| Ito T, Okada T, Mimuro J, Miyashita H, Uchibori R, Urabe M, Mizukami H, Kume A, Takahashi M, Ikeda U, Sakata Y, Shimada K, Ozawa K |
Adenoassociated Virus–Mediated Prostacyclin Synthase Expression Prevents Pulmonary Arterial Hypertension in Rats |
Hypertension, Sep 2007; 50: 531 - 536 |
SPC-320 |
rat |
hypertension • pulmonary • gene therapy • remodeling • prostacyclin synthase |
| Farahmand P, Weisel RD, Menasche P, Li R-K |
Abstract 2673: Myoblast Transplantation Improves Cardiac Function Whether the Cells are Implanted Early or Late After Coronary Ligation |
Circulation, Oct 2007; 116: II_592 |
Millar catheter |
rat |
myocardial infarction |
| Behnke BJ, Delp MD, Poole DC, Musch TI |
Aging potentiates the effect of congestive heart failure on muscle microvascular oxygenation |
J Appl Physiol, Nov 2007; 103: 1757 - 1763 |
2-Fr catheter-tip pressure manometer |
rat |
heart failure; skeletal muscle; oxygen exchange |
| Chen-Izu Y, Chen L, Bányász T, McCulle SL, Norton B, Scharf SM, Agarwal A, Patwardhan A, zu LT, Balke CW |
Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3301 - H3310 |
SPR-249A, SPR-671 |
rat |
heart failure; action potential; L-type Ca2+ channel; ryanodine receptor |
| Lee T-M, Lin M-S, Chang N-C |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3617 - H3626 |
SPR-407 |
rat |
immunohistochemistry; ion channels; myocardial infarction; norepinephrine; polymerase chain reaction |
| Hydock DS, Lien C-Y, Schneider CM, Hayward R |
Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats |
Am J Physiol Heart Circ Physiol, Dec 2007; 293: H3254 - H3264 |
SPR-671 |
rat |
echocardiography; myosin heavy chain; orchiectomy; ovariectomy; sex hormones |
| Chang K-C, Liang J-T, Tseng C-D, Wu E-T, Hsu K-L, Wu M-S, Lin Y-T, Tseng Y-Z |
Aminoguanidine prevents fructose-induced deterioration in left ventricular?arterial coupling in Wistar rats |
British Journal of Pharmacology 151, 341 - 346 (02 Apr 2007) |
SPC-320 |
rat |
aminoguanidine, effective arterial volume elastance, fructose loading, end-systolic elastance, ventricular–arterial coupling |
| Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W |
Left ventricular pressure-volume relationship in conscious mice |
Am J Physiol Heart Circ Physiol 292:369-377, 2007. |
SPR-719 |
mouse |
ventricular function; mouse physiology |
| |
---------------------------------------------Published in 2006--------------------------------------------- |
| Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R |
Apoptosis Repressor With Caspase Recruitment Domain Is Required for Cardioprotection in Response to Biomechanical and Ischemic Stress |
Circulation, Mar 2006; 113: 1203 - 1212 |
high-fidelity catheter tip transducer, 1.4F |
mouse |
apoptosis, heart failure, hypertophy, ischemia, myocardial infarction |
| Peng X, Kraus MS, Wei H, Shen T-L, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan J-L |
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice |
J Clin Invest. 2006 January 4; 116(1): 217–227 |
1.4-F Millar catheter–tip micromanometer catheter |
mouse |
cytoplasmic tyrosine kinase, CFKO |
| Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA |
Soy diet worsens heart disease in mice |
J. Clin. Invest. 116:209-216 (2006). |
1.4-fr Millar Mikro-tip pressure transducer |
mouse |
glycogen synthase kinase 3ß, caspase-3 activation, fibrosis, ß-myosin heavy chain, hypertrophic cardiomyopathy |
| Lindsey ML, Escobar GP, Dobrucki LW, Goshorn DK, Bouges S, Mingoia JT, McClister Jr DM, Su H, Gannon J, MacGillivray C, Lee RT, Sinusas AJ, Spinale FG |
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction |
Am J Physiol Heart Circ Physiol, Jan 2006; 290: H232 - H239 |
SPR-671 |
mouse |
leukocytes; remodeling; imaging |
| Li Y, Takemura G, Okada H, Miyata S, Esaki M, Maruyama R, Kanamori H, Li L, Ogino A, Misao Y, Khai NC, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H |
Treatment with granulocyte colony-stimulating factor ameliorates chronic heart failure |
Laboratory Investigation 86, 32-44 (01 Jan 2006) |
SPR-407 |
mouse |
chronic heart failure; cytokines; G-CSF; remodeling; signal transduction |
| Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD |
GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation |
Circ. Res., Feb 2006; 98: 342 - 350 |
1.4F Millar catheter |
mouse |
cardiac • signaling • hypertrophy • growth factors • mouse genetics |
| Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, . Wollert KC |
The Transforming Growth Factor-ß Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury |
Circ. Res., Feb 2006; 98: 351 - 360 |
1.4 F Millar catheter |
mouse |
growth-differentiation factor-15 • ischemia/reperfusion • apoptosis • PI3K • Akt |
| Fitch RM, Rutledge JC, Wang Y-X, Powers AF, Tseng J-L, Clary T, Rubanyi GM |
Synergistic effect of angiotensin II and nitric oxide synthase inhibitor in increasing aortic stiffness in mice |
Am J Physiol Heart Circ Physiol, Mar 2006; 290: H1190 - H1198 |
1.4-Fr Millar Mikrotip pressure transducer |
mouse |
blood pressure; vascular smooth muscle; collagen; elastin; Nω-nitro-L-arginine methyl ester |
| Kakkar R, Ye B, Stoller DA, Smelley M, Shi N-Q, Galles K, Hadhazy M, Makielski JC, McNally EM |
Spontaneous Coronary Vasospasm in KATP Mutant Mice Arises From a Smooth Muscle–Extrinsic Process |
Circ. Res., Mar 2006; 98: 682 - 689 |
pressure-sensing catheter |
mouse |
KATP channel • sulfonylurea receptor • vasospasm • smooth muscle |
| Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R |
Apoptosis Repressor With Caspase Recruitment Domain Is Required for Cardioprotection in Response to Biomechanical and Ischemic Stress |
Circulation, Mar 2006; 113: 1203 - 1212 |
1.4F |
mouse |
ARC, tissue-specific antiapoptotic factor |
| Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim I-H, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld A-J, Collen D, Busse R, Janssens S |
Cytochrome P450 Epoxygenase Gene Function in Hypoxic Pulmonary Vasoconstriction and Pulmonary Vascular Remodeling |
Hypertension, Apr 2006; 47: 762 - 770 |
1.4F Millar catheter |
mouse |
endothelium-derived factors • arachidonic acids • endothelium-derived factors • lung • remodeling |
| Matsushima S, Ide T, Yamato M, Matsusaka H, Hattori F, Ikeuchi M, Kubota T, Sunagawa K, Hasegawa Y, Kurihara T, Oikawa S, Kinugawa S, Tsutsui H |
Overexpression of Mitochondrial Peroxiredoxin-3 Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice |
Circulation, Apr 2006; 113: 1779 - 1786 |
Millar catheter (1.4 F) |
mouse |
myocyte hypertrophy, interstitial fibrosis, apoptosis |
| Yamamoto K, Ohishi M, Katsuya T, Ito N, Ikushima M, Kaibe M, Tatara Y, Shiota A, Sugano S, Takeda S, Rakugi H, Ogihara T |
Deletion of Angiotensin-Converting Enzyme 2 Accelerates Pressure Overload-Induced Cardiac Dysfunction by Increasing Local Angiotensin II |
Hypertension, Apr 2006; 47: 718 - 726 |
micro-tip catheter |
mouse |
hypertrophy • remodeling • angiotensin antagonist • receptors, angiotensin |
| Matsusaka H, Ide T, Matsushima S, Ikeuchi M, Kubota T, Sunagawa K, Kinugawa S, Tsutsui H |
Targeted Deletion of Matrix Metalloproteinase 2 Ameliorates Myocardial Remodeling in Mice With Chronic Pressure Overload |
Hypertension, Apr 2006; 47: 711 - 717 |
1.4-Fr micromanometer-tipped catheter |
mouse |
hypertrophy • heart failure • fibrosis • extracellular matrix • hypertension, experimental • myocardium |
| Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS |
Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin |
J. Clin. Invest., May 2006; 116: 1337 - 1345 |
Millar 1.4 French blood pressure probe and transducer |
mouse |
FSGS, end-stage renal disease |
| MacGowan GA, Kirk JA, Evans C, Shroff SG |
Pressure-calcium relationships in perfused mouse hearts |
Am J Physiol Heart Circ Physiol, Jun 2006; 290: H2614 - H2624 |
MPC-500 |
mouse |
murine heart; length-dependent activation; load-dependent relaxation; excitation-contraction coupling; model-based analysis |
| Okere IC, MChandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, Tserng K-Y, Hoit BD, Ernsberger P, Young ME, Stanley WC |
Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H38 - H44 |
3.5-Fr pressure transducer |
mouse |
myocardial infarction; cardiac injury; murine model |
| Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M |
Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H379 - H384 |
SPR-671 |
mouse |
myocardial infarction; cardiac injury; murine model |
| Rodriguez WE,Joshua IG, Falcone JC, Tyagi SC |
Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H81 - H87 |
pressure-tipped Millar catheter |
mouse |
endothelial myocyte coupling; nitric oxide; matrix metalloproteinase; homocysteine; heart failure; acetylcholine; nitroprusside; cardiac rings; peroxisome proliferator |
| Kuhlencordt PJ, Hötten S, Schödel J, Rützel S, Hu K, Widder J, Marx A, Huang PL, Ertl G |
Atheroprotective Effects of Neuronal Nitric Oxide Synthase in Apolipoprotein E Knockout Mice |
Arterioscler. Thromb. Vasc. Biol., Jul 2006; 26: 1539 - 1544 |
1.4 F |
mouse |
nitric oxide • nitric oxide synthase • arteriosclerosis • blood pressure • gene expression |
| Larsen K-O, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G |
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H507 - H516 |
SPR-671 |
mouse |
diastole; calcium; echocardiography |
| Neilan TG, Doherty GA, Chen G, Deflandre C, McAllister H, Butler RK, McClelland SE, Kay E, Ballou LR, Fitzgerald DJ |
Disruption of COX-2 modulates gene expression and the cardiac injury response to doxorubicin |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H532 - H536 |
SPR-671, ARIA pressure conductance system |
mouse |
apoptosis; cyclooxygenase |
| Zhou H_Z, Swanson RA, Simonis U, Ma X, Cecchini G, Gray MO |
Poly(ADP-ribose) polymerase-1 hyperactivation and impairment of mitochondrial respiratory chain complex I function in reperfused mouse hearts |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H714 - H723 |
micromanometer catheter |
mouse |
oxidative stress; energetics; metabolism; glycolysis |
| Tong XY, Porter LM, Liu GX, Dhar-Chowdhury P, Srivastava S, Pountney DJ, Yoshida H, Artman M, Fishman GI, Yu C, Iyer R, Morley GE, Gutstein DE, Coetzee WA |
Consequences of cardiac myocyte-specific ablation of KATP channels in transgenic mice expressing dominant negative Kir6 subunits |
Am J Physiol Heart Circ Physiol, Aug 2006; 291: H543 - H551 |
1.4F Mikro-Tip catheter pressure transducer |
mouse |
potassium channels; ATP-sensitive K+ channel; heart; ventricle; stress responses |
| Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, Kimball TF, Hewett TE, Dorn II GW, Koch WJ, Molkentin JD |
Pharmacological- and Gene Therapy-Based Inhibition of Protein Kinase Cα/ß Enhances Cardiac Contractility and Attenuates Heart Failure |
Circulation, Aug 2006; 114: 574 - 582 |
1.4F Millar catheter |
mouse |
Ro-32-0432, Ro-31-8220 |
| Kawano S, Kubota T, Monden Y, Tsutsumi T,Inoue T, Kawamura N, Tsutsui T, Sunagawa K |
Blockade of NF-κB improves cardiac function and survival after myocardial infarction |
Am J Physiol Heart Circ Physiol, Sep 2006; 291: H1337 - H1344 |
1.4-F micromanometer-tipped catheter |
mouse |
cardiac remodeling; inflammation; mitogen-activated protein kinases |
| Sheikh F, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard J-C, Chen J |
α-E-Catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction, Resulting in Cardiomyopathy and Susceptibility to Wall Rupture |
Circulation, Sep 2006; 114: 1046 - 1055 |
1.4F Millar catheter-tip micromanometer catheter |
mouse |
cardiomyocyte |
| Matsushima S, Kinugawa S, Ide T, Matsusaka H, Inoue N, Ohta Y, Yokota T, Sunagawa L, Tsutsui H |
Overexpression of glutathione peroxidase attenuates myocardial remodeling and preserves diastolic function in diabetic heart |
Am J Physiol Heart Circ Physiol, Nov 2006; 291: H2237 - H2245 |
1.4-Fr micromanometer-tipped catheter |
mouse |
oxidative stress; diabetes mellitus; heart failure; antioxidant; hypertrophy; glutathione peroxidase |
| Weiss RM, Ohashi M, Miller JD, Young SG, Heistad DD |
Calcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice |
Circulation, Nov 2006; 114: 2065 - 2069 |
1.4F microtransducer-tipped catheter |
mouse |
calcification and oxidative stress in the aortic valve |
| Belke DD, Gloss B, Hollander JM, Swanson EA, Duplain H, Dillmann WH |
n vivo gene delivery of HSP70i by adenovirus and adeno-associated virus preserves contractile function in mouse heart following ischemia-reperfusion |
Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2905 - H2910 |
2-Fr Millar pressure transducer |
mouse |
inducible heat shock protein 70; left ventricle |
| Bloch O, Auguste KI, Manley GT, Verkman AS |
Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice |
Journal of Cerebral Blood Flow & Metabolism 26, 1527 - 1537 |
SPR-320, TC-510 |
mouse |
AQP4, blood–brain barrier, hydrocephalus, interstitial edema, water channel |
| Sakamoto M, Minamino M, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I |
Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy |
Circ. Res., Dec 2006; 99: 1411 - 1418 |
polyethylene catheter |
mouse |
pressure overload • exercise • heart failure |
| Vercauteren M, Remy E, Devaux C, Dautreaux B, Henry J-P, Bauer F, Mulder P, van Huijsduijnen RH, Bombrun A, Thuillez C, Richard V |
Improvement of Peripheral Endothelial Dysfunction by Protein Tyrosine Phosphatase Inhibitors in Heart Failure |
Circulation, Dec 2006; 114: 2498 - 2507 |
1.2F micromanometer |
mouse |
Chronic heart failure |
| Krummen S, Drouin A, Gendron M-E, Falck JR, Thorin E |
ROS-sensitive cytochrome P450 activity maintains endothelial dilatation in ageing but is transitory in dyslipidaemic mice |
British Journal of Pharmacology 147, 897 - 904 (01 Apr 2006) |
Millar catheter |
mouse |
Endothelium, gracilis artery, EDHF, hypercholesterolaemia, triglycerides, ageing, reactive oxygen species, mouse |
| Zhou H, Liu H, Porvasnik SL, Terada N, Agarwal A, Cheng Y, Visner GA |
Heme oxygenase-1 mediates the protective effects of rapamycin in monocrotaline-induced pulmonary hypertension |
Laboratory Investigation (2006) 86, 62-71 |
Millar catheter |
rat |
animal model; aorta; heme oxygenase; monocrotaline; pulmonary hypertension; rapamycin |
| Hacker TA, McKiernan SH, Douglas PS, Wanagat J, Aiken JM |
Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats |
Am J Physiol Heart Circ Physiol, Jan 2006; 290: H304 - H311 |
2-French micromanometer-tipped catheter |
rat |
hybrid rat; echocardiography |
| Souzeau E, Llamas B, Bélanger S, Picard S, Deschepper CF |
A Genetic Locus Accentuates the Effect of Volume Overload on Adverse Left Ventricular Remodeling in Male and Female Rats |
Hypertension, Jan 2006; 47: 128 - 133 |
2-F single sensor pressure catheter |
rat |
hypertrophy • myocardium • myocytes • heart failure • genetics • gender • natriuretic peptides |
| Chicco AJ, Hydock DS, Schneider CM, Hayward R |
Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity |
J Appl Physiol, Feb 2006; 100: 519 - 527 |
microtip catheter pressure transducer |
rat |
adriamycin; apoptosis; physical activity; cardioprotection; myosin heavy chain |
| Burgoyne JR, Brennan JP, Eaton P |
BSCR AUTUMN MEETING 2005, 001 STUDIES ASSESSING PROTEIN S-NITROSYLATION IN THE RAT HEART |
Heart, Feb 2006; 92: e1 |
1.4 F Millar catheter |
rat |
S-nitrosylated proteins |
| Ha T, Hua F, Li Y, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C |
Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo |
Am J Physiol Heart Circ Physiol, Mar 2006; 290: H985 - H994 |
microconductance pressure catheter |
rat |
dominant negative myeloid differentiation factor-88; nuclear factor-κB; signal transduction |
| Kennedy DJ, Vetteth S, Periyasamy SM, Kanj M, Fedorova L, Khouri S, Kahaleh MB, Xie Z, Malhotra D, Kolodkin NI, Lakatta EG, Fedorova OV, Bagrov AY, Shapiro JI |
Central Role for the Cardiotonic Steroid Marinobufagenin in the Pathogenesis of Experimental Uremic Cardiomyopathy |
Hypertension, Mar 2006; 47: 488 - 495 |
2F Millar Microtip Catheter |
rat |
cardiomyopathy • sarcoplasmic reticulum • cardiotonic agents • fibrosis • renal failure • reactive oxygen species |
| Schellings MWM, Baumann M, van Leeuwen REW, Duisters RFJJ, Janssen SHP, Schroen B, Peutz-Kootstra CJ, Heymans S, Pinto YM |
Imatinib Attenuates End-Organ Damage in Hypertensive Homozygous TGR(mRen2)27 Rats |
Hypertension, Mar 2006; 47: 467 - 474 |
2F Millar microtip catheter |
rat |
platelet-derived growth factor • angiotensin II • hypertrophy • fibrosis |
| Varagic J, Frohlich ED, Díez J, Susic D, Ahn J, González A, López B |
Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR |
Am J Physiol Heart Circ Physiol, Apr 2006; 290: H1503 - H1509 |
Micro-Tip 3F |
rat |
sodium excess; left and right ventricular function; spontaneously hypertensive rats; Wistar-Kyoto rats |
| Frank Langer , Filiberto Rodriguez, Allen Cheng, Saskia Ortiz, Tom C. Nguyen, Mary K. Zasio, David Liang, George T. Daughters, Neil B. Ingels, and D. Craig Miller |
Homing of intravenously infused embryonic stem cell-derived cells to injured hearts after myocardial infarction |
J. Thorac. Cardiovasc. Surg., Apr 2006; 131: 889 - 897 |
Millar catheter |
rat |
Ventricular function, regional blood flow, and arteriole density |
| Morgan EE, Rennison JH, Young ME, McElfresh TA, Kung TA, Tserng K-Y, Hoit BD, Stanley WC, Chandler MP |
Effects of chronic activation of peroxisome proliferator-activated receptor- or high-fat feeding in a rat infarct model of heart failure |
Am J Physiol Heart Circ Physiol, May 2006; 290: H1899 - H1904 |
3,5 Fr |
rat |
cardiac; left ventricular dysfunction; ceramide; triglycerides; fatty acids |
| Carroll JF, Zenebe WJ, Strange TB |
Cardiovascular Function in a Rat Model of Diet-Induced Obesity |
Hypertension, May 2006; doi:10.1161/01.HYP.0000224147.01024.77 |
SPR-249 |
rat |
hypertrophy • echocardiography • blood pressure • cardiac output • rats • diurnal rhythm |
| Lunde PK, Sejersted OM, Thorud H-MS, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J |
Effects of Congestive Heart Failure on Ca2+ Handling in Skeletal Muscle During Fatigue |
Circ. Res., May 2006; doi:10.1161/01.RES.0000226529.66545.e5 |
SPR-407 |
rat |
skeletal muscle • congestive heart failure • muscle fatigue • Ca2+ |
| Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL |
An Abnormal Mitochondrial–Hypoxia Inducible Factor-1–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension |
Circulation, Jun 2006; 113: 2630 - 2641 |
1.4F Millar catheters |
rat |
Serial Doppler echocardiograms |
| Lunde PK, Sejersted OM, Thorud H-MS, Tønnessen T, Henriksen UL, Christensen G, Westerblad H, Bruton J |
Effects of Congestive Heart Failure on Ca2+ Handling in Skeletal Muscle During Fatigue |
Circ. Res., Jun 2006; 98: 1514 - 1519 |
SPR-407 |
rat |
skeletal muscle • congestive heart failure • muscle fatigue • Ca2+ |
| Sekine H, Shimizu T, Yang J, Kobayashi E, Okano T |
Pulsatile myocardial tubes fabricated with cell sheet engineering |
Circulation 2006;114;87-93 |
SPR-320 |
rat |
cardiac tube cell sheet transplantation |
| Okere IC, Chandler MP, McElfresh TA, Rennison JH, Sharov V, Sabbah HN, Tserng K-Y, Hoit BD,Ernsberger P, Young ME, Stanley WC |
Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin |
Am J Physiol Heart Circ Physiol, Jul 2006; 291: H38 - H44 |
3.5-Fr pressure transducer |
rat |
ceramide; fatty acids; heart; lipotoxicity; mitochondria; obesity |
| Dean SA, Tan J, White R, O’Brien ER, Leenen FHH |
Regulation of components of the brain and cardiac renin-angiotensin systems by 17β-estradiol after myocardial infarction in female rats |
Am J Physiol Regulatory Integrative Comp Physiol, Jul 2006; 291: R155 - R162 |
SPR-407 |
rat |
ovariectomy; heart failure; estrogens |
| Sekine H, Shimizu T, Yang J, Kobayashi E, Okano T |
Pulsatile Myocardial Tubes Fabricated With Cell Sheet Engineering |
Circulation, Jul 2006; 114: I-87 - I-93 |
SPR-320 |
rat |
cardiac tube • cell sheet • transplantation |
| Carroll JF, Zenebe WJ, Strange TB |
Cardiovascular Function in a Rat Model of Diet-Induced Obesity |
Hypertension, Jul 2006; 48: 65 - 72 |
SPR-249 |
rat |
hypertrophy • echocardiography • blood pressure • cardiac output • rats • diurnal rhythm |
| Jasmin J-F, Mercier I, Dupuis J, Tanowitz HB, Lisanti MP |
Short-Term Administration of a Cell-Permeable Caveolin-1 Peptide Prevents the Development of Monocrotaline-Induced Pulmonary Hypertension and Right Ventricular Hypertrophy |
Circulation, Aug 2006; 114: 912 - 920 |
SPR-249 |
rat |
pulmonary artery medial hypertrophy |
| Jazbutyte V, Hu K, Kruchten P, Bey E, Maier SKG, Fritzemeier K-H, Prelle K, Hegele-Hartung C, Hartmann RW, Neyses L, Ertl G, Pelzer T |
Aging Reduces the Efficacy of Estrogen Substitution to Attenuate Cardiac Hypertrophy in Female Spontaneously Hypertensive Rats |
Hypertension, Aug 2006; doi:10.1161/01.HYP.0000240053.48517.c7 |
microtip manometer |
rat |
estrogen receptors • cardiac hypertrophy • aging • hypertension |
| Masuyama H, Tsuruda T, Kato J, Imamura T, Asada Y, Stasch J-P, Kitamura K, Eto T |
Soluble Guanylate Cyclase Stimulation on Cardiovascular Remodeling in Angiotensin II-Induced Hypertensive Rats |
Hypertension, Sep 2006; doi:10.1161/01.HYP.0000241087.12492.47 |
SPC-721, TCB-500 |
rat |
hypertension • fibrosis • soluble guanylate cyclase • cGMP • extracellular matrix |
| Kang Y-M, Zhang Z-H, Johnson RF, Yu Y, Beltz T, Johnson AK, Weiss RM, Felder RB |
Novel Effect of Mineralocorticoid Receptor Antagonism to Reduce Proinflammatory Cytokines and Hypothalamic Activation in Rats With Ischemia-Induced Heart Failure |
Circ. Res., Sep 2006; 99: 758 - 766 |
SPR-671 |
rat |
congestive heart failure • aldosterone • cytokines • cyclooxygenase-2 • nervous system |
| Lourenço AP, Roncon-Albuquerque Jr R, Brás-Silva C, Faria B, Wieland J, Henriques-Coelho T, Correia-Pinto J, Leite-Moreira AF |
Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1587 - H1594 |
SPR-407 |
rat |
gene expression; myocardial contractility; neuroendocrine stimulation; endothelin |
| Li J, Coven DL, Miller EJ, Hu X, Young ME, Carling D, Sinusas AJ, Young LH |
Activation of AMPK α- and γ-isoform complexes in the intact ischemic rat heart |
Am J Physiol Heart Circ Physiol, Oct 2006; 291: H1927 - H1934 |
transmyocardial Millar 1.5-F pressure transducer |
rat |
adenosine monophosphate-activated protein kinase; ischemia; subunits; isoforms |
| Thai H, Castellano L, Juneman E, Phan H, Do R, Gaballa MA, Goldman S |
Pretreatment With Angiotensin Receptor Blockade Prevents Left Ventricular Dysfunction and Blunts Left Ventricular Remodeling Associated With Acute Myocardial Infarction |
Circulation, Oct 2006; 114: 1933 - 1939 |
1-mm micromanometer-tipped catheter |
rat |
candesartan |
| Jazbutyte V, Hu K, Kruchten P, Bey E, Maier SKG, Fritzemeier K-H, Prelle K, Hegele-Hartung C, Hartmann RW, Neyses L, Ertl G, Pelzer T |
Aging Reduces the Efficacy of Estrogen Substitution to Attenuate Cardiac Hypertrophy in Female Spontaneously Hypertensive Rats |
Hypertension, Oct 2006; 48: 579 - 586 |
microtip manometer |
rat |
estrogen receptors • cardiac hypertrophy • aging • hyperten |
| Wakeno M, Minamino T, Seguchi O, Okazaki H, Tsukamoto O, Okada K, Hirata A, Fujita M, Asanuma H, Kim J, Komamura K, Takashima S, Mochizuki N, Kitakaze M |
Long-Term Stimulation of Adenosine A2b Receptors Begun After Myocardial Infarction Prevents Cardiac Remodeling in Rats |
Circulation, Oct 2006; 114: 1923 - 1932 |
3.5F Millar pressure catheter |
rat |
hypertrophy of cardiomyocytes, heart failure |
| Masuyama H, Tsuruda T, Kato J, Imamura T, Asada Y, Stasch J-P, Kitamura K, Eto T |
Soluble Guanylate Cyclase Stimulation on Cardiovascular Remodeling in Angiotensin II–Induced Hypertensive Rats |
Hypertension, Nov 2006; 48: 972 - 978 |
SPC-721, TCB-500 |
rat |
hypertension • fibrosis • soluble guanylate cyclase • cGMP • extracellular matrix |
| Chang K-C, Hsu K-L, Tseng C-D, Lin Y-D, Cho Y-L, Tseng Y-Z |
Aminoguanidine prevents arterial stiffening and cardiac hypertrophy in streptozotocin-induced diabetes in rats |
British Journal of Pharmacology 147, 944 - 950 (01 Apr 2006) |
SPC-320 |
rat |
Advanced glycation endproducts, aminoguanidine, aortic input impedance, streptozotocin-diabetic rats, pulse wave reflection |
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| Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG |
S100B Expression Modulates Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2005;111:598-606 |
Millar microtip catheter transducer |
mouse |
hypertrophy • proteins • myocardial infarction • apoptosis • remodeling |
| Chiu H-C, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE |
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy |
Circulation Research. 2005;96:225 |
1.4 Fr micromanometer catheter |
mouse |
lipids • metabolism • cardiomyopathy |
| Finsen AV, Christensen G, Sjaastad I |
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse |
J Appl Physiol 98: 680-689, 2005 |
SPR-671 |
mouse |
hemodynamic measurements; left ventricular function; heart failure |
| Ozerdem U, Hargens AR |
A simple method for measuring intersitial fluid pressure in cancer tissues |
Microvascular Research 70 (2005) 116 – 120 |
SPC-320, TC-510 |
mouse |
| cancer, pericyte, NG2, interstitial, fluid, pressure, targeting, wick-in-needle |
|
| Jones SP, Greer JJM, Ware PD, Yang Y, Walsh K, Lefer DJ |
Deficiency of iNOS does not attenuate severe congestive heart failure in mice |
Am J Physiol Heart Circ Physiol 288: H365-H370, 2005 |
SPR-671 |
mouse |
myocardial infarction; nitric oxide; physiology; inducible nitric oxide synthase |
| Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG |
S100B Expression Modulates Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2005;111:598-606 |
Millar microtip catheter transducer |
mouse |
hypertrophy • proteins • myocardial infarction • apoptosis • remodeling |
| Chiu H-C, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE |
Transgenic Expression of Fatty Acid Transport Protein 1 in the Heart Causes Lipotoxic Cardiomyopathy |
Circulation Research. 2005;96:225 |
1.4 Fr micromanometer catheter |
mouse |
lipids • metabolism • cardiomyopathy |
| Finsen AV, Christensen G, Sjaastad I |
Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse |
J Appl Physiol 98: 680-689, 2005 |
SPR-671 |
mouse |
hemodynamic measurements; left ventricular function; heart failure |
| Segers P, Georgakopoulos D, Afanasyeva M, Champion HC, Judge DP, Millar HD, Verdonck P, Kass DA, Stergiopulos N, Westerhof N |
Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice |
Am J Physiol Heart Circ Physiol, Mar 2005; 288: H1157 - H1164 |
catheter with a dual-pressure sensor |
mouse |
hemodynamics; augmentation index; windkessel; arterial stiffness; compliance; ventriculovascular coupling |
| Nassar R, Malouf NN, Mao L, Rockman HA, Oakeley AE, Frye JR, Herlong JR, Sanders SP, Anderson PAW |
cTnT1, a cardiac troponin T isoform, decreases myofilament tension and affects the left ventricular pressure waveform |
Am J Physiol Heart Circ Physiol, Mar 2005; 288: H1147 - H1156 |
1.4-Fr micromanometer catheter |
mouse |
thin filaments; transgenic mice; ventricular function; myocardium |
| Xiao C-Y, Chen M, Zsengellér Z, Li H, Kiss L, Kollai M, Szabó C |
Poly(ADP-Ribose) Polymerase Promotes Cardiac Remodeling, Contractile Failure, and Translocation of Apoptosis-Inducing Factor in a Murine Experimental Model of Aortic Banding and Heart Failure |
JPET 312:891-898, 2005 |
1.4F |
mouse |
hypertrophy, mouse |
| Kuzume K, Kuzume K, Cao Z, Liu L, Van Winkle DM |
Long-term infusion of Met5-enkephalin fails to protect murine hearts against ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1717 - H1723 |
SPR-671 |
mouse |
infarction; ischemic preconditioning; myocardial; peptides; opioid |
| Royer A, van Veen TAB, Le Bouter S, Marionneau C, Griol-Charhbili V, Léoni A-L, Steenman M, van Rijen HVM, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JMT, Grace AA, Escande D, Charpentier F |
Mouse Model of SCN5A-Linked Hereditary Lenègre’s Disease: Age-Related Conduction Slowing and Myocardial Fibrosis |
Circulation, Apr 2005; 111: 1738 - 1746 |
Mikrotip 1.4F |
mouse |
conduction • ion channels • remodeling |
| Hayashida K, Fujita J, Miyake Y, Kawada H, Ando K, Ogawa S, Fukuda K |
Bone Marrow-Derived Cells Contribute to Pulmonary Vascular Remodeling in Hypoxia-Induced Pulmonary Hypertension |
Chest, May 2005; 127: 1793 - 1798 |
SPR-671 |
mouse |
bone marrow transplantation • hypoxia • myofibroblast • progenitor cell • pulmonary hypertension • vascular remodeling |
| Sebag IA, Handschumacher MD, Ichinose F, Morgan JG, Hataishi R, Rodrigues ACT, Guerrero JL, Steudel W, Raher MJ, Halpern EF, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M |
Quantitative Assessment of Regional Myocardial Function in Mice by Tissue Doppler Imaging: Comparison With Hemodynamics and Sonomicrometry |
Circulation, May 2005; 111: 2611 - 2616 |
1.4F high-fidelity micromanometer catheter |
mouse |
echocardiography • systole • inotropic agents |
| Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H |
Postinfarction Gene Therapy Against Transforming Growth Factor-ß Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure |
Circulation, May 2005; 111: 2430 - 2437 |
SPR-407 |
mouse |
heart failure • gene therapy • myocardial infarction • transforming growth factors |
| Katada J, Meguro T, Saito H, Ohashi A, Anzai T, Ogawa S, Yoshikawa T |
Persistent Cardiac Aldosterone Synthesis in Angiotensin II Type 1A Receptor–Knockout Mice After Myocardial Infarction |
Circulation, May 2005; 111: 2157 - 2164 |
1.4F high-fidelity catheter |
mouse |
myocardial infarction • remodeling • angiotensin |
| Gao X-M, Kiriazis H, Moore X-L, Feng X-H, Sheppard K, Dart A, Du X-J |
Regression of pressure overload-induced left ventricular hypertrophy in mice |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2702 - H2707 |
1.4-Fr Millar catheter |
mouse |
aortic banding; cardiac function/remodeling; model |
| Moshal KS, Tyagi N, Henderson B, Ovechkin AV, Tyagi SC |
Protease-activated receptor and endothelial-myocyte uncoupling in chronic heart failure |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2770 - H2777 |
pressure-tipped Millar catheter |
mouse |
proteomics; shedding; nitric oxide; NADPH oxidase; cardiac ring; contraction; relaxation; dilatation; matrix metalloproteinase; nitrotyrosine; tissue inhibitors of metalloproteinase; coupling |
| Barandon L, Dufourcq P, Costet P, Moreau C, Allières C, Daret D, Dos Santos P, Lamazière J-M, Couffinhal T, Duplàa C |
Involvement of FrzA/sFRP-1 and the Wnt/Frizzled Pathway in Ischemic Preconditioning |
Circ. Res., Jun 2005; 96: 1299 - 1306 |
1.4 Fr microtipped transducer |
mouse |
animal models of human disease • cell signaling/signal transduction • genetically-altered mice • ischemia • heart |
| Zhao X, He G, Chen Y-R, Pandian RP, Kuppusamy P, Zweier JL |
Endothelium-Derived Nitric Oxide Regulates Postischemic Myocardial Oxygenation and Oxygen Consumption by Modulation of Mitochondrial Electron Transport |
Circulation, Jun 2005; 111: 2966 - 2972 |
SPR-261 |
mouse |
nitric oxide • enzymes • free radicals • reperfusion • ischemia |
| Song Y, Jones JE, Beppu H, Keaney Jr JF, Loscalzo J, Zhang Y-Y |
Increased Susceptibility to Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice |
Circulation, Jul 2005; 112: 553 - 562 |
1.4F Millar Mikro-Tip pressure catheter |
mouse |
inflammation • hypertension, pulmonary • vasoconstriction • bone morphogenetic proteins • thromboxane |
| Qianli Yu, Ronald R. Watson, John J. Marchalonis, and Douglas F. Larson |
A role for T lymphocytes in mediating cardiac diastolic function |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H643 - H651 |
1.4-Fr |
mouse |
LP-BM5 retrovirus; T-helper cell; cardiac fibroblast; extracellular matrix; collagen types I and III; T helper 1; T helper 2; cross-linking; T-cell receptor peptide |
| Woldbæk PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T |
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H708 - H714 |
SPR-671 |
mouse |
cytokines; heart failure; contractile function; calcium |
| Gaussin V, Morley GE, Cox L, Zwijsen A, Vance KM, Emile L, Tian Y, Liu J, Hong C, Myers D, Conway SJ, Depre C, Mishina Y, Behringer RR, Hanks MC, Schneider MD, Huylebroeck D, Fishman GI, Burch JBE, Vatner SF |
Alk3/Bmpr1a Receptor Is Required for Development of the Atrioventricular Canal Into Valves and Annulus Fibrosus |
Circ. Res., Aug 2005; 97: 219 - 226 |
1.4F micromanometer catheter |
mouse |
bone morphogenetic protein signaling • heart development • atrioventricular canal • Cre-lox system |
| Ikeuchi M, Matsusaka H, Kang D, Matsushima S, Ide T, Kubota T, Fujiwara T, Hamasaki N, Takeshita A, Sunagawa K, Tsutsui H |
Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction |
Circulation, Aug 2005; 112: 683 - 690 |
1.4F micromanometer-tipped catheter |
mouse |
free radicals • genes • heart failure • myocardial infarction • remodeling |
| Patel JB, Valencik ML, Pritchett AM,Burnett Jr JC, McDonald JA, Redfield MM |
Cardiac-specific attenuation of natriuretic peptide A receptor activity accentuates adverse cardiac remodeling and mortality in response to pressure overload |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H777 - H784 |
1.4-Fr manometer-tipped catheter |
mouse |
natriuretic peptides; diastole; hypertrophy; fibrosis |
| Bridgman P, Aronovitz MA, Kakkar R, Oliverio MI, Coffman TM, Rand WM, Konstam MA, Mendelsohn ME, Patten RD |
Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor |
Am J Physiol Heart Circ Physiol 289: H586-H592, 2005 |
1.4-Fr micro-tip pressure transducer |
mouse |
angiotensin II receptors; ventricular remodeling; myocyte; hypertrophy |
| van den Bos EJ, Mees BME, de Waard MC, de Crom R, Duncker DJ |
A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1291 - H1300 |
1.4-Fr Millar catheter |
mouse |
heart function; cardiac remodeling; echocardiography |
| Gutstein DE, Danik SB, Lewitton S, France D, Liu F, Chen FL, Zhang J, Ghodsi N, Morley GE, Fishman GI |
Focal gap junction uncoupling and spontaneous ventricular ectopy |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1091 - H1098 |
1.4-Fr Mikro-Tip catheter pressure transducer |
mouse |
connexin43; ventricular dysfunction; chimera |
| Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP |
Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1209 - H1217 |
catheter |
mouse |
catheter |
| Kiriazis HK, Du X-J, Feng X, Hotchkin E, Marshall T, Finch S, Gao X-M, Lambert G, Choate JK, Kaye DM |
Preserved left ventricular structure and function in mice with cardiac sympathetic hyperinnervation |
Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1359 - H1365 |
1.4-Fr Millar Mikro-Tip catheter |
mouse |
echocardiography; myocardial contraction; catecholamine; transgenic; nerve growth factor |
| Boudina S, Sena S, O’Neill BT, Tathireddy P, Young ME, Abel ED |
Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity |
Circulation, Oct 2005; 112: 2686 - 2695 |
Millar transducer |
mouse |
myocardial oxygen consumption, reduced cardiac efficiency |
| Limana F, Germani A, Zacheo A, Kajstura J, Di Carlo A, Borsellino G, Leoni O, Palumbo R, Battistin L, Rastaldo R, Müller S, Pompilio G, Anversa P, Bianchi ME, Capogrossi MC |
Exogenous High-Mobility Group Box 1 Protein Induces Myocardial Regeneration After Infarction via Enhanced Cardiac C-Kit+ Cell Proliferation and Differentiation |
Circ. Res., Oct 2005; 97: e73 - e83 |
Millar 1.4F |
mouse |
myocardial infarction • regeneration • stem cells • cytokines |
| Kato T, Muraski J, Chen Y, Tsujita Y, Wall J, Glembotski CC, Schaefer E, Beckerle M, Sussman MA |
Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt |
J. Clin. Invest., Oct 2005; 115: 2716 - 2730 |
Millar transducer |
mouse |
cardioprotective stimuli |
| Arteaga GM, Warren CM, Milutinovic S, Martin AF, Solaro RJ |
Specific enhancement of sarcomeric response to Ca2+ protects murine myocardium against ischemia-reperfusion dysfunction |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H2183 - H2192 |
SPR-671, TCB-500 |
mouse |
troponin I; calcium sensitizers; phosphorylation; stunning; cross bridge-dependent activation |
| Matsusaka H, Ikeuchi M, Matsushima S, Ide T, Kubota T, Feldman AM, Takeshita A, Sunagawa K, Tsutsui H |
Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Nov 2005; 289: H1858 - H1864 |
1.4-Fr micromanometer-tipped catheter |
mouse |
metalloproteinases; heart failure; tumor necrosis factor |
| Zhai P, Yamamoto M, Galeotti J, Liu J, Masurekar M, Thaisz J, Irie K, Holle E, Yu X, Kupershmidt S, Roden DM, Wagner T, Yatani A, Vatner DE, Vatner SF, Sadoshima J |
Cardiac-specific overexpression of AT1 receptor mutant lacking Gαq/Gαi coupling causes hypertrophy and bradycardia in transgenic mice |
J. Clin. Invest., Nov 2005; 115: 3045 - 3056 |
1.4-French (Millar Instruments Inc.) catheter-tip micromanometer catheter, EPR-800 |
mouse |
heterotrimeric G protein–dependent |
| Liu Y-H, Carretero OA, Cingolani OH, Liao T-D, Sun Y, Xu J, Li LY, Pagano PJ, Yang JJ, Yang X-P |
Role of inducible nitric oxide synthase in cardiac function and remodeling in mice with heart failure due to myocardial infarction |
Am J Physiol Heart Circ Physiol, Dec 2005; 289: H2616 - H2623 |
4-Fr. micromanometer pressure catheter |
mouse |
oxidative stress; reactive oxygen species; ejection time |
| Ovechkin AV, Tyagi N, Rodriguez WE, Hayden MR, Moshal KS, Tyagi SC |
Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in mice |
J Appl Physiol, Dec 2005; 99: 2398 - 2405 |
pressure-tipped Millar catheter |
mouse |
arteriovenous fistula; endocardial dysfunction; extracellular matrix remodeling; terminal deoxynucleotidyl nick-end labeling; connexin-43; protease-activated receptors-1; a disintegrin and metalloproteinase-12; congestive heart failure |
| Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV |
Phospholipase C Modulates ß-Adrenergic Receptor– Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy |
Circ. Res., Dec 2005; 97: 1305 - 1313 |
Millar pressure transducer |
mouse |
phospholipase C • ß-adrenergic receptor • heart failure • contractility |
| Ditting T, Hilgers KF, Scrogin KE, Stetter A, Linz P, Veelken R |
Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats |
Am J Physiol Heart Circ Physiol 288: H541-H552, 2005 |
SPC-320 |
rat |
cardiac afferent C fiber; renal sympathetic nerve activity; cardiorenal reflexes |
| Wang Y, Liu X-F, Cornish KG, Zucker IH, Patel KP |
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure |
Am J Physiol Heart Circ Physiol 288: H205-H213, 2005 |
3.5-F catheter transducer |
rat |
oligonucleotides; gene expression; sympathetic nerve activity |
| Ditting T, Hilgers KF, Scrogin KE, Stetter A, Linz P, Veelken R |
Mechanosensitive cardiac C-fiber response to changes in left ventricular filling, coronary perfusion pressure, hemorrhage, and volume expansion in rats |
Am J Physiol Heart Circ Physiol 288: H541-H552, 2005 |
SPC-320 |
rat |
cardiac afferent C fiber; renal sympathetic nerve activity; cardiorenal reflexes |
| Izumiyama H, Tanaka H, Egi K, Sunamori M, Hirata Y, Shichiri M |
Synthetic Salusins as Cardiac Depressors in Rat |
Hypertension, Mar 2005; 45: 419 - 425 |
Millar Microtip catheter pressure transducer system |
rat |
cardiac output • heart rate • blood pressure • vascular resistance |
| Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, Stewart DJ |
Rescue of Monocrotaline-Induced Pulmonary Arterial Hypertension Using Bone Marrow–Derived Endothelial-Like Progenitor Cells: Efficacy of Combined Cell and eNOS Gene Therapy in Established Disease |
Circ. Res., Mar 2005; 96: 442 - 450 |
3F Millar microtip catheter |
rat |
progenitor cells • pulmonary hypertension • endothelium • endothelial nitric oxide synthase |
| Lou H, Danelisen I, Singal PK |
Involvement of mitogen-activated protein kinases in adriamycin-induced cardiomyopathy |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1925 - H1930 |
SPR-249 |
rat |
dilated cardiomyopathy; oxidative stress and apoptosis |
| Shao Q, Ren B, Saini HK, Netticadan T, Takeda N, Dhalla NS |
Sarcoplasmic reticulum Ca2+ transport and gene expression in congestive heart failure are modified by imidapril treatment |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1674 - H1682 |
SPR-249 |
rat |
myocardial infarction; cardiac gene expression; renin-angiotensin system |
| Pourdjabbar A, Parker TG, Nguyen QT, Desjardins J-F, Lapointe N, Tsoporis JN, Rouleau J-L |
Effects of pre-, peri-, and postmyocardial infarction treatment with losartan in rats: effect of dose on survival, ventricular arrhythmias, function, and remodeling |
Am J Physiol Heart Circ Physiol, Apr 2005; 288: H1997 - H2005 |
microtip catheter transducer |
rat |
angiotensin II receptor blockers; heart failure; infarction; remodeling; hypotension |
| Thomas TA, Kuzman JA, Anderson BE, Andersen SMK, Schlenker EH, Holder MS, Gerdes AM |
Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure |
Am J Physiol Heart Circ Physiol, May 2005; 288: H2118 - H2122 |
Millar Mikro-tip catheter |
rat |
shape; ventricular remodeling; wall stress; myosin ratio |
| Huang BS, Leenen FHH |
Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI |
Am J Physiol Heart Circ Physiol, May 2005; 288: H2491 - H2497 |
SPC-350 |
rat |
myocardial infarction; cardiac dysfunction; aldosterone |
| Huang BS, Leenen FHH |
Blockade of brain mineralocorticoid receptors or Na+ channels prevents sympathetic hyperactivity and improves cardiac function in rats post-MI |
Am J Physiol Heart Circ Physiol 288: H2491-H2497, 2005 |
SPR-407 |
rat |
myocardial infarction; cardiac dysfunction; aldosterone |
| Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, Diz DI, Gallagher PE |
Effect of Angiotensin-Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin-Converting Enzyme 2 |
Circulation, May 2005; 111: 2605 - 2610 |
SPR-671 |
rat |
angiotensin • receptors • inhibitors • genetics • myocardium |
| Sakaguchi G, Tambara K, Sakakibara Y, Ozeki M, Yamamoto M, Premaratne G, Lin X, Hasegawa K, Tabata Y, Nishimura K, Komeda M |
Control-Released Hepatocyte Growth Factor Prevents the Progression of Heart Failure in Stroke-Prone Spontaneously Hypertensive Rats |
Ann. Thorac. Surg., May 2005; 79: 1627 - 1634 |
2F micromanometer-tipped catheter |
rat |
hydrogel sheet |
| Shao Q, Ren B, Elimban V, Tappia PS, Takeda N, Dhalla NS |
Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2637 - H2646 |
SPR-249 |
rat |
cardiac sarcolemma; Na+-K+-ATPase isoforms; cardiac gene expression; congestive heart failure; angiotensin-converting enzyme inhibitors |
| Thukkani AK, Martinson BD, Albert CJ, Vogler GA, Ford DA |
Neutrophil-mediated accumulation of 2-ClHDA during myocardial infarction: 2-ClHDA-mediated myocardial injury |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2955 - H2964 |
6-F pressure-transducer catheter |
rat |
2-chlorohexadecanal; myeloperoxidase; ischemia; fatty aldehyde |
| Waller C, Engelhorn T, Hiller K-H, Heusch G, Ertl G, Bauer WR, Schulz R |
Impaired resting perfusion in viable myocardium distal to chronic coronary stenosis in rats |
Am J Physiol Heart Circ Physiol, Jun 2005; 288: H2588 - H2593 |
micromanometer |
rat |
ischemic cardiomyopathy; necrosis |
| Gao L, Schultz HD, Patel KP, Zucker IH, Wang W |
Augmented Input From Cardiac Sympathetic Afferents Inhibits Baroreflex in Rats With Heart Failure |
Hypertension, Jun 2005; 45: 1173 - 1181 |
SPR-524 |
rat |
baroreflex • cardiac function • heart failure • reflex • renal nerves • sympathetic nervous system |
| McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S, Puttagunta L, Michelakis ED |
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension |
J. Clin. Invest., Jun 2005; 115: 1479 - 1491 |
high-fidelity Millar catheters |
human, rat |
bone morphogenetic protein axis, vascular mitochondria-dependent apoptosis |
| Wang X, Sentex E, Saini HK, Chapman D, Dhalla NS |
Upregulation of β-adrenergic receptors in heart failure due to volume overload |
Am J Physiol Heart Circ Physiol, Jul 2005; 289: H151 - H159 |
SPR-249 |
rat |
β-adrenoceptors; congestive heart failure; G protein-coupled receptor kinase; renin-angiotensin system blockade |
| Campbell KB, Wu Y, Simpson AM, Kirkpatrick RD, Shroff SG, Granzier HL, Slinker BK |
Dynamic myocardial contractile parameters from left ventricular pressure-volume measurements |
Am J Physiol Heart Circ Physiol, Jul 2005; 289: H114 - H130 |
3-Fr catheter-tip Millar pressure transducer |
rat |
heart function; muscle; mathematical model; cardiac fiber; force |
| Chicco AJ, Schneider CM, Hayward R |
Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart |
Am J Physiol Regulatory Integrative Comp Physiol, Aug 2005; 289: R424 - R431 |
microtip catheter pressure transducer |
rat |
adriamycin; cardioprotection; heart; physical activity; cardiac function |
| Eklund KE, K. Hageman KS, Poole DC, Musch TI |
Impact of aging on muscle blood flow in chronic heart failure |
J Appl Physiol, Aug 2005; 99: 505 - 514 |
TC-510 |
rat |
myocardial infarction; exercise; fiber type; left ventricular dysfunction; exercise hyperemia |
| Tambara K, Premaratne GU, Sakaguchi G, Kanemitsu N, Lin X, Nakajima H, Sakakibara Y, Kimura Y, Yamamoto M, Tabata Y, Ikeda T, Komeda M |
Administration of Control-Released Hepatocyte Growth Factor Enhances the Efficacy of Skeletal Myoblast Transplantation in Rat Infarcted Hearts by Greatly Increasing Both Quantity and Quality of the Graft |
Circulation, Aug 2005; 112: I-129 - I-134 |
2 F micromanometer-tipped catheter |
rat |
apoptosis • cells • muscles • myocardial infarction • transplantation |
| Nagaya N, Kangawa K, Itoh T, Iwase T, SMurakami S, Miyahara Y, Fujii T, Uematsu M, Ohgushi H, Yamagishi M, Tokudome T, Mori H, Miyatake K, Kitamura S |
Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy |
Circulation, Aug 2005; 112: 1128 - 1135 |
1.5F micromanometer-tipped catheter |
rat |
myocardial fibrosis |
| Lekgabe ED, Kiriazis H, Zhao C, Xu Q, Moore XL, Su Y, Bathgate RAD, Du X-J, Samuel CS |
Relaxin Reverses Cardiac and Renal Fibrosis in Spontaneously Hypertensive Rats |
Hypertension, Aug 2005; 46: 412 - 418 |
2Fr Millar catheter |
rat |
rats • extracellular matrix • remodeling • fibrosis |
| Souzeau E, Bélanger S, Picard S, Deschepper CF |
Dietary isoflavones during pregnancy and lactation provide cardioprotection to offspring rats in adulthood |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H715 - H721 |
Fr-2 single sensor pressure catheter (2F) |
rat |
phytoestrogen; dilated ventricular hypertrophy; neonatal exposure; congestive heart failure; isolated adult rat cardiomyocytes |
| Phillipson A, Peterman EE, Taormina Jr P, Harvey M, Brue RJ, Atkinson N, Omiyi D, Chukwu U, Young LH |
Protein kinase C- inhibition exerts cardioprotective effects in ischemia-reperfusion injury |
Am J Physiol Heart Circ Physiol, Aug 2005; 289: H898 - H907 |
SPR-524 |
rat |
neutrophils; superoxide radicals; left ventricular developed pressure; endothelial dysfunction |
| Omiyi D, Brue RJ, Taormina II P, Harvey M, Atkinson N, Young LH |
Protein Kinase Cβ II Peptide Inhibitor Exerts Cardioprotective Effects in Rat Cardiac Ischemia/Reperfusion Injury |
JPET 314:542-551, 2005 |
SPR-524 |
rat |
polymorphonuclear leukocytes |
| Slama M, Ahn J, Peltier M, Maizel J, Chemla D, Varagic J, Susic D, Tribouilloy C, Frohlich ED |
Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats |
Am J Physiol Heart Circ Physiol, Sep 2005; 289: H1131 - H1136 |
catheter-tipped transducer |
rat |
spontaneously hypertensive rats; diastolic function; left ventricle; echocardiography |
| Supinski GS, Callahan LA |
Diaphragmatic free radical generation increases in an animal model of heart failure |
J Appl Physiol, Sep 2005; 99: 1078 - 1084 |
microtip catheter |
rat |
oxidative stress |
| Partovian C, Zhuang Z, Moodie K, Lin M, Ouchi N, Sessa WC, Walsh K, Simons M |
PKα Activates eNOS and Increases Arterial Blood Flow In Vivo |
Circ. Res., Sep 2005; 97: 482 - 487 |
Millar transducer |
rat |
protein kinase C • blood flow • nitric oxide synthase • endothelial cells |
| Malhotra A, Begley R, Kang BPS, Rana I, Liu J, Yang G, Mochly-Rosen D, Meggs LG |
PKC-ε-dependent survival signals in diabetic hearts |
Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1343 - H1350 |
SPR-671 |
|
hyperglycemia; diabetes mellitus; protein kinase C; isozymes; translocation activator; cardioprotection |
| Thorud H-MS, Verburg E, Lunde PK, Strømme TA, Sjaastad I, Sejersted OM |
Temperature-dependent skeletal muscle dysfunction in rats with congestive heart failure |
J Appl Physiol, Oct 2005; 99: 1500 - 1507 |
SPR-407 |
rat |
soleus muscle |
| Xu J, Nagata K, Obata K, Ichihara S, Izawa H, Noda A, Nagasaka T, Iwase M, Naoe T, Murohara T, Yokota M |
Nicorandil Promotes Myocardial Capillary and Arteriolar Growth in the Failing Heart of Dahl Salt-Sensitive Hypertensive Rats |
Hypertension, Oct 2005; 46: 719 - 724 |
SPR-407 |
rat |
endothelial growth factors • fibroblast growth factor • potassium channels • heart failure |
| Zakrzeska A, Schlicker E, Kwolek G, Kozowska H, Malinowska B |
Positive inotropic and lusitropic effects mediated via the low-affinity state of β1-adrenoceptors in pithed rats |
British Journal of Pharmacology 146, 760 - 768 (01 Nov 2005) |
SPR-407 |
rat |
Pithed rat, positive chronotropic effect, positive inotropic effect, positive lusitropic effect, low-affinity state of b1-adrenoceptor, mesenteric blood flow, CGP 12177, cyanopindolol, CGP 20712A, bupranolol |
| Saini HK, Shao Q, Musat S, Takeda N, Tappia PS, Dhalla NS |
Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction |
British Journal of Pharmacology 144, 202 - 211 (01 Jan 2005) |
SPR-249 |
rat |
ATP-mediated responses, congestive heart failure, isolated cardiomyocytes, intracellular calcium, angiotensin blockade |
| Ke Q, Yang Y, Rana JS, Chen Y, Morgan JP, Xiao Y-F |
Embryonic stem cells cultured in biodegradable scaffold repair infarcted myocardium in mice |
Acta Physiologica Sinica, December 25, 2005, 57 (6): 673-681 |
pressure transducer |
mouse |
myocardial infarction; embryonic stem cell; scaffold; patch; cardiac repair |
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---------------------------------------------Published in 2004---------------------------------------------
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| Diwan A, Dibbs Z, Nemoto S, DeFreitas G, Carabello BA, Sivasubramanian N, Wilson EM, Spinale FG, Mann DL |
Targeted Overexpression of Noncleavable and Secreted Forms of Tumor Necrosis Factor Provokes Disparate Cardiac Phenotypes |
Circulation. 2004;109:262-268 |
1.4F Mikro-Tip catheter |
mouse |
hypertrophy • remodeling • metalloproteinases |
| Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M |
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency |
Am J Physiol Heart Circ Physiol 286:H1070-H1075, 2004 |
1.4F Mikro-Tip catheter |
mouse |
hert failure; remodeling |
| Shiomi T, Tsutsui H, Matsusaka H, Murakami K, Hayashidani S, Ikeuchi M, Wen J, Kubota T, Utsumi H, Takeshita A |
Overexpression of Glutathione Peroxidase Prevents Left Ventricular Remodeling and Failure After Myocardial Infarction in Mice |
Circulation. 2004;109:544-549 |
1.4F Mikro-Tip catheter |
mouse |
myocardial infarction • heart failure • remodeling • antioxidants • free radicals |
| van Rooij E, Doevendans PA, Crijns HJGM, Heeneman S, Lips DJ, van Bilsen M, Williams RS, Olson EN, Bassel-Duby R, Rothermel BA, De Windt LJ |
MCIP1 Overexpression Suppresses Left Ventricular Remodeling and Sustains Cardiac Function After Myocardial Infarction |
Circulation Research. 2004;94:e18 |
1.4F Mikro-Tip catheter |
mouse |
myocardial infarction • heart failure • calcineurin • signaling • hypertrophy |
| Wang Q, Brunner HR, Burnier M |
Determination of cardiac contractility in awake unsedated mice with a fluid-filled catheter |
Am J Physiol Heart Circ Physiol 286: H806-H814, 2004 |
1.4F Mikro-Tip catheter |
mouse |
anesthesia; Millar; Pebax catheter; frequency; deoxycorticosterone acetate-salt |
| Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, Takeshita A |
Long-Term Inhibition of Rho-Kinase Suppresses Left Ventricular Remodeling After Myocardial Infarction in Mice |
Circulation. 2004;109:2234-2239 |
1.4F Mikro-Tip Catheter |
|
myocardial infarction • heart failure • myocardium • remodeling • signal transduction |
| Janssens S, Pokreisz P, Schoonjans L, Pellens M, Vermeersch P, Tjwa M, Jans P, Scherrer-Crosbie M, Picard MH, Szelid Z, Gillijns H, Van de Werf F, Collen D, Bloch KD |
Cardiomyocyte-Specific Overexpression of Nitric Oxide Synthase 3 Improves Left Ventricular Performance and Reduces Compensatory Hypertrophy After Myocardial Infarction |
Circulation Research. 2004;94:1256 |
1.4F Mikro-Tip Catheter |
mouse |
nitric oxide synthase • myocardial infarction • left ventricular remodeling • myocyte hypertrophy |
| Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH |
Taurine Supplementation Reduces Oxidative Stress and Improves Cardiovascular Function in an Iron-Overload Murine Model |
Circulation. 2004;109:1877-1885 |
1.4F Mikro-Tip Catheter |
mouse |
hemochromatosis • cardiomyopathy • taurine • stress, oxidative • glutathione |
| Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM |
Inhibition of PKC phosphorylation of cTnI improves cardiac performance in vivo |
Am J Physiol Heart Circ Physiol 286: H2089-H2095, 2004 |
1.4F Mikro-Tip Catheter |
mouse |
troponin; protein kinase C; contractility; mouse |
| Yang LL, Gros R, Kabir MG, Sadi A, Gotlieb AI, Husain M, Stewart DJ |
Conditional Cardiac Overexpression of Endothelin-1 Induces Inflammation and Dilated Cardiomyopathy in Mice |
Circulation. 2004;109:255-261 |
1.4F sensor, 2F catheter |
mouse |
endothelin • myocarditis • hypertrophy • heart failure |
| Suarez J, Belke DD, Gloss B, Dieterle T, McDonough PM, Kim Y-K, Brunton LL, Dillmann WH |
In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy |
Am J Physiol Heart Circ Physiol 286: H68-H75, 2004 |
2F Mikro-Tip catheter |
mouse |
calcium handling; gene therapy |
| Schultz JEJ, Glascock BJ, Witt SA, Nieman ML, Nattamai KJ, Liu LH, Lorenz JN, Shull GE, Kimball TR, Periasamy M |
Accelerated onset of heart failure in mice during pressure overload with chronically deceased SERCA2 calcium pump activity |
|
Mikro-Tip catheter |
mouse |
sarco(endo)plasmic reticulum calcium-adenosine 5'-triphosphatase pump; knockout mice; echocardiography; cardiac dysfunction |
| Abella BS, Zhao D, Alvarado J, Hamann K, Vanden Hoek TL, Becker LB |
Intra-Arrest Cooling Improves Outcomes in a Murine Cardiac Arrest Model |
Circulation. 2004;109:2786-2791 |
SPR-671 |
mouse |
cardiopulmonary resuscitation • heart arrest • death, sudden • circulation |
| Ishizaka S, Sievers RE, Zhu B-Q, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W |
New technique for measurement of left ventricular pressure in conscious mice |
Am J Physiol Heart Circ Physiol 286: H1146-h1153, 2004 |
SPR-671 |
mouse |
left ventricular hemodynamics; first derivative of left ventricular pressure; anesthesia; mouse physiology |
| Jones SP, Greer JJM, Kakkar AK, Ware D, Turnage RH, Hicks M, van Haperen R, de Crom R, Kawashima S, Yokoyama M, Lefer DJ |
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury |
Am J Physiol Heart Circ Physiol 286: H276-H282, 2004 |
SPR-671 |
mouse |
myocardial infarction; cardiac dysfunction; murine model |
| Chen H, Liu LL, Ye LL, McGuckin C, Tamowski S, Scowen P, Tian H, Murray K, Hatton WJ, Duan D |
Targeted Inactivation of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Gene Prevents Ischemic Preconditioning in Isolated Mouse Heart |
Circulation. 2004;110:700-704 |
1.4/0.8F pressure transducer |
mouse |
ischemia • myocardial infarction • hemodynamics • ion channels • genes |
| Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang Y-Y |
Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats |
Am J Physiol Heart Circ Physiol 286: H1775-H1784, 2004 |
1.4-Fr Millar Mikro-Tip pressure catheter |
rat |
inflammation; monocrotaline |
| Bos R, Mougenot N, Médiani O, Vanhoutte PM, Lechat P |
Potassium Canrenoate, an Aldosterone Receptor Antagonist, Reduces Isoprenaline-Induced Cardiac Fibrosis in the Rat |
JPET 309:1160-1166, 2004 |
2F Mikro-Tip Catheter |
rat |
norepinephrine |
| Kuwahara F; Kai H; Tokuda T; Takeya M; Takeshita A; Egashira K; Imaizumi T |
Hypertensive Myocardial Fibrosis and Diastolic Dysfunction: Another Model of Inflammation? |
Hypertension. 2004;43:73 |
2F Mikro-Tip Catheter |
rat |
macrophages • fibrosis • hypertension • diastole |
| Wang H, Huang BS, Ganten D, Leenen FHH |
Prevention of Sympathetic and Cardiac Dysfunction After Myocardial Infarction in Transgenic Rats Deficient in Brain Angiotensinogen |
Circulation Research. 2004;94:843 |
2F Mikro-Tip Catheter |
rat |
angiotensin • brain • cardiac remodeling • left ventricular dysfunction • arterial baroreflex |
| Hu K, Naumann A, Fraccarollo D, Gaudron P, Kaden JJ, Neubauer S, Ertl G |
Heart rate reduction by zatebradine reduces infarct size and mortality but promotes remodeling in rats with experimental myocardial infarction |
Am J Physiol Heart Circ Physiol 286: H1281-H1288, 2004 |
Mikro-Tip Catheter |
rat |
neurohumoral systems; heart failure; bradycardia |
| Mulder P, Barbier S, Chagraoui A, Richard V, Henry JP; Lallemand F; Renet S; Lerebours G, Mahlberg-Gaudin F, Thuillez C |
Long-Term Heart Rate Reduction Induced by the Selective If Current Inhibitor Ivabradine Improves Left Ventricular Function and Intrinsic Myocardial Structure in Congestive Heart Failure |
Circulation. 2004;109:1674-1679 |
Mikro-Tip Catheter |
rat |
heart failure • heart rate • drugs • pathology |
| Li M, Zheng C, Sato T, Kawada T, Sugimachi M, Sunagawa K |
Vagal Nerve Stimulation Markedly Improves Long-Term Survival After Chronic Heart Failure in Rats |
Circulation. 2004;109:120-124.) |
SPC-320 |
rat |
electrical stimulation • heart failure • myocardial infarction • remodeling • vagus nerve |
| Chen L, Chen CX, Gan XT, Beier N, Scholz, W, Karmazyn M |
Inhibition and reversal of myocardial infarction-induced hypertrophy and heart failure by NHE-1 inhibition |
Am J Physiol Heart Circ Physiol 286: H381-H387, 2004 |
SPR 249 |
rat |
coronary artery ligation; EMD-87580; atrial natriuretic peptide; Na-H exchange |
| Yndestad A, Ueland T, Øie E, Florholmen G, Halvorsen B, Attramadal H, Simonsen S, Frøland S, Gullestad L, Christensen G, Damås JK, Aukrust P |
Elevated Levels of Activin A in Heart Failure |
Circulation. 2004; 109: 1379-1385 |
SPR-407 |
rat |
heart failure • inflammation • leukocytes • myocardium |
| Gao L, Zhu Z, Zucker IH, Wang W |
Cardiac sympathetic afferent stimulation impairs baroreflex control of renal sympathetic nerve activity in rats |
Am J Physiol Heart Circ Physiol 286: H1706-H1711, 2004 |
SPR-524 |
rat |
angiotensin type 1 receptor |
Sándor Bátkai, Pál Pacher, Zoltán Járai, Jens A. Wagner, George
Kunos |
Cannabinoid antagonist SR141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors |
Am J Physiol Heart Circ Physiol (April 1, 2004). 10.1152/ajpheart.00184.2004 |
SPR-524 |
rat |
trangenics, toxemia, pharmaceuticals, endotoxin; cannabinoids; hypotension; negative inotropy |
| Jin H, Fedorowicz G, Yang R, Ogasawara A, Peale F, Pham T, Paoni NF |
Thyrotropin-Releasing Hormone Is Induced in the Left Ventricle of Rats With Heart Failure and Can Provide Inotropic Support to the Failing Heart |
Circulation. 2004;109:2240-2245 |
SPR-629 |
rat |
hormones • heart failure • myocardial infarction • inotropic agents |
| Pearson JT, PhD; Mikiyasu Shirai M, Ito H, Tokunaga N, Tsuchimochi H, Nishiura N; Schwenke DO, Ishibashi-Ueda H, Akiyama R, Mori H, Kangawa K, Suga H, Yagi N |
In Situ Measurements of Crossbridge Dynamics and Lattice Spacing in Rat Hearts by X-Ray Diffraction |
Circulation. 2004;109:2976-2979 |
SPR-671 |
rat |
ischemia • myocardial contraction • myosin • radiography |
| Dent MR, Dhalla NS, Tappia PS |
Phospholipase C gene expression, protein content, and activities in cardiac hypertrophy and heart failure due to volume overload |
Am J Physiol Heart Circ Physiol 287: H719-H727, 2004. |
SPR-249 |
rat |
cardiac sarcolemma; signal transduction |
| Xiao C-Y, Chen M, Zsengellér Z, Szabó C |
Poly(ADP-Ribose) Polymerase Contributes to the Development of Myocardial Infarction in Diabetic Rats and Regulates the Nuclear Translocation of Apoptosis-Inducing Factor |
JPET 310:498-504, 2004 |
SPR-524< |
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